O Schakman

Summary

Country: Belgium

Publications

  1. ncbi Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats
    O Schakman
    Universite Catholique de Louvain, School of Medicine, Diabetes and Nutrition Unit, B 1200 Bruxelles, Belgium
    Endocrinology 149:3900-8. 2008
  2. ncbi Mechanisms of muscle atrophy induced by glucocorticoids
    O Schakman
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, Brussels, Belgium
    Horm Res 72:36-41. 2009
  3. ncbi Role of IGF-I and the TNFα/NF-κB pathway in the induction of muscle atrogenes by acute inflammation
    O Schakman
    Pole of Endocrinology, Diabetes, and Nutrition EDIN, Institut de Recherche Expérimentale et Clinique IREC, Universite Catholique de Louvain, Ave Hippocrate 55 bte B1 55 06, B 1200 Brussels, Belgium
    Am J Physiol Endocrinol Metab 303:E729-39. 2012
  4. ncbi The type 1 insulin-like growth factor receptor (IGF-IR) pathway is mandatory for the follistatin-induced skeletal muscle hypertrophy
    S Kalista
    Pole of Endocrinology, Diabetes, and Nutrition, Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, Avenue Hippocrate 55 bte B1 55 06, B 1200 Brussels, Belgium
    Endocrinology 153:241-53. 2012
  5. ncbi Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy
    H Gilson
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Endocrinology 148:452-60. 2007
  6. ncbi Mechanisms of glucocorticoid-induced myopathy
    O Schakman
    Unite de Diabetologie et Nutrition, Faculte de Medecine, Universite Catholique de Louvain, 54 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Endocrinol 197:1-10. 2008
  7. ncbi Insulin-like growth factor-I gene transfer by electroporation prevents skeletal muscle atrophy in glucocorticoid-treated rats
    O Schakman
    , , 54 Avenue Hippocrate, B-1200 Brussels, Belgium
    Endocrinology 146:1789-97. 2005

Collaborators

Detail Information

Publications7

  1. ncbi Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats
    O Schakman
    Universite Catholique de Louvain, School of Medicine, Diabetes and Nutrition Unit, B 1200 Bruxelles, Belgium
    Endocrinology 149:3900-8. 2008
    ..In conclusion, this work indicates that Akt, GSK-3beta, and beta-catenin probably contribute together to the IGF-I anti-atrophic effect in GC-induced muscle atrophy...
  2. ncbi Mechanisms of muscle atrophy induced by glucocorticoids
    O Schakman
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, Brussels, Belgium
    Horm Res 72:36-41. 2009
    ..CONCLUSIONS: Recent progress in understanding the role of growth factors in GC-induced muscle atrophy allows investigation into new therapies to minimize this myopathy...
  3. ncbi Role of IGF-I and the TNFα/NF-κB pathway in the induction of muscle atrogenes by acute inflammation
    O Schakman
    Pole of Endocrinology, Diabetes, and Nutrition EDIN, Institut de Recherche Expérimentale et Clinique IREC, Universite Catholique de Louvain, Ave Hippocrate 55 bte B1 55 06, B 1200 Brussels, Belgium
    Am J Physiol Endocrinol Metab 303:E729-39. 2012
    ..In conclusion, we show that increased GC production plays a more crucial role than decreased IGF-I and increased TNFα/NF-κB pathway for the induction of the proteolytic systems caused by acute inflammation...
  4. ncbi The type 1 insulin-like growth factor receptor (IGF-IR) pathway is mandatory for the follistatin-induced skeletal muscle hypertrophy
    S Kalista
    Pole of Endocrinology, Diabetes, and Nutrition, Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, Avenue Hippocrate 55 bte B1 55 06, B 1200 Brussels, Belgium
    Endocrinology 153:241-53. 2012
    ..In conclusion, the IGF-IR/Akt/mTOR pathway plays a critical role in FS-induced muscle hypertrophy. In contrast, induction of IGF-II expression and S6K activity by FS are not required for the hypertrophic action of FS...
  5. ncbi Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy
    H Gilson
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Endocrinology 148:452-60. 2007
    ....
  6. ncbi Mechanisms of glucocorticoid-induced myopathy
    O Schakman
    Unite de Diabetologie et Nutrition, Faculte de Medecine, Universite Catholique de Louvain, 54 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Endocrinol 197:1-10. 2008
    ..Promising new therapeutic approaches for treating glucocorticoid-induced muscle atrophy are also presented in this review...
  7. ncbi Insulin-like growth factor-I gene transfer by electroporation prevents skeletal muscle atrophy in glucocorticoid-treated rats
    O Schakman
    , , 54 Avenue Hippocrate, B-1200 Brussels, Belgium
    Endocrinology 146:1789-97. 2005
    ..Our observation supports the important role of decreased muscle IGF-I in the muscle atrophy caused by glucocorticoids...