Aubert Maquille

Summary

Country: Belgium

Publications

  1. ncbi request reprint Electron beam and gamma radiolysis of solid-state metoclopramide
    Aubert Maquille
    Unité d Analyse Chimique et Physico chimique des Médicaments CHAM 7230, Universite Catholique de Louvain, Avenue E Mounier 72, B 1200, Brussels, Belgium
    Pharm Res 23:1343-9. 2006
  2. ncbi request reprint Radiosterilization of drugs in aqueous solutions may be achieved by the use of radioprotective excipients
    Aubert Maquille
    Laboratory of Chemical and Physico chemical Analysis of Drugs CHAM, Universite Catholique de Louvain, Brussels, Belgium
    Int J Pharm 349:74-82. 2008
  3. doi request reprint Cryo-irradiation as a terminal method for the sterilization of drug aqueous solutions
    Aubert Maquille
    Laboratory of Chemical and Physico chemical Analysis of Drugs CHAM, Universite Catholique de Louvain, Brussels, Belgium
    Eur J Pharm Biopharm 69:358-63. 2008
  4. ncbi request reprint Irradiation of human insulin in aqueous solution, first step towards radiosterilization
    Hélène Terryn
    Laboratory of Chemical and Physicochemical Analysis of Drugs CHAM, Universite Catholique de Louvain, Brussels, Belgium
    Int J Pharm 343:4-11. 2007
  5. ncbi request reprint Chemical analysis of solid-state irradiated human insulin
    Hélène Terryn
    Laboratory of Chemical and Physicochemical Analysis of Drugs CHAM, Universite Catholique de Louvain, CHAM 72 30, avenue E Mounier, 72, B 1200, Brussels, Belgium
    Pharm Res 23:2141-8. 2006

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Electron beam and gamma radiolysis of solid-state metoclopramide
    Aubert Maquille
    Unité d Analyse Chimique et Physico chimique des Médicaments CHAM 7230, Universite Catholique de Louvain, Avenue E Mounier 72, B 1200, Brussels, Belgium
    Pharm Res 23:1343-9. 2006
    ..Study the radiolysis of solid-state metoclopramide hydrochloride at various absorbed doses. Elucidate the structure of the degradation products to gain information on the radiolysis mechanisms...
  2. ncbi request reprint Radiosterilization of drugs in aqueous solutions may be achieved by the use of radioprotective excipients
    Aubert Maquille
    Laboratory of Chemical and Physico chemical Analysis of Drugs CHAM, Universite Catholique de Louvain, Brussels, Belgium
    Int J Pharm 349:74-82. 2008
    ..Similar radiolysis products were detected for gamma and electron beam irradiations but the chromatographic profiles were different (differences in the distribution of radiolysis products)...
  3. doi request reprint Cryo-irradiation as a terminal method for the sterilization of drug aqueous solutions
    Aubert Maquille
    Laboratory of Chemical and Physico chemical Analysis of Drugs CHAM, Universite Catholique de Louvain, Brussels, Belgium
    Eur J Pharm Biopharm 69:358-63. 2008
    ..Only one fragmentation product was observed in irradiated metoprolol frozen solutions. For both drugs, radiosterilization of frozen solutions, even at high doses (25 kGy), was found to be possible...
  4. ncbi request reprint Irradiation of human insulin in aqueous solution, first step towards radiosterilization
    Hélène Terryn
    Laboratory of Chemical and Physicochemical Analysis of Drugs CHAM, Universite Catholique de Louvain, Brussels, Belgium
    Int J Pharm 343:4-11. 2007
    ..Only the combination of these two approaches (addition of scavenger and freezing) enables the irradiated human insulin in aqueous solution to meet the European Pharmacopoeia requirements for chemical potency (>or=90%)...
  5. ncbi request reprint Chemical analysis of solid-state irradiated human insulin
    Hélène Terryn
    Laboratory of Chemical and Physicochemical Analysis of Drugs CHAM, Universite Catholique de Louvain, CHAM 72 30, avenue E Mounier, 72, B 1200, Brussels, Belgium
    Pharm Res 23:2141-8. 2006
    ..To study the chemical modifications induced upon irradiation of solid human insulin at radiosterilization doses and investigate the influence of the absorbed dose on radiolysis...