Research Topics
| Michel C MilinkovitchSummaryCountry: Belgium Publications
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Publications
Escaping the mouse trap: the selection of new Evo-Devo model speciesMichel C Milinkovitch
Laboratory of Evolutionary Genetics, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, Gosselies, Belgium
J Exp Zool B Mol Dev Evol 308:337-46. 2007....
Giant Galápagos tortoises; molecular genetic analyses identify a trans-island hybrid in a repatriation program of an endangered taxonMichel C Milinkovitch
Laboratory of Evolutionary Genetics, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, rue Jeener and Brachet 12, 6041 Gosselies, Belgium
BMC Ecol 7:2. 2007..However, analysis of 118 samples from released individuals indicated that the bias sex ratio and large variance in reproductive success among the 15 breeders has severely reduced the effective population size (Ne)...
Genetic analysis of a successful repatriation programme: giant Galápagos tortoisesMichel C Milinkovitch
Laboratory of Evolutionary Genetics, Institute of Molecular Biology and Medicine, Free University of Brussels, cp 300, rue Jeener and Brachet 12, B 6041 Gosselies, Belgium
Proc Biol Sci 271:341-5. 2004..Contributions of the breeders are highly skewed. This has led to a further loss of genetic variation that is detrimental to the long-term survival of the population. Modifications to the breeding programme could alleviate this problem...- Molecular phylogenetic analyses indicate extensive morphological convergence between the "yeti" and primatesMichel Milinkovitch
Evolutionary Genetics, Institute of Molecular Biology and Medicine, Free University of Brussels (ULB, Gosselies, Belgium
Mol Phylogenet Evol 31:1-3. 2004 
Population structure of an endemic vulnerable species, the Jamaican boa (Epicrates subflavus)Athanasia C Tzika
Laboratory of Evolutionary Genetics, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, B6041 Gosselies, Belgium
Mol Ecol 17:533-44. 2008....- A non-linear optimization procedure to estimate distances and instantaneous substitution rate matrices under the GTR modelDaniele Catanzaro
Laboratory of Evolutionary Genetics, Institute for Molecular Biology and Medicine, IBMM, , Rue Jeener et Brachet 12, B-6041, Gosselies, Belgium
Bioinformatics 22:708-15. 2006..Finally, we provide an analysis on the goodness of the solution we propose. A numerical example is discussed... - MANTIS: a phylogenetic framework for multi-species genome comparisonsAthanasia C Tzika
Laboratory of Evolutionary Genetics, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, Belgium
Bioinformatics 24:151-7. 2008..Furthermore, the field would greatly benefit from a better integration of this wealth of data with evolutionary concepts... - Evaluating intraspecific "network" construction methods using simulated sequence data: do existing algorithms outperform the global maximum parsimony approach?Insa Cassens
Laboratory of Evolutionary Genetics, Institute of Molecular Biology and Medicine, Universite Libre de Bruxelles, Rue Jeener et Brachet 12, 6041 Gosselies, Belgium
Syst Biol 54:363-72. 2005..Moreover, our analyses indicate that, when internal node haplotypes are not sampled, the median-joining and MP methods provide the best estimate of the true genealogy whereas the minimum-spanning algorithm shows very poor performances... - Inferring contemporary levels of gene flow and demographic history in a local population of the leaf beetle Gonioctena olivacea from mitochondrial DNA sequence variationPatrick Mardulyn
Laboratory of Evolutionary Genetics, Universite Libre de Bruxelles, Rue Jeener et Brachet 12, 6041 Gosselies, Belgium
Mol Ecol 14:1641-53. 2005..However, a metapopulation structure alone (without the need to invoke a population expansion event) cannot be dismissed as the cause of this star shape... - Controlling population evolution in the laboratory to evaluate methods of historical inferencePatrick Mardulyn
Laboratory of Evolutionary Genetics, Universite Libre de Bruxelles, Gosselies, Belgium
PLoS ONE 3:e2960. 2008.... - An ant colony optimization algorithm for phylogenetic estimation under the minimum evolution principleDaniele Catanzaro
Laboratory of Evolutionary Genetics, Institute for Molecular Biology and Medicine IBMM, Université Libre de Bruxelles U, L, B, CP300, Rue Jeener et Brachet 12, B 6041, Gosselies, Belgium
BMC Evol Biol 7:228. 2007..The major difficulty for its application is that the number of possible phylogenies grows exponentially with the number of taxa analyzed and the minimum evolution principle is known to belong to the NRho- hard class of problems... - OligoFaktory: a visual tool for interactive oligonucleotide designColas Schretter
Unit of Evolutionary Genetics, Institute of Molecular Biology and Medicine, Free University of Brussels, Gosselies, Belgium
Bioinformatics 22:115-6. 2006..The design pipeline can use BLAST servers to evaluate specificity of selected oligonucleotides. AVAILABILITY: The web portal http://ueg.ulb.ac.be/oligofaktory/; the software for Macintosh: http://www.oligofaktory.org/.. - Structure and evolution of the mitochondrial control region of leaf beetles (Coleoptera: Chrysomelidae): a hierarchical analysis of nucleotide sequence variationPatrick Mardulyn
Free University of Brussels, Rue Jeener et Brachet 12, 6041, Gosselies, Belgium
J Mol Evol 56:38-45. 2003..Our analyses allowed us to identify portions of the control region with enough variation for population genetic or phylogeographic studies... - Separate-component-stabilization system for protein and DNA production without the use of antibioticsCédric Y Szpirer
Laboratory of Evolutionary Genetics, Institute of Molecular Biology and Medicine, Universite Libre de Bruxelles, Charleroi Gosselies, Belgium
Biotechniques 38:775-81. 2005..Finally, we demonstrate that the SCS system increases by five the yield in DNA production, a result especially important for the design and production of gene therapy constructs void of any antibiotic resistance gene... - Investigation of the population genetic structure and mating system in the ant Pheidole pallidulaDenis Fournier
Department of Animal Biology, Unit of Animal Communities CP 160 12, Free University of Brussels ULB, Avenue F D Roosevelt, 50, B 1050 Brussels, Belgium
Mol Ecol 11:1805-14. 2002..Finally, our analyses indicate that colonies are genetically differentiated and form a population exhibiting significant isolation-by-distance, suggesting that some colonies originate through budding... - Automated discovery and phylogenetic analysis of new toxin-antitoxin systemsJulien Guglielmini
Laboratory of Evolutionary Genetics, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles ULB, 12 rue Jeener and Brachet, 6041 Gosselies, Belgium
BMC Microbiol 8:104. 2008..Thus, a cell exhibiting a TA system on a plasmid is 'condemned' either not to loose it or to die... - Evidence for male dispersal along the coasts but no migration in pelagic waters in dusky dolphins (Lagenorhynchus obscurus)Insa Cassens
Laboratory of Evolutionary Genetics, Institute of Molecular Biology and Medicine, , rue Jeener and Brachet 12, 6041 Gosselies, Belgium
Mol Ecol 14:107-21. 2005..Only the Peruvian dusky dolphin stock is highly differentiated, especially at mitochondrial loci, suggesting that major fluctuations in its population size have led to an increased rate of genetic drift... - A hidden Markov model for progressive multiple alignmentAri Löytynoja
Unit of Evolutionary Genetics, Free University of Brussels ULB, cp 300, Institute of Molecular Biology and Medicine, rue Jeener and Brachet 12, B 6041 Gosselies, Belgium
Bioinformatics 19:1505-13. 2003.... - The metapopulation genetic algorithm: An efficient solution for the problem of large phylogeny estimationAlan R Lemmon
Laboratory of Evolutionary Genetics, Free University of Brussels (ULB, cp 300, Institute of Molecular Biology and Medicine, rue Jeener and Brachet 12, B-6041 Gosselies, Belgium
Proc Natl Acad Sci U S A 99:10516-21. 2002..Branch support values produced by the metapopulation genetic algorithm might closely approximate the posterior probabilities of the corresponding branches... - Characterization of microsatellite loci in the European pond turtle Emys orbicularisClaudio Ciofi
Molecular Ecology Laboratory, Department of Animal Biology and Genetics, University of Florence, Via Romana 17, 50125 Florence, Italy, Laboratory of Evolutionary Genetics, Institute of Molecular Biology and Medicine, Universite Libre de Bruxelles, rue Jeener and Brachet 12, B 6041 Gosselies, Belgium, Wetland of Kerkini Management Authority, Kerkini, Kato Poroia, Greece
Mol Ecol Resour 9:189-91. 2009..738 and 0.921. This novel set of loci will be particularly useful to assess fine-scale population structure and for parentage analysis in E. orbicularis... - Dual chemical sequestration: a key mechanism in transitions among ecological specializationArnaud Termonia
Unit of Evolutionary Genetics, Institute of Molecular Biology and Medicine, , cp 300, rue Jeener and Brachet 12, B-6041 Gosselies, Belgium
Proc Biol Sci 269:1-6. 2002..The analyses indicate that dual sequestration could be the key mechanistic means by which transitions among ecological specializations (i.e. restricted host-plant affiliations) are made possible... - Development of 10 highly-polymorphic microsatellite markers in the vulnerable Galápagos land iguanas (genus Conolophus)Sabrina F P Rosa
Laboratory of Evolutionary Genetic, Institute of Molecular Biology and Medicine, Universite Libre de Bruxelles, Rue Jeener et Brachet 12, 6041 Gosselies, Belgium Laboratory of Natural and Artificial Evolution, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
Mol Ecol Resour 9:376-9. 2009..These markers will be useful for Conolophus population genetic analyses as well as for guiding ongoing captive breeding programmes... - Mitochondrial genome and nuclear sequence data support myzostomida as part of the annelid radiationChristoph Bleidorn
Unit of Evolutionary Biology Systematic Zoology, Institute of Biochemistry and Biology, University of Potsdam, Potsdam Golm, Germany
Mol Biol Evol 24:1690-701. 2007..Using Bayes factor comparison, alternative hypotheses are shown to lack support. Thus, myzostomids probably evolved from a segmented ancestor and gained a derived anatomy during their long evolutionary history as echinoderm symbionts... - Phylogeny and biogeography of a cosmopolitan frog radiation: Late cretaceous diversification resulted in continent-scale endemism in the family ranidaeFranky Bossuyt
Biology Department, Unit of Ecology and Systematics, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
Syst Biol 55:579-94. 2006..Most importantly, all hypotheses make clear predictions as to where to expect key fossils and where to sample other living ranids, and thus constitute a strong basis for further research... - Local endemism within the Western Ghats-sri Lanka biodiversity hotspotFranky Bossuyt
Biology Department, Unit of Ecology and Systematics, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium
Science 306:479-81. 2004..Future conservation programs for the subcontinent should take into account such patterns of local endemism at the finest scale at which they may occur... - Molecular phylogenetic analyses indicate a wide and ancient radiation of African hepatitis delta virus, suggesting a deltavirus genus of at least seven major cladesNadjia Radjef
, , , , Signalisation Cellulaire, , , Bobigny, France
J Virol 78:2537-44. 2004..These results relate the geographic distribution of HDV more closely to the genetic variability of its helper HBV... - Microsatellite analysis of genetic divergence among populations of giant Galápagos tortoisesClaudio Ciofi
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520 8106, USA
Mol Ecol 11:2265-83. 2002..Our study complements previous investigation based on mtDNA diversity and provides further information that may help devising tortoise management plans... - Conceptual bases for quantifying the role of the environment on gene evolution: the participation of positive selection and neutral evolutionAnthony Levasseur
Phylogenomics Laboratory, EA 3781 Evolution Biologique Université de Provence, Case 19, Pl V Hugo, 13331 Marseille Cedex 03, France
Biol Rev Camb Philos Soc 82:551-72. 2007..Therefore, the second aim herein is to review evidence for the mechanisms leading to fixation... - Molecular phylogenetic analyses indicate multiple independent emergences of parasitism in Myzostomida (Protostomia)Deborah Lanterbecq
Marine Biology Laboratory, University of Mons Hainaut, 6 Avenue du Champ de Mars, Life Sciences Building, 7000 Mons, Belgium
Syst Biol 55:208-27. 2006....