Research Topics
Genomes and Genes | A NoelSummaryCountry: Belgium Publications
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Publications
Membrane associated proteases and their inhibitors in tumour angiogenesisA Noel
Laboratory of Tumour and Development Biology, University of Liege, Sart Tilman, B 4000 Liege, Belgium
J Clin Pathol 57:577-84. 2004..As knowledge in the field of protease biology has improved, the unforeseen complexities of cell associated enzymes and their interaction with physiological inhibitors have emerged, often revealing unexpected mechanisms of action...
Emerging roles for proteinases in cancerA Noel
Laboratory of Tumor and Development Biology, University of Liege, Sart Tilman, Belgium
Invasion Metastasis 17:221-39. 1997..Further elucidation of the functions of proteinases is essential for the development of novel anticancer strategies...- Inhibition of stromal matrix metalloproteases: effects on breast-tumor promotion by fibroblastsA Noel
Laboratory of Tumor and Developmental Biology, Sart Tilman, Belgium
Int J Cancer 76:267-73. 1998..These findings emphasize the importance of fibroblasts in cancer progression, and suggest that their role could be related at least in part to production of proteases which can induce the release of factors from the extracellular matrix... 
Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesisM El Hour
Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cancer GIGA Cancer, University of Liege, Liège B 4000, Belgium
Oncogene 29:3025-32. 2010..Altogether, our results show that ADAMTS-12 displays antiangiogenic properties and protect the host toward tumor progression...- New functions of stromal proteases and their inhibitors in tumor progressionA Noel
Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie, Liege, Belgium
Surg Oncol Clin N Am 10:417-32, x-xi. 2001..Recent observations suggest a much more complex role of these inhibitors in tumor progression than expected initially... - Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularizationK Bajou
Laboratory of Tumor and Developmental Biology, University of Liege, Belgium
Nat Med 4:923-8. 1998..This experimental evidence demonstrates that host-produced PAI is essential for cancer cell invasion and angiogenesis... - MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary diseaseD Cataldo
Department of Pneumology, University of Liege, Liege, Belgium
Int Arch Allergy Immunol 123:259-67. 2000..The course of asthma and chronic obstructive pulmonary disease (COPD) is associated with bronchial morphological changes. Metalloproteinases are thought to play a role in these structural changes... - MT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosisE Maquoi
Laboratory of Tumor and Developmental Biology, GIGA Cancer, Institute of Pathology, University of Liege, Liege, Belgium
Oncogene 31:480-93. 2012..These findings reveal a new mechanism whereby MMP-14 activity promotes tumor progression by circumventing apoptosis... - Quantification of in vivo tumor invasion and vascularization by computerized image analysisS Blacher
Laboratory of Tumor and Development Biology, Centre de Recherche en cancérologie Expérimentale, Groupe Interdisciplinaire de Génoprotéomique Apliquée, University of Liege, Tour de Pathologie, CHU B23, Sart Tilman, Liege, Belgium
Microvasc Res 75:169-78. 2008..This methodology is validated by evaluating the contribution of matrix metalloproteases (MMPs) in skin carcinoma invasion and vascularization through pharmacological and genetic approaches... - The role of stroma in breast carcinoma growth in vivoA Noel
Laboratory of Tumor and Developmental Biology, University of Liege, Belgium
J Mammary Gland Biol Neoplasia 3:215-25. 1998..These animal models are likely to provide a useful tool to evaluate new antitumor treatments... - A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancerA Bonnomet
Laboratory of Tumor and Developmental Biology, GIGA Cancer, University of Liege, Liege, Belgium
Oncogene 31:3741-53. 2012..They further suggest that mesenchymal-to-epithelial phenomena occur in secondary organs, facilitating the metastatic growth... - Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblastsA Noel
Laboratory of Cellular Biology, Tour de Pathologie, Sart Tilman, Liege, Belgium
Br J Cancer 68:909-15. 1993..These data suggest that human tumours may be reconstituted and grown in athymic nude mice using basement membrane components and fibroblasts as inductors... - Pathogenic role of matrix metalloproteases and their inhibitors in asthma and chronic obstructive pulmonary disease and therapeutic relevance of matrix metalloproteases inhibitorsD D Cataldo
Department of Tumours and Developmental Biology, University of Liege, Tower of Pathology B23, CHU Sart Tilman, 4000 Liege, Belgium
Cell Mol Biol (Noisy-le-grand) 49:875-84. 2003.... - Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesisN E Sounni
Laboratory of Tumor and Development Biology, , Sart Tilman, Belgium
Matrix Biol 22:55-61. 2003..As our knowledge on the field of MT1-MMP biology has grown, the unforeseen complexities of this enzyme and its interaction with its inhibitor TIMP-2 have emerged, often revealing unexpected mechanisms of action... - Heterotransplantation of primary and established human tumour cells in nude miceA Noel
Laboratory of Biology, University of Liege, Belgium
Anticancer Res 15:1-7. 1995..Breast primary tumours or cell lines gave rise to poorly differentiated carcinomas. The other tumours presented histopathological patterns typical of differentiated human cancers... - Whole slide quantification of stromal lymphatic vessel distribution and peritumoral lymphatic vessel density in early invasive cervical cancer: a method descriptionC Balsat
Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA Cancer, University of Liege, Pathology Tower B23, 4000 Liege, Belgium
ISRN Obstet Gynecol 2011:354861. 2011..The proposed technique can be useful to better characterize lymphatic vessel interactions with tumor cells and could potentially impact on prognosis and therapeutic decisions... - Presence of oestrogen receptor type beta in human retinaC Munaut
Laboratory of Tumor and Development Biology, University of Liege, Pathology Tower B23, Sart Tilman, B 4000 Liege, Belgium
Br J Ophthalmol 85:877-82. 2001..Since important pathologies of human eye could be linked to hormonal status, the expression of ORbeta in ocular posterior segment was sought... - 3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivoI Kempen
Centre Interfacultaire de Recherche en Pharmacochimie des substances naturelles et synthétiques, Laboratoire de Chimie Pharmaceutique, Universite de Liege, Belgique
Br J Cancer 88:1111-8. 2003..The mechanism of action of the drugs remains to be elucidated. However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents... - Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitroJ M Lewalle
Laboratory of Cellular Biology, University of Liege, CHU, Sart Tilman, Belgium
Exp Cell Res 237:347-56. 1997..Our data suggest that tumor cells modulate AJ protein distribution and phosphorylation in EC and may, thereby, facilitate EC dissociation... - Effects of a progestogen on normal human breast epithelial cell apoptosis in vitro and in vivoJ Desreux
Laboratory of Tumor and Development Biology, University Hospital, University of Liege, Sart Tilman, B 4000 Liege, Belgium
Breast 12:142-9. 2003..These observations open up new perspectives in the prevention of hyperplasia and breast cancer... - Progesterone receptor activation. an alternative to SERMs in breast cancerJ Desreux
Laboratory of Tumor and Development Biology, Tour de Pathologie 3 B23, Sart Tilman, B4000, Liege, Belgique
Eur J Cancer 36:S90-1. 2000..Fibro-adenoma and cancerous cells do not show this regulation of apoptosis. Progesterone seems to be important in normal breast homeostasis... - Influence of plasminogen activator inhibitor type 1 on choroidal neovascularizationV Lambert
Laboratory of Tumor and Development Biology, University of Liege, B 4000 Liege, Belgium
FASEB J 15:1021-7. 2001..They identify therefore PAI-1 as a potential target for therapeutic ocular anti-angiogenic strategies... - Curcumin-cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancerN Rocks
Laboratory of Tumor and Development Biology, GIGA Research Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA Cancer and GIGA I, University of Liege and CHU of Liege, Sart Tilman, 4000 Liege, Belgium
Br J Cancer 107:1083-92. 2012..Overall clinical outcome for advanced lung cancer remains very disappointing despite recent advances in treatment. Curcumin has been reported as potentially active against cancer... - Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque-type psoriasisA Henno
Department of Dermatology, University Hospital of Liege, University of Liege, Belgium
Br J Dermatol 160:581-90. 2009..Vascular alterations are significant events in the pathomechanism of psoriasis. A disorder in the mechanisms regulating skin angiogenesis and lymphangiogenesis could participate in the pathogenesis of the disease... - Regulation of vimentin by SIP1 in human epithelial breast tumor cellsS Bindels
Laboratory of Tumor and Developmental Biology, Center for Biomedical Integrated Genoproteomics, University of Liege, CHU Sart Tilman, Liege, Belgium
Oncogene 25:4975-85. 2006..Our results therefore implicate SIP1 in the regulation of vimentin observed in the EMT associated with breast tumor cell migration, a pathway that may contribute to the metastatic progression of breast cancer... - MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expressionN E Sounni
Laboratory of Tumor and Development Biology, Laboratory of Connective Tissues Biology, , Sart Tilman, , Belgium
FASEB J 16:555-64. 2002..These results emphasize the importance of MT1-MMP during tumor angiogenesis and open new opportunities for the development of anti-angiogenic strategies combining inhibitors of MT1-MMP and VEGF antagonists... - Nuclear delivery of a therapeutic peptide by long circulating pH-sensitive liposomes: benefits over classical vesiclesE Ducat
Laboratory of Pharmaceutical Technology, CIRM, Department of Pharmacy, University of Liege, B36, Tour 4, Level 2, Avenue de l Hopital, 1, B 4000 Liege, Belgium
Int J Pharm 420:319-32. 2011..Most importantly, when encapsulated in pH-sensitive stealth liposomes, the peptide was able to reach the nucleus of tumorigenic and non tumorigenic breast cancer cells... - Human chorionic gonadotropin and growth factors at the embryonic-endometrial interface control leukemia inhibitory factor (LIF) and interleukin 6 (IL-6) secretion by human endometrial epitheliumS Perrier d'Hauterive
Center of Immunology and Laboratory of Tumour and Developmental Biology, Institute of Pathology CHU B23, University of Liege, B 4000 Liege Sart Tilman, Belgium
Hum Reprod 19:2633-43. 2004.... - Induction of SPARC by VEGF in human vascular endothelial cellsY Kato
Laboratory of Tumor and Developmental Biology, University of Liege Faculty of Medicine, B 4000 Liege, Belgium
Biochem Biophys Res Commun 287:422-6. 2001.... - Membrane type-matrix metalloproteinases and tumor progressionN E Sounni
Laboratory of Tumor and Development Biology, , Sart-Tilman B23, , Belgium
Biochimie 87:329-42. 2005..This review sheds light on the new functions of MT-MMPs and their inhibitors in tumor development and angiogenesis, and presents recent investigations that document their influence on various cell functions... - Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditionsP Carmeliet
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium
Nat Med 7:575-83. 2001..By upregulating PlGF and the signaling subtype of VEGFR-1, endothelial cells amplify their responsiveness to VEGF during the 'angiogenic switch' in many pathological disorders... - Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertensionH Lepetit
INSERM U492, Dept de Physiologie, Faculte de Medecine, CHU Henri Mondor Créteil, 94010 Creteil, France
Eur Respir J 25:834-42. 2005..Whether these abnormalities are potential therapeutic targets deserves further investigation... - Emerging roles of ADAM and ADAMTS metalloproteinases in cancerN Rocks
Department of Biology of Tumours and Development, GIGA Research Groupe Interdisciplinaire de Génoprotéomique Appliquée and Center for Experimental Cancer Research CECR, University of Liege and CHU of Liege, Liege, Belgium
Biochimie 90:369-79. 2008..The current review addresses the contribution of these proteinases in the positive and negative regulation of cancer progression as mainly mediated by the regulation of growth factor activities and integrin functions...