Djiotsa J, Verbruggen V, Giacomotto J, Ishibashi M, Manning E, Rinkwitz S, et al
. Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expression. BMC Dev Biol. 2012;12:37 pubmed publisher
..These data suggests that the main original function of Pax4 during vertebrate evolution was to modulate the number of pancreatic ?-cells and its role in ?-cells differentiation appeared later in vertebrate evolution. ..
Delporte F, Pasque V, Devos N, Manfroid I, Voz M, Motte P, et al
. Expression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factors. BMC Dev Biol. 2008;8:53 pubmed publisher
..This study also provides a striking example of how adaptative evolution of gene regulatory sequences upon gene duplication progressively leads to subfunctionalization of the paralogous gene pair. ..
TarifeÃ±o Saldivia E, Lavergne A, Bernard A, Padamata K, Bergemann D, Voz M, et al
. Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes. BMC Biol. 2017;15:21 pubmed publisher
Flasse L, Pirson J, Stern D, Von Berg V, Manfroid I, Peers B, et al
. Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish. BMC Biol. 2013;11:78 pubmed publisher
..It is repressed by Notch signaling that prevents pancreatic cell differentiation by maintaining precursors in an undifferentiated state...
Manfroid I, Delporte F, Baudhuin A, Motte P, Neumann C, Voz M, et al
. Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development. Development. 2007;134:4011-21 pubmed
Manfroid I, Ghaye A, Naye F, Detry N, Palm S, Pan L, et al
. Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration. Dev Biol. 2012;366:268-78 pubmed publisher
..Furthermore, beta cell recovery after specific ablation is severely compromised in sox9b mutant larvae. Our data position sox9b as a key player in the generation of secondary endocrine cells deriving from pancreatic ducts in zebrafish...
Ghaye A, Bergemann D, TarifeÃ±o Saldivia E, Flasse L, Von Berg V, Peers B, et al
. Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration. BMC Biol. 2015;13:70 pubmed publisher
..Our findings support the hypothesis that nkx6.1+ pancreatic progenitors contribute to beta cell regeneration. Further characterization of these cells will open up new perspectives for anti-diabetic therapies. ..