Dominique Lison

Summary

Country: Belgium

Publications

  1. pmc The nanosilica hazard: another variable entity
    Dorota Napierska
    Unit of Lung Toxicology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Part Fibre Toxicol 7:39. 2010
  2. pmc Confounders in the assessment of the renal effects associated with low-level urinary cadmium: an analysis in industrial workers
    Nahida Haddam
    Laboratory of Medical Toxicology, Faculty of Medicine, University Abou Bekr Belkaid, Tlemcen, Algeria
    Environ Health 10:37. 2011
  3. doi request reprint Nominal and effective dosimetry of silica nanoparticles in cytotoxicity assays
    Dominique Lison
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Avenue E Mounier 53 02, 1200 Brussels, Belgium
    Toxicol Sci 104:155-62. 2008
  4. doi request reprint Sintered indium-tin-oxide (ITO) particles: a new pneumotoxic entity
    Dominique Lison
    Industrial Toxicology and Occupational Medicine Unit, Catholic University of Louvain, Brussels, Belgium
    Toxicol Sci 108:472-81. 2009
  5. pmc Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis
    Francois Huaux
    Louvain Centre for Toxicology and Applied Pharmacology LTAP, Institute of Experimental and Clinical Research IREC, Universite Catholique de Louvain UCL, Brussels, Belgium
    PLoS ONE 8:e64341. 2013
  6. ncbi request reprint Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis
    Magali Meyer
    Department of Clinical Chemistry, Universite Catholique de Louvain, Brussels, Belgium
    Am J Respir Cell Mol Biol 41:590-602. 2009
  7. ncbi request reprint B lymphocytes are critical for lung fibrosis control and prostaglandin E2 regulation in IL-9 transgenic mice
    Mohammed Arras
    Unit of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, UCL, Clos Chapelle aux Champs, 30 54, 1200 Brussels, Belgium
    Am J Respir Cell Mol Biol 34:573-80. 2006
  8. ncbi request reprint Profibrotic effect of IL-9 overexpression in a model of airway remodeling
    Sybille van den Brule
    Unit of Industrial Toxicology and Occupational Medicine, Universite Catholique de Louvain, Avenue Mounier, 53 02, 1200 Brussels, Belgium
    Am J Respir Cell Mol Biol 37:202-9. 2007
  9. ncbi request reprint Type 2 immune response associated with silicosis is not instrumental in the development of the disease
    Pierre Misson
    Unit of Industrial Toxicology and Occupational Medicine, Universite Catholique de Louvain, 53 02 Ave E Mounier, 1200 Brussels, Belgium
    Am J Physiol Lung Cell Mol Physiol 292:L107-13. 2007
  10. doi request reprint Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: toxicological aspects
    Julie Muller
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Brussels, Belgium
    Chem Res Toxicol 21:1698-705. 2008

Detail Information

Publications84

  1. pmc The nanosilica hazard: another variable entity
    Dorota Napierska
    Unit of Lung Toxicology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Part Fibre Toxicol 7:39. 2010
    ....
  2. pmc Confounders in the assessment of the renal effects associated with low-level urinary cadmium: an analysis in industrial workers
    Nahida Haddam
    Laboratory of Medical Toxicology, Faculty of Medicine, University Abou Bekr Belkaid, Tlemcen, Algeria
    Environ Health 10:37. 2011
    ..Few studies have considered the possibility that these associations might be non causal and arise from confounding by factors influencing the renal excretion of Cd and proteins...
  3. doi request reprint Nominal and effective dosimetry of silica nanoparticles in cytotoxicity assays
    Dominique Lison
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Avenue E Mounier 53 02, 1200 Brussels, Belgium
    Toxicol Sci 104:155-62. 2008
    ..This observation has important bearings on the experimental design and the interpretation of in vitro toxicological studies with nanoparticles...
  4. doi request reprint Sintered indium-tin-oxide (ITO) particles: a new pneumotoxic entity
    Dominique Lison
    Industrial Toxicology and Occupational Medicine Unit, Catholic University of Louvain, Brussels, Belgium
    Toxicol Sci 108:472-81. 2009
    ..The inflammatory and genotoxic activities of ITO dust indicate that a strict control of exposure is needed in industrial settings...
  5. pmc Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis
    Francois Huaux
    Louvain Centre for Toxicology and Applied Pharmacology LTAP, Institute of Experimental and Clinical Research IREC, Universite Catholique de Louvain UCL, Brussels, Belgium
    PLoS ONE 8:e64341. 2013
    ..Proinflammatory and fibrogenic functions of fibroblasts are upregulated in CF and are reduced by vardenafil. This study provides compelling new support for targeting cGMP signaling pathway in CF pharmacotherapy...
  6. ncbi request reprint Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis
    Magali Meyer
    Department of Clinical Chemistry, Universite Catholique de Louvain, Brussels, Belgium
    Am J Respir Cell Mol Biol 41:590-602. 2009
    ..Azithromycin down-regulates inflammatory cytokine production by M1-polarized CF alveolar macrophages...
  7. ncbi request reprint B lymphocytes are critical for lung fibrosis control and prostaglandin E2 regulation in IL-9 transgenic mice
    Mohammed Arras
    Unit of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, UCL, Clos Chapelle aux Champs, 30 54, 1200 Brussels, Belgium
    Am J Respir Cell Mol Biol 34:573-80. 2006
    ..We conclude that B lymphocytes are essential for the protection against lung fibrosis and macrophage overexpression of PGE2 in IL-9 transgenic animals...
  8. ncbi request reprint Profibrotic effect of IL-9 overexpression in a model of airway remodeling
    Sybille van den Brule
    Unit of Industrial Toxicology and Occupational Medicine, Universite Catholique de Louvain, Avenue Mounier, 53 02, 1200 Brussels, Belgium
    Am J Respir Cell Mol Biol 37:202-9. 2007
    ..These data also highlight a dual role of IL-9 in lung fibrosis, being anti- or profibrotic depending on the alveolar or airway localization of the process, respectively...
  9. ncbi request reprint Type 2 immune response associated with silicosis is not instrumental in the development of the disease
    Pierre Misson
    Unit of Industrial Toxicology and Occupational Medicine, Universite Catholique de Louvain, 53 02 Ave E Mounier, 1200 Brussels, Belgium
    Am J Physiol Lung Cell Mol Physiol 292:L107-13. 2007
    ..Our data clearly indicate that the type 2 immune response associated with silicosis in mice is not required for the development of this inflammatory and fibrotic disease...
  10. doi request reprint Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: toxicological aspects
    Julie Muller
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Brussels, Belgium
    Chem Res Toxicol 21:1698-705. 2008
    ....
  11. ncbi request reprint Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles
    Virginie Barbarin
    Unit of Industrial Toxicology and Occupational Medicine, University Hospital of Mont Godinne, Universite Catholique de Louvain, 30 54, Clos Chapelle aux Champs, 1200 Brussels, Belgium
    Am J Physiol Lung Cell Mol Physiol 288:L841-8. 2005
    ..Together, these data indicate that the increased expression of IL-10 significantly contributed to silica-induced lung fibrosis by exacerbating the Th2 response and the production of the profibrotic cytokines IL-4 and IL-13...
  12. ncbi request reprint Characterization of the effect of interleukin-10 on silica-induced lung fibrosis in mice
    Virginie Barbarin
    Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, University Hospital of Mont Godinne, Yvoir, Universite Catholique de Louvain, Brussels, Belgium
    Am J Respir Cell Mol Biol 31:78-85. 2004
    ..These effects appear to be independent of the enhanced lung CD4+ T-lymphocytosis observed in IL-10-deficient mice...
  13. ncbi request reprint 1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation
    Laure Elens
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, St Luc Hospital, Brussels, Belgium
    Pharmacogenet Genomics 17:873-83. 2007
    ....
  14. doi request reprint Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients
    Laure Elens
    Louvain Centre for Toxicology and applied Pharmacology, Universite Catholique de Louvain, 53 02, avenue E Mounier, 1200 Bruxelles, Belgium
    Pharmacogenomics 11:1223-34. 2010
    ..Previous studies have identified some possible genetic determinants of the variability in plasma concentrations. However, their impact on EFV intracellular pharmacokinetics remains mostly unexplored...
  15. ncbi request reprint Respiratory toxicity of multi-wall carbon nanotubes
    Julie Muller
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Clos Chapelle aux Champs, 30 54 1200 Brussels, Belgium
    Toxicol Appl Pharmacol 207:221-31. 2005
    ..These results suggest that carbon nanotubes are potentially toxic to humans and that strict industrial hygiene measures should to be taken to limit exposure during their manipulation...
  16. doi request reprint Influence of size, surface area and microporosity on the in vitro cytotoxic activity of amorphous silica nanoparticles in different cell types
    Virginie Rabolli
    Louvain Centre for Toxicology and Applied Pharmacology LTAP, Universite Catholique de Louvain, Brussels, Belgium
    Nanotoxicology 4:307-18. 2010
    ..These determinants are, however, complex and vary with cell type, reflecting the pleiotropic interactions of nanoparticles with biological systems...
  17. doi request reprint Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice
    Virginie Rabolli
    Louvain Centre for Toxicology and Applied Pharmacology LTAP, Institute of Experimental and Clinical Research IREC, Universite Catholique de Louvain, Brussels, Belgium
    Toxicol Lett 203:127-34. 2011
    ....
  18. doi request reprint The cytotoxic activity of amorphous silica nanoparticles is mainly influenced by surface area and not by aggregation
    Virginie Rabolli
    Louvain Centre for Toxicology and Applied Pharmacology LTAP, Institute of Experimental and Clinical Research IREC, Universite Catholique de Louvain, Avenue E Mounier 53 02, Brussels, Belgium
    Toxicol Lett 206:197-203. 2011
    ..e. a high specific surface area and a nanosize dimension. This conclusion does, however, not necessarily hold true for other toxicity endpoints for which the determinants may be different and possibly modified by the aggregation process...
  19. ncbi request reprint Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis
    Giulia Giordano
    Louvain Centre for Toxicology and applied Pharmacology, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Toxicol Sci 116:682-92. 2010
    ..Type I IFN is, however, dispensable in the development of silica-induced acute lung inflammation and pulmonary fibrosis...
  20. pmc The role of pro- and anti-inflammatory responses in silica-induced lung fibrosis
    Virginie Barbarin
    Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, Universite Catholique de Louvain, Clos Chapelle aux champs 30 54, 1200 Brussels, Belgium
    Respir Res 6:112. 2005
    ..It has been generally well accepted that chronic inflammation is a necessary component of lung fibrosis but this concept has recently been challenged...
  21. doi request reprint The D prostanoid receptor agonist BW245C [(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid] inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice
    Sybille van den Brule
    Louvain Centre for Toxicology and applied Pharmacology, Universite Catholique de Louvain, 53 02 Avenue Emmanuel Mounier, B 1200, Brussels, Belgium
    J Pharmacol Exp Ther 335:472-9. 2010
    ..Our results indicate that BW245C can reduce lung fibrosis in part via its activity on fibroblast proliferation and suggest that DP activation should be considered as a new therapeutic target in fibroproliferative lung diseases...
  22. doi request reprint Azithromycin fails to reduce increased expression of neutrophil-related cytokines in primary-cultured epithelial cells from cystic fibrosis mice
    Ximena Gavilanes
    Clinical Chemistry, Universite Catholique de Louvain, Ave Hippocrate 10, B 1200 Brussels, Belgium
    J Cyst Fibros 8:203-10. 2009
    ..Beneficial effects of azithromycin in cystic fibrosis (CF) have been reported, however, its mechanism of action remains unclear. The present study aimed at investigating the effect of azithromycin on CF airway epithelial cells...
  23. ncbi request reprint IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells
    Valérie Steenwinckel
    Ludwig Institute for Cancer Research and Experimental Medicine Unit, Universite Catholique de Louvain, Avenue Hippocrate 74, Brussels, Belgium
    J Immunol 178:3244-51. 2007
    ....
  24. ncbi request reprint Serum dioxin-like compounds and aromatase (CYP19) expression in endometriotic tissues
    Jean François Heilier
    Universite Catholique de Louvain, Faculty of Medicine, Industrial Toxicology and Occupational Medicine Unit, 53 02 Avenue E Mounier, B 1200 Brussels, Belgium
    Toxicol Lett 167:238-44. 2006
    ..We conclude that DLCs do probably not facilitate the growth of endometriotic lesions by up-regulating the local expression of aromatase...
  25. pmc IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins
    Mohammed Arras
    Unit of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, UCL, Clos Chapelle aux Champs, 30 54, 1200 Brussels, Belgium
    Am J Pathol 166:107-15. 2005
    ..Indomethacin treatment, which inhibited PGE2 production in both strains, suppressed the protection in Tg5 mice, supporting the idea that IL-9 controls blm-induced lung injury through a prostaglandin-dependent mechanism...
  26. ncbi request reprint Environmental and host-associated risk factors in endometriosis and deep endometriotic nodules: a matched case-control study
    Jean François Heilier
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, 30 54 Clos Chapelle aux Champs B 1200 Brussels, Belgium
    Environ Res 103:121-9. 2007
    ..We conclude that PE and DEN share similar patterns of risk or protective factors...
  27. doi request reprint Exploring the aneugenic and clastogenic potential in the nanosize range: A549 human lung carcinoma cells and amorphous monodisperse silica nanoparticles as models
    Laetitia Gonzalez
    Department of Biology, Vrije Universiteit Brussel, Brussels, Belgium
    Nanotoxicology 4:382-95. 2010
    ..This line of investigation will contribute to adequately design and interpret nanogenotoxicity assays...
  28. ncbi request reprint Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients
    Laure Elens
    Louvain Center for Toxicology and Applied Pharmacology LTAP, Universite Catholique de Louvain, 53 02 Avenue E Mounier, 1200 Bruxelles, Belgium
    Pharmacogenomics 10:1589-97. 2009
    ....
  29. ncbi request reprint Markers of macrophage differentiation in experimental silicosis
    Pierre Misson
    Industrial Toxicology and Occupational Medicine, Universite Catholique de Louvain, Belgium
    J Leukoc Biol 76:926-32. 2004
    ..Our data indicate that the modifications of M1/M2 marker expression are limited to the early inflammatory stage of silicosis and that the establishment of a fibrotic process is not necessarily associated with M2 polarization...
  30. pmc Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-beta
    Sybille van den Brule
    Universite Catholique de Louvain, Clos Chapelle aux Champs, 30 54, 1200 Brussels, Brussels, Belgium
    Respir Res 6:84. 2005
    ..To examine whether cathepsin(s) (Cat) are important in the development of pulmonary fibrosis, we assessed the expression of four Cat known for their collagenolytic activity in a model of silica-induced lung fibrosis...
  31. doi request reprint Parental occupational exposure to pesticides as risk factor for brain tumors in children and young adults: a systematic review and meta-analysis
    Geneviève Van Maele-Fabry
    Universite Catholique de Louvain, SSS IREC LTAP Louvain Center for Toxicology and Applied Pharmacology, Avenue E Mounier 52, bte B1 52 12, B 1200 Brussels, Belgium
    Environ Int 56:19-31. 2013
    ..To examine the potential association between parental occupational exposure to pesticides and the occurrence of brain tumors in children and young adults...
  32. doi request reprint Occupational exposure to cobalt is not associated with incipient signs of dilated cardiomyopathy in a Belgian refinery
    Anne Catherine Lantin
    Louvain Centre for Toxicology and applied Pharmacology, Institut de Recherche Expérimentale et Clinique IREC, Universite Catholique de Louvain, Brussels, Belgium
    Occup Environ Med 70:386-92. 2013
    ..Excessive absorption of cobalt has been associated with cases of dilated cardiomyopathy in the past, but it is unclear whether occupationally exposed populations are at risk...
  33. doi request reprint Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis
    Sandra Lo Re
    Louvain Centre for Toxicology and applied Pharmacology, Institute of Experimental and Clinical Research, Universite Catholique de Louvain, Brussels, Belgium
    Am J Respir Crit Care Med 184:1270-81. 2011
    ..There is evidence that CD4(+) effector T lymphocytes (T eff) participate in the development of lung fibrosis, but the role of their CD4(+) regulatory T-cell (T reg) counterparts remains to be determined...
  34. doi request reprint Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat
    Julie Muller
    Industrial Toxicology and Occupational Medicine Unit, Catholic University of Louvain, 1200 Brussels, Belgium
    Toxicol Sci 110:442-8. 2009
    ....
  35. ncbi request reprint Evaluation of urinary biomarkers of exposure to benzene: correlation with blood benzene and influence of confounding factors
    Perrine Hoet
    Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    Int Arch Occup Environ Health 82:985-95. 2009
    ....
  36. doi request reprint CD4+ T lymphocytes in lung fibrosis: diverse subsets, diverse functions
    Sandra Lo Re
    Institute of Experimental and Clinical Research IREC, Universite Catholique de Louvain, Avenue Mounier 52, Brussels, Belgium
    J Leukoc Biol 93:499-510. 2013
    ..Integrating our recent understanding of the contrasting functions of T lymphocyte subsets in fibrosis provides new insights and opportunities for improved treatment strategies...
  37. doi request reprint Occupational exposure to indium: what does biomonitoring tell us?
    Perrine Hoet
    Louvain Centre for Toxicology and Applied Pharmacology LTAP, Universite Catholique de Louvain UCL, Brussels, Belgium
    Toxicol Lett 213:122-8. 2012
    ..Validated biomarkers to assess exposure to indium are not available...
  38. pmc Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice
    Rachida Legssyer
    Clinical Chemistry, Universite Catholique de Louvain, Ave Hippocrate 10, Brussels, Belgium
    Respir Res 7:134. 2006
    ..Azithromycin is used for the treatment of cystic fibrosis lung disease, although its mechanisms of action are poorly understood. We tested the hypothesis that azithromycin modulates lung inflammation in cystic fibrosis mice...
  39. ncbi request reprint The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients
    Vincent Haufroid
    Industrial and Environmental Toxicology Unit, Kidney and Pancreas Transplantation Unit, Clinical Chemistry Department, Universite Catholique de Louvain, St Luc Hospital, Brussels, Belgium
    Pharmacogenetics 14:147-54. 2004
    ..Beside non-genetic factors (e.g. steroids dosing, drugs interactions), CYP3A5 pharmacogenetic testing performed just before transplantation could contribute to a better individualization of immunosuppressive therapy...
  40. ncbi request reprint Organochlorines and endometriosis: a mini-review
    Jean François Heilier
    Universite Catholique de Louvain, Faculty of Medicine, Industrial Toxicology and Occupational Medicine Unit, Brussels, Belgium
    Chemosphere 71:203-10. 2008
    ..The type of control women, the nature of the chemicals measured, and the definition of the disease could modulate the ability to detect the possible relationship between endometriosis and organochlorine exposure...
  41. ncbi request reprint Increased dioxin-like compounds in the serum of women with peritoneal endometriosis and deep endometriotic (adenomyotic) nodules
    Jean François Heilier
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Brussels, Belgium
    Fertil Steril 84:305-12. 2005
    ..To investigate the possible association between the body burden of dioxin-like compounds and endometriotic disease...
  42. ncbi request reprint Local and systemic immune responses to intratracheal instillation of antigen and DNA vaccines in mice
    Catherine Lombry
    Department of Pharmaceutical Technology, School of Pharmacy, Universite Catholique de Louvain, Brussels, Belgium
    Pharm Res 21:127-35. 2004
    ....
  43. doi request reprint Residential exposure to pesticides and childhood leukaemia: a systematic review and meta-analysis
    Geneviève Van Maele-Fabry
    Universite Catholique de Louvain, Louvain Center for Toxicology and Applied Pharmacology LTAP, Brussels, Belgium
    Environ Int 37:280-91. 2011
    ..To conduct a systematic review of published studies on the association between residential/household/domestic exposure to pesticides and childhood leukaemia, and to provide a quantitative estimate of the risk...
  44. doi request reprint IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis
    Sandra Lo Re
    Louvain Centre for Toxicology and applied Pharmacology, de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    J Immunol 184:6367-77. 2010
    ..Although the acute alveolitis induced by silica is IL-17A dependent, this cytokine appears dispensable for the development of the late inflammatory and fibrotic lung responses to silica...
  45. doi request reprint Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells
    Julie Muller
    Unité de toxicologie industrielle et médecine du travail, Universite Catholique de Louvain, Avenue Mounier, 53 02, 1200 Bruxelles, Belgium
    Carcinogenesis 29:427-33. 2008
    ..Finally, we found that MWCNT induced both centromere-positive and -negative MN in MCF-7 cells. Overall, this study provides the first evidence of the potential of MWCNT to induce clastogenic as well as aneugenic events...
  46. ncbi request reprint Sirolimus and tacrolimus trough concentrations and dose requirements after kidney transplantation in relation to CYP3A5 and MDR1 polymorphisms and steroids
    Michel Mourad
    Kidney and Pancreas Transplantation Unit, Universite Catholique de Louvain, Saint Luc University Hospital, Brussels, Belgium
    Transplantation 80:977-84. 2005
    ..The aim is to determine whether these polymorphisms also affect sirolimus trough concentrations and dose requirements after kidney transplantation...
  47. doi request reprint Occupational exposure to pesticides and Parkinson's disease: a systematic review and meta-analysis of cohort studies
    Geneviève Van Maele-Fabry
    Universite Catholique de Louvain, SSS IREC LTAP, Louvain Center for Toxicology and Applied Pharmacology, Avenue E Mounier 52, bte B1 52 12, B 1200 Brussels, Belgium
    Environ Int 46:30-43. 2012
    ..To systematically review available cohort studies and estimate quantitatively the association between occupational exposure to pesticides and Parkinson's disease (PD)...
  48. doi request reprint Acute kidney injury following acute liver failure: potential role of systemic cadmium mobilization?
    Perrine Hoet
    Louvain Centre for Toxicology and applied Pharmacology, Brussels, Belgium
    Intensive Care Med 38:467-73. 2012
    ..We tested the hypothesis that a release of Cd during ALF may cause a redistribution of Cd from the liver to the kidneys and play a role in the occurrence of ALF-associated AKI...
  49. doi request reprint Functional defect caused by the 4544G>A SNP in ABCC2: potential impact for drug cellular disposition
    Laure Elens
    Louvain Centre for Toxicology and applied Pharmacology, Catholic University of Louvain, Brussels, Belgium
    Pharmacogenet Genomics 21:884-93. 2011
    ..The aim of the present study was to investigate whether the 4544G>A SNP causes alterations in ABCC2-mediated transport towards different substrates and to explore the underlying molecular mechanisms...
  50. doi request reprint Co-assessment of cell cycle and micronucleus frequencies demonstrates the influence of serum on the in vitro genotoxic response to amorphous monodisperse silica nanoparticles of varying sizes
    Laetitia Gonzalez
    Laboratory for Cell Genetics, Vrije Universiteit Brussel, Brussels, Belgium
    Nanotoxicology 8:876-84. 2014
    ..However, this recommendation applies only if the cell line used is able to proliferate under serum-free conditions because cell division is a prerequisite for MN expression...
  51. doi request reprint Reference values and upper reference limits for 26 trace elements in the urine of adults living in Belgium
    Perrine Hoet
    Louvain Centre for Toxicology and Applied Pharmacology LTAP, Institut de Recherche Expérimentale et Clinique IREC, Universit e catholique de Louvain, Avenue Mounier, 52 bte B1 52 12, 1200 Brussels, Belgium
    Clin Chem Lab Med 51:839-49. 2013
    ....
  52. doi request reprint Childhood leukaemia and parental occupational exposure to pesticides: a systematic review and meta-analysis
    Geneviève Van Maele-Fabry
    Louvain Center for Toxicology and Applied Pharmacology LTAP, Universite Catholique de Louvain, Avenue E Mounier 53 02, 1200, Brussels, Belgium
    Cancer Causes Control 21:787-809. 2010
    ..To conduct a systematic review and meta-analysis of published studies on the association between parental occupational exposure to pesticides and childhood leukaemia...
  53. ncbi request reprint Interest of genotyping and phenotyping of drug-metabolizing enzymes for the interpretation of biological monitoring of exposure to styrene
    Vincent Haufroid
    Industrial Toxicology and Occupational Medicine Unit, Catholic University of Louvain, Brussels, Belgium
    Pharmacogenetics 12:691-702. 2002
    ....
  54. pmc Towards predicting the lung fibrogenic activity of nanomaterials: experimental validation of an in vitro fibroblast proliferation assay
    Giulia Vietti
    Louvain Centre for Toxicology and applied Pharmacology, Universite Catholique de Louvain, Avenue E, Mounier, 52 bte B1, 52, 12, 1200 Brussels, Belgium
    Part Fibre Toxicol 10:52. 2013
    ..We developed and validated experimentally here a simple and rapid in vitro assay to evaluate the capacity of a nanomaterial to exert a direct pro-fibrotic effect on fibroblasts...
  55. ncbi request reprint Risk of leukaemia among pesticide manufacturing workers: a review and meta-analysis of cohort studies
    Geneviève Van Maele-Fabry
    Universite Catholique de Louvain, Industrial Toxicology and Occupational Medicine Unit, Avenue E Mounier 53, bte 5302, B 1200 Brussels, Belgium
    Environ Res 106:121-37. 2008
    ..The purpose of this paper is to review available cohort studies and to estimate quantitatively the association between occupational exposure in plants manufacturing pesticides and leukaemia...
  56. ncbi request reprint Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum
    Jean François Heilier
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Belgium
    Fertil Steril 85:1516-8. 2006
    ..Compared with peritoneal endometriosis, ovarian endometriosis exhibits an 8-fold higher expression of aromatase, which suggests that aromatase inhibitors may be particularly active in this form of endometriosis...
  57. ncbi request reprint A systematic review of myeloid leukemias and occupational pesticide exposure
    Geneviève Van Maele-Fabry
    Unité de toxicologie industrielle et médecine du travail, Universite Catholique de Louvain, Avenue E Mounier 53, bte 5302, Brussels, 1200, Belgium
    Cancer Causes Control 18:457-78. 2007
    ..To conduct a systematic review and meta-analyses of published studies examining the association between myeloid leukemias (ML) and occupational pesticide exposure...
  58. ncbi request reprint Characterization of p40 and IL-10 in the BALF of patients with pulmonary sarcoidosis
    Virginie Barbarin
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Brussels, Belgium
    J Interferon Cytokine Res 23:449-56. 2003
    ..The present data also suggest that BALF p40 concentrations may be indicative of the sarcoidosis clinical course...
  59. ncbi request reprint Exposure to ethylene oxide in hospitals: biological monitoring and influence of glutathione S-transferase and epoxide hydrolase polymorphisms
    Vincent Haufroid
    Industrial Toxicology and Occupational Medicine Unit, Catholic University of Louvain, Brussels, Belgium
    Cancer Epidemiol Biomarkers Prev 16:796-802. 2007
    ....
  60. ncbi request reprint Clinical evaluation of a lead mobilization test using the chelating agent dimercaptosuccinic acid
    Perrine Hoet
    Unit of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium
    Clin Chem 52:88-96. 2006
    ..We propose a safe and convenient protocol for this test, to assess concomitant copper and zinc excretion and to determine the size of the chelatable lead pool in nonoccupationally exposed adults...
  61. doi request reprint Ototoxicity of toluene and styrene: state of current knowledge
    Perrine Hoet
    Industrial Toxicology Unit, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    Crit Rev Toxicol 38:127-70. 2008
    ....
  62. ncbi request reprint Cytochrome P4502E1 phenotyping by the measurement of the chlorzoxazone metabolic ratio: assessment of its usefulness in workers exposed to styrene
    Vincent Haufroid
    Industrial Toxicology and Occupational Medicine Unit, Catholic University of Louvain, Clos Chapelle aux champs 30 54, 1200 Brussels, Belgium
    Int Arch Occup Environ Health 75:453-8. 2002
    ....
  63. ncbi request reprint Systemic delivery of parathyroid hormone (1-34) using inhalation dry powders in rats
    Valérie Codrons
    Universite Catholique de Louvain, School of Pharmacy, Department of Pharmaceutical Technology, avenue E Mounier, 73 UCL 73 20 1200 Brussels, Belgium
    J Pharm Sci 92:938-50. 2003
    ..No acute inflammation appeared in the lung up to 48 h after a single inhalation. The increased bioavailability of the optimized powder aerosol of PTH makes it a promising alternative to subcutaneous injection...
  64. ncbi request reprint Comparison of atomic absorption and fluorescence spectroscopic methods for the routine determination of urinary arsenic
    Jean François Heilier
    Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, Universite Catholique de Louvain, 30 54 Clos Chapelle aux Champs, 1200 Brussels, Belgium
    Int Arch Occup Environ Health 78:51-9. 2005
    ..The objective of this study was to develop a rapid and robust technique for the measurement of the sum of inorganic arsenic metabolites...
  65. doi request reprint Elevated blood lead levels and sources of exposure in the population of Kinshasa, the capital of the Democratic Republic of Congo
    Joel Tuakuila
    Environmental Chemistry, Faculty of Sciences, Universite de Kinshasa, Kinshasa, Democratic Republic of Congo
    J Expo Sci Environ Epidemiol 23:81-7. 2013
    ..The traditional use of fired clay for the treatment of gastritis by pregnant women is another significant contributor for elevated BLL in children...
  66. ncbi request reprint Assessment of cadmium impregnation in women suffering from endometriosis: a preliminary study
    Jean François Heilier
    Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, Universite Catholique de Louvain, 30 54 Clos Chapelle aux Champs, B 1200 Brussels, Belgium
    Toxicol Lett 154:89-93. 2004
    ..These data, therefore, do not support a role for cadmium in the onset or the growth of endometriosis or deep endometriotic (adenomyotic) nodules of the recto-vaginal septum...
  67. ncbi request reprint Review and meta-analysis of risk estimates for prostate cancer in pesticide manufacturing workers
    Geneviève Van Maele-Fabry
    Unité de toxicologie industrielle et médecine du travail, Ecole de Santé Publique, Universite Catholique de Louvain, Bruxelles, Belgium
    Cancer Causes Control 17:353-73. 2006
    ....
  68. ncbi request reprint First epileptic seizure induced by occupational nickel poisoning
    Roger Denays
    Department of Neurology, Brugmann University Hospital, Free University of Brussels, Brussels, Belgium
    Epilepsia 46:961-2. 2005
    ..Urine analysis revealed a high nickel concentration, suggestive of acute nickel poisoning...
  69. ncbi request reprint A profibrotic function of IL-12p40 in experimental pulmonary fibrosis
    Francois Huaux
    Units of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Brussels, Belgium
    J Immunol 169:2653-61. 2002
    ..Together, our data suggest that IL-12p40 plays an important role in silica-induced pulmonary inflammation and fibrosis, possibly by exacerbating macrophage recruitment...
  70. ncbi request reprint Cadmium, lung and prostate cancer: a systematic review of recent epidemiological data
    Violaine Verougstraete
    Industrial Toxicology and Occupational Medicine Unit, School of Public Health, Universite Catholique de Louvain, Brussels, Belgium
    J Toxicol Environ Health B Crit Rev 6:227-55. 2003
    ..The association between cadmium exposure and prostate cancer was not confirmed in the latest available updates. Studies in environmentally exposed populations do not indicate an increased relative risk of cancer...
  71. ncbi request reprint Lung function changes in workers exposed to cobalt compounds: a 13-year follow-up
    Violaine Verougstraete
    Industrial Toxicology and Occupational Medicine Unit, School of Public Health, Universite Catholique de Louvain, Brussels, Belgium
    Am J Respir Crit Care Med 170:162-6. 2004
    ....
  72. ncbi request reprint The influence of genetic polymorphisms of cytochrome P450 3A5 and ABCB1 on starting dose- and weight-standardized tacrolimus trough concentrations after kidney transplantation in relation to renal function
    Michel Mourad
    Kidney and Pancreas Transplantation Unit, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Clin Chem Lab Med 44:1192-8. 2006
    ..We hypothesized that Tc pharmacokinetics may be affected by genetic mutations subsequent to starting doses...
  73. ncbi request reprint Comparison of cytochrome P4502E1 (CYP2E1) activity and hepatic and lymphocyte mRNA expression in patients with chronic hepatitis C
    Vincent Haufroid
    Industrial and Environmental Toxicology Unit, Universite Catholique de Louvain, Clos Chapelle aux champs 30 54, B 1200, St Luc Hospital, Brussels B 1200, Belgium
    Toxicol Lett 155:171-7. 2005
    ..In this disease, the determination of the CMR at t = 2 h represents a reliable index to assess CYP2E1 activity. The measurement of CYP2E1 expression, at the mRNA level, in PBLs or in liver is not useful for that purpose...
  74. ncbi request reprint Contribution of CYP2E1 to N-methyl-2-pyrrolidone metabolism
    Danuta Ligocka
    Industrial Toxicology and Occupational Medicine Unit, Catholic University of Louvain, Clos Chapelle aux champs 30 54, 1200, Brussels, Belgium
    Arch Toxicol 77:261-6. 2003
    ....
  75. ncbi request reprint Potentiation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)-induced liver toxicity by ethanol in guinea-pigs
    Perrine Hoet
    Universite Catholique de Louvain, Faculty of Medicine, Industrial Toxicology and Occupational Medicine Unit, Clos Chapelle aux Champs, 30 54, 1200 Brussels, Belgium
    Arch Toxicol 76:707-14. 2002
    ....
  76. ncbi request reprint Cytochrome P4502E1 (CYP2E1) expression in peripheral blood lymphocytes: evaluation in hepatitis C and diabetes
    Vincent Haufroid
    Industrial Toxicology and Occupational Medicine Unit, Catholic University of Louvain, Clos Chapelle aux champs 30 54, 1200 Brussels, Belgium
    Eur J Clin Pharmacol 59:29-33. 2003
    ..To further explore the relevance of this approach we assessed CYP2E1 expression in PBLs in two contrasting conditions, chronic hepatitis C and insulin-dependent diabetes (IDD), illustrating an organ and a systemic disease, respectively...
  77. ncbi request reprint Urinary protein excretion in humans exposed to arsenic and cadmium
    Jean Pierre Buchet
    Unité de toxicologie industrielle et médecine du travail, Universite Catholique de Louvain, Clos Chapelle aux Champs, 30 54, 1200 Brussels, Belgium
    Int Arch Occup Environ Health 76:111-20. 2003
    ..To verify the existence of such an interaction in humans, cohorts slightly (Belgian) and moderately (Chinese) exposed to both elements were examined...
  78. ncbi request reprint Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers
    Lode Godderis
    Katholieke Universiteit Leuven, Laboratorium Voor Arbeidshygiëne en Toxicologie, 3000 Leuven, Belgium
    Environ Mol Mutagen 44:293-303. 2004
    ..The in vitro DNA repair phenotype assay might be a valuable method to estimate the susceptibility of workers...
  79. ncbi request reprint Increased serum polychlorobiphenyl levels in Belgian women with adenomyotic nodules of the rectovaginal septum
    Jean François Heilier
    Fertil Steril 81:456-8. 2004
    ..The sum of bulk polychlorobiphenyl levels was significantly higher in women with rectovaginal adenomyosis than in women with endometriosis and controls...
  80. ncbi request reprint In vitro genotoxic effects of different combinations of cobalt and metallic carbide particles
    Marlies De Boeck
    Laboratorium voor Cellulaire Genetica and Eenheid Fysische Colloïdchemie, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussel, Belgium
    Mutagenesis 18:177-86. 2003
    ..These data indicate that particular interaction of a metal carbide with Co leading to enhanced mutagenicity is not specific for WC...
  81. ncbi request reprint Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene oxide, ethylene oxide and gamma-radiation
    Lode Godderis
    Katholieke Universiteit Leuven K U L, Laboratorium Voor Arbeidshygiëne en Toxicologie, Kapucijnenvoer 35 6, 3000 Leuven, Belgium
    Toxicology 219:220-9. 2006
    ..The influence of hOGG1326 on TL was borderline dose-dependent. We conclude that the influence of genetic polymorphisms of enzymes involved in DNA repair on induced genotoxicity depends on exposure dose...
  82. ncbi request reprint Reactivity of carbon nanotubes: free radical generation or scavenging activity?
    Ivana Fenoglio
    Dipartimento di Chimica Inorganica, Chimica Fisica e Chimica dei Materiali, Interdepartmental Center G Scansetti for Studies on Asbestos, Italy
    Free Radic Biol Med 40:1227-33. 2006
    ..It is therefore possible that the inflammatory reaction reported in vivo must be ascribed to MWCNT features other than particle-derived free radical generation...
  83. ncbi request reprint Lung and systemic responses to carbon nanotubes (CNT) in mice
    Dominique Lison
    Toxicol Sci 101:179-80; author reply 181-2. 2008
  84. ncbi request reprint In vivo genotoxicity of hard metal dust: induction of micronuclei in rat type II epithelial lung cells
    Marlies De Boeck
    Vrije Universiteit Brussel, Laboratorium voor Cellulaire Genetica, Pleinlaan 2, 1050 Brussels, Belgium
    Carcinogenesis 24:1793-800. 2003
    ..This study indicates the potential to detect chromosome/genome mutations (micronuclei) in relevant target cells (type II pneumocytes) after i.t. instillation of a particle mixture...