A Noel

Summary

Country: Belgium

Publications

  1. pmc Membrane associated proteases and their inhibitors in tumour angiogenesis
    A Noel
    Laboratory of Tumour and Development Biology, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    J Clin Pathol 57:577-84. 2004
  2. ncbi request reprint Emerging roles for proteinases in cancer
    A Noel
    Laboratory of Tumor and Development Biology, University of Liege, Sart Tilman, Belgium
    Invasion Metastasis 17:221-39. 1997
  3. ncbi request reprint Inhibition of stromal matrix metalloproteases: effects on breast-tumor promotion by fibroblasts
    A Noel
    Laboratory of Tumor and Developmental Biology, Sart Tilman, Belgium
    Int J Cancer 76:267-73. 1998
  4. doi request reprint Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis
    M El Hour
    Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer GIGA Cancer, University of Liege, Liège B 4000, Belgium
    Oncogene 29:3025-32. 2010
  5. ncbi request reprint New functions of stromal proteases and their inhibitors in tumor progression
    A Noel
    Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie, Liege, Belgium
    Surg Oncol Clin N Am 10:417-32, x-xi. 2001
  6. ncbi request reprint Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
    K Bajou
    Laboratory of Tumor and Developmental Biology, University of Liege, Belgium
    Nat Med 4:923-8. 1998
  7. ncbi request reprint MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease
    D Cataldo
    Department of Pneumology, University of Liege, Liege, Belgium
    Int Arch Allergy Immunol 123:259-67. 2000
  8. doi request reprint MT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis
    E Maquoi
    Laboratory of Tumor and Developmental Biology, GIGA Cancer, Institute of Pathology, University of Liege, Liege, Belgium
    Oncogene 31:480-93. 2012
  9. ncbi request reprint Quantification of in vivo tumor invasion and vascularization by computerized image analysis
    S Blacher
    Laboratory of Tumor and Development Biology, Centre de Recherche en cancérologie Expérimentale, Groupe Interdisciplinaire de Génoprotéomique Apliquée, University of Liege, Tour de Pathologie, CHU B23, Sart Tilman, Liege, Belgium
    Microvasc Res 75:169-78. 2008
  10. ncbi request reprint The role of stroma in breast carcinoma growth in vivo
    A Noel
    Laboratory of Tumor and Developmental Biology, University of Liege, Belgium
    J Mammary Gland Biol Neoplasia 3:215-25. 1998

Collaborators

Detail Information

Publications33

  1. pmc Membrane associated proteases and their inhibitors in tumour angiogenesis
    A Noel
    Laboratory of Tumour and Development Biology, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    J Clin Pathol 57:577-84. 2004
    ..As knowledge in the field of protease biology has improved, the unforeseen complexities of cell associated enzymes and their interaction with physiological inhibitors have emerged, often revealing unexpected mechanisms of action...
  2. ncbi request reprint Emerging roles for proteinases in cancer
    A Noel
    Laboratory of Tumor and Development Biology, University of Liege, Sart Tilman, Belgium
    Invasion Metastasis 17:221-39. 1997
    ..Further elucidation of the functions of proteinases is essential for the development of novel anticancer strategies...
  3. ncbi request reprint Inhibition of stromal matrix metalloproteases: effects on breast-tumor promotion by fibroblasts
    A Noel
    Laboratory of Tumor and Developmental Biology, Sart Tilman, Belgium
    Int J Cancer 76:267-73. 1998
    ..These findings emphasize the importance of fibroblasts in cancer progression, and suggest that their role could be related at least in part to production of proteases which can induce the release of factors from the extracellular matrix...
  4. doi request reprint Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis
    M El Hour
    Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer GIGA Cancer, University of Liege, Liège B 4000, Belgium
    Oncogene 29:3025-32. 2010
    ..Altogether, our results show that ADAMTS-12 displays antiangiogenic properties and protect the host toward tumor progression...
  5. ncbi request reprint New functions of stromal proteases and their inhibitors in tumor progression
    A Noel
    Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie, Liege, Belgium
    Surg Oncol Clin N Am 10:417-32, x-xi. 2001
    ..Recent observations suggest a much more complex role of these inhibitors in tumor progression than expected initially...
  6. ncbi request reprint Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
    K Bajou
    Laboratory of Tumor and Developmental Biology, University of Liege, Belgium
    Nat Med 4:923-8. 1998
    ..This experimental evidence demonstrates that host-produced PAI is essential for cancer cell invasion and angiogenesis...
  7. ncbi request reprint MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease
    D Cataldo
    Department of Pneumology, University of Liege, Liege, Belgium
    Int Arch Allergy Immunol 123:259-67. 2000
    ..The course of asthma and chronic obstructive pulmonary disease (COPD) is associated with bronchial morphological changes. Metalloproteinases are thought to play a role in these structural changes...
  8. doi request reprint MT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis
    E Maquoi
    Laboratory of Tumor and Developmental Biology, GIGA Cancer, Institute of Pathology, University of Liege, Liege, Belgium
    Oncogene 31:480-93. 2012
    ..These findings reveal a new mechanism whereby MMP-14 activity promotes tumor progression by circumventing apoptosis...
  9. ncbi request reprint Quantification of in vivo tumor invasion and vascularization by computerized image analysis
    S Blacher
    Laboratory of Tumor and Development Biology, Centre de Recherche en cancérologie Expérimentale, Groupe Interdisciplinaire de Génoprotéomique Apliquée, University of Liege, Tour de Pathologie, CHU B23, Sart Tilman, Liege, Belgium
    Microvasc Res 75:169-78. 2008
    ..This methodology is validated by evaluating the contribution of matrix metalloproteases (MMPs) in skin carcinoma invasion and vascularization through pharmacological and genetic approaches...
  10. ncbi request reprint The role of stroma in breast carcinoma growth in vivo
    A Noel
    Laboratory of Tumor and Developmental Biology, University of Liege, Belgium
    J Mammary Gland Biol Neoplasia 3:215-25. 1998
    ..These animal models are likely to provide a useful tool to evaluate new antitumor treatments...
  11. doi request reprint A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancer
    A Bonnomet
    Laboratory of Tumor and Developmental Biology, GIGA Cancer, University of Liege, Liege, Belgium
    Oncogene 31:3741-53. 2012
    ..They further suggest that mesenchymal-to-epithelial phenomena occur in secondary organs, facilitating the metastatic growth...
  12. pmc Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts
    A Noel
    Laboratory of Cellular Biology, Tour de Pathologie, Sart Tilman, Liege, Belgium
    Br J Cancer 68:909-15. 1993
    ..These data suggest that human tumours may be reconstituted and grown in athymic nude mice using basement membrane components and fibroblasts as inductors...
  13. ncbi request reprint Pathogenic role of matrix metalloproteases and their inhibitors in asthma and chronic obstructive pulmonary disease and therapeutic relevance of matrix metalloproteases inhibitors
    D D Cataldo
    Department of Tumours and Developmental Biology, University of Liege, Tower of Pathology B23, CHU Sart Tilman, 4000 Liege, Belgium
    Cell Mol Biol (Noisy-le-grand) 49:875-84. 2003
    ....
  14. ncbi request reprint Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis
    N E Sounni
    Laboratory of Tumor and Development Biology, University of Liege, Sart Tilman, Belgium
    Matrix Biol 22:55-61. 2003
    ..As our knowledge on the field of MT1-MMP biology has grown, the unforeseen complexities of this enzyme and its interaction with its inhibitor TIMP-2 have emerged, often revealing unexpected mechanisms of action...
  15. ncbi request reprint Heterotransplantation of primary and established human tumour cells in nude mice
    A Noel
    Laboratory of Biology, University of Liege, Belgium
    Anticancer Res 15:1-7. 1995
    ..Breast primary tumours or cell lines gave rise to poorly differentiated carcinomas. The other tumours presented histopathological patterns typical of differentiated human cancers...
  16. pmc Whole slide quantification of stromal lymphatic vessel distribution and peritumoral lymphatic vessel density in early invasive cervical cancer: a method description
    C Balsat
    Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA Cancer, University of Liege, Pathology Tower B23, 4000 Liege, Belgium
    ISRN Obstet Gynecol 2011:354861. 2011
    ..The proposed technique can be useful to better characterize lymphatic vessel interactions with tumor cells and could potentially impact on prognosis and therapeutic decisions...
  17. pmc Presence of oestrogen receptor type beta in human retina
    C Munaut
    Laboratory of Tumor and Development Biology, University of Liege, Pathology Tower B23, Sart Tilman, B 4000 Liege, Belgium
    Br J Ophthalmol 85:877-82. 2001
    ..Since important pathologies of human eye could be linked to hormonal status, the expression of ORbeta in ocular posterior segment was sought...
  18. pmc 3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo
    I Kempen
    Centre Interfacultaire de Recherche en Pharmacochimie des substances naturelles et synthétiques, Laboratoire de Chimie Pharmaceutique, Universite de Liege, Belgique
    Br J Cancer 88:1111-8. 2003
    ..The mechanism of action of the drugs remains to be elucidated. However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents...
  19. ncbi request reprint Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro
    J M Lewalle
    Laboratory of Cellular Biology, University of Liege, CHU, Sart Tilman, Belgium
    Exp Cell Res 237:347-56. 1997
    ..Our data suggest that tumor cells modulate AJ protein distribution and phosphorylation in EC and may, thereby, facilitate EC dissociation...
  20. ncbi request reprint Effects of a progestogen on normal human breast epithelial cell apoptosis in vitro and in vivo
    J Desreux
    Laboratory of Tumor and Development Biology, University Hospital, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    Breast 12:142-9. 2003
    ..These observations open up new perspectives in the prevention of hyperplasia and breast cancer...
  21. ncbi request reprint Progesterone receptor activation. an alternative to SERMs in breast cancer
    J Desreux
    Laboratory of Tumor and Development Biology, Tour de Pathologie 3 B23, Sart Tilman, B4000, Liege, Belgique
    Eur J Cancer 36:S90-1. 2000
    ..Fibro-adenoma and cancerous cells do not show this regulation of apoptosis. Progesterone seems to be important in normal breast homeostasis...
  22. ncbi request reprint Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization
    V Lambert
    Laboratory of Tumor and Development Biology, University of Liege, B 4000 Liege, Belgium
    FASEB J 15:1021-7. 2001
    ..They identify therefore PAI-1 as a potential target for therapeutic ocular anti-angiogenic strategies...
  23. pmc Curcumin-cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancer
    N Rocks
    Laboratory of Tumor and Development Biology, GIGA Research Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA Cancer and GIGA I, University of Liege and CHU of Liege, Sart Tilman, 4000 Liege, Belgium
    Br J Cancer 107:1083-92. 2012
    ..Overall clinical outcome for advanced lung cancer remains very disappointing despite recent advances in treatment. Curcumin has been reported as potentially active against cancer...
  24. doi request reprint Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque-type psoriasis
    A Henno
    Department of Dermatology, University Hospital of Liege, University of Liege, Belgium
    Br J Dermatol 160:581-90. 2009
    ..Vascular alterations are significant events in the pathomechanism of psoriasis. A disorder in the mechanisms regulating skin angiogenesis and lymphangiogenesis could participate in the pathogenesis of the disease...
  25. ncbi request reprint Regulation of vimentin by SIP1 in human epithelial breast tumor cells
    S Bindels
    Laboratory of Tumor and Developmental Biology, Center for Biomedical Integrated Genoproteomics, University of Liege, CHU Sart Tilman, Liege, Belgium
    Oncogene 25:4975-85. 2006
    ..Our results therefore implicate SIP1 in the regulation of vimentin observed in the EMT associated with breast tumor cell migration, a pathway that may contribute to the metastatic progression of breast cancer...
  26. ncbi request reprint MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression
    N E Sounni
    Laboratory of Tumor and Development Biology, Laboratory of Connective Tissues Biology, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    FASEB J 16:555-64. 2002
    ..These results emphasize the importance of MT1-MMP during tumor angiogenesis and open new opportunities for the development of anti-angiogenic strategies combining inhibitors of MT1-MMP and VEGF antagonists...
  27. doi request reprint Nuclear delivery of a therapeutic peptide by long circulating pH-sensitive liposomes: benefits over classical vesicles
    E Ducat
    Laboratory of Pharmaceutical Technology, CIRM, Department of Pharmacy, University of Liege, B36, Tour 4, Level 2, Avenue de l Hopital, 1, B 4000 Liege, Belgium
    Int J Pharm 420:319-32. 2011
    ..Most importantly, when encapsulated in pH-sensitive stealth liposomes, the peptide was able to reach the nucleus of tumorigenic and non tumorigenic breast cancer cells...
  28. ncbi request reprint Human chorionic gonadotropin and growth factors at the embryonic-endometrial interface control leukemia inhibitory factor (LIF) and interleukin 6 (IL-6) secretion by human endometrial epithelium
    S Perrier d'Hauterive
    Center of Immunology and Laboratory of Tumour and Developmental Biology, Institute of Pathology CHU B23, University of Liege, B 4000 Liege Sart Tilman, Belgium
    Hum Reprod 19:2633-43. 2004
    ....
  29. ncbi request reprint Induction of SPARC by VEGF in human vascular endothelial cells
    Y Kato
    Laboratory of Tumor and Developmental Biology, University of Liege Faculty of Medicine, B 4000 Liege, Belgium
    Biochem Biophys Res Commun 287:422-6. 2001
    ....
  30. ncbi request reprint Membrane type-matrix metalloproteinases and tumor progression
    N E Sounni
    Laboratory of Tumor and Development Biology, University of Liege, Sart Tilman B23, B4000 Liege, Belgium
    Biochimie 87:329-42. 2005
    ..This review sheds light on the new functions of MT-MMPs and their inhibitors in tumor development and angiogenesis, and presents recent investigations that document their influence on various cell functions...
  31. ncbi request reprint Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium
    Nat Med 7:575-83. 2001
    ..By upregulating PlGF and the signaling subtype of VEGFR-1, endothelial cells amplify their responsiveness to VEGF during the 'angiogenic switch' in many pathological disorders...
  32. ncbi request reprint Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertension
    H Lepetit
    INSERM U492, Dept de Physiologie, Faculte de Medecine, CHU Henri Mondor Créteil, 94010 Creteil, France
    Eur Respir J 25:834-42. 2005
    ..Whether these abnormalities are potential therapeutic targets deserves further investigation...
  33. ncbi request reprint Emerging roles of ADAM and ADAMTS metalloproteinases in cancer
    N Rocks
    Department of Biology of Tumours and Development, GIGA Research Groupe Interdisciplinaire de Génoprotéomique Appliquée and Center for Experimental Cancer Research CECR, University of Liege and CHU of Liege, Liege, Belgium
    Biochimie 90:369-79. 2008
    ..The current review addresses the contribution of these proteinases in the positive and negative regulation of cancer progression as mainly mediated by the regulation of growth factor activities and integrin functions...