F E Roufosse

Summary

Country: Belgium

Publications

  1. ncbi request reprint The hypereosinophilic syndrome revisited
    Florence Roufosse
    Department of Internal Medicine Université Libre de Bruxelles, B 1070 Brussels, Belgium
    Annu Rev Med 54:169-84. 2003
  2. doi request reprint Molecular profiling of CD3-CD4+ T cells from patients with the lymphocytic variant of hypereosinophilic syndrome reveals targeting of growth control pathways
    Marie Ravoet
    Molecular Immunology Unit, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Blood 114:2969-83. 2009
  3. pmc Eosinophils affect functions of in vitro-activated human CD3-CD4+ T cells
    Issam Harfi
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    J Transl Med 11:112. 2013
  4. doi request reprint Lymphoproliferative disorders associated with hypereosinophilia
    Florence Roufosse
    Department of Internal Medicine, Hopital Erasme, Universite Libre de Bruxelles, 808 Route de Lennik, B 1070 Brussels, Belgium
    Semin Hematol 49:138-48. 2012
  5. pmc Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome
    Florence Roufosse
    Department of Internal Medicine, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Allergy Clin Immunol 126:828-835.e3. 2010
  6. ncbi request reprint [Practical approach to hypereosinophilia]
    F Roufosse
    Departement de Medecine Interne, Hopital Erasme, Bruxelles
    Rev Med Brux 29:400-8. 2008
  7. ncbi request reprint Systemic sclerosis (scleroderma)
    F E Roufosse
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    Acta Clin Belg 62:323-9. 2007
  8. ncbi request reprint Lymphocytic variant hypereosinophilic syndromes
    Florence Roufosse
    Department of Internal Medicine, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, B 1070 Brussels, Belgium
    Immunol Allergy Clin North Am 27:389-413. 2007
  9. pmc Hypereosinophilic syndromes
    Florence E Roufosse
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    Orphanet J Rare Dis 2:37. 2007
  10. ncbi request reprint Hypereosinophilic syndrome: lymphoproliferative and myeloproliferative variants
    Florence Roufosse
    Department of Internal Medicine Erasme Hospital, Brussels, Belgium
    Semin Respir Crit Care Med 27:158-70. 2006

Collaborators

Detail Information

Publications16

  1. ncbi request reprint The hypereosinophilic syndrome revisited
    Florence Roufosse
    Department of Internal Medicine Université Libre de Bruxelles, B 1070 Brussels, Belgium
    Annu Rev Med 54:169-84. 2003
    ..This review defines the "myeloproliferative" and "lymphocytic" variants of the HES and addresses the management of each variant, focusing on diagnosis and treatment of the newly identified lymphocytic variant...
  2. doi request reprint Molecular profiling of CD3-CD4+ T cells from patients with the lymphocytic variant of hypereosinophilic syndrome reveals targeting of growth control pathways
    Marie Ravoet
    Molecular Immunology Unit, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Blood 114:2969-83. 2009
    ....
  3. pmc Eosinophils affect functions of in vitro-activated human CD3-CD4+ T cells
    Issam Harfi
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    J Transl Med 11:112. 2013
    ..On the other hand, previous studies have shown that eosinophils support CD4 T-cell activation, suggesting that targeted eosinophil depletion may negatively regulate these cells...
  4. doi request reprint Lymphoproliferative disorders associated with hypereosinophilia
    Florence Roufosse
    Department of Internal Medicine, Hopital Erasme, Universite Libre de Bruxelles, 808 Route de Lennik, B 1070 Brussels, Belgium
    Semin Hematol 49:138-48. 2012
    ..The mechanisms leading to blood and tissue eosinophilia in the setting of lymphoproliferative disorders, as well as the clinical complications and prognostic implications of hypereosinophilia, are discussed in this review...
  5. pmc Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome
    Florence Roufosse
    Department of Internal Medicine, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Allergy Clin Immunol 126:828-835.e3. 2010
    ..Lymphocytic variant hypereosinophilic syndrome (L-HES) is characterized by marked overproduction of IL-5 by dysregulated T cells...
  6. ncbi request reprint [Practical approach to hypereosinophilia]
    F Roufosse
    Departement de Medecine Interne, Hopital Erasme, Bruxelles
    Rev Med Brux 29:400-8. 2008
    ....
  7. ncbi request reprint Systemic sclerosis (scleroderma)
    F E Roufosse
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    Acta Clin Belg 62:323-9. 2007
    ..Furthermore, an increased interest in understanding the pathogenic mechanisms of this complex disease has opened new perspectives for therapy, targeting the diverse and inter-related components of the characteristic triad...
  8. ncbi request reprint Lymphocytic variant hypereosinophilic syndromes
    Florence Roufosse
    Department of Internal Medicine, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, B 1070 Brussels, Belgium
    Immunol Allergy Clin North Am 27:389-413. 2007
    ..Therapeutic strategies should target pathogenic T cells in addition to eosinophils, but the practical implications remain largely unexplored...
  9. pmc Hypereosinophilic syndromes
    Florence E Roufosse
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    Orphanet J Rare Dis 2:37. 2007
    ..Prognosis has improved significantly since definition of HES, and currently depends on development of irreversible heart failure, as well as eventual malignant transformation of myeloid or lymphoid cells...
  10. ncbi request reprint Hypereosinophilic syndrome: lymphoproliferative and myeloproliferative variants
    Florence Roufosse
    Department of Internal Medicine Erasme Hospital, Brussels, Belgium
    Semin Respir Crit Care Med 27:158-70. 2006
    ..It is currently unclear whether timely therapeutic intervention in such patients could interfere with long-term progression toward malignant hematological disorders...
  11. ncbi request reprint Defective CD3gamma gene transcription is associated with NFATc2 overexpression in the lymphocytic variant of hypereosinophilic syndrome
    Karen E Willard-Gallo
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Exp Hematol 33:1147-59. 2005
    ..Determine the molecular defects underlying the CD3(-)CD4(+) T-cell phenotype and persistence of this clonal population in patients with hypereosinophilic syndrome...
  12. ncbi request reprint 6q- is an early and persistent chromosomal aberration in CD3-CD4+ T-cell clones associated with the lymphocytic variant of hypereosinophilic syndrome
    Marie Ravoet
    Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium
    Haematologica 90:753-65. 2005
    ..In this study, LV-HES was used as a model of pre-malignancy to identify specific marker(s) predictive of the potential for malignant transformation...
  13. ncbi request reprint High serum thymus and activation-regulated chemokine levels in the lymphocytic variant of the hypereosinophilic syndrome
    Aurore de Lavareille
    Department of Immunology, Hopital Erasme, ULB, Brussels, Belgium
    J Allergy Clin Immunol 110:476-9. 2002
    ..In contrast, serum thymus and activation-regulated chemokine levels are consistently increased in such patients compared with others with persistent idiopathic hyper-eosinophilia and could therefore represent a useful diagnostic tool...
  14. pmc Practical approach to the patient with hypereosinophilia
    Florence Roufosse
    Department of Internal Medicine, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Allergy Clin Immunol 126:39-44. 2010
    ....
  15. doi request reprint Treatment of patients with the hypereosinophilic syndrome with mepolizumab
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    N Engl J Med 358:1215-28. 2008
    ..Although most patients have a response to corticosteroids, side effects are common and can lead to considerable morbidity...
  16. ncbi request reprint Hypereosinophilic syndrome
    Florence E Roufosse
    N Engl J Med 348:2687; author reply 2687. 2003