Jean Charles Preiser

Summary

Country: Belgium

Publications

  1. pmc Intensive insulin therapy to control hyperglycemia in the critically ill: a look back at the evidence shapes the challenges ahead
    James Krinsley
    Division of Critical Care, Stamford Hospital, 190 West Broad Street, Stamford, CT 06902, USA
    Crit Care 14:330. 2010
  2. pmc Moving beyond tight glucose control to safe effective glucose control
    James S Krinsley
    Division of Critical Care, Stamford Hospital, 190 West Broad Street, Stamford, CT 06902, USA
    Crit Care 12:149. 2008
  3. pmc Organ failure and tight glycemic control in the SPRINT study
    J Geoffrey Chase
    Department of Mechanical Engineering, Centre for Bio Engineering, University of Canterbury, Christchurch, Private Bag, New Zealand
    Crit Care 14:R154. 2010
  4. pmc Restoring normoglycaemia: not so harmless
    Jean Charles Preiser
    Crit Care 12:116. 2008
  5. pmc Year in review 2008: Critical Care--metabolism
    Jean Charles Preiser
    Department of General Intensive Care, University Hospital Centre of Liege, Domaine Universitaire du Sart Tilman B 35, 4000 Liege, Belgium
    Crit Care 13:228. 2009
  6. pmc NICE-SUGAR: the end of a sweet dream?
    Jean Charles Preiser
    Department of Intensive Care, Centre Hospitalier Universitaire du Sart Tilman, 4000 Liege, Belgium
    Crit Care 13:143. 2009
  7. doi Which factors influence glycemic control in the intensive care unit?
    Jean Charles Preiser
    Department of General Intensive Care, University Hospital Centre of Liege, Liege, Belgium
    Curr Opin Clin Nutr Metab Care 13:205-10. 2010
  8. doi A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study
    Jean Charles Preiser
    Department of General Intensive Care, University Hospital, Liege, Belgium
    Intensive Care Med 35:1738-48. 2009
  9. pmc An overview of hypoglycemia in the critically ill
    Jean Claude Lacherade
    Medico surgical ICU, Poissy Saint Germain Hospital, Poissy, France
    J Diabetes Sci Technol 3:1242-9. 2009
  10. ncbi Clinical experience with tight glucose control by intensive insulin therapy
    Jean Charles Preiser
    Department of General Intensive Care, University Hospital Center, University of Liege, Domaine Universitaire du Sart Tilman, Liege, Belgium
    Crit Care Med 35:S503-7. 2007

Collaborators

Detail Information

Publications47

  1. pmc Intensive insulin therapy to control hyperglycemia in the critically ill: a look back at the evidence shapes the challenges ahead
    James Krinsley
    Division of Critical Care, Stamford Hospital, 190 West Broad Street, Stamford, CT 06902, USA
    Crit Care 14:330. 2010
    ..These new findings have important implications for the design of future interventional trials of intensive insulin therapy in the intensive care unit setting...
  2. pmc Moving beyond tight glucose control to safe effective glucose control
    James S Krinsley
    Division of Critical Care, Stamford Hospital, 190 West Broad Street, Stamford, CT 06902, USA
    Crit Care 12:149. 2008
    ....
  3. pmc Organ failure and tight glycemic control in the SPRINT study
    J Geoffrey Chase
    Department of Mechanical Engineering, Centre for Bio Engineering, University of Canterbury, Christchurch, Private Bag, New Zealand
    Crit Care 14:R154. 2010
    ..The sequential organ failure assessment (SOFA) score is used to evaluate the impact of a successful tight glycemic control (TGC) intervention (SPRINT) on organ failure, morbidity, and thus mortality...
  4. pmc Restoring normoglycaemia: not so harmless
    Jean Charles Preiser
    Crit Care 12:116. 2008
    ..This commentary briefly discusses the potential mechanisms and reminds the potential benefits of physiological stress hyperglycemia...
  5. pmc Year in review 2008: Critical Care--metabolism
    Jean Charles Preiser
    Department of General Intensive Care, University Hospital Centre of Liege, Domaine Universitaire du Sart Tilman B 35, 4000 Liege, Belgium
    Crit Care 13:228. 2009
    ..Important reports of the effects of hormone analogues, such as vasopressin and hydrocortisone, and early antioxidants in selected subpopulations were also available in 2008...
  6. pmc NICE-SUGAR: the end of a sweet dream?
    Jean Charles Preiser
    Department of Intensive Care, Centre Hospitalier Universitaire du Sart Tilman, 4000 Liege, Belgium
    Crit Care 13:143. 2009
    ..Future research will probably focus on several questions raised by the divergent results reported from investigations in the field of glucose control in the critically ill...
  7. doi Which factors influence glycemic control in the intensive care unit?
    Jean Charles Preiser
    Department of General Intensive Care, University Hospital Centre of Liege, Liege, Belgium
    Curr Opin Clin Nutr Metab Care 13:205-10. 2010
    ..4-6.1 mmol/l) was found to improve survival of critically ill patients in one pioneering proof-of-concept study performed in a surgical intensive care unit. The external validity of these findings was investigated...
  8. doi A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study
    Jean Charles Preiser
    Department of General Intensive Care, University Hospital, Liege, Belgium
    Intensive Care Med 35:1738-48. 2009
    ..An optimal target for glucose control in ICU patients remains unclear. This prospective randomized controlled trial compared the effects on ICU mortality of intensive insulin therapy (IIT) with an intermediate glucose control...
  9. pmc An overview of hypoglycemia in the critically ill
    Jean Claude Lacherade
    Medico surgical ICU, Poissy Saint Germain Hospital, Poissy, France
    J Diabetes Sci Technol 3:1242-9. 2009
    ..Severe hypoglycemia is statistically associated with adverse outcomes in intensive care unit patients, although a direct causal relationship has not been demonstrated...
  10. ncbi Clinical experience with tight glucose control by intensive insulin therapy
    Jean Charles Preiser
    Department of General Intensive Care, University Hospital Center, University of Liege, Domaine Universitaire du Sart Tilman, Liege, Belgium
    Crit Care Med 35:S503-7. 2007
    ..To describe the current status and the clinical data related to the effects of tight glucose control by intensive insulin therapy in critically ill patients...
  11. ncbi [Management of blood glucose level in intensive care]
    J C Preiser
    Service de Soins Intensifs Généraux, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 62:51-4. 2007
    ..Also, recent data raised new closely related and relevant issues including the variability of blood glucose, the risks of hypoglycaemia, and the delineation of the categories of patients in whom TGCIIT could bring an actual benefit...
  12. pmc Second pilot trials of the STAR-Liege protocol for tight glycemic control in critically ill patients
    Sophie Penning
    Cardiovascular Research Centre, Institut de Physique, Universite de Liege, Institut de Physics, Allee du 6 Aout, 17 Bât B5, Liege, B4000 Liege, Liege, Belgium
    Biomed Eng Online 11:58. 2012
    ..The main objective is reducing measurement frequency while maintaining performance and safety of the glycemic control...
  13. ncbi Current controversies around tight glucose control in critically ill patients
    Philippe Devos
    Department of Intensive Care, Centre Hospitalier, Universitaire du Sart Tilman, Liege, Belgium
    Curr Opin Clin Nutr Metab Care 10:206-9. 2007
    ..This review updates our knowledge on the benefits and risks of tight glucose control by intensive insulin therapy in critically ill patients, as well as discussing unanswered questions related to the subject...
  14. pmc Tight blood glucose control: a recommendation applicable to any critically ill patient?
    Philippe Devos
    Department of Intensive Care, Centre Hospitalier Universitaire du Sart Tilman, Liege, Belgium
    Crit Care 8:427-9. 2004
    ..These arguments emphasize the need to study the effects of tight glucose control in a large heterogeneous cohort of intensive care unit patients...
  15. ncbi Glucose, insulin and myocardial ischaemia
    Philippe Devos
    Department of Intensive Care, Sart Tilman University Hospital, Liege, Belgium
    Curr Opin Clin Nutr Metab Care 9:131-9. 2006
    ....
  16. pmc Combination therapy versus monotherapy: a randomised pilot study on the evolution of inflammatory parameters after ventilator associated pneumonia [ISRCTN31976779]
    Pierre Damas
    Department of General Intensive Care, University Hospital Centre, Domaine Universitaire du Sart Tilman, B 4000 Liege, Belgium
    Crit Care 10:R52. 2006
    ..The aim of the present study was to compare the clinical outcome and the course of biological variables in patients treated for a VAP, using a monotherapy with a beta-lactam versus a combination therapy...
  17. doi Procalcitonin usefulness for the initiation of antibiotic treatment in intensive care unit patients
    Nathalie Layios
    Department of General Intensive Care, University Hospital of Liege, Domaine Universitaire de Liège, Liege, Belgium
    Crit Care Med 40:2304-9. 2012
    ..To test the usefulness of procalcitonin serum level for the reduction of antibiotic consumption in intensive care unit patients...
  18. pmc Insulin-treated diabetes is not associated with increased mortality in critically ill patients
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:R12. 2010
    ..This was a planned substudy from the European observational Sepsis Occurrence in Acutely ill Patients (SOAP) study to investigate the possible impact of insulin-treated diabetes on morbidity and mortality in ICU patients...
  19. pmc Is it time for implementation of tight glycaemia control by intensive insulin therapy in every ICU?
    Philippe Devos
    Department of General Intensive Care, University Hospital Centre, University of Liege, Domaine Universitaire du Sart Tilman, B 4000 Liege, Belgium
    Crit Care 10:130. 2006
    ....
  20. ncbi Diarrhoea in the critically ill
    Patricia Wiesen
    Department of Intensive Care, Centre Hospitalier, Universitaire du Sart Tilman, Liege, Belgium
    Curr Opin Crit Care 12:149-54. 2006
    ..Epidemiological data will be discussed, with special emphasis on diarrhoea in tube-fed patients and during antibiotic therapy. The possible preventive and therapeutic measures will be presented...
  21. doi Intensive care unit acquired infection and organ failure
    Pierre Damas
    Department of General Intensive Care, University Hospital Center, University of Liege, Domaine Universitaire du Sart Tilman, 4000 Liege, Belgium
    Intensive Care Med 34:856-64. 2008
    ..To assess the temporal relationship between ICU-acquired infection (IAI) and the prevalence and severity of organ dysfunction or failure (OD/F)...
  22. pmc Year in review 2009: Critical Care--metabolism
    Vincent Huberlant
    Department of General Intensive Care, University Hospital Centre of Liege, Domaine Universitaire du Sart Tilman, 4000 Liege, Belgium
    Crit Care 14:238. 2010
    ..Finally, understanding of some critical-illness-related endocrine and neuromuscular disorders improved through new experimental and clinical findings...
  23. ncbi Antioxidant therapy in intensive care
    Robin Lovat
    Department of Intensive Care Centre hospitalo Universitaire du Sart Tilman, Liege, Belgium
    Curr Opin Crit Care 9:266-70. 2003
    ....
  24. pmc Tight glucose control: should we move from intensive insulin therapy alone to modulation of insulin and nutritional inputs?
    Pierre Kalfon
    Department of General Intensive Care, Hospital of Chartres, 34, rue du Docteur Maunoury, 28000 Chartres, France
    Crit Care 12:156. 2008
    ..It achieved a better glycaemic control in a severely ill critical cohort than their previous method for glycaemic control in a matched historical cohort. Reductions in mortality were also observed...
  25. ncbi Nutritional papers in ICU patients: what lies between the lines?
    Jean Charles Preiser
    Department of Intensive Care, RHMS, 80 chaussée de Saint Amand, 7500 Tournai, Belgium
    Intensive Care Med 29:156-66. 2003
    ..We suggest simple strategies or study design that will allow important questions to be answered by future clinical trials...
  26. doi Are prospective cohort studies an appropriate tool to answer clinical nutrition questions?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 16:182-6. 2013
    ....
  27. doi First pilot trial of the STAR-Liege protocol for tight glycemic control in critically ill patients
    Sophie Penning
    Cardiovascular Research Centre, Institut de Physique, Universite de Liege, Department of Intensive Care, Liege University Hospital, Allee du 6 Aout, 17 Bât B5, B4000 Liege, Belgium
    Comput Methods Programs Biomed 108:844-59. 2012
    ..STAR effectively managed this variability with no hypoglycemia. Improved stochastic models will be used to prospectively test these outcomes in further ongoing clinical pilot trials in this and other units...
  28. doi Nutrition disorders during acute renal failure and renal replacement therapy
    Patricia Wiesen
    Department of General Intensive Care, University Hospital Centre of Liege, Belgium
    JPEN J Parenter Enteral Nutr 35:217-22. 2011
    ..5-1.8 g/kg/d is recommended during continuous renal replacement therapy. Supplemental vitamin B(1) (100 mg/d), vitamin C (250 mg/d), and selenium (100 mcg/d) are also recommended...
  29. ncbi Hemodynamic effects of glibenclamide during endotoxemia: contrasting findings in vitro versus in vivo
    Jean Charles Preiser
    Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Shock 19:223-8. 2003
    ..As different effects of glibenclamide were observed in vivo, the importance of the opening of KATP channels in endotoxic shock may be limited...
  30. ncbi Monocyte CD40 expression in severe sepsis
    Kenji Sugimoto
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Shock 19:24-7. 2003
    ..Further studies on monocyte phenotype and function may help to assess the immune status of patients with sepsis and perhaps be useful to guide immunomodulatory strategy in the future...
  31. ncbi Biomarkers of oxidative stress in critically ill patients: what should be measured, when and how?
    Thierry Lemineur
    Department of General Intensive Care, University Hospital Centre, University of Liege, Domaine Universitaire du Sart Tilman, B 35, B 4000 Liege, Belgium
    Curr Opin Clin Nutr Metab Care 9:704-10. 2006
    ....
  32. ncbi Pancreatic cellular injury after cardiac surgery with cardiopulmonary bypass: frequency, time course and risk factors
    Monique Nys
    Departments of Anesthesia and Intensive Care Medicine, University Hospital of Liege, Liege, Belgium
    Shock 27:474-81. 2007
    ..These data support a high prevalence of postoperative PCI after cardiac surgery with cardiopulmonary bypass, typically biphasic and clinically silent, especially when pancreatic enzymes were elevated preoperatively...
  33. pmc Do we need an assessment of the nutrition risk in the critically ill patient?
    Jean Charles Preiser
    Department of Intensive Care, Erasme University Hospital, 808 Route de Lennik, 1070 Brussels, Belgium
    Crit Care 16:101. 2012
    ..Meanwhile the educational value of a score of nutrition risk is undisputed in settings where the use of scores is incorporated into the usual practice...
  34. doi SAPS 3 admission score: an external validation in a general intensive care population
    Didier Ledoux
    Soins Intensifs Generaux, Centre Hospitalier Universitaire de Liege, Domaine Universitaire de Sart Tilman Bat B35, 4000 Liege, Belgium
    Intensive Care Med 34:1873-7. 2008
    ..To validate the SAPS 3 admission score in an independent general intensive care case mix and to compare its performances with the APACHE II and the SAPS II scores...
  35. ncbi Microvascular blood flow is altered in patients with sepsis
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Am J Respir Crit Care Med 166:98-104. 2002
    ..The topical application of acetylcholine totally reversed these alterations. In conclusion, microvascular blood flow alterations are frequent in patients with sepsis and are more severe in patients with a worse outcome...
  36. ncbi Differential effects of a selective inhibitor of soluble guanylyl cyclase on global and regional hemodynamics during canine endotoxic shock
    Jean Charles Preiser
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Shock 20:465-8. 2003
    ..In the presence of endotoxin, ODQ administration increased MBF and prevented the restoration of FBF. Hence, selective inhibition of sGC may increase splanchnic blood flow in septic shock...
  37. ncbi Tight control of glycaemia in critically ill patients
    Jean Charles Preiser
    Department of Intensive Care of RHMS Tournai and Erasme University Hospital, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 5:533-7. 2002
    ..This manuscript attempts to review the effects associated with hyperglycaemia in critically ill patients and the effects of various insulin regimens. The available clinical findings and pertinent experimental data are examined...
  38. doi Tight glucose control and hypoglycemia
    Jean Charles Preiser
    Crit Care Med 36:1391; author reply 1391-2. 2008
  39. ncbi Steps for the implementation and validation of tight glucose control
    Jean Charles Preiser
    Intensive Care Med 33:570-1. 2007
  40. doi In vivo assessment of oxidative stress: a continuing challenge
    Jean Charles Preiser
    Crit Care Med 36:1015-6. 2008
  41. ncbi Does aprotinin influence the inflammatory response to cardiopulmonary bypass in patients?
    Denis Schmartz
    Department of Anesthesiology, Erasme University Hospital, Brussels, Belgium
    J Thorac Cardiovasc Surg 125:184-90. 2003
    ..This prospective, randomized, double-blind study evaluated the influence of aprotinin on various blood markers of inflammation during and after cardiopulmonary bypass...
  42. ncbi A comparison among portal lactate, intramucosal sigmoid Ph, and deltaCO2 (PaCO2 - regional Pco2) as indices of complications in patients undergoing abdominal aortic aneurysm surgery
    Abele Donati
    Department of Neuroscience, Anesthesia and Intensive Care Unit, Marche Polytechnique University, Ancona, Italy
    Anesth Analg 99:1024-31, table of contents. 2004
    ..9 +/- 1.2 g/dL versus 9.1 +/- 1.9 g/dL). In conclusion, both pHi and DeltaCO(2) are reasonably sensitive prognostic indices of organ failures after AAA surgery, but they are less specific and accurate than portal venous lactate...
  43. ncbi The use of protocols for nutritional support is definitely needed in the intensive care unit
    Jean Charles Preiser
    Crit Care Med 32:2354-5. 2004
  44. ncbi Goal-directed intraoperative therapy reduces morbidity and length of hospital stay in high-risk surgical patients
    Abele Donati
    Department of Neuroscience, Anesthesia, and Intensive Care Unit, Marche Polytechnique University, Torrette di Ancona, Italy
    Chest 132:1817-24. 2007
    ..The primary aim of this study was to compare the number of patients with postoperative organ failure and length of hospital stay between those randomized to conventional vs a protocolized strategy designed to maintain O2ER < 27%...
  45. ncbi Position paper of the ESICM Working Group on Nutrition and Metabolism. Metabolic basis of nutrition in intensive care unit patients: ten critical questions
    Gianni Biolo
    Istituto di Clinico Medica, University of Trieste, Ospedale di Cattinara, 34100 Trieste, Italy
    Intensive Care Med 28:1512-20. 2002
    ..This review focuses on the metabolic specificities of critically ill patients and also includes an analysis of the adequacy of tools to monitor the metabolic status and the adequacy of the nutritional support...
  46. pmc Glucose variability and mortality in patients with sepsis
    Naeem A Ali
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine and Center for Critical Care, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio, USA
    Crit Care Med 36:2316-21. 2008
    ..Our objective was to determine the association between glucose variability and hospital mortality in septic patients and the expression of glucose variability that best reflects this risk...
  47. ncbi Is parenteral nutrition guilty?
    Peter Varga
    Intensive Care Med 29:1861-4. 2003