W J Malaisse

Summary

Country: Belgium

Publications

  1. ncbi request reprint Pharmacology of the meglitinide analogs: new treatment options for type 2 diabetes mellitus
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Treat Endocrinol 2:401-14. 2003
  2. ncbi request reprint Insulin release: the receptor hypothesis
    Willy J Malaisse
    Department of Biochemistry, Universite Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium
    Diabetologia 57:1287-90. 2014
  3. pmc Intermittent fasting modulation of the diabetic syndrome in streptozotocin-injected rats
    Louiza Belkacemi
    Laboratoire de Technologie Alimentaire et Nutrition, Université de Mostaganem, 1070 Mostaganem, Algeria
    Int J Endocrinol 2012:962012. 2012
  4. doi request reprint Insulinotropic action of Citrullus colocynthis seed extracts in rat pancreatic islets
    Nabila Benariba
    Laboratory of Antibiotic and Antifungal Physico Chemistry, Synthesis and Biological Activity, Faculty of Sciences, University Abou Bekr Belakaïd, Tlemcen, Algeria
    Mol Med Rep 7:233-6. 2013
  5. ncbi request reprint Intermittent fasting modulation of the diabetic syndrome in sand rats. II. In vivo investigations
    Louiza Belkacemi
    Laboratoire de Technologie Alimentaire et Nutrition, Université de Mostaganem, Mostaganem, Algeria
    Int J Mol Med 26:759-65. 2010
  6. doi request reprint Dietary sardine protein lowers insulin resistance, leptin and TNF-α and beneficially affects adipose tissue oxidative stress in rats with fructose-induced metabolic syndrome
    Zohra Madani
    Department of Biology, Es Sénia University, Oran, Algeria
    Int J Mol Med 29:311-8. 2012
  7. doi request reprint Intermittent fasting modulation of the diabetic syndrome in sand rats. III. Post-mortem investigations
    Louiza Belkacemi
    Laboratoire de Technologie Alimentaire et Nutrition, Université de Mostaganem, Mostaganem, Algeria
    Int J Mol Med 27:95-102. 2011
  8. doi request reprint The metabolic syndrome of fructose-fed rats: effects of long-chain polyunsaturated ω3 and ω6 fatty acids. V. Post-mortem findings
    Zoheir Mellouk
    Department of Biology, Es Sénia University, Es Sénia 31000, Oran, Algeria
    Mol Med Rep 6:1399-403. 2012
  9. doi request reprint Imaging of the β-cells of the islets of Langerhans
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes Res Clin Pract 98:11-8. 2012
  10. doi request reprint (19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Universite Libre de Bruxelles, Brussels, Belgium
    Arch Biochem Biophys 517:138-43. 2012

Collaborators

Detail Information

Publications153 found, 100 shown here

  1. ncbi request reprint Pharmacology of the meglitinide analogs: new treatment options for type 2 diabetes mellitus
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Treat Endocrinol 2:401-14. 2003
    ..The meglitinide analogs offer the advantage over the long-acting antihyperglycemic sulfonylurea glibenclamide of minimizing the risk of undesirable hypoglycemia...
  2. ncbi request reprint Insulin release: the receptor hypothesis
    Willy J Malaisse
    Department of Biochemistry, Universite Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium
    Diabetologia 57:1287-90. 2014
    ....
  3. pmc Intermittent fasting modulation of the diabetic syndrome in streptozotocin-injected rats
    Louiza Belkacemi
    Laboratoire de Technologie Alimentaire et Nutrition, Université de Mostaganem, 1070 Mostaganem, Algeria
    Int J Endocrinol 2012:962012. 2012
    ..Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects...
  4. doi request reprint Insulinotropic action of Citrullus colocynthis seed extracts in rat pancreatic islets
    Nabila Benariba
    Laboratory of Antibiotic and Antifungal Physico Chemistry, Synthesis and Biological Activity, Faculty of Sciences, University Abou Bekr Belakaïd, Tlemcen, Algeria
    Mol Med Rep 7:233-6. 2013
    ..The results of the present study are relevant for further investigations which aim to identify compounds exhibiting positive insulinotropic actions. These agents may be suitable for the treatment of human diabetic subjects. ..
  5. ncbi request reprint Intermittent fasting modulation of the diabetic syndrome in sand rats. II. In vivo investigations
    Louiza Belkacemi
    Laboratoire de Technologie Alimentaire et Nutrition, Université de Mostaganem, Mostaganem, Algeria
    Int J Mol Med 26:759-65. 2010
    ..These findings reveal that, at least in sand rats, intermittent daily fasting prevents the progressive deterioration of glucose tolerance otherwise taking place when these animals are exposed to a hypercaloric diet...
  6. doi request reprint Dietary sardine protein lowers insulin resistance, leptin and TNF-α and beneficially affects adipose tissue oxidative stress in rats with fructose-induced metabolic syndrome
    Zohra Madani
    Department of Biology, Es Sénia University, Oran, Algeria
    Int J Mol Med 29:311-8. 2012
    ....
  7. doi request reprint Intermittent fasting modulation of the diabetic syndrome in sand rats. III. Post-mortem investigations
    Louiza Belkacemi
    Laboratoire de Technologie Alimentaire et Nutrition, Université de Mostaganem, Mostaganem, Algeria
    Int J Mol Med 27:95-102. 2011
    ....
  8. doi request reprint The metabolic syndrome of fructose-fed rats: effects of long-chain polyunsaturated ω3 and ω6 fatty acids. V. Post-mortem findings
    Zoheir Mellouk
    Department of Biology, Es Sénia University, Es Sénia 31000, Oran, Algeria
    Mol Med Rep 6:1399-403. 2012
    ..Consideration is given to the possible biological determinants of these perturbations and their attenuation in rats exposed to safflower or salmon oil...
  9. doi request reprint Imaging of the β-cells of the islets of Langerhans
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Universite Libre de Bruxelles, Brussels, Belgium
    Diabetes Res Clin Pract 98:11-8. 2012
    ....
  10. doi request reprint (19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Universite Libre de Bruxelles, Brussels, Belgium
    Arch Biochem Biophys 517:138-43. 2012
    ..These findings are compatible with the view that selected (19)F-heptuloses may represent suitable tools for the non-invasive imaging of hepatocytes and insulin-producing cells by (19)F MRI...
  11. pmc Hepatic steatosis in n-3 fatty acid depleted mice: focus on metabolic alterations related to tissue fatty acid composition
    B D Pachikian
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    BMC Physiol 8:21. 2008
    ..This experiment carried out in mice aims at studying the impact of dietary n-3 polyunsaturated fatty acids (PUFA) depletion on hepatic metabolism...
  12. ncbi request reprint Perturbation of 11-eicosenoate metabolism in female diabetic rats
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Int J Mol Med 22:133-7. 2008
    ..These contrasting findings may be relevant to the higher coronary heart disease risk prevailing in female, as compared to male, diabetic subjects...
  13. ncbi request reprint Gliquidone contributes to improvement of type 2 diabetes mellitus management: a review of pharmacokinetic and clinical trial data
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Drugs R D 7:331-7. 2006
    ..In particular, the metabolism and route of excretion of the drug allow its use in patients who have or may be at risk of diabetic nephropathy...
  14. ncbi request reprint The metabolic syndrome of omega3-depleted rats. I. Liver data
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    Int J Mol Med 24:111-23. 2009
    ..Moreover, the results suggest that to oppose such consequences, e.g. liver steatosis, it may be necessary to combine the dietary supply of omega3 acids with a suitable control of food intake, in both qualitative and quantitative terms...
  15. ncbi request reprint Perturbation and age-related changes in the fatty acid pattern of soleus muscle phospholipids and triglycerides in rats depleted in long-chain polyunsaturated omega3 fatty acids
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 20:897-904. 2007
    ..Emphasis is placed, therefore, on the unusual situation found in the soleus muscle of omega3-depleted rats, in which both lipid and metabolic variables may be either favourably or adversely affected by the same environmental factor(s)...
  16. ncbi request reprint Metabolism of 13C-enriched D-fructose in hepatocytes from Goto-Kakizaki rats
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 13:697-703. 2004
    ....
  17. ncbi request reprint Mitiglinide: a rapid- and short-acting non-sulfonylurea insulinotropic agent for the treatment of type 2 diabetic patients
    Willy J Malaisse
    Brussels Free University, Laboratory of Experimental Hormonology, 808 Route de Lennik, B 1070 Brussels, Belgium
    Expert Opin Pharmacother 9:2691-8. 2008
    ....
  18. doi request reprint Noninvasive imaging of pancreatic beta cells
    Willy J Malaisse
    Universite Libre de Bruxelles, Brussels, Belgium
    Nat Rev Endocrinol 5:394-400. 2009
    ..Attention is also drawn to the latest approaches for noninvasive imaging and functional characterization of pancreatic beta cells. None of these procedures is used in clinical practice yet...
  19. ncbi request reprint Brain phospholipid and triglyceride fatty acid content and pattern in Type 1 and Type 2 diabetic rats
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, 808 Route de Lennik, B 1070 Brussels, Belgium
    Neurosci Lett 409:75-9. 2006
    ....
  20. ncbi request reprint Fatty acid content and pattern of epididymal and parametrial adipose tissue lipids in streptozotocin (type 1) and Goto-Kakizaki (type 2) diabetic rats
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 18:1231-4. 2006
    ....
  21. ncbi request reprint Non-invasive imaging of the endocrine pancreas (review)
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 15:243-6. 2005
    ..In the light of results obtained with 6-deoxy-6-iodo-D-glucose, it is proposed that 7-deoxy-7-iodo-D-mannoheptulose could be used for the non-invasive imaging of the endocrine pancreas...
  22. ncbi request reprint Anomeric specificity of D-glucose production by rat hepatocytes
    W J Malaisse
    Laboratory of Experimental Hormonology ULB and High Resolution NMR Centre VUB, Brussels Free Universities, Brussels, Belgium
    Mol Cell Biochem 266:145-50. 2004
    ....
  23. ncbi request reprint Delayed interconversion of D-glucose anomers in D2O
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    Int J Mol Med 13:855-7. 2004
    ..Thus, even over 60-min incubation at 30 degrees C, the integrated mean abundance of alpha- and beta-D-glucose would remain close to 82 and 89%, respectively, of the corresponding initial value (100%)...
  24. ncbi request reprint Stimulation of proinsulin biosynthesis by K+ in rat pancreatic islets
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Endocrine 23:51-7. 2004
    ..0 mM to 5.6 or 16.7 mM. These findings may suggest that the effect of D-glucose to increase the K+ content of islet cells represents one modality for coupling a rise in D-glucose concentration to stimulation of proinsulin biosynthesis...
  25. ncbi request reprint Isotopic discrimination between D-[1-(13)C]fructose and D-[2-(13)C]fructose in rat liver cells
    Willy J Malaisse
    Laboratory of Experimental Hormonology Université Libre de Bruxelles and High Resolution NMR Center Vrije Universiteit Brussel, Brussels Free Universities, Brussels, Belgium
    Biochimie 86:119-25. 2004
    ..005). It is proposed that these findings indicate isotopic discrimination at the phosphoglucoisomerase level between (12)C and (13)C for the carbon atom in position 1 (as compared to that in position 2) of D-fructose 6-phosphate...
  26. ncbi request reprint Metabolism of D-glucose anomers in pancreatic islets (review)
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, Route de Lennik 808, B 1070 Brussels, Belgium
    Int J Mol Med 12:911-6. 2003
    ..It is proposed that the anomeric specificity of D-glucose metabolism is essential to a sound understanding of carbohydrate homeostasis in health and disease...
  27. ncbi request reprint Enzyme-to-enzyme channelling in the early steps of glycolysis in rat pancreatic islets
    W J Malaisse
    Laboratory of Experimental Hormonology, Faculty of Medicine, Brussels Free University, 808 Route de Lennik, B 1070 Brussels, Belgium
    Int J Biochem Cell Biol 36:1510-20. 2004
    ..These findings are consistent with the postulated enzyme-to-enzyme tunnelling of glycolytic intermediates between hexokinase isoenzyme(s), phosphoglucoisomerase and, possibly, phosphofructokinase...
  28. ncbi request reprint Mathematical modelling of alpha- and beta-D-glucose metabolism in pancreatic islets exposed to equilibrated D-glucose
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, 808 Route de Lennik, B 1070 Brussels, Belgium
    Int J Mol Med 14:677-82. 2004
    ....
  29. ncbi request reprint Metabolism of D-glucose anomers in rat pancreatic islets exposed to equilibrated D-glucose
    W J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Horm Metab Res 36:281-5. 2004
    ....
  30. ncbi request reprint Effects of thioacetamide on pancreatic islet B-cell function
    Willy J Malaisse
    Laboratories of Experimental Hormonology and Pharmacology, Brussels Free University, Brussels, Belgium
    Endocrine 24:83-91. 2004
    ..These findings are interpreted as indicative of an impaired capacity of Ca2+ sequestration by intracellular organelles in the islet B-cells of thioacetamide-treated rats...
  31. ncbi request reprint Enzyme-to-enzyme channeling in the early steps of glycolysis in rat pancreatic islets
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Endocrine 24:105-9. 2004
    ....
  32. ncbi request reprint Effects of D-glucose upon D-fructose metabolism in rat hepatocytes: A 13C NMR study
    W J Malaisse
    Mol Cell Biochem 241:103-6. 2002
    ....
  33. ncbi request reprint Insulin-dependent diabetes and gut dysfunction: the BB rat model
    W J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Horm Metab Res 36:585-94. 2004
    ..In all these cases, the findings in rats fed a diabetes-promoting diet are compared to those collected in animals receiving a protective diabetes-retardant diet...
  34. ncbi request reprint Stimulation by D-glucose of 36Cl- efflux from prelabeled rat pancreatic islets
    Willy J Malaisse
    Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Endocrine 25:23-5. 2004
    ....
  35. ncbi request reprint European Association for the Study of Diabetes--40th Annual Meeting. 5-9 September 2004, Munich, Germany
    Willy Malaisse
    Universite Libre de Bruxelles, Laboratoire de Medecine Experimentale, CP 618, Route de Lennik 808, B 1070 Bruxelles, Belgium
    IDrugs 7:981-3. 2004
  36. ncbi request reprint Pancreatic and hepatic glycogen content in normoglycemic and hyperglycemic rats
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Mol Cell Biochem 219:45-9. 2001
    ....
  37. ncbi request reprint Uptake of 1-deoxy-1-[125I]iodo-D-mannoheptulose by different cell types: in vitro and in vivo experiments
    A Sener
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Int J Mol Med 7:495-500. 2001
    ..Taken as a whole, these findings suggest that 1-deoxy-1-[125I]iodo-D-mannoheptulose does not display the same specificity towards GLUT2, as that previously documented in the case of D-[3H]- mannoheptulose...
  38. ncbi request reprint Assessment of islet beta-cell mass in isolated rat pancreases perfused with D-[(3)H]mannoheptulose
    L Ladriere
    Laboratory of Experimental Medicine, Brussels Free University, B 1070 Brussels, Belgium
    Am J Physiol Endocrinol Metab 281:E298-303. 2001
    ..The present procedure may thus allow the assessment of the relative contribution of islet beta-cells to the total mass of the pancreatic gland...
  39. ncbi request reprint Uptake of D-mannoheptulose by normal and tumoral pancreatic islet cells
    R Ramirez
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Int J Mol Med 7:631-8. 2001
    ....
  40. ncbi request reprint Possible participation of an islet B-cell calcium-sensing receptor in insulin release
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Endocrine 11:293-300. 1999
    ....
  41. ncbi request reprint Stimulus-secretion coupling of arginine-induced insulin release. Uptake of metabolized and nonmetabolized cationic amino acids by pancreatic islets
    F Blachier
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Endocrinology 124:134-41. 1989
    ....
  42. ncbi request reprint Pancreatic fate of 6-deoxy-6-[125I]iodo-D-glucose: in vitro experiments
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Endocrine 13:411-6. 2000
    ....
  43. doi request reprint Rapid reduction of liver steatosis in omega3-depleted rats injected with a novel lipid emulsion
    Y A Carpentier
    L Deloyers Laboratory for Experimental Surgery, Brussels Free University, Brussels, Belgium
    Horm Metab Res 40:875-9. 2008
    ....
  44. ncbi request reprint Assessment by D-[(3)H]mannoheptulose uptake of B-cell density in isolated pancreatic islets from Goto-Kakizaki rats
    A Sener
    Laboratory of Experimental Medicine, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 8:177-80. 2001
    ..These findings provide further support to the validity of D-[3H]mannoheptulose uptake as a tool to assess the density of insulin-producing cells in isolated islets...
  45. ncbi request reprint Uptake of D-mannoheptulose by rat erythrocytes, hepatocytes and parotid cells
    R Ramirez
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Int J Mol Med 8:37-42. 2001
    ..These findings are compatible with the hypothesis that D-mannoheptulose is transported into cells mainly, if not exclusively, at the intervention of GLUT2...
  46. ncbi request reprint Pancreatic fate of 6-deoxy-6-[125I]iodo-D-glucose: in vivo experiments
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Endocrine 13:95-101. 2000
    ....
  47. ncbi request reprint Stimulation by hexose esters of lactate production by rat erythrocytes: insensitivity to 3-O-methyl-D-glucose and inhibition by 2-deoxy-D-glucose and its tetraacetic ester
    L Ladriere
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Mol Cell Biochem 183:175-82. 1998
    ..It is proposed that selected esters of saccharides represent useful tools to bypass defects in hexose transport, and to increase their nutritional or therapeutic efficiency...
  48. ncbi request reprint Cationic and secretory effects of 6-O-acetyl-D-glucose in rat pancreatic islets
    H Jijakli
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Biochem Mol Biol Int 43:233-40. 1997
    ..These findings indicate that the cationic events coupling the recognition of D-glucose to the stimulation of insulin release are not identical in islets exposed to the hexose or its ester...
  49. ncbi request reprint D-mannoheptulose phosphorylation by hexokinase isoenzymes
    P Courtois
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Int J Mol Med 7:359-63. 2001
    ..relative values (by reference to the phosphorylation rate of 10 mM D-glucose), and sensitivity to inhibition by D-glucose (10 mM)...
  50. ncbi request reprint Labeling of pancreatic glycogen by D-[U-14c]glucose in hyperglycemic rats
    L Ladriere
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Endocrine 14:383-97. 2001
    ....
  51. ncbi request reprint Effects of D-mannoheptose and D-glycero-D-gulo-heptose upon D-glucose metabolism and insulinotropic action in rat pancreatic islets and D-glucose phosphorylation by hexokinase isoenzymes: comparison with D-mannoheptulose
    P Courtois
    Laboratory of Experimental Medicine, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 6:171-5. 2000
    ..It is concluded, therefore, that neither D-mannoheptose nor D-glycero-D-guloheptose can be considered as suitable substitutes of D-mannoheptulose...
  52. ncbi request reprint Underestimation of D-glucose utilisation as judged from the conversion of D-[3-(3)H]glucose to (3)HOH
    A Sener
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Diabetologia 45:1274-80. 2002
    ..The conversion of D-[3-(3)H]glucose to (3) HOH is currently measured to assess D-glucose utilisation. The validity of such a procedure was re-evaluated...
  53. ncbi request reprint Esterification of D-mannoheptulose confers to the heptose inhibitory action on D-glucose metabolism in parotid cells
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Biochem Mol Biol Int 44:625-33. 1998
    ..The ester of D-mannoheptulose could thus represent a useful tool to inhibit hexose phosphorylation and interfere with cell growth in cells otherwise resistant to the heptose...
  54. ncbi request reprint Alteration of adipocyte metabolism in omega3 fatty acid-depleted rats
    B Oguzhan
    Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Horm Metab Res 38:789-98. 2006
    ..These features were compared to those prevailing in liver and plasma lipids. The present study thus extends knowledge on the alteration of lipid metabolism resulting from a deficiency in long-chain polyunsaturated omega3 fatty acids...
  55. ncbi request reprint Interference of D-mannoheptulose with D-glucose phosphorylation, metabolism and functional effects: comparison between liver, parotid cells and pancreatic islets
    O Scruel
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Mol Cell Biochem 187:113-20. 1998
    ..These findings suggest that factors such as the intracellular transport and availability of the heptose may interfere with the expression of its antagonistic action upon D-glucose metabolism...
  56. ncbi request reprint Accelerated clearance of plasma triglycerides and free fatty acids in omega3-depleted rats
    Y A Carpentier
    Laboratoire de Chirurgie Experimentale, Universite Libre de Bruxelles, Brussels, Belgium
    Horm Metab Res 39:295-305. 2007
    ....
  57. ncbi request reprint Insulinotropic action of alpha-D-glucose pentaacetate: metabolic aspects
    A Sener
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, B 1070, Belgium
    Mol Genet Metab 64:135-47. 1998
    ....
  58. ncbi request reprint Metabolism of tritiated D-glucose anomers in rat erythrocytes
    Y Zhang
    Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Mol Cell Biochem 259:101-4. 2004
    ..The regulation of this process thus tightly depends on the identity of the hexokinase enzyme mainly responsible for the phosphorylation of D-glucose in distinct cell types...
  59. ncbi request reprint Effects of artificial sweeteners on insulin release and cationic fluxes in rat pancreatic islets
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Cell Signal 10:727-33. 1998
    ....
  60. ncbi request reprint Pancreatic fate of 14C-labelled hexoses
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Cell Biochem Funct 18:281-91. 2000
    ....
  61. ncbi request reprint Pancreatic fate of D-[3H] mannoheptulose
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Cell Biochem Funct 19:171-9. 2001
    ..Suitably radiolabelled D-mannoheptulose or an analogue of the heptose could thus conceivably be used for quantification of the endocrine pancreatic mass...
  62. ncbi request reprint Oscillations in glycolysis: multifactorial quantitative analysis in muscle extract
    G Marynissen
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Mol Cell Biochem 113:105-21. 1992
    ..g. hepatocytes and pancreatic islet cells, in which no oscillation of glycolysis was so far observed...
  63. doi request reprint Glycerol metabolism alteration in adipocytes from n3-PUFA-depleted rats, an animal model for metabolic syndrome
    L Portois
    Laboratory of Experimental Surgery L Deloyers, Universite Libre de Bruxelles, Brussels, Belgium
    Horm Metab Res 44:28-32. 2012
    ..Our data show a reduced expression of AQP7 at the protein level in adipose tissue from n3-PUFA-depleted rats, without any changes at the mRNA levels. [U-(14)C]-Glycerol uptake was not modified in adipocytes from n3-PUFA-depleted animals...
  64. ncbi request reprint Assessment of B-cell mass in isolated islets exposed to D-[3H]mannoheptulose
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 7:405-6. 2001
    ..0 mM). These findings indicate that the present approach indeed allows to assess the relative contribution of B-cells to total islet mass for purpose of comparison between animals with different metabolic and/or hormonal status...
  65. ncbi request reprint Kinetics and specificity of human B-cell glucokinase: relevance to hexose-induced insulin release
    A Sener
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Biochim Biophys Acta 1312:73-8. 1996
    ..It is concluded that the intrinsic catalytic properties of B-cell glucokinase cannot fully account for the concentration dependency and sugar specificity of the secretory response to D-glucose or other hexoses in pancreatic islets...
  66. ncbi request reprint Pancreatic fate of 6-deoxy-6-[125I]iodo-D-glucose: in vitro experiments
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Endocrine 13:89-94. 2000
    ....
  67. ncbi request reprint Pancreatic glycogen content in Goto-Kakizaki rats
    L Ladriere
    Laboratory of Experimental Medicine, Brussels Free University, 808 Route de Lennik, B-1070 Brussels, Belgium
    Int J Mol Med 7:173-5. 2001
    ..The GK rats thus apparently represent a suitable model for further studies on the in vivo labelling of B-cell glycogen in the perspective of the non-invasive imaging and quantification of the endocrine pancreas...
  68. ncbi request reprint Enzymic activities in two populations of purified rat islet beta-cells
    A Sener
    Laboratory of Experimental Medicine, Brussels Free University, B-1070 Brussels, Belgium
    Int J Mol Med 8:285-9. 2001
    ..These findings thus argue against a low expression of either low-Km hexokinase(s) or lactate dehydrogenase as major determinants of the glucose-sensing device in beta-cells...
  69. ncbi request reprint Pancreatic islet function in omega-3 fatty acid-depleted rats: alteration of calcium fluxes and calcium-dependent insulin release
    Y Zhang
    Laboratory of Experimental Hormonology, Brussels Free University, 808 Route de Lennik, B 1070 Brussels, Belgium
    Am J Physiol Endocrinol Metab 291:E441-8. 2006
    ....
  70. ncbi request reprint Effects of D-mannoheptulose and its hexaacetate ester upon D-glucose metabolism in rat hepatocytes
    L Ladriere
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Int J Mol Med 1:967-70. 1998
    ..These findings suggest that an insufficient uptake of the heptose accounts, in part at least, for its poor efficiency as inhibitor of D-glucose catabolism in liver, and presumably islet cells exposed to low concentrations of the hexose...
  71. ncbi request reprint Uptake of tritiated D-mannoheptulose by liver, pancreatic exocrine and endocrine cells
    L Crenier
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Int J Mol Med 8:155-7. 2001
    ..It is proposed that suitably radiolabelled D-mannoheptulose could be used to label preferentially the endocrine moiety of the pancreatic gland, e.g., in the perspective of its non-invasive imaging...
  72. ncbi request reprint The riddle of formycin A insulinotropic action
    W J Malaisse
    Laboratorie of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Biochem Mol Med 57:47-63. 1996
    ..It is concluded, therefore, that the mechanism of action of formycin A in the pancreatic beta-cell remains to be elucidated...
  73. ncbi request reprint Deleterious effect of formycin A on tumor islet cells
    J Rasschaert
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Biochem Mol Med 54:138-41. 1995
    ..This study thus reveals that formycin A may display cytotoxic potential in the same range of concentrations in which it causes a progressive increase of glucose-stimulated insulin secretion in normal pancreatic islets...
  74. ncbi request reprint D-glucose metabolism in cross-linked pancreatic islets
    C Vanhoutte
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Biochem Biophys Res Commun 217:561-5. 1995
    ....
  75. ncbi request reprint Impairment by cytochalasin B of the inhibitory action of D-mannoheptulose upon D-glucose metabolism in rat pancreatic islets
    P Courtois
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Int J Mol Med 5:385-8. 2000
    ..These findings support the view that the entry of D-mannoheptulose into cells may be mediated by a cytochalasin B-sensitive transport system, such as the GLUT2 carrier...
  76. ncbi request reprint Sustained enrichment of liver phospholipids and triglycerides in eicosapentaenoate after a bolus intravenous injection of a medium-chain triglycerides:fish oil emulsion to streptozotocin (Type 1) and Goto-Kakizaki (Type 2) diabetic rats
    Yvon A Carpentier
    Laboratories of Experimental Surgery and Physiology and Pharmacology, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 17:643-7. 2006
    ..In light of these and previous findings, it is proposed that the beneficial metabolic and functional events of the MCT:FO emulsion may display not solely a rapid but also sustained time course...
  77. ncbi request reprint Fatty acid content and pattern of spleen phospholipids and triglycerides in normal and either type-1 or type-2 diabetic rats
    Laurence Portois
    Laboratory of Experimental Surgery, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 19:523-8. 2007
    ....
  78. ncbi request reprint Pharmacodynamics, insulinotropic action and hypoglycemic effect of nateglinide and glibenclamide in normal and diabetic rats
    Philippe Courtois
    Laboratory of Experimental Medicine, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 11:105-9. 2003
    ..This study thus emphasizes the vastly different pharmacodynamics of nateglinide and glibenclamide in both control and diabetic rats...
  79. ncbi request reprint Effect of D-mannoheptulose upon the cationic and secretory responses to alpha-D-glucose pentaacetate in perifused rat pancreatic islets
    H Jijakli
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Endocrine 10:219-24. 1999
    ....
  80. ncbi request reprint Pancreatic islet function in omega3 fatty acid-depleted rats: Glucose metabolism and nutrient-stimulated insulin release
    Berrin Oguzhan
    Laboratories of Experimental Hormonology and Surgery, Brussels Free University, Brussels, Belgium
    Endocrine 29:457-66. 2006
    ....
  81. ncbi request reprint Monosaccharide esters: new tools in biomedicine
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, 808 Route de Lennik, B 1070 Brussels, Belgium
    Acta Clin Belg 57:49-52. 2002
    ..This topic was first reviewed in 1998 (2). The major aim of the present report is to briefly evoke the background and present knowledge in this field...
  82. ncbi request reprint Glycogen accumulation in rat pancreatic islets: in vitro experiments
    M Doherty
    Laboratory of Experimental Medicine, Brussels Free University, Belgium
    Endocrine 14:303-9. 2001
    ..These findings may help to define the experimental conditions optimal for the labeling and accumulation of islet glycogen in vivo...
  83. ncbi request reprint Anomeric specificity of D-[U-14C]glucose incorporation into glycogen in rat hemidiaphragms
    Ying Zhang
    Laboratory of Experimental Hormonology, Erasmus Medical School, Brussels Free University, 808 Route de Lennik, B 1070 Brussels, Belgium
    Biochimie 86:913-8. 2004
    ....
  84. doi request reprint Lipid peroxidation is not a prerequisite for the development of obesity and diabetes in high-fat-fed mice
    Florence M Sohet
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Louvain Drug Research Institute, Universite Catholique de Louvain, Avenue E Mounier 73 69, Brussels, Belgium
    Br J Nutr 102:462-9. 2009
    ..Thus, lipid peroxidation in key organs is not necessarily related to the development of metabolic disorders associated with diabetes and obesity...
  85. ncbi request reprint Phospholipid fatty acid pattern and D-glucose metabolism in muscles from omega3 fatty acid-depleted rats
    Eda Agascioglu
    Laboratory of Experimental Hormonology, Brussels Free University, 808 Route de Lennik, 1070 Brussels, Belgium
    Biochimie 89:374-82. 2007
    ....
  86. ncbi request reprint Glycogen accumulation in cultured tumoral or normal pancreatic islet and acinar cells
    J Rasschaert
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Int J Mol Med 8:63-5. 2001
    ..g. by 11C-labelled D-glucose or 2-deoxy-2-[18F]fluoro-D-glucose, may allow identification and localization of insulinomas in the pancreatic gland by a non-invasive imaging procedure...
  87. ncbi request reprint Labelling of lipids by D-[1-14C]glucose, D-[6-14C] glucose and D-[3-3H]glucose in pancreatic islets from normal and GK rats
    H X Zhang
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Mol Cell Biochem 252:247-51. 2003
    ....
  88. ncbi request reprint Rapid lipid enrichment in omega3 fatty acids: plasma data
    Yvon A Carpentier
    Laboratories of Experimental Hormonology and Surgery, Brussels Free University, Brussels, Belgium
    Int J Mol Med 21:355-65. 2008
    ..Moreover, in the uninjected omega3-depleted rats the comparison between individual plasma and liver measurements indicated positive correlations in the fatty acid profile of phospholipids and triglycerides...
  89. ncbi request reprint Altered K+ fluxes and insulin release in pancreatic islets from omega3 fatty acid-depleted rats
    Abdullah Sener
    Laboratorie of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Endocrine 30:207-11. 2006
    ..In conclusion, an impaired activity of the Na,K-ATPase in insulin-producing cells apparently represents a key determinant of altered islet function in omega3-depleted rats...
  90. doi request reprint Direct effects of eicosapentaenoic and docosahexaenoic acids on phospholipid and triglyceride fatty acid pattern, glucose metabolism, 86rubidium net uptake and insulin release in BRIN-BD11 cells
    Ying Zhang
    Laboratory of Experimental Hormonology, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    Endocrine 35:438-48. 2009
    ....
  91. ncbi request reprint The metabolic syndrome of omega3-depleted rats. II. Body weight, adipose tissue mass and glycemic homeostasis
    Abdullah Sener
    Laboratory of Experimental Hormonology, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    Int J Mol Med 24:125-9. 2009
    ..However, the supply of exogenous omega3 fatty acids to the omega3-depleted rats failed to oppose visceral obesity, possibly as a result of the orexigenic effects of these omega3 fatty acids...
  92. ncbi request reprint Effects of D-mannoheptulose upon D-glucose metabolism in pancreatic B and non-B islet cells
    Remedios Ramirez
    Laboratory of Experimental Medicine, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 9:159-63. 2002
    ..It could be attributable, in part at least, to D-glucose and D-mannoheptulose countertransport, resulting inter alia in a greater net uptake of the heptose by B cells exposed to a high concentration of the hexose...
  93. ncbi request reprint Alteration of lipid fatty acid profile and cationic fluxes in ventricular cardiomyocytes from omega3-depleted rats
    Sebastien Peltier
    Laboratory of Experimental Surgery, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    Int J Mol Med 24:343-52. 2009
    ..The cationic alterations were corrected, in part at least, by the prior intravenous injection of the medium-chain triglyceride:fish oil emulsion 60 min before sacrifice of the omega3-depleted rats...
  94. ncbi request reprint The stimulus-secretion coupling of amino acid-induced insulin release. Insulinotropic action of L-alanine
    Abdullah Sener
    Faculty of Medicine, Laboratory of Experimental Medicine, Brussels Free University, 808 Route de Lennik, Belgium
    Biochim Biophys Acta 1573:100-4. 2002
    ..However, the possible role of Na(+) co-transport in the secretory response to L-alanine cannot be ignored...
  95. ncbi request reprint Impaired enzyme-to-enzyme channelling between hexokinase isoenzyme(s) and phosphoglucoisomerase in rat pancreatic islets incubated at a low concentration of D-glucose
    Ying Zhang
    Laboratory of Experimental Hormonology, Brussels Free University, Brussels, Belgium
    Cell Biochem Funct 23:15-21. 2005
    ..8 mM, rather than 8.3 mM D-glucose. These findings suggest, therefore, that the postulated process of enzyme-to-enzyme channelling involves mainly glucokinase...
  96. ncbi request reprint Pancreatic uptake of [2-(14)C]alloxan
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 7:311-5. 2001
    ....
  97. ncbi request reprint Pancreatic fate of a (125)I-labelled mouse monoclonal antibody directed against pancreatic B-cell surface ganglioside(s) in control and diabetic rats
    L Ladriere
    Laboratory of Experimental Medicine Brussels Free University, Brussels, Belgium
    Cell Biochem Funct 19:107-15. 2001
    ..g. by single photon emission computerized tomography...
  98. ncbi request reprint On the track to the beta-cell
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Diabetologia 44:393-406. 2001
    ..In the same perspective, it is proposed that advantage could be taken of the much greater accumulation of glycogen in insulin-producing cells, as compared to other pancreatic cell types, in situations of sustained hyperglycaemia...
  99. ncbi request reprint Fate of 2-deoxy-2-[18F]fluoro-D-glucose in hyperglycemic rats
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, B 1070 Brussels, Belgium
    Int J Mol Med 6:549-52. 2000
    ..It is proposed, therefore, that 11C-labelled D-glucose, rather than 2-deoxy-2-[18F]fluoro-D-glucose should be used in the perspective of the non-invasive imaging of the endocrine pancreas...
  100. doi request reprint Vitamin E transfer from lipid emulsions to plasma lipoproteins: mediation by multiple mechanisms
    M Hacquebard
    Universite Libre de Bruxelles, 1070, Brussels, Belgium
    Lipids 43:663-71. 2008
    ....
  101. ncbi request reprint Effects of aliphatic dioic acids and glycerol-1,2,3-tris(dodecanedioate) on D-glucose-stimulated insulin release in rat pancreatic islets
    W J Malaisse
    Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
    Br J Nutr 84:733-6. 2000
    ..It is speculated that these findings may extend to insulin-producing cells, the knowledge that aliphatic dioic acids or their esters may act as energy substrates, e.g. in parenteral nutrition...