F E Roufosse

Summary

Country: Belgium

Publications

  1. ncbi The hypereosinophilic syndrome revisited
    Florence Roufosse
    Department of Internal Medicine Université Libre de Bruxelles, B 1070 Brussels, Belgium
    Annu Rev Med 54:169-84. 2003
  2. ncbi Molecular profiling of CD3-CD4+ T cells from patients with the lymphocytic variant of hypereosinophilic syndrome reveals targeting of growth control pathways
    Marie Ravoet
    Molecular Immunology Unit, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Blood 114:2969-83. 2009
  3. ncbi Lymphoproliferative disorders associated with hypereosinophilia
    Florence Roufosse
    Department of Internal Medicine, Hopital Erasme, Universite Libre de Bruxelles, 808 Route de Lennik, B 1070 Brussels, Belgium
    Semin Hematol 49:138-48. 2012
  4. ncbi Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome
    Florence Roufosse
    Department of Internal Medicine, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Allergy Clin Immunol 126:828-835.e3. 2010
  5. ncbi [Practical approach to hypereosinophilia]
    F Roufosse
    Departement de Medecine Interne, Hopital Erasme, Bruxelles
    Rev Med Brux 29:400-8. 2008
  6. ncbi Systemic sclerosis (scleroderma)
    F E Roufosse
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    Acta Clin Belg 62:323-9. 2007
  7. ncbi Lymphocytic variant hypereosinophilic syndromes
    Florence Roufosse
    Department of Internal Medicine, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, B 1070 Brussels, Belgium
    Immunol Allergy Clin North Am 27:389-413. 2007
  8. ncbi Hypereosinophilic syndromes
    Florence E Roufosse
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    Orphanet J Rare Dis 2:37. 2007
  9. ncbi Hypereosinophilic syndrome: lymphoproliferative and myeloproliferative variants
    Florence Roufosse
    Department of Internal Medicine Erasme Hospital, Brussels, Belgium
    Semin Respir Crit Care Med 27:158-70. 2006
  10. ncbi Defective CD3gamma gene transcription is associated with NFATc2 overexpression in the lymphocytic variant of hypereosinophilic syndrome
    Karen E Willard-Gallo
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Exp Hematol 33:1147-59. 2005

Collaborators

Detail Information

Publications15

  1. ncbi The hypereosinophilic syndrome revisited
    Florence Roufosse
    Department of Internal Medicine Université Libre de Bruxelles, B 1070 Brussels, Belgium
    Annu Rev Med 54:169-84. 2003
    ..This review defines the "myeloproliferative" and "lymphocytic" variants of the HES and addresses the management of each variant, focusing on diagnosis and treatment of the newly identified lymphocytic variant...
  2. ncbi Molecular profiling of CD3-CD4+ T cells from patients with the lymphocytic variant of hypereosinophilic syndrome reveals targeting of growth control pathways
    Marie Ravoet
    Molecular Immunology Unit, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Blood 114:2969-83. 2009
    ....
  3. ncbi Lymphoproliferative disorders associated with hypereosinophilia
    Florence Roufosse
    Department of Internal Medicine, Hopital Erasme, Universite Libre de Bruxelles, 808 Route de Lennik, B 1070 Brussels, Belgium
    Semin Hematol 49:138-48. 2012
    ..The mechanisms leading to blood and tissue eosinophilia in the setting of lymphoproliferative disorders, as well as the clinical complications and prognostic implications of hypereosinophilia, are discussed in this review...
  4. ncbi Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome
    Florence Roufosse
    Department of Internal Medicine, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Allergy Clin Immunol 126:828-835.e3. 2010
    ..Lymphocytic variant hypereosinophilic syndrome (L-HES) is characterized by marked overproduction of IL-5 by dysregulated T cells...
  5. ncbi [Practical approach to hypereosinophilia]
    F Roufosse
    Departement de Medecine Interne, Hopital Erasme, Bruxelles
    Rev Med Brux 29:400-8. 2008
    ....
  6. ncbi Systemic sclerosis (scleroderma)
    F E Roufosse
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    Acta Clin Belg 62:323-9. 2007
    ..Furthermore, an increased interest in understanding the pathogenic mechanisms of this complex disease has opened new perspectives for therapy, targeting the diverse and inter-related components of the characteristic triad...
  7. ncbi Lymphocytic variant hypereosinophilic syndromes
    Florence Roufosse
    Department of Internal Medicine, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, B 1070 Brussels, Belgium
    Immunol Allergy Clin North Am 27:389-413. 2007
    ..Therapeutic strategies should target pathogenic T cells in addition to eosinophils, but the practical implications remain largely unexplored...
  8. ncbi Hypereosinophilic syndromes
    Florence E Roufosse
    Institute for Medical Immunology, Universite Libre de Bruxelles, Gosselies, Belgium
    Orphanet J Rare Dis 2:37. 2007
    ..Prognosis has improved significantly since definition of HES, and currently depends on development of irreversible heart failure, as well as eventual malignant transformation of myeloid or lymphoid cells...
  9. ncbi Hypereosinophilic syndrome: lymphoproliferative and myeloproliferative variants
    Florence Roufosse
    Department of Internal Medicine Erasme Hospital, Brussels, Belgium
    Semin Respir Crit Care Med 27:158-70. 2006
    ..It is currently unclear whether timely therapeutic intervention in such patients could interfere with long-term progression toward malignant hematological disorders...
  10. ncbi Defective CD3gamma gene transcription is associated with NFATc2 overexpression in the lymphocytic variant of hypereosinophilic syndrome
    Karen E Willard-Gallo
    Laboratory of Experimental Hematology, Institut Jules Bordet, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Exp Hematol 33:1147-59. 2005
    ..Determine the molecular defects underlying the CD3(-)CD4(+) T-cell phenotype and persistence of this clonal population in patients with hypereosinophilic syndrome...
  11. ncbi 6q- is an early and persistent chromosomal aberration in CD3-CD4+ T-cell clones associated with the lymphocytic variant of hypereosinophilic syndrome
    Marie Ravoet
    Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium
    Haematologica 90:753-65. 2005
    ..INTERPRETATION AND CONCLUSIONS: Our data suggest that the 6q deletion represents an early cytogenetic marker for T-cell transformation...
  12. ncbi High serum thymus and activation-regulated chemokine levels in the lymphocytic variant of the hypereosinophilic syndrome
    Aurore de Lavareille
    Department of Immunology, , ULB, Brussels, Belgium
    J Allergy Clin Immunol 110:476-9. 2002
    ..In contrast, serum thymus and activation-regulated chemokine levels are consistently increased in such patients compared with others with persistent idiopathic hyper-eosinophilia and could therefore represent a useful diagnostic tool...
  13. ncbi Practical approach to the patient with hypereosinophilia
    Florence Roufosse
    Department of Internal Medicine, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Allergy Clin Immunol 126:39-44. 2010
    ....
  14. ncbi Treatment of patients with the hypereosinophilic syndrome with mepolizumab
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    N Engl J Med 358:1215-28. 2008
    ..Although most patients have a response to corticosteroids, side effects are common and can lead to considerable morbidity...
  15. ncbi Hypereosinophilic syndrome
    Florence E Roufosse
    N Engl J Med 348:2687; author reply 2687. 2003