W Pitchot

Summary

Country: Belgium

Publications

  1. doi request reprint Shock-like sensations associated with duloxetine discontinuation
    William Pitchot
    Ann Clin Psychiatry 20:175. 2008
  2. ncbi request reprint Duloxetine in major depressed patients resistant to SSRIs and/or venlafaxine
    William Pitchot
    University of Liege, Department of Psychiatry, CHU Sart Tilman B35, 4000 Liege, Belgium
    Psychiatr Danub 22:S106-7. 2010
  3. ncbi request reprint [Antipsychotics in depression]
    W Pitchot
    Service de Psychiatrie, CHU de Liege, Belgique
    Rev Med Liege 68:521-6. 2013
  4. ncbi request reprint [Medication of the month. asenapine (Sycrest]
    W Pitchot
    Service de Psychiatrie et de Psychologie Médicale, CHU de Liege, Belgique
    Rev Med Liege 68:196-200. 2013
  5. ncbi request reprint [Is there a place for the physician's hopelesness in the treatment of depression?]
    W Pitchot
    Service de Psychologie médicale, CHU de Liege, Belgique
    Rev Med Liege 68:61-4. 2013
  6. ncbi request reprint [Clinical and therapeutical approach of depression in old age]
    W Pitchot
    Service de Psychiatrie et Psychologie médicale, CHU de Liege, Belgique
    Rev Med Liege 67:566-72. 2012
  7. ncbi request reprint [Bipolar disorder: a multifactorial disease]
    W Pitchot
    Service de Psychiatrie et de Psychologie Médicale, CHU de Liege, Belgique
    Rev Med Liege 67:366-73. 2012
  8. ncbi request reprint Catecholamine and HPA axis dysfunction in depression: relationship with suicidal behavior
    William Pitchot
    Psychiatric Unit, CHU Sart Tilman, Liege, Belgium
    Neuropsychobiology 47:152-7. 2003
  9. ncbi request reprint Hormonal and temperature responses to the 5-HT1A receptor agonist flesinoxan in normal volunteers
    William Pitchot
    Psychiatric Unit, CHU Sart Tilman, 4000 Liege, Belgium
    Psychopharmacology (Berl) 164:27-32. 2002
  10. ncbi request reprint Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study
    William Pitchot
    Psychiatric Unit, CHU Sart Tilman, B 4000 Liege, Belgium
    Eur Neuropsychopharmacol 14:151-5. 2004

Detail Information

Publications50

  1. doi request reprint Shock-like sensations associated with duloxetine discontinuation
    William Pitchot
    Ann Clin Psychiatry 20:175. 2008
  2. ncbi request reprint Duloxetine in major depressed patients resistant to SSRIs and/or venlafaxine
    William Pitchot
    University of Liege, Department of Psychiatry, CHU Sart Tilman B35, 4000 Liege, Belgium
    Psychiatr Danub 22:S106-7. 2010
    ..Remission was achieved in 48% of the patients. The tolerance was excellent. This study suggests the potential interest of duloxetine in some treatment-resistant depressed patients...
  3. ncbi request reprint [Antipsychotics in depression]
    W Pitchot
    Service de Psychiatrie, CHU de Liege, Belgique
    Rev Med Liege 68:521-6. 2013
    ..Second generation antipsychotics have been investigated in clinical trials in treatment resistant depression and in bipolar depression. Scientific data are available particularly for aripiprazole and quetiapine XR...
  4. ncbi request reprint [Medication of the month. asenapine (Sycrest]
    W Pitchot
    Service de Psychiatrie et de Psychologie Médicale, CHU de Liege, Belgique
    Rev Med Liege 68:196-200. 2013
    ..Asenapine is associated with a good tolerability profile. In particular, asenapine induces a moderate weight gain, and does not increase serum levels of lipids or fasting glucose...
  5. ncbi request reprint [Is there a place for the physician's hopelesness in the treatment of depression?]
    W Pitchot
    Service de Psychologie médicale, CHU de Liege, Belgique
    Rev Med Liege 68:61-4. 2013
    ..In the present paper, we describe the case of a patient suffering from treatment-resistant chronic depression that remitted with a combination of duloxetine (Cymbalta) and aripiprazole (Abilify)...
  6. ncbi request reprint [Clinical and therapeutical approach of depression in old age]
    W Pitchot
    Service de Psychiatrie et Psychologie médicale, CHU de Liege, Belgique
    Rev Med Liege 67:566-72. 2012
    ..Depression is also frequently associated with somatic illnesses, with alcoholism, anxiety and a significant risk of suicide. In this context, a systematic screening of depression and an adequate treatment are a priority...
  7. ncbi request reprint [Bipolar disorder: a multifactorial disease]
    W Pitchot
    Service de Psychiatrie et de Psychologie Médicale, CHU de Liege, Belgique
    Rev Med Liege 67:366-73. 2012
    ..The complexity and heterogeneity of bipolar disorder require the identification of homogenous sub-groups with the use of biomarkers that could help reduce the etiological heterogeneity and better target the therapeutical options...
  8. ncbi request reprint Catecholamine and HPA axis dysfunction in depression: relationship with suicidal behavior
    William Pitchot
    Psychiatric Unit, CHU Sart Tilman, Liege, Belgium
    Neuropsychobiology 47:152-7. 2003
    ....
  9. ncbi request reprint Hormonal and temperature responses to the 5-HT1A receptor agonist flesinoxan in normal volunteers
    William Pitchot
    Psychiatric Unit, CHU Sart Tilman, 4000 Liege, Belgium
    Psychopharmacology (Berl) 164:27-32. 2002
    ..Flesinoxan is a highly potent and selective 5-HT(1A) agonist and appears to be a potentially interesting neuroendocrine serotonergic probe...
  10. ncbi request reprint Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study
    William Pitchot
    Psychiatric Unit, CHU Sart Tilman, B 4000 Liege, Belgium
    Eur Neuropsychopharmacol 14:151-5. 2004
    ..In a recent study, in normal volunteers, flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature...
  11. ncbi request reprint 5-Hydroxytryptamine 1A receptors, major depression, and suicidal behavior
    William Pitchot
    Psychiatric Unit, Centre Hospitalier Universitaire Sart Tilman, Liege, Belgium
    Biol Psychiatry 58:854-8. 2005
    ..Therefore, the aim of our study was to use a neuroendocrine strategy to test the hypothesis of a role for 5-HT1A receptors in the biology of suicidal behavior...
  12. ncbi request reprint Reduced dopaminergic activity in depressed suicides
    W Pitchot
    Psychiatric Unit, CHU Sart Tilman, B 4000, Liege, Belgium
    Psychoneuroendocrinology 26:331-5. 2001
    ..6 +/- 4.1 ng/ml vs 18.9 +/- 14.2 ng/ml, U = 30, Z = -2.33, P = 0.02. Our results tend to confirm the role of dopamine in the biology of suicide in depression...
  13. ncbi request reprint HPA axis dysfunction in major depression: relationship to 5-HT(1A) receptor activity
    W Pitchot
    Psychiatric Unit, CHU du Sart Tilman, Liege, Belgium
    Neuropsychobiology 44:74-7. 2001
    ..Dexamethasone nonsuppressors exhibited lower ACTH responses to flesinoxan as compared with dexamethasone suppressors. The results showed that a dysfunction in 5-HT(1A) receptor activity could be due to a hypersecretion of cortisol...
  14. ncbi request reprint Alpha-2-adrenoreceptors in depressed suicide attempters: relationship with medical lethality of the attempt
    W Pitchot
    Psychiatric Unit, CHU Sart Tilman, Liege, Belgium
    Neuropsychobiology 44:91-4. 2001
    ..1, 38, p = 0.12). Moreover, GH peak responses to clonidine were not related to the degree of lethality of the attempt. The results of the present study do not support a major role for noradrenaline in the biology of suicidal behavior...
  15. ncbi request reprint [Antidepressants of the future: role of the glutamatergic system]
    W Pitchot
    Service de Psychiatrie et Psychologie médicale, CHU Liege, Universite de Liege, Belgique
    Rev Med Liege 66:195-8. 2011
    ..In this context, the glutamatergic system plays a role in the pathophysiology of depression. Agents modulating glutamatergic activity could act as antidepressants...
  16. ncbi request reprint Reduced dopamine function in depressed patients is related to suicidal behavior but not its lethality
    W Pitchot
    Psychiatric Unit, CHU Sart Tilman, B 4000, Liege, Belgium
    Psychoneuroendocrinology 26:689-96. 2001
    ..In conclusion, the results of the present study support a role for dopamine in the biology of suicidal behaviour. More specifically, an impaired GH response to apomorphine could be a marker of suicide risk...
  17. ncbi request reprint AVP- and OT-neurophysins response to apomorphine and clonidine in major depression
    G Scantamburlo
    Department of Psychiatry, Psychoneuroendocrinology Unit, CHU of Liege, Belgium
    Psychoneuroendocrinology 30:839-45. 2005
    ..Moreover, we did not find any influence of acute apomorphine or clonidine injections on vasopressin-neurophysin or oxytocin-neurophysin in depressive patients...
  18. ncbi request reprint 5-HT1A dysfunction in borderline personality disorder
    M Hansenne
    Department of Psychiatry, University of Liege, CHU Sart Tilman, Belgium
    Psychol Med 32:935-41. 2002
    ..Therefore, we tested whether subjects with BPD showed a blunted prolactin (PRL) response to flesinoxan, a highly potent and selective 5-HT1A agonist...
  19. ncbi request reprint Neuroendocrine evaluation of 5-HT1A function in male alcoholic patients
    E Pinto
    University of Liege, Department of Psychiatry, CHU du Sart Tilman B35, B 4000 Liege, Belgium
    Psychoneuroendocrinology 27:873-9. 2002
    ..Preclinical evidences support the hypothesis of a serotonergic dysfunction in alcohol preference. In human, studies have demonstrated a serotonergic hypoactivity in alcoholism. However, little is known about the role of 5-HT1A receptors...
  20. ncbi request reprint Mismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects
    M Hansenne
    Department of Cognitive Sciences, University of Liege, Belgium
    Hum Psychopharmacol 18:201-5. 2003
    ..However, given the complexity of the central neurotransmitter systems, these results cannot be considered as definitive evidence against a relationship between dopaminergic and noradrenergic activity and the MMN...
  21. ncbi request reprint Plasma oxytocin levels and anxiety in patients with major depression
    G Scantamburlo
    Department of Psychiatry, University of Liege, Psychoneuroendocrinology Unit, CHU of Liege, B35, B 4000 Liege, Belgium
    Psychoneuroendocrinology 32:407-10. 2007
    ..Results showed a significant negative correlation between oxytocin and the scored symptoms depression (r=-0.58, p=0.003) and anxiety (r=-0.61, p=0.005)...
  22. ncbi request reprint Role of dopamine in non-depressed patients with a history of suicide attempts
    W Pitchot
    Psychiatric Unit, CHU Sart Tilman, , Belgium
    Eur Psychiatry 16:424-7. 2001
    ..4 +/- 8.2 ng/mL vs 27.3 +/- 13.1 ng/ml, F = 9.0, P = 0.009. In conclusion, dopaminergic disturbances seem to play a role in the biology of inward-directed aggression in non-depressed patients...
  23. ncbi request reprint Serotonergic-1a activity and contingent negative variation
    M Hansenne
    Department of Psychiatry, University of Liege, CHU du Sart Tilman B 35, B 4000, Liege, Belgium
    Biol Psychol 52:259-65. 2000
    ..In depressed patients, the relationships were not significant. Overall, this study does not support serotonergic effects on CNV. However, this information is indirect (correlations) and is limited to 5-HT(1A) activity...
  24. ncbi request reprint [Discontinuation syndrome associated with antidepressants]
    W Pitchot
    Service de Psychiatrie et de Psychologie Médicale, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 62:624-7. 2007
    ..Sometimes, in the presence of a severe syndrome, reintroduction of the antidepressant induces a rapid resolution of the symptoms. In fact, the discontinuation of the antidepressant should be progressive...
  25. ncbi request reprint [Zolpidem dependence and withdrawal seizure]
    W Pitchot
    Service de Psychiatrie et de Psychologie Médicale, CHU de Liege, Belgique
    Rev Med Liege 64:407-8. 2009
    ..However, in the past 10 years, several cases of zolpidem abuse, dependence and withdrawal reactions have been described in the litterature. Here, we describe a case of dependence and withdrawal seizure...
  26. ncbi request reprint [Dopamine and depression: the forgotten neurotransmitter]
    W Pitchot
    Service de Psychiatrie et de Psychologie Médicale, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 63:378-84. 2008
    ..Recent developments of molecular biology and new imaging techniques provide interesting perspectives that could bring a better comprehension of the real implication of dopamine in depression...
  27. ncbi request reprint The transsexual: what about the future?
    A Michel
    Department of Clinical Psychology, University of Liege, Boulevard du Rectorat B33, 4000 Liege, Belgium
    Eur Psychiatry 17:353-62. 2002
    ..Studies show that there is less than 1% of regrets, and a little more than 1% of suicides among operated subjects. The empirical research does not confirm the opinion that suicide is strongly associated with surgical transformation...
  28. ncbi request reprint The lack of relationship between DST nonsuppression in the dexamethasone suppression test and EEG abnormalities
    W Pitchot
    Psychiatric Unit, Centre Hospitalier Universitaire du Sart Tilman, , Belgium
    Eur Arch Psychiatry Clin Neurosci 241:193-4. 1991
    ..A total of 23 patients exhibited DST nonsuppression (44%) and 18 patients had EEG abnormalities (35%). No relationship existed between DST and EEG results...
  29. ncbi request reprint [Neurohypophyseal neuropeptides and unipolar depression: which future?]
    G Scantamburlo
    Service de Psychiatrie et de Psychologie Médicale, Unité de Psychoneuroendocrinologie, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 63:385-90. 2008
    ..A selective AVP V1b receptor, SSR1419415, has been characterized and is endowed with anxiolytic- an and antidepressant-like properties. This paper proposes an overview of neurohypophyseal hormones in major depression...
  30. ncbi request reprint Vasopressin-neurophysin and DST in major depression: relationship with suicidal behavior
    William Pitchot
    Department of Psychiatry, Psychoneuroendocrinology Unit, University of Liege, CHU of Liege, B 4000 Liege, Belgium
    J Psychiatr Res 42:684-8. 2008
    ..29+/-0.13 ng/ml vs 0.36+/-0.21 ng/ml, (F=1.1, df=1, 27, p=0.30). Suicide attempters did not differ from nonattempters for AVP-neurophysins levels. Our results fail to support a role of AVP in the early cortisol escape...
  31. ncbi request reprint [Cocaine addiction]
    W Pitchot
    Service de Psychologie Médicale et de Psychiatrie, CHU de Liege, Belgique
    Rev Med Liege 68:294-7. 2013
    ..Somatic and psychiatric consequences of cocaine addiction are major and clinically relevant. The increasing consumption of cocaine and the importance of its consequences justify an update of our knowledge about cocaine addiction...
  32. ncbi request reprint [Tricyclic antidepressants and monoamine oxidase inhibitors - do they still have a role in the treatment of depression?]
    W Pitchot
    Service de Psychiatrie et de Psychologie Médicale, CHU de Liege, Belgique
    Rev Med Liege 66:144-52. 2011
    ..But, their prescription requires a good knowledge of the potential complications...
  33. ncbi request reprint [Antidepressants in bipolar disorder: beware of risks!]
    W Pitchot
    Service de Psychiatrie et de Psychologique médicale, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 63:391-5. 2008
    ..The prescription of antidepressants might be envisaged in case of therapeutic failure with a thymostabilizing agent, and always in association with a preventive therapy...
  34. ncbi request reprint [Therapeutic potential of repetitive transcranial magnetic stimulation in brain disorders]
    A Fumal
    Service Universitaire de Neurologie, CHR Citadelle, Liege, Belgique
    Rev Med Liege 63:330-7. 2008
    ..In this review, we discuss the clinical and scientific bases for the therapeutic use of TMS, and review the results of trials in psychiatric and neurological disorders to date...
  35. ncbi request reprint Event-related potentials to emotional and neutral stimuli in alcoholism
    Michel Hansenne
    Department of Cognitive Sciences, University of Liege, Liege, Belgium
    Neuropsychobiology 48:77-81. 2003
    ..Besides, the results imply that information processing was delayed in female alcoholic patients. Therefore this study demonstrates a gender-dependent impact of alcohol-related stimuli on information processing...
  36. doi request reprint The short allele of the serotonin transporter promoter polymorphism influences relapse in alcohol dependence
    Emmanuel Pinto
    Department of Psychiatry, University of Liege, CHU Sart Tilman B35, B 4000 Liege, Belgium
    Alcohol Alcohol 43:398-400. 2008
    ..The short (S) allele of the serotonin transporter gene promoter polymorphism (5-HTTLPR) contributes to the risk of alcohol dependence and co-occurring clinical features. We studied the putative link between this allele and relapse...
  37. doi request reprint The TaqI A DRD2 polymorphism in type II alcohol dependence: a marker of age at onset or of a familial disease?
    Emmanuel Pinto
    Department of Psychiatry, University of Liege, CHU Sart Tilman B35, Liege, Belgium
    Alcohol 43:271-5. 2009
    ..However, the A1 allele of the DRD2 may be a marker of male familial alcoholism, which has been associated with type II alcohol dependence...
  38. ncbi request reprint [Affective dependency]
    G Scantamburlo
    Universite de Liege, Chef de Clinique, Liege
    Rev Med Liege 68:340-7. 2013
    ..We also focus on the interrelations between dependent personality, domestic violence and addictions. The objective for the clinician is to propose a restoration of self-esteem and therapeutic strategies focused on autonomy...
  39. ncbi request reprint [How to cope with the bad reputation of depression]
    W Pitchot
    Service de Psychiatrie et de Psychologie Médicale, CHU de Liege, Belgique
    Rev Med Liege 68:186-9. 2013
    ....
  40. ncbi request reprint [New prospects in the treatment of affective disorders]
    W Pitchot
    Service en Psychiatrie, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 62:451-6. 2007
    ..The future will include the developement of new original pharmacological agents outside the field of the classical monoaminergic hypothesis of depression...
  41. ncbi request reprint [Depression and neuroplasticity]
    W Pitchot
    Service de Psychiatrie et de Psychologie Médicale, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 63:372-7. 2008
    ..In the present review, we will summarize recent crucial data that establish the link between depression and neuroplasticity...
  42. ncbi request reprint [Neurobiology and pharmacotherapy of obsessive-compulsive disorder]
    M Ansseau
    Universite de Liege, Service de Psychiatrie et de Psychologie Médicale, Liege, Belgique
    Rev Med Liege 63:359-63. 2008
    ..Several augmentation strategies have been proposed for resistant patients. Very recently, brain neurostimulation techniques using implanted electrodes have demonstrated their interest in case of failure of other treatment strategies...
  43. ncbi request reprint [Suicidal behaviour: psycho-social and psycho-pathological risk factor]
    W Pitchot
    Service de Psychiatrie et de Psychologique médicale, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 63:396-403. 2008
    ..Suicide is determined by the interaction of all these factors. The purpose of this paper is to present recent data from the literature concerning psychosocial and psychopathological risk factors...
  44. ncbi request reprint [Medication of the month. Duloxetine (Cymbalta)]
    W Pitchot
    Universite de Liege, Service de Psychiatrie et de Psychologie Médicale, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 61:787-90. 2006
    ..The side-effect profile of duloxetine is particularly good and similar to selective serotonin reuptake inhibitors with mainly nausea. In total, duloxetine represents a real progress in the pharmacological treatment of major depression...
  45. ncbi request reprint [The acute management of agitation]
    S Bakay
    Service de Psychiatrie et de Psychologie Médicale, CHU de Liege
    Rev Med Liege 68:553-6. 2013
    ..Indeed, acute agitation can hide serious somatic traps and be life threatening...
  46. ncbi request reprint [Affective disorders: a pharmacological approach]
    W Pitchot
    Service de Psychiatrie, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 62:21-4. 2007
    ....
  47. ncbi request reprint [Psychostimulants]
    E Pinto
    Service de Psychiatrie et Psychologie médicale, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 63:411-6. 2008
    ..These substances may lead to real dependence and may cause serious somatic and psychiatric damage. In this perspective, we reviewed the available literature concerning problematic psychoactive drug use in Belgium...
  48. ncbi request reprint [Pathological gambling : conceptual evolution, clinical characteristics and psychotherapeutical perspectives]
    P Gijsen
    Psychologue, Psy Pluriel, Liege, Belgique
    Rev Med Liege 68:359-64. 2013
    ..Individual as well as group psychotherapeutic care modalities exist. Cognitive-behavioural therapies and their current developments are presented in this article...
  49. ncbi request reprint [Post-traumatic stress disorder and psychological debriefing: a controversial topic]
    C Debabèche
    Service de Psychiatrie et de Psychologie Médicale, CHU de Liege, Belgique
    Rev Med Liege 67:11-5. 2012
    ..The objective of the present paper is to define the interest of psychological debriefing, but also alternative therapeutical strategies for people exposed to traumatic events...
  50. ncbi request reprint Comparisons of two groups of sex-change applicants based on the MMPI
    A Michel
    Department of Clinical Psychology, University of Liege, Belgium
    Psychol Rep 91:233-40. 2002
    ....