C Focan

Summary

Affiliation: rue de Hesbaye
Country: Belgium

Publications

  1. ncbi request reprint [A trans-hospital pilot programme for onco-geriatry. The experience of the CHC-Liege]
    C Focan
    Département d Onco Hématologie, CHC Clinique Saint Joseph, Liege, Belgique
    Rev Med Liege 68:110-7. 2013
  2. doi request reprint Evaluation of biological rhythms in elderly cancer patients. A complementary translational research within the frame of the trans-hospital pilot program of oncogeriatrics launched at CHC-Liège
    C Focan
    CHC Clinique Saint Joseph, rue de Hesbaye, 75, 4000 Liege, Belgium Electronic address
    Pathol Biol (Paris) 61:e33-7. 2013
  3. doi request reprint Phase I - II study to assess the feasibility and activity of the triple combination of 5-fluorouracil/folinic acid, carboplatin and irinotecan (CPT-11) administered by chronomodulated infusion for the treatment of advanced colorectal cancer. Final report
    C Focan
    Oncology Department, CHC Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, Belgium Electronic address
    Pathol Biol (Paris) 61:e27-31. 2013
  4. pmc The use of chemotherapy regimens carrying a moderate or high risk of febrile neutropenia and the corresponding management of febrile neutropenia: an expert survey in breast cancer and non-Hodgkin's lymphoma
    Laetitia Gerlier
    Health Economics and Outcomes Research Department, IMS Health Consulting, Medialaan 38, 1800 Vilvoorde, Belgium
    BMC Cancer 10:642. 2010
  5. ncbi request reprint Sequential administration of epirubicin and paclitaxel for advanced breast cancer. A phase I randomised trial
    C Focan
    CHC Clinique Saint Joseph, Liege, Belgium
    Anticancer Res 25:1211-7. 2005
  6. ncbi request reprint [Chronotherapy combining 5-fluorouracil, folinic acid and carboplatin as first line treatment in metastatic colorectal cancer. A phase 2 study]
    C Focan
    Département d oncologie médicale CHC, Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, Belgique
    Pathol Biol (Paris) 53:273-6. 2005
  7. ncbi request reprint [Adjuvant chemotherapy for Dukes B2 and C colon cancer combining 5-fluorouracil and folinic acid with or without carboplatin. Feasibility and comparison between standard and chronomodulated deliveries]
    C Focan
    Departement d Oncologie Medicale, CHC Clinique Saint Joseph, rue de Hesbaye, 75, 4000 Liege, Belgique
    Pathol Biol (Paris) 53:281-4. 2005
  8. ncbi request reprint [Circadian behaviour of host versus tumour outcome. A review]
    C Focan
    Departement de Medecine Interne, Oncologie, CHC Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, Belgique
    Pathol Biol (Paris) 55:178-80. 2007
  9. ncbi request reprint [Interest of chronotherapy in multidisciplinary management of oesophageal and gastric cancers]
    C Focan
    Departement de Medecine Interne, Oncologie, CHC, Clinique Saint Joseph, rue de Hesbaye 75, B 4000 Liege, Belgique
    Pathol Biol (Paris) 55:181-5. 2007
  10. ncbi request reprint High-dose oral medroxyprogesterone acetate or tamoxifen as adjuvant hormone therapy for node-negative early-stage breast cancer: randomized trial with 7-year update
    Christian Focan
    Clinique Saint Joseph, Centre Hospitalier Chretien a Liege, Belgium
    Clin Breast Cancer 5:136-41. 2004

Collaborators

Detail Information

Publications28

  1. ncbi request reprint [A trans-hospital pilot programme for onco-geriatry. The experience of the CHC-Liege]
    C Focan
    Département d Onco Hématologie, CHC Clinique Saint Joseph, Liege, Belgique
    Rev Med Liege 68:110-7. 2013
    ....
  2. doi request reprint Evaluation of biological rhythms in elderly cancer patients. A complementary translational research within the frame of the trans-hospital pilot program of oncogeriatrics launched at CHC-Liège
    C Focan
    CHC Clinique Saint Joseph, rue de Hesbaye, 75, 4000 Liege, Belgium Electronic address
    Pathol Biol (Paris) 61:e33-7. 2013
    ..Future steps could be developed aiming at the restoration of circadian structure disturbances with revalidation (physical exercise, tai-chi, yoga) and resynchronization (melatonin, hydrocortisone, bright light…) programs...
  3. doi request reprint Phase I - II study to assess the feasibility and activity of the triple combination of 5-fluorouracil/folinic acid, carboplatin and irinotecan (CPT-11) administered by chronomodulated infusion for the treatment of advanced colorectal cancer. Final report
    C Focan
    Oncology Department, CHC Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, Belgium Electronic address
    Pathol Biol (Paris) 61:e27-31. 2013
    ..8months of progression free and 15.6months overall survivals. More prolonged survivals were observed in chemotherapy naive patients. Seven patients (19%) could be reoperated from their residual disease...
  4. pmc The use of chemotherapy regimens carrying a moderate or high risk of febrile neutropenia and the corresponding management of febrile neutropenia: an expert survey in breast cancer and non-Hodgkin's lymphoma
    Laetitia Gerlier
    Health Economics and Outcomes Research Department, IMS Health Consulting, Medialaan 38, 1800 Vilvoorde, Belgium
    BMC Cancer 10:642. 2010
    ..The existence of a medical need for G-CSF primary and secondary prophylaxis with these regimens was investigated in a real-life setting...
  5. ncbi request reprint Sequential administration of epirubicin and paclitaxel for advanced breast cancer. A phase I randomised trial
    C Focan
    CHC Clinique Saint Joseph, Liege, Belgium
    Anticancer Res 25:1211-7. 2005
    ..The recommended sequence of both drugs in combination therapy, mainly to avoid neutropenia, is epirubicin day 1 followed by paclitaxel on day 2. Cardiac toxicity remains problematic in either sequence of administration...
  6. ncbi request reprint [Chronotherapy combining 5-fluorouracil, folinic acid and carboplatin as first line treatment in metastatic colorectal cancer. A phase 2 study]
    C Focan
    Département d oncologie médicale CHC, Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, Belgique
    Pathol Biol (Paris) 53:273-6. 2005
    ..Our observations suggest the interest to incorporate carboplatin in the combined infusional treatment of colorectal cancer...
  7. ncbi request reprint [Adjuvant chemotherapy for Dukes B2 and C colon cancer combining 5-fluorouracil and folinic acid with or without carboplatin. Feasibility and comparison between standard and chronomodulated deliveries]
    C Focan
    Departement d Oncologie Medicale, CHC Clinique Saint Joseph, rue de Hesbaye, 75, 4000 Liege, Belgique
    Pathol Biol (Paris) 53:281-4. 2005
    ..The two carboplatin arms presented an enhanced haematological toxicity, while some more cutaneous toxicity was observed in the chronomodulated arm with the three drugs...
  8. ncbi request reprint [Circadian behaviour of host versus tumour outcome. A review]
    C Focan
    Departement de Medecine Interne, Oncologie, CHC Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, Belgique
    Pathol Biol (Paris) 55:178-80. 2007
    ..The authors reviewed experimental and clinical data emphasizing the importance for host to keep a reference circadian rythmicity. This assessment seems true both in the cancerogenesis phase, as well in the active phase of tumoural disease...
  9. ncbi request reprint [Interest of chronotherapy in multidisciplinary management of oesophageal and gastric cancers]
    C Focan
    Departement de Medecine Interne, Oncologie, CHC, Clinique Saint Joseph, rue de Hesbaye 75, B 4000 Liege, Belgique
    Pathol Biol (Paris) 55:181-5. 2007
    ..The median survival of oesophageal cancer was limited to 9.2 months; the one of disseminated gastric cancer was 12.7 months but 72% of curatively resected patients were alive at 5+ years...
  10. ncbi request reprint High-dose oral medroxyprogesterone acetate or tamoxifen as adjuvant hormone therapy for node-negative early-stage breast cancer: randomized trial with 7-year update
    Christian Focan
    Clinique Saint Joseph, Centre Hospitalier Chretien a Liege, Belgium
    Clin Breast Cancer 5:136-41. 2004
    ..81% in the MPA arm [P = 0.02], and in patients > or = 50 years of age, 90% in the tamoxifen arm vs. 82% in the MPA arm [P = 0.16]). Also, the overall survival rate at 7 years was lower in women < 50 years of age (P = 0.04)...
  11. ncbi request reprint [Feasibility survey (Phase I-II) of a four drugs combination (5-fluorouracil, folinic acid, carboplatin and irinotecan) delivered using a chronomodulated infusion in the treatment of advanced colorectal cancer]
    C Focan
    Service d Oncologie, CHC Clinique Saint Joseph, 75, rue de Hesbaye, 4000 Liege, Belgique
    Pathol Biol (Paris) 53:277-80. 2005
    ..An interesting tumoral outcome has been observed: 88% major responses with no progression; median time to progression: nine months and median survival: 19.7 months...
  12. ncbi request reprint Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion
    C Focan
    Les Cliniques Saint Joseph, Liege, Belgium
    Anticancer Drugs 10:385-92. 1999
    ..The results support the need for further exploration of chronotherapy of colorectal cancer liver metastases with combined arterial and venous fluoropyrimidine chemotherapy...
  13. ncbi request reprint [Chronobiological considerations for the management of human head and neck cancer]
    C Focan
    Service d Oncologie Medicale, Clinique Saint Joseph, rue de Hesbaye, 75, 4000, Liege, Belgique
    Pathol Biol (Paris) 51:201-3. 2003
    ..A complex infusional chronotherapyschedule (with 5-fluorouracil, folinic acid and carboplatin) was administered to 48 patients. Excellent tolerance and interesting tumour outcome allowed to conclude to an optimised therapeutic index...
  14. ncbi request reprint Chronotherapy with 5-fluorouracil, folinic acid and carboplatin for metastatic colorectal cancer; an interesting therapeutic index in a phase II trial
    C Focan
    Department of Medical Oncology, Les Cliniques Saint Joseph, Rue de Hesbaye 75 4000, Liege, Belgium
    Eur J Cancer 36:341-7. 2000
    ....
  15. ncbi request reprint Adjuvant intraportal chemotherapy for Dukes B2 and C colorectal cancer also receiving systemic treatment: results of a multicenter randomized trial. Groupe Régional d'Etude du Cancer Colo-Rectal (Belgium)
    C Focan
    Les Cliniques St Joseph, Liege, Belgium
    Anticancer Drugs 11:549-54. 2000
    ..The frequency of hepatic metastases (21 versus 18%) was also similar in both groups...
  16. ncbi request reprint [Randomised study to evaluate the chronotolerance of a combination infusional chemotherapy with 5-fluorouracil, folinic acid and carboplatin in non small cell lung cancer (NSCLC) patients]
    C Focan
    Service d Oncologie Medicale, Clinique Saint Joseph, rue de Hesbaye, 75, 4000, Liege, Belgique
    Pathol Biol (Paris) 51:204-5. 2003
    ..m. for carboplatin; +/-8 h). The reference schedule appeared best tolerated (regarding hematology and mucositis). This study has prospectively validated the chronotolerance concepts of this complex combination chemotherapy...
  17. ncbi request reprint [Evaluation of rest-activity rhythms in advanced non-small-cell lung cancer (NSCLC) patients. Importance of corticotherapy?]
    C Focan
    Service d Oncologie Medicale, Clinique Saint Joseph, rue de Hesbaye 75, 4000, Liege, Belgique
    Pathol Biol (Paris) 51:206-7. 2003
    ..e. rest-activity cycle) was evaluated by actometry in a group of 25 advanced NSCLC patients. A better circadian profile was observed in the 6 patients treated with corticosteroïds. However those patients had also a shortened survival...
  18. ncbi request reprint [Chemotherapy for human gastric cancer: a review]
    G Demolin
    Service d Oncologie Médicale et Gastroentérologie, CHC Clinique Saint Joseph, Liege, Belgique
    Rev Med Liege 63:532-41. 2008
    ....
  19. ncbi request reprint [Hemolytic uremic syndrome induced by gemcitabine. A poorly recognized complication?]
    M P Graas
    CHC Saint Joseph, Liege, Belgique
    Rev Med Liege 67:644-8. 2012
    ..Based on the authors experience, the frequency of an HUS complication after protracted gemcitabine treatment could be as high as 2.7 %...
  20. ncbi request reprint Pharmaco-economic comparative evaluation of combination chronotherapy vs. standard chemotherapy for colorectal cancer
    C Focan
    Les Cliniques Saint Joseph, Liege, Belgium
    Chronobiol Int 19:289-97. 2002
    ..Finally, selection of the Melodie brand infusion pump to deliver the chronotherapy resulted in a further 18% reduction of overall costs and made it possible for patients to enjoy increased autonomy and improved quality of life...
  21. pmc Adjuvant high-dose medroxyprogesterone acetate for early breast cancer: 13 years update in a multicentre randomized trial
    C Focan
    , Belgium
    Br J Cancer 85:1-8. 2001
    ..For both NN and NP patients, differences in overall survivals observed in older women with a shorter follow-up, were no longer detected...
  22. ncbi request reprint It's time for chronotherapy!
    B Coudert
    Centre Georges Francois Leclerc, 1 rue du Professeur Marion, BP 77980, 21079, Dijon Cedex, France
    Eur J Cancer 38:S50-3. 2002
    ....
  23. ncbi request reprint Phase II trial of chronomodulated infusion of high-dose fluorouracil and l-folinic acid in previously untreated patients with metastatic colorectal cancer
    H Cure
    Centre Jean Perrin and L Institut National de la Santé et de la Recherche Médicale U484, Clermont Ferrand, France
    J Clin Oncol 20:1175-81. 2002
    ....
  24. ncbi request reprint The feasibility of classical cyclophosphamide, methotrexate, 5-fluorouracil (CMF) for pre- and post-menopausal node-positive breast cancer patients in a Belgian multicentric trial: a study of consistency in relative dose intensity (RDI) and cumulative dos
    A F Ferreira Filho
    Jules Bordet Institute, Brussels, Belgium
    Ann Oncol 13:416-21. 2002
    ..Concern has been raised regarding the feasibility of this regimen, especially in postmenopausal patients...
  25. pmc Preclinical relevance of dosing time for the therapeutic index of gemcitabine-cisplatin
    X M Li
    INSERM E 354 Chronothérapeutique des Cancers and Université Paris XI, Hopital Paul Brousse, 14 16 Avenue Paul Vaillant Couturier, Villejuif 94800, France
    Br J Cancer 92:1684-9. 2005
    ..02). The optimal schedule would correspond to the delivery of gemcitabine upon awakening and cisplatin near mid-activity in cancer patients...
  26. ncbi request reprint It is time for chronotherapy!
    B Coudert
    Centre Georges Francois Leclerc, 1, rue du Professeur Marion, BP 77980, 21079 cedex, Dijon, France
    Pathol Biol (Paris) 51:197-200. 2003
    ....
  27. ncbi request reprint Adjuvant treatment with high dose medroxyprogesterone acetate in node-negative early breast cancer. A 3-year interim report on a randomized trial (I)
    C Focan
    Clin. St Joseph-Ste Elisabeth, , Belgium
    Acta Oncol 28:237-40. 1989
    ..m. twice weekly for the 5 following months. After a median follow-up time of 3 years, relapse-free survival and overall survival appeared significantly improved in the HD-MPA arm. Side effects were tolerable...
  28. ncbi request reprint [Synchronizing effect of corticosterone's circadian rhythm on the DNA synthesis rate in the liver of the young rat]
    H Barbason
    Universite de Liege, cancérologie expérimentale, rue Belle Maison no 7, 4877, Olne, Belgique
    Pathol Biol (Paris) 51:210-1. 2003
    ..During the 25th nycthemeron, the corticosterone circadian wave peaking at 18 h is followed by the circadian variations of the 3 proliferation parameters peaking at 24 h...