C Focan

Summary

Affiliation: rue de Hesbaye
Country: Belgium

Publications

  1. ncbi request reprint [Chronotherapy with 5-fluorouracil folinic acid and oxaliplatin delivered over 48 hours every second week in colorectal cancer. The CHC-Liège experience (Belgium)]
    C Focan
    CHC Liege, Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, France Electronic address
    Pathol Biol (Paris) 61:e71-4. 2013
  2. ncbi request reprint [A trans-hospital pilot programme for onco-geriatry. The experience of the CHC-Liege]
    C Focan
    Département d Onco Hématologie, CHC Clinique Saint Joseph, Liege, Belgique
    Rev Med Liege 68:110-7. 2013
  3. doi request reprint Evaluation of biological rhythms in elderly cancer patients. A complementary translational research within the frame of the trans-hospital pilot program of oncogeriatrics launched at CHC-Liège
    C Focan
    CHC Clinique Saint Joseph, rue de Hesbaye, 75, 4000 Liege, Belgium
    Pathol Biol (Paris) 61:e33-7. 2013
  4. doi request reprint Phase I - II study to assess the feasibility and activity of the triple combination of 5-fluorouracil/folinic acid, carboplatin and irinotecan (CPT-11) administered by chronomodulated infusion for the treatment of advanced colorectal cancer. Final report
    C Focan
    Oncology Department, CHC Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, Belgium
    Pathol Biol (Paris) 61:e27-31. 2013
  5. pmc The use of chemotherapy regimens carrying a moderate or high risk of febrile neutropenia and the corresponding management of febrile neutropenia: an expert survey in breast cancer and non-Hodgkin's lymphoma
    Laetitia Gerlier
    Health Economics and Outcomes Research Department, IMS Health Consulting, Medialaan 38, 1800 Vilvoorde, Belgium
    BMC Cancer 10:642. 2010
  6. ncbi request reprint Sequential administration of epirubicin and paclitaxel for advanced breast cancer. A phase I randomised trial
    C Focan
    CHC Clinique Saint Joseph, Liege, Belgium
    Anticancer Res 25:1211-7. 2005
  7. ncbi request reprint [Chronotherapy combining 5-fluorouracil, folinic acid and carboplatin as first line treatment in metastatic colorectal cancer. A phase 2 study]
    C Focan
    Département d oncologie médicale CHC, Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, Belgique
    Pathol Biol (Paris) 53:273-6. 2005
  8. ncbi request reprint [Adjuvant chemotherapy for Dukes B2 and C colon cancer combining 5-fluorouracil and folinic acid with or without carboplatin. Feasibility and comparison between standard and chronomodulated deliveries]
    C Focan
    Departement d Oncologie Medicale, CHC Clinique Saint Joseph, rue de Hesbaye, 75, 4000 Liege, Belgique
    Pathol Biol (Paris) 53:281-4. 2005
  9. ncbi request reprint [Circadian behaviour of host versus tumour outcome. A review]
    C Focan
    Departement de Medecine Interne, Oncologie, CHC Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, Belgique
    Pathol Biol (Paris) 55:178-80. 2007
  10. ncbi request reprint [Interest of chronotherapy in multidisciplinary management of oesophageal and gastric cancers]
    C Focan
    Departement de Medecine Interne, Oncologie, CHC, Clinique Saint Joseph, rue de Hesbaye 75, B 4000 Liege, Belgique
    Pathol Biol (Paris) 55:181-5. 2007

Collaborators

Detail Information

Publications29

  1. ncbi request reprint [Chronotherapy with 5-fluorouracil folinic acid and oxaliplatin delivered over 48 hours every second week in colorectal cancer. The CHC-Liège experience (Belgium)]
    C Focan
    CHC Liege, Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, France Electronic address
    Pathol Biol (Paris) 61:e71-4. 2013
    ..Older patients (>=70) experienced worsened survival. In conclusion, we think that our chrono-FOLFOX 2-12 should be proposed as standard treatment for colorectal cancer patients...
  2. ncbi request reprint [A trans-hospital pilot programme for onco-geriatry. The experience of the CHC-Liege]
    C Focan
    Département d Onco Hématologie, CHC Clinique Saint Joseph, Liege, Belgique
    Rev Med Liege 68:110-7. 2013
    ....
  3. doi request reprint Evaluation of biological rhythms in elderly cancer patients. A complementary translational research within the frame of the trans-hospital pilot program of oncogeriatrics launched at CHC-Liège
    C Focan
    CHC Clinique Saint Joseph, rue de Hesbaye, 75, 4000 Liege, Belgium
    Pathol Biol (Paris) 61:e33-7. 2013
    ..Future steps could be developed aiming at the restoration of circadian structure disturbances with revalidation (physical exercise, tai-chi, yoga) and resynchronization (melatonin, hydrocortisone, bright light…) programs...
  4. doi request reprint Phase I - II study to assess the feasibility and activity of the triple combination of 5-fluorouracil/folinic acid, carboplatin and irinotecan (CPT-11) administered by chronomodulated infusion for the treatment of advanced colorectal cancer. Final report
    C Focan
    Oncology Department, CHC Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, Belgium
    Pathol Biol (Paris) 61:e27-31. 2013
    ..8 months of progression free and 15.6 months overall survivals. More prolonged survivals were observed in chemotherapy naive patients. Seven patients (19%) could be reoperated from their residual disease...
  5. pmc The use of chemotherapy regimens carrying a moderate or high risk of febrile neutropenia and the corresponding management of febrile neutropenia: an expert survey in breast cancer and non-Hodgkin's lymphoma
    Laetitia Gerlier
    Health Economics and Outcomes Research Department, IMS Health Consulting, Medialaan 38, 1800 Vilvoorde, Belgium
    BMC Cancer 10:642. 2010
    ..The existence of a medical need for G-CSF primary and secondary prophylaxis with these regimens was investigated in a real-life setting...
  6. ncbi request reprint Sequential administration of epirubicin and paclitaxel for advanced breast cancer. A phase I randomised trial
    C Focan
    CHC Clinique Saint Joseph, Liege, Belgium
    Anticancer Res 25:1211-7. 2005
    ..The recommended sequence of both drugs in combination therapy, mainly to avoid neutropenia, is epirubicin day 1 followed by paclitaxel on day 2. Cardiac toxicity remains problematic in either sequence of administration...
  7. ncbi request reprint [Chronotherapy combining 5-fluorouracil, folinic acid and carboplatin as first line treatment in metastatic colorectal cancer. A phase 2 study]
    C Focan
    Département d oncologie médicale CHC, Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, Belgique
    Pathol Biol (Paris) 53:273-6. 2005
    ..Our observations suggest the interest to incorporate carboplatin in the combined infusional treatment of colorectal cancer...
  8. ncbi request reprint [Adjuvant chemotherapy for Dukes B2 and C colon cancer combining 5-fluorouracil and folinic acid with or without carboplatin. Feasibility and comparison between standard and chronomodulated deliveries]
    C Focan
    Departement d Oncologie Medicale, CHC Clinique Saint Joseph, rue de Hesbaye, 75, 4000 Liege, Belgique
    Pathol Biol (Paris) 53:281-4. 2005
    ..The two carboplatin arms presented an enhanced haematological toxicity, while some more cutaneous toxicity was observed in the chronomodulated arm with the three drugs...
  9. ncbi request reprint [Circadian behaviour of host versus tumour outcome. A review]
    C Focan
    Departement de Medecine Interne, Oncologie, CHC Clinique Saint Joseph, rue de Hesbaye 75, 4000 Liege, Belgique
    Pathol Biol (Paris) 55:178-80. 2007
    ..The authors reviewed experimental and clinical data emphasizing the importance for host to keep a reference circadian rythmicity. This assessment seems true both in the cancerogenesis phase, as well in the active phase of tumoural disease...
  10. ncbi request reprint [Interest of chronotherapy in multidisciplinary management of oesophageal and gastric cancers]
    C Focan
    Departement de Medecine Interne, Oncologie, CHC, Clinique Saint Joseph, rue de Hesbaye 75, B 4000 Liege, Belgique
    Pathol Biol (Paris) 55:181-5. 2007
    ..The median survival of oesophageal cancer was limited to 9.2 months; the one of disseminated gastric cancer was 12.7 months but 72% of curatively resected patients were alive at 5+ years...
  11. ncbi request reprint High-dose oral medroxyprogesterone acetate or tamoxifen as adjuvant hormone therapy for node-negative early-stage breast cancer: randomized trial with 7-year update
    Christian Focan
    Clinique Saint Joseph, Centre Hospitalier Chretien a Liege, Belgium
    Clin Breast Cancer 5:136-41. 2004
    ..81% in the MPA arm [P = 0.02], and in patients > or = 50 years of age, 90% in the tamoxifen arm vs. 82% in the MPA arm [P = 0.16]). Also, the overall survival rate at 7 years was lower in women < 50 years of age (P = 0.04)...
  12. ncbi request reprint [Feasibility survey (Phase I-II) of a four drugs combination (5-fluorouracil, folinic acid, carboplatin and irinotecan) delivered using a chronomodulated infusion in the treatment of advanced colorectal cancer]
    C Focan
    Service d Oncologie, CHC Clinique Saint Joseph, 75, rue de Hesbaye, 4000 Liege, Belgique
    Pathol Biol (Paris) 53:277-80. 2005
    ..An interesting tumoral outcome has been observed: 88% major responses with no progression; median time to progression: nine months and median survival: 19.7 months...
  13. ncbi request reprint Continuous delivery of venous 5-fluorouracil and arterial 5-fluorodeoxyuridine for hepatic metastases from colorectal cancer: feasibility and tolerance in a randomized phase II trial comparing flat versus chronomodulated infusion
    C Focan
    Les Cliniques Saint Joseph, Liege, Belgium
    Anticancer Drugs 10:385-92. 1999
    ..The results support the need for further exploration of chronotherapy of colorectal cancer liver metastases with combined arterial and venous fluoropyrimidine chemotherapy...
  14. ncbi request reprint Chronotherapy with 5-fluorouracil, folinic acid and carboplatin for metastatic colorectal cancer; an interesting therapeutic index in a phase II trial
    C Focan
    Department of Medical Oncology, Les Cliniques Saint Joseph, Rue de Hesbaye 75 4000, Liege, Belgium
    Eur J Cancer 36:341-7. 2000
    ....
  15. ncbi request reprint [Chronobiological considerations for the management of human head and neck cancer]
    C Focan
    Service d Oncologie Medicale, Clinique Saint Joseph, rue de Hesbaye, 75, 4000, Liege, Belgique
    Pathol Biol (Paris) 51:201-3. 2003
    ..A complex infusional chronotherapyschedule (with 5-fluorouracil, folinic acid and carboplatin) was administered to 48 patients. Excellent tolerance and interesting tumour outcome allowed to conclude to an optimised therapeutic index...
  16. ncbi request reprint Adjuvant intraportal chemotherapy for Dukes B2 and C colorectal cancer also receiving systemic treatment: results of a multicenter randomized trial. Groupe Régional d'Etude du Cancer Colo-Rectal (Belgium)
    C Focan
    Les Cliniques St Joseph, Liege, Belgium
    Anticancer Drugs 11:549-54. 2000
    ..The frequency of hepatic metastases (21 versus 18%) was also similar in both groups...
  17. ncbi request reprint [Randomised study to evaluate the chronotolerance of a combination infusional chemotherapy with 5-fluorouracil, folinic acid and carboplatin in non small cell lung cancer (NSCLC) patients]
    C Focan
    Service d Oncologie Medicale, Clinique Saint Joseph, rue de Hesbaye, 75, 4000, Liege, Belgique
    Pathol Biol (Paris) 51:204-5. 2003
    ..m. for carboplatin; +/-8 h). The reference schedule appeared best tolerated (regarding hematology and mucositis). This study has prospectively validated the chronotolerance concepts of this complex combination chemotherapy...
  18. ncbi request reprint [Evaluation of rest-activity rhythms in advanced non-small-cell lung cancer (NSCLC) patients. Importance of corticotherapy?]
    C Focan
    Service d Oncologie Medicale, Clinique Saint Joseph, rue de Hesbaye 75, 4000, Liege, Belgique
    Pathol Biol (Paris) 51:206-7. 2003
    ..e. rest-activity cycle) was evaluated by actometry in a group of 25 advanced NSCLC patients. A better circadian profile was observed in the 6 patients treated with corticosteroïds. However those patients had also a shortened survival...
  19. ncbi request reprint Pharmaco-economic comparative evaluation of combination chronotherapy vs. standard chemotherapy for colorectal cancer
    C Focan
    Les Cliniques Saint Joseph, Liege, Belgium
    Chronobiol Int 19:289-97. 2002
    ..Finally, selection of the Melodie brand infusion pump to deliver the chronotherapy resulted in a further 18% reduction of overall costs and made it possible for patients to enjoy increased autonomy and improved quality of life...
  20. ncbi request reprint [Hemolytic uremic syndrome induced by gemcitabine. A poorly recognized complication?]
    M P Graas
    CHC Saint Joseph, Liege, Belgique
    Rev Med Liege 67:644-8. 2012
    ..Based on the authors experience, the frequency of an HUS complication after protracted gemcitabine treatment could be as high as 2.7 %...
  21. ncbi request reprint [Chemotherapy for human gastric cancer: a review]
    G Demolin
    Service d Oncologie Médicale et Gastroentérologie, CHC Clinique Saint Joseph, Liege, Belgique
    Rev Med Liege 63:532-41. 2008
    ....
  22. pmc Adjuvant high-dose medroxyprogesterone acetate for early breast cancer: 13 years update in a multicentre randomized trial
    C Focan
    , Belgium
    Br J Cancer 85:1-8. 2001
    ..For both NN and NP patients, differences in overall survivals observed in older women with a shorter follow-up, were no longer detected...
  23. ncbi request reprint It's time for chronotherapy!
    B Coudert
    Centre Georges Francois Leclerc, 1 rue du Professeur Marion, BP 77980, 21079, Dijon Cedex, France
    Eur J Cancer 38:S50-3. 2002
    ....
  24. ncbi request reprint Phase II trial of chronomodulated infusion of high-dose fluorouracil and l-folinic acid in previously untreated patients with metastatic colorectal cancer
    H Cure
    Centre Jean Perrin and L Institut National de la Santé et de la Recherche Médicale U484, Clermont Ferrand, France
    J Clin Oncol 20:1175-81. 2002
    ....
  25. ncbi request reprint The feasibility of classical cyclophosphamide, methotrexate, 5-fluorouracil (CMF) for pre- and post-menopausal node-positive breast cancer patients in a Belgian multicentric trial: a study of consistency in relative dose intensity (RDI) and cumulative dos
    A F Ferreira Filho
    Jules Bordet Institute, Brussels, Belgium
    Ann Oncol 13:416-21. 2002
    ..Concern has been raised regarding the feasibility of this regimen, especially in postmenopausal patients...
  26. ncbi request reprint It is time for chronotherapy!
    B Coudert
    Centre Georges Francois Leclerc, 1, rue du Professeur Marion, BP 77980, 21079 cedex, Dijon, France
    Pathol Biol (Paris) 51:197-200. 2003
    ....
  27. pmc Preclinical relevance of dosing time for the therapeutic index of gemcitabine-cisplatin
    X M Li
    INSERM E 354 Chronothérapeutique des Cancers and Université Paris XI, Hopital Paul Brousse, 14 16 Avenue Paul Vaillant Couturier, Villejuif 94800, France
    Br J Cancer 92:1684-9. 2005
    ..02). The optimal schedule would correspond to the delivery of gemcitabine upon awakening and cisplatin near mid-activity in cancer patients...
  28. ncbi request reprint Adjuvant treatment with high dose medroxyprogesterone acetate in node-negative early breast cancer. A 3-year interim report on a randomized trial (I)
    C Focan
    Clin. St Joseph-Ste Elisabeth, , Belgium
    Acta Oncol 28:237-40. 1989
    ..m. twice weekly for the 5 following months. After a median follow-up time of 3 years, relapse-free survival and overall survival appeared significantly improved in the HD-MPA arm. Side effects were tolerable...
  29. ncbi request reprint [Synchronizing effect of corticosterone's circadian rhythm on the DNA synthesis rate in the liver of the young rat]
    H Barbason
    Universite de Liege, cancérologie expérimentale, rue Belle Maison no 7, 4877, Olne, Belgique
    Pathol Biol (Paris) 51:210-1. 2003
    ..During the 25th nycthemeron, the corticosterone circadian wave peaking at 18 h is followed by the circadian variations of the 3 proliferation parameters peaking at 24 h...