Christophe Moreno

Summary

Country: Belgium

Publications

  1. doi request reprint Antiviral activity of TMC435 monotherapy in patients infected with HCV genotypes 2-6: TMC435-C202, a phase IIa, open-label study
    Christophe Moreno
    Department of Gastroenterology and Hepatopancreatology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    J Hepatol 56:1247-53. 2012
  2. ncbi request reprint [Management of chronic hepatitis C in 2012 in Belgium]
    C Moreno
    Clinique d Hépatologie, Service de Gastroenterologie, Hépatopancréatologie et Oncologie digestive, Hopital Erasme, Bruxelles
    Rev Med Brux 33:223-7. 2012
  3. doi request reprint Enteral nutrition with or without N-acetylcysteine in the treatment of severe acute alcoholic hepatitis: a randomized multicenter controlled trial
    Christophe Moreno
    Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Hepatol 53:1117-22. 2010
  4. doi request reprint Transoral gastroplasty is safe, feasible, and induces significant weight loss in morbidly obese patients: results of the second human pilot study
    C Moreno
    Department of Gastroenterology and Hepatopancreatology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Endoscopy 40:406-13. 2008
  5. doi request reprint Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease
    Eric Trépo
    Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Hepatol 55:906-12. 2011
  6. pmc The ST2 pathway is involved in acute pancreatitis: a translational study in humans and mice
    Romy Ouziel
    Laboratory of Experimental Gastroenterology, Erasme Hospital, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Am J Pathol 180:2330-9. 2012
  7. ncbi request reprint Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver
    Thierry Gustot
    Division of Gastroenterology and Hepato Pancreatology, Erasme Hospital, Brussels, Belgium
    Hepatology 43:989-1000. 2006
  8. ncbi request reprint Chemokine receptor CCR5 deficiency exacerbates cerulein-induced acute pancreatitis in mice
    Christophe Moreno
    Division of Gastroenterology and Hepatopancreatology, Erasme Hospital, Brussels B 1070, Belgium
    Am J Physiol Gastrointest Liver Physiol 291:G1089-99. 2006
  9. doi request reprint Marked 25-hydroxyvitamin D deficiency is associated with poor prognosis in patients with alcoholic liver disease
    Eric Trépo
    Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Hepatol 59:344-50. 2013
  10. doi request reprint Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C
    Eric Trépo
    Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, Erasme Hospital, Brussels, Belgium
    Hepatology 54:60-9. 2011

Collaborators

Detail Information

Publications36

  1. doi request reprint Antiviral activity of TMC435 monotherapy in patients infected with HCV genotypes 2-6: TMC435-C202, a phase IIa, open-label study
    Christophe Moreno
    Department of Gastroenterology and Hepatopancreatology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    J Hepatol 56:1247-53. 2012
    ..This phase IIa study (TMC435-C202; NCT00812331) was conducted to investigate the antiviral activity, safety, tolerability, and pharmacokinetics of TMC435 in treatment-naїve patients infected with HCV genotypes 2-6...
  2. ncbi request reprint [Management of chronic hepatitis C in 2012 in Belgium]
    C Moreno
    Clinique d Hépatologie, Service de Gastroenterologie, Hépatopancréatologie et Oncologie digestive, Hopital Erasme, Bruxelles
    Rev Med Brux 33:223-7. 2012
    ..Several new antiviral compounds are currently in clinical development and might lead to viral eradication in the vast majority of infected patients in the near future...
  3. doi request reprint Enteral nutrition with or without N-acetylcysteine in the treatment of severe acute alcoholic hepatitis: a randomized multicenter controlled trial
    Christophe Moreno
    Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Hepatol 53:1117-22. 2010
    ..Therefore, the aim of the present study was to evaluate the efficacy of N-acetylcysteine in combination with adequate nutritional support in patients with severe acute alcoholic hepatitis...
  4. doi request reprint Transoral gastroplasty is safe, feasible, and induces significant weight loss in morbidly obese patients: results of the second human pilot study
    C Moreno
    Department of Gastroenterology and Hepatopancreatology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Endoscopy 40:406-13. 2008
    ..Palo Alto, CA) at 6 months. Here we report the 6-month results of the second phase of the pilot trial with the TOGA system, with technical improvements to the device...
  5. doi request reprint Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease
    Eric Trépo
    Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Hepatol 55:906-12. 2011
    ..Our aim was to study the influence of this polymorphism on European Caucasian patients with histologically suggestive ALD...
  6. pmc The ST2 pathway is involved in acute pancreatitis: a translational study in humans and mice
    Romy Ouziel
    Laboratory of Experimental Gastroenterology, Erasme Hospital, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Am J Pathol 180:2330-9. 2012
    ..Furthermore, our experimental data suggest a protective role for ST2 during AP, highlighting the potential regulatory role of mast cells and the possibility of the ST2 pathway as a new therapeutic target in AP...
  7. ncbi request reprint Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver
    Thierry Gustot
    Division of Gastroenterology and Hepato Pancreatology, Erasme Hospital, Brussels, Belgium
    Hepatology 43:989-1000. 2006
    ..In conclusion, EtOH-fed mice exhibited an oxidative stress dependent on upregulation of multiple TLRs in the liver and are sensitive to liver inflammation induced by multiple bacterial products recognized by TLRs...
  8. ncbi request reprint Chemokine receptor CCR5 deficiency exacerbates cerulein-induced acute pancreatitis in mice
    Christophe Moreno
    Division of Gastroenterology and Hepatopancreatology, Erasme Hospital, Brussels B 1070, Belgium
    Am J Physiol Gastrointest Liver Physiol 291:G1089-99. 2006
    ....
  9. doi request reprint Marked 25-hydroxyvitamin D deficiency is associated with poor prognosis in patients with alcoholic liver disease
    Eric Trépo
    Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Hepatol 59:344-50. 2013
    ..Furthermore, we explored the effect of vitamin D treatment on ALD patient peripheral blood mononuclear cells (PBMCs), and in a murine experimental model of ALD...
  10. doi request reprint Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C
    Eric Trépo
    Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, Erasme Hospital, Brussels, Belgium
    Hepatology 54:60-9. 2011
    ..64, 95% CI 1.22-5.67, P = 0.013). Conversely, rs738409 was not independently associated with treatment failure (OR 1.07, 95% CI 0.46-2.49, P = 0.875) and did not influence clinical or biological variables...
  11. doi request reprint Expansion of memory-type CD8+ T cells correlates with the failure of early immunosuppression withdrawal after cadaver liver transplantation using high-dose ATG induction and rapamycin
    Vincent Donckier
    Department of Abdominal Surgery and Transplantation, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    Transplantation 96:306-15. 2013
    ..We report on a pilot study investigating the feasibility of early immunosuppression withdrawal after liver transplantation (LT) using antithymocyte globulin (ATG) induction and rapamycin...
  12. ncbi request reprint Lean non-alcoholic fatty liver disease (Lean-NAFLD): a major cause of cryptogenic liver disease
    Bertrand Vos
    Department of Gastroenterology and Hepato Pancreatology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Acta Gastroenterol Belg 74:389-94. 2011
    ..Based on a large series of liver biopsies, we have evaluated the clinical, biochemical, metabolic and pathological characteristics of a new entity, which we refer to as "lean-NAFLD"...
  13. doi request reprint Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents
    Charles Nicaise
    Laboratory of Experimental Gastroenterology, Universite Libre de Bruxelles, Brussels, Belgium
    Hepatology 48:1184-92. 2008
    ..Modulation of ammonia was abolished after administration of the strain deficient in the ammonium transporter. Intestinal pH was clearly lowered for all strains and no changes in gut flora were observed...
  14. doi request reprint The interleukin-17 pathway is involved in human alcoholic liver disease
    Arnaud Lemmers
    Department of Gastroenterology and Hepato Pancreatology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Hepatology 49:646-57. 2009
    ..In alcoholic hepatitis, liver infiltration with IL-17-secreting cell infiltrates is a key feature that might contribute to liver neutrophil recruitment. (Clinical trials number NCT00610597)...
  15. doi request reprint Shortened treatment duration in treatment-naive genotype 1 HCV patients with rapid virological response: a meta-analysis
    Christophe Moreno
    Department of Gastroenterology and Hepatopancreatology, Hopital Erasme, Universite Libre de Bruxelles, Bruxelles, Belgium
    J Hepatol 52:25-31. 2010
    ....
  16. ncbi request reprint Safety, feasibility and weight loss after transoral gastroplasty: First human multicenter study
    J Deviere
    Department of Gastroenterology and Hepatopancreatology, ULB, Hopital Erasme, Route de Lennik 808, B 1070, Brussels, Belgium
    Surg Endosc 22:589-98. 2008
    ..To evaluate the safety and feasibility in human subjects of a new transoral restrictive procedure for the treatment of obesity...
  17. ncbi request reprint Capsule endoscopy examination of patients with obscure gastrointestinal bleeding: evaluation of clinical impact
    C Moreno
    Department of Gastroenterology, Erasme University Hospital, Brussels, Belgium
    Acta Gastroenterol Belg 68:10-4. 2005
    ..Nevertheless, clinical impact data is lacking. The aim of our study was to determine the clinical outcome of patients undergoing WVCE for OGB...
  18. pmc An inhibitor of interleukin-6 trans-signalling, sgp130, contributes to impaired acute phase response in human chronic liver disease
    A Lemmers
    Department of Gastroenterology, Hepato Pancreatology and Digestive Oncology, Erasme Hospital, Universite Libre de Bruxelles ULB, Bruxelles, Belgium
    Clin Exp Immunol 156:518-27. 2009
    ..This might explain the poor acute phase response induced by IL-6 in chronic liver disease...
  19. doi request reprint Induction of tolerance in solid organ transplantation: the rationale to develop clinical protocols in liver transplantation
    V Donckier
    Medicosurgical Department of Gastroenterology, Clinic of Abdominal Transplantation, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    Transplant Proc 41:603-6. 2009
    ..In conclusion, significant efforts must be made to achieve reliable strategies for immunosuppression minimization or withdrawal after organ transplantation into the clinics...
  20. doi request reprint Ethical considerations regarding early liver transplantation in patients with severe alcoholic hepatitis not responding to medical therapy
    Vincent Donckier
    Department of Abdominal Surgery, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium Electronic address
    J Hepatol 60:866-71. 2014
    ..The next steps should include transparent communication with the public and further studies to reproduce these results and identify the selection criteria that provide the best long-term outcomes...
  21. doi request reprint Invasive aspergillosis in patients with severe alcoholic hepatitis
    Thierry Gustot
    Department of Gastroenterology and Hepato Pancreatology, Erasme Hospital, Brussels, Belgium Laboratory of Experimental Gastroenterology, Universite Libre de Bruxelles, Brussels, Belgium INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Paris, France Electronic address
    J Hepatol 60:267-74. 2014
    ..Severe alcoholic hepatitis (AH) has a poor short-term prognosis. Although infections are frequent complications of AH, the incidence of invasive aspergillosis (IA) and its impact on outcome remain unknown...
  22. doi request reprint Acute liver transplant rejection upon immunosuppression withdrawal in a tolerance induction trial: potential role of IFN-gamma-secreting CD8+ T cells
    Vincent Donckier
    Department of Abdominal Surgery, Liver Transplantation Unit, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    Transplantation 87:S91-5. 2009
    ..In conclusion, lymphopenia-induced IL-7 production after induction with ATG and sirolimus might lead to emergence of IFN-gamma-secreting CD8+ T-cells responsible for acute rejection after immunosuppression withdrawal...
  23. doi request reprint Role of a cirrhosis risk score for the early prediction of fibrosis progression in hepatitis C patients with minimal liver disease
    Eric Trépo
    Universite Libre de Bruxelles, Brussels, Belgium
    J Hepatol 55:38-44. 2011
    ..In addition, we evaluated the potential benefit, for prediction accuracy, of a recently described non-invasive fibrosis staging assay, the Enhanced Liver Fibrosis (ELF) test...
  24. ncbi request reprint Resource use and cost of hepatitis C-related care
    Frederik Nevens
    Department of Hepatology, University Hospitals KULeuven, Leuven, Belgium
    Eur J Gastroenterol Hepatol 24:1191-8. 2012
    ..Chronic hepatitis because of the hepatitis C virus (CHC) is a major health problem that can lead to decompensated cirrhosis, hepatocellular carcinoma, and eventually death, all of which are associated with significant healthcare costs...
  25. ncbi request reprint CCR5 deficiency exacerbates T-cell-mediated hepatitis in mice
    Christophe Moreno
    Division of Gastroenterology and Hepato Pancreatology, Erasme Hospital, Brussels, Belgium
    Hepatology 42:854-62. 2005
    ....
  26. ncbi request reprint Liver transplantation for acute liver failure in adults
    V Lucidi
    Medicosurgical Unit of Liver Transplantation, Erasme Hospital Free University of Brussels, Brussels, Belgium
    Minerva Gastroenterol Dietol 54:49-55. 2008
    ....
  27. doi request reprint Survival in patients with uveal melanoma in Europe
    Gianni Virgili
    Department of Oto Neuro Ophthalmological Surgical Sciences, University of Florence, Viale Morgagni 85, Florence 50134, Italy
    Arch Ophthalmol 126:1413-8. 2008
    ..To estimate survival in patients in whom uveal melanoma was diagnosed between January 1, 1983, and December 31, 1994, in Europe...
  28. ncbi request reprint Immunotherapy safety: a prospective multi-centric monitoring study of biologically standardized therapeutic vaccines for allergic diseases
    C Moreno
    Allergy Department, Hospital Reina Sofia, Cordoba, Spain
    Clin Exp Allergy 34:527-31. 2004
    ..The goal of the study was to carry out a prospective and multi-centric trial to evaluate the safety, risk factors and compliance degree of commercially available SIT...
  29. ncbi request reprint Airborne plane-tree (Platanus hispanica) pollen distribution in the city of Córdoba, South-western Spain, and possible implications on pollen allergy
    P Alcázar
    Department of Plant Biology Botany, University of Cordoba, Spain
    J Investig Allergol Clin Immunol 14:238-43. 2004
    ..Platanus allergy is a particular problem for city-dwellers, where these trees are commonly used as ornamentals...
  30. ncbi request reprint [Present situation and future perspectives of the epidemic of HIV and AIDS in Spain]
    J Castilla
    Instituto de Salud Publica de Navarra, Pamplona
    An Sist Sanit Navar 29:13-25. 2006
    ..8 per 100,000 inhabitants) and over 1,600 deaths from AIDS (3.8 per 100,000). One third of the people who developed AIDS in 2004 had not until then been diagnosed with HIV, which prevented starting the antiretroviral treatment in time...
  31. ncbi request reprint [Study of vascular risk in Navarre: objectives and design. Prevalence of metabolic syndrome and of vascular risk factors]
    J J Viñes
    Servicio de Docencia e Investigación, Departamento de Salud, Gobierno de Navarra, Pamplona
    An Sist Sanit Navar 30:113-24. 2007
    ..To determine in a representative sample of the population the prevalence of risk factors and metabolic syndrome; their association with sub-clinical atherosclerotic lesions and their impact on cardiocerebrovascular disease 10 years after...
  32. ncbi request reprint [Rectal irrigation and bowel decontamination for the prevention of postoperative enterocolitis in Hirschsprung's disease]
    R Nunez
    Servicio de Cirugia Pediatrica, Hospital Universitario Materno Infantil, Badajoz
    Cir Pediatr 20:96-100. 2007
    ..The object is to determine the utility of rectal irrigation (RI) and bowel decontamination for the prevention of postoperative enterocolitis in Hirschsprung's disease...
  33. ncbi request reprint Predicting patients at high-risk of systemic reactions to cluster allergen immunotherapy: a pilot prospective observational study
    J L Justicia
    Allergy Service, Reina Sofia University Hospital, Cordoba, Spain
    J Investig Allergol Clin Immunol 17:386-92. 2007
    ..The purpose of this study was to identify factors associated with increased risk of adverse systemic reactions to cluster allergen immunotherapy and to create a preliminary predictive clinical model...
  34. ncbi request reprint Efficacy and quality of life with once-daily sublingual immunotherapy with grasses plus olive pollen extract without updosing
    A Moreno-Ancillo
    Hospital Virgen del Puerto, Plasencia, Spain
    J Investig Allergol Clin Immunol 17:399-405. 2007
    ..Reduction in symptoms and medication use was the primary endpoint...
  35. doi request reprint Influence of morphology on survival for non-Hodgkin lymphoma in Europe and the United States
    Milena Sant
    Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, I 20133, Milan, Italy
    Eur J Cancer 44:579-87. 2008
    ..Interpretation of marked variation in survival with morphology is complicated by classification inconsistencies. The completeness and standardisation of cancer registry morphology data needs to be improved...
  36. ncbi request reprint The optimal immunotherapy cluster schedule in clinical practice
    L Fernández-Távora
    Servicio de Alergia, Ambulatorio Virgen de la Cinta, Huelva, Spain
    J Investig Allergol Clin Immunol 13:193-201. 2003
    ..5%, without increasing the rate of side effects. We think clustered schedules could lead to a better compliance and to a broader use of injective immunotherapy...