Affiliation: Lab of Pediatric Hepatology & Cell Therapy
Location: Brussels, Belgiu
Ezhilarasan D, Evraerts J, Sid B, Calderon P, Karthikeyan S, Sokal E, et al
. Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression. Hepatobiliary Pancreat Dis Int. 2017;16:80-87 pubmed
..The anti-proliferative effect of silibinin on LX-2 human stellate cells is via the inhibition of the expressions of various cell cycle targets including p27, Akt and sirtuin signaling. ..
Najimi M, Berardis S, El Kehdy H, Rosseels V, Evraerts J, Lombard C, et al
. Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation. Stem Cell Res Ther. 2017;8:131 pubmed publisher
..These data provide evidence for a direct inhibitory effect of ADHLSCs on activated HSCs, which supports their development for the treatment of liver fibrosis. ..
Sargiacomo C, El Kehdy H, Dallmeier K, De Kock J, Hernandez Kelly C, Rogiers V, et al
. Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry. Stem Cell Res Ther. 2017;8:204 pubmed publisher
..Recently, our group demonstrated that human umbilical cord matrix stem cells (UCMSCs) become susceptible to HBV after in-vitro hepatogenic differentiation (D-UCMSCs)...