Francoise Mascart

Summary

Country: Belgium

Publications

  1. ncbi request reprint Modulation of the infant immune responses by the first pertussis vaccine administrations
    F Mascart
    Laboratory of Vaccinology and Mucosal Immunity, Erasme Hosp, Route de Lennik, 1070 Brussels, Belgium
    Vaccine 25:391-8. 2007
  2. pmc Heparin-binding haemagglutinin, a new tool for the detection of latent Mycobacterium tuberculosis infection in hemodialysis patients
    Rodrigue Dessein
    Laboratory of Vaccinology and Mucosal Immunity, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS ONE 8:e71088. 2013
  3. pmc Heparin-binding-hemagglutinin-induced IFN-gamma release as a diagnostic tool for latent tuberculosis
    Jean Michel Hougardy
    Laboratory of Vaccinology and Mucosal Immunity, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS ONE 2:e926. 2007
  4. pmc Risk stratification of latent tuberculosis defined by combined interferon gamma release assays
    Véronique Corbière
    Laboratory of Vaccinology and Mucosal Immunity, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS ONE 7:e43285. 2012
  5. pmc Both CD4⁺ and CD8⁺ lymphocytes participate in the IFN-γ response to filamentous hemagglutinin from Bordetella pertussis in infants, children, and adults
    Violette Dirix
    Laboratory of Vaccinology and Mucosal Immunity, Universite Libre de Bruxelles ULB, 1070 Brussels, Belgium
    Clin Dev Immunol 2012:795958. 2012
  6. ncbi request reprint Differential T and B cell responses against Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin in infected healthy individuals and patients with tuberculosis
    Chantal Masungi
    Laboratory of Immunology, Erasme Hospital, Brussels, Belgium
    J Infect Dis 185:513-20. 2002
  7. pmc Cellular immune responses of preterm infants after vaccination with whole-cell or acellular pertussis vaccines
    Françoise Vermeulen
    Pediatric Department, Laboratory of Vaccinology and Mucosal Immunity, Universite Libre De Bruxelles U L B, Brussels, Belgium
    Clin Vaccine Immunol 17:258-62. 2010
  8. doi request reprint Heparin-binding, hemagglutinin-specific IFN-gamma synthesis at the site of infection during active tuberculosis in humans
    Sammy Place
    Laboratory of Vaccinology and Mucosal Immunity, Hopital Brugmann, Universite Libre de Bruxelles, Brussels, Belgium
    Am J Respir Crit Care Med 182:848-54. 2010
  9. ncbi request reprint Bordetella pertussis infection in 2-month-old infants promotes type 1 T cell responses
    Francoise Mascart
    Laboratory of Immunology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    J Immunol 170:1504-9. 2003
  10. ncbi request reprint Regulatory T cells depress immune responses to protective antigens in active tuberculosis
    Jean Michel Hougardy
    Laboratory of Vaccinology and Mucosal Immunity, Hopital Erasme, Brussels, Belgium
    Am J Respir Crit Care Med 176:409-16. 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Modulation of the infant immune responses by the first pertussis vaccine administrations
    F Mascart
    Laboratory of Vaccinology and Mucosal Immunity, Erasme Hosp, Route de Lennik, 1070 Brussels, Belgium
    Vaccine 25:391-8. 2007
    ..Large prospective studies would be warranted to evaluate the possible long-term consequences of this early modulation of the cytokine responses in infants...
  2. pmc Heparin-binding haemagglutinin, a new tool for the detection of latent Mycobacterium tuberculosis infection in hemodialysis patients
    Rodrigue Dessein
    Laboratory of Vaccinology and Mucosal Immunity, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS ONE 8:e71088. 2013
    ..Interferon-gamma release assays (IGRAs) were reported to be more sensitive than tuberculin skin tests for the detection of infected individuals in dialysis patients...
  3. pmc Heparin-binding-hemagglutinin-induced IFN-gamma release as a diagnostic tool for latent tuberculosis
    Jean Michel Hougardy
    Laboratory of Vaccinology and Mucosal Immunity, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS ONE 2:e926. 2007
    ..We have therefore evaluated the potential of the novel antigen heparin-binding hemagglutinin (HBHA) for in vitro detection of LTBI...
  4. pmc Risk stratification of latent tuberculosis defined by combined interferon gamma release assays
    Véronique Corbière
    Laboratory of Vaccinology and Mucosal Immunity, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS ONE 7:e43285. 2012
    ..Here, we provide an approach to stratify LTBI based on IFN-γ responses to two antigens, the recombinant Early-Secreted Antigen Target-6 (rESAT-6) and the latency antigen Heparin-Binding Haemagglutinin (HBHA)...
  5. pmc Both CD4⁺ and CD8⁺ lymphocytes participate in the IFN-γ response to filamentous hemagglutinin from Bordetella pertussis in infants, children, and adults
    Violette Dirix
    Laboratory of Vaccinology and Mucosal Immunity, Universite Libre de Bruxelles ULB, 1070 Brussels, Belgium
    Clin Dev Immunol 2012:795958. 2012
    ..The role of this dual IFN-γ secretion by CD4⁺ and CD8⁺ T lymphocytes in pertussis remains to be investigated...
  6. ncbi request reprint Differential T and B cell responses against Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin in infected healthy individuals and patients with tuberculosis
    Chantal Masungi
    Laboratory of Immunology, Erasme Hospital, Brussels, Belgium
    J Infect Dis 185:513-20. 2002
    ..These observations indicate that HBHA is recognized differently by the immune systems of patients with tuberculosis and infected healthy individuals and might provide a marker for protection against tuberculosis...
  7. pmc Cellular immune responses of preterm infants after vaccination with whole-cell or acellular pertussis vaccines
    Françoise Vermeulen
    Pediatric Department, Laboratory of Vaccinology and Mucosal Immunity, Universite Libre De Bruxelles U L B, Brussels, Belgium
    Clin Vaccine Immunol 17:258-62. 2010
    ..We conclude that like full-term infants, most preterm infants are able to mount a specific cellular immune response to the administration of the first doses of an acellular or a whole-cell pertussis vaccine...
  8. doi request reprint Heparin-binding, hemagglutinin-specific IFN-gamma synthesis at the site of infection during active tuberculosis in humans
    Sammy Place
    Laboratory of Vaccinology and Mucosal Immunity, Hopital Brugmann, Universite Libre de Bruxelles, Brussels, Belgium
    Am J Respir Crit Care Med 182:848-54. 2010
    ..Tuberculosis (TB) remains a major cause of mortality. A better understanding of the immune responses to mycobacterial antigens may be helpful to develop improved vaccines and diagnostics...
  9. ncbi request reprint Bordetella pertussis infection in 2-month-old infants promotes type 1 T cell responses
    Francoise Mascart
    Laboratory of Immunology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    J Immunol 170:1504-9. 2003
    ..We conclude that the immune system of 2-mo-old infants is developmentally mature enough to develop Th1 responses in vivo upon infection by B. pertussis or vaccination with whole-cell pertussis vaccines...
  10. ncbi request reprint Regulatory T cells depress immune responses to protective antigens in active tuberculosis
    Jean Michel Hougardy
    Laboratory of Vaccinology and Mucosal Immunity, Hopital Erasme, Brussels, Belgium
    Am J Respir Crit Care Med 176:409-16. 2007
    ..Patients with latent TB infection develop strong IFN-gamma responses to the protective antigen heparin-binding hemagglutinin (HBHA), whereas patients with active TB do not...
  11. ncbi request reprint Optimal kinetics for quantification of antigen-induced cytokines in human peripheral blood mononuclear cells by real-time PCR and by ELISA
    Slavka Listvanova
    Laboratory of Immunology, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik, 808, B 1070 Brussels, Belgium
    J Immunol Methods 281:27-35. 2003
    ....
  12. doi request reprint Persistence at one year of age of antigen-induced cellular immune responses in preterm infants vaccinated against whooping cough: comparison of three different vaccines and effect of a booster dose
    Françoise Vermeulen
    Pediatric Department, Universite Libre De Bruxelles U L B, Brussels, Belgium
    Vaccine 31:1981-6. 2013
    ....
  13. ncbi request reprint Helicobacter pylori modulation of gastric and duodenal mucosal T cell cytokine secretions in children compared with adults
    Patrick Bontems
    Department of Immunology and Gastroenterology Erasme Hospital, Brussels, Belgium
    Helicobacter 8:216-26. 2003
    ..Since immunological determinants influence the outcome of H. pylori infection, we have investigated mucosal T cell responses in H. pylori-infected children and compared them with those of adults and negative controls...
  14. ncbi request reprint In vitro expansion of CD4+CD25highFOXP3+CD127low/- regulatory T cells from peripheral blood lymphocytes of healthy Mycobacterium tuberculosis-infected humans
    Jean Michel Hougardy
    Laboratory of Vaccinology and Mucosal Immunity, Universite Libre de Bruxelles, Belgium
    Microbes Infect 9:1325-32. 2007
    ....
  15. ncbi request reprint Effector functions of heparin-binding hemagglutinin-specific CD8+ T lymphocytes in latent human tuberculosis
    Stephane T Temmerman
    Laboratory of Vaccinology and Mucosal Immunity, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    J Infect Dis 192:226-32. 2005
    ..Because of the recently recognized importance of CD8(+) T lymphocytes in anti-TB immunity, we characterized the CD8(+) T lymphocyte responses to HBHA in subjects with latent TB...
  16. ncbi request reprint Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin
    Stephane Temmerman
    Laboratory of Immunology, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik, 808, B 1070 Brussels, Belgium
    Nat Med 10:935-41. 2004
    ..Thus, post-translational modifications of proteins may be crucial for their ability to induce protective T cell-mediated immunity against infectious diseases such as tuberculosis...
  17. doi request reprint Different T cell memory in preadolescents after whole-cell or acellular pertussis vaccination
    Kaatje Smits
    Laboratory of Vaccinology and Mucosal Immunity, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Vaccine 32:111-8. 2013
    ..This study supports at the immunological level recent epidemiological studies indicating that infant vaccination with wP induces longer lasting immunity than vaccination with aP-vaccines. ..
  18. pmc Phenotypic characteristics of human type II alveolar epithelial cells suitable for antigen presentation to T lymphocytes
    Véronique Corbière
    Laboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles U, L, B, Brussels, Belgium
    Respir Res 12:15. 2011
    ..Thus, this study aimed at defining the most relevant model of accessory antigen presenting cells by carefully comparing the two models for their expression of surface molecules necessary for efficient antigen presentation...
  19. doi request reprint Key role of effector memory CD4+ T lymphocytes in a short-incubation heparin-binding hemagglutinin gamma interferon release assay for the detection of latent tuberculosis
    Chloé Wyndham-Thomas
    Laboratory of Vaccinology and Mucosal Immunity, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Clin Vaccine Immunol 21:321-8. 2014
    ..The IFN-γ detected by the 24-h nHBHA-IGRA was mainly secreted by effector memory CD4(+) T lymphocytes, a finding suggestive of continuous HBHA presentation during latency. ..
  20. ncbi request reprint Evolution of immunoglobulin and mannose binding protein levels after renal transplantation: association with infectious complications
    Emine Nilufer Broeders
    Department of Nephrology, Hospital Erasme, Route de Lennik, Brussels, Belgium
    Transpl Int 21:57-64. 2008
    ..Hypo-IgG at T0 and combined Igs deficts at T3 were associated with more infections. MBP deficiency might emerge as an important determinant of the post-transplant infectious risk...
  21. ncbi request reprint [The immunology-hematology-transfusion department]
    M Goldman
    Rev Med Brux 23:87-91. 2002
    ..In this paper, we illustrate how the Department of Immunology can contribute to the development of these new treatments within a academic hospital such as the Erasme Hospital at the Université Libre de Bruxelles...
  22. doi request reprint Basophil activation tests for the diagnosis of food allergy in children
    A Ocmant
    Clinique d Immunobiologie, Hopital Erasme, Universite Libre de Bruxelles ULB, Brussels, Belgium
    Clin Exp Allergy 39:1234-45. 2009
    ..Positive skin prick tests (SPT) for food allergens and specific IgE (sIgE) in serum indicate sensitization but do not enable distinction between sensitized but tolerant and clinically allergic patients...
  23. doi request reprint Pneumococcal aetiology and serotype distribution in paediatric community-acquired pneumonia
    Iris De Schutter
    Department of Pediatric Pulmonology, Cystic Fibrosis Clinic and Pediatric Infectious Diseases, Universitair Ziekenhuis Brussel UZ Brussel, Brussels, Belgium
    PLoS ONE 9:e89013. 2014
    ..The use of recently developed methods improves diagnosis of pneumococcal aetiology. ..
  24. doi request reprint Expression of galectin-3 in the tumor immune response in colon cancer
    Patrick Dumont
    Laboratory of Pathology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Lab Invest 88:896-906. 2008
    ..These data suggest an involvement of gal-3 in the response of colon cancer cells to proinflammatory stimuli, such as the conditioned medium from activated macrophages...
  25. doi request reprint Cytokine and antibody profiles in 1-year-old children vaccinated with either acellular or whole-cell pertussis vaccine during infancy
    V Dirix
    Laboratory of Vaccinology and Mucosal Immunity, Universite Libre De Bruxelles U L B, 808 Route de Lennik, 1070 Brussels, Belgium
    Vaccine 27:6042-7. 2009
    ..In addition, the global Th2 bias observed in 6-month-old infants vaccinated with a Pa vaccine was normalized at 13 months...
  26. doi request reprint IL-12Rβ1 deficiency and disseminated Mycobacterium tilburgii disease
    Kinda Schepers
    Immune Deficiencies Treatment Unit, ULB Erasme, Brussels, Belgium
    J Clin Immunol 33:1285-8. 2013
    ..We describe a case of M. tilburgii infection in an otherwise healthy 33-year-old woman, who was found to carry bi-allelic mutations of the gene encoding the β1 chain of the IL-12 receptor. ..
  27. doi request reprint NF-κB Activation and Severity of Gastritis in Helicobacter pylori-Infected Children and Adults
    Patrick Bontems
    Paediatric Gastroenterology Hepatology, Queen Fabiola Children s University Hospital, Universite Libre de Bruxelles, Av JJ Crocq 15, 1020, Brussels, Belgium Laboratory of Vaccinology and Mucosal Immunity, Universite Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium
    Helicobacter 19:157-67. 2014
    ..In contrast to adults, Helicobacter pylori gastritis in children is reported as milder and ulcer disease as uncommon, but unequivocal data are lacking...
  28. ncbi request reprint Dose-effect of interleukin-10 and its immunoregulatory role in Crohn's disease
    Alain Schmit
    Department of Immunology, Hopital Erasme, Universite Libre de Bruxelles, 808 Route de Lennik, B 1070 Brussels, Belgium
    Eur Cytokine Netw 13:298-305. 2002
    ..Only marginal effects have, however, been reported, and the dose-response curve was bell-shaped contrasting with the reported data from in vitro experiments...
  29. pmc Monocyte-derived interleukin-10 depresses the Bordetella pertussis- specific gamma interferon response in vaccinated infants
    V Dirix
    Laboratory of Vaccinology and Mucosal Immunity, Universite Libre de Bruxelles, Brussels, Belgium
    Clin Vaccine Immunol 16:1816-21. 2009
    ..This IL-10 secretion was not associated with polymorphisms at positions -1082, -819, and -592 of the IL-10 gene promoter, suggesting that other genetic or environmental factors affect IL-10 expression and secretion...
  30. doi request reprint Modulation of the complement system in monocytes contributes to tuberculosis-associated immune reconstitution inflammatory syndrome
    Huyen T T Tran
    Cellular and Molecular Immunology Unit, Vrije Universiteit Brussel, Brussels, Belgium
    AIDS 27:1725-34. 2013
    ..This study investigated a putative contribution of monocytes to the development of TB-IRIS...
  31. doi request reprint Large decrease of anti-tetanus anatoxin and anti-pneumococcal antibodies at one year after renal transplantation
    Emine Nilufer Broeders
    Universite Libre de Bruxelles, Brussels, Belgium
    Clin Nephrol 79:313-7. 2013
    ..We here report in a prospective cohort study, the effects of mycophenolate mofetil (MMF) associated to a calcineurin inhibitor on plasma levels of anti-tetanus anatoxin Ab (TAnAb) and anti-pneumococcal Ab (PnPsAb)...
  32. ncbi request reprint Seroprotection against tetanus in patients attending an emergency department in Belgium and evaluation of a bedside immunotest
    Muriel Stubbe
    Department of Emergency Medicine, Erasme University Hospital, Brussels, Belgium
    Eur J Emerg Med 14:14-24. 2007
    ..In most emergency departments, tetanus prophylaxis currently relies on vaccination history. Bedside evaluation of tetanus immunity may improve this process...
  33. pmc Optimal assessment of the ability of children with recurrent respiratory tract infections to produce anti-polysaccharide antibodies
    D Tuerlinckx
    Departement de Pediatrie, Universite Catholique de Louvain, Cliniques Universitaires de Mont Godinne, Yvoir, Belgique
    Clin Exp Immunol 149:295-302. 2007
    ..After immunization, SSA should be used only in case of a low response in OA. Only the absence of or a very low antibody response detected by both tests should be used as a diagnostic criterion for SPAD...
  34. ncbi request reprint [Immune deficiencies: diagnosis, management, some perspectives]
    C M Farber

    Rev Med Brux 22:73-82. 2001
    ..The inclusion of Belgian data in this register should allow essential progresses essential for our patients...