Jan Lerut

Summary

Country: Belgium

Publications

  1. ncbi request reprint Anti-CD2 monoclonal antibody and tacrolimus in adult liver transplantation
    Jan Lerut
    Liver Transplant Unit, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Transplantation 80:1186-93. 2005
  2. pmc Leiomyoma mimicking an incarcerated inguinal hernia: A rare complication of laparoscopic hysterectomy
    Carlos Apestegui
    Department of Abdominal and Transplantation Surgery University Hospitals Saint Luc, Universite Catholique de Louvain UCL, 1200 Brussels Belgium
    J Minim Access Surg 7:151-3. 2011
  3. doi request reprint Minimalization of immunosuppression in liver transplantation: steps from 'how' to 'now'. Interview by Emily Reeve
    Jan Lerut
    Department of Abdominal and Transplantation Surgery, Universite Catholique de Louvain, UCL, Brussels, Belgium
    Expert Rev Clin Immunol 8:605-7. 2012
  4. doi request reprint Hepatocellular cancer and liver transplantation: a Western experience
    Jan Lerut
    Department of Imaging Interventional Radiology, Universite Catholique de Louvain UCL, Brussels, Belgium
    Recent Results Cancer Res 190:127-44. 2013
  5. pmc A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma
    Andreas A Schnitzbauer
    University Hospital Regensburg, Department of Surgery, Regensburg, Germany
    BMC Cancer 10:190. 2010
  6. doi request reprint Tacrolimus monotherapy in liver transplantation: one-year results of a prospective, randomized, double-blind, placebo-controlled study
    Jan Lerut
    Department of Abdominal and Transplantation Surgery Unit of Abdominal Transplantation, Université Catholique de Louvain Cliniques Universitaires Saint Luc, Brussels, Belgium
    Ann Surg 248:956-67. 2008
  7. doi request reprint Minimization of steroids in liver transplantation
    Jan Lerut
    Department of Abdominal and Transplantation Surgery, Universite Catholique de Louvain, Brussels, Belgium
    Transpl Int 22:2-19. 2009
  8. doi request reprint Correlation of tacrolimus levels in peripheral blood mononuclear cells with histological staging of rejection after liver transplantation: preliminary results of a prospective study
    Arnaud Capron
    Clinical Chemistry Department, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Transpl Int 25:41-7. 2012
  9. ncbi request reprint Extension of the adult hepatic allograft pool using split liver transplantation
    Roberto Sampietro
    Liver Transplant Unit, Universite Catholique de Louvain, University Hospital St Luc, Brussels, Belgium
    Acta Gastroenterol Belg 68:369-75. 2005
  10. doi request reprint Liver transplantation for hepatocellular cancer: UCL experience in 137 adult cirrhotic patients. Alpha-foetoprotein level and locoregional treatment as refined selection criteria
    Olga Ciccarelli
    Starzl Unit Abdominal Transplantation, University Hospitals St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Transpl Int 25:867-75. 2012

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Anti-CD2 monoclonal antibody and tacrolimus in adult liver transplantation
    Jan Lerut
    Liver Transplant Unit, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Transplantation 80:1186-93. 2005
    ..Blockade of costimulation and adhesion signaling is an attractive approach to interfere with graft rejection..
  2. pmc Leiomyoma mimicking an incarcerated inguinal hernia: A rare complication of laparoscopic hysterectomy
    Carlos Apestegui
    Department of Abdominal and Transplantation Surgery University Hospitals Saint Luc, Universite Catholique de Louvain UCL, 1200 Brussels Belgium
    J Minim Access Surg 7:151-3. 2011
    ..Tumour development in the inguinal canal after laparoscopic gynaecological surgery should be kept in mind in the differential diagnosis of inguinal hernia and other uncommon pathologies...
  3. doi request reprint Minimalization of immunosuppression in liver transplantation: steps from 'how' to 'now'. Interview by Emily Reeve
    Jan Lerut
    Department of Abdominal and Transplantation Surgery, Universite Catholique de Louvain, UCL, Brussels, Belgium
    Expert Rev Clin Immunol 8:605-7. 2012
    From the very start of his surgical career, Jan Lerut was involved in organ transplantation...
  4. doi request reprint Hepatocellular cancer and liver transplantation: a Western experience
    Jan Lerut
    Department of Imaging Interventional Radiology, Universite Catholique de Louvain UCL, Brussels, Belgium
    Recent Results Cancer Res 190:127-44. 2013
    ..In the future, identification of imaging or molecular prognostic markers could help to better define transplantation criteria...
  5. pmc A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma
    Andreas A Schnitzbauer
    University Hospital Regensburg, Department of Surgery, Regensburg, Germany
    BMC Cancer 10:190. 2010
    ..Therefore, we designed a prospective RCT to determine if the mTOR inhibitor sirolimus can improve hepatocellular carcinoma (HCC)-free patient survival in liver transplant (LT) recipients with a pre-transplant diagnosis of HCC...
  6. doi request reprint Tacrolimus monotherapy in liver transplantation: one-year results of a prospective, randomized, double-blind, placebo-controlled study
    Jan Lerut
    Department of Abdominal and Transplantation Surgery Unit of Abdominal Transplantation, Université Catholique de Louvain Cliniques Universitaires Saint Luc, Brussels, Belgium
    Ann Surg 248:956-67. 2008
    ..Minimal immunosuppression (IS) is desirable in organ transplantation to reduce side effects and to promote the process of tolerance induction...
  7. doi request reprint Minimization of steroids in liver transplantation
    Jan Lerut
    Department of Abdominal and Transplantation Surgery, Universite Catholique de Louvain, Brussels, Belgium
    Transpl Int 22:2-19. 2009
    ..The tendency in clinical practice is to move more and more from steroid withdrawal to steroid avoidance protocols...
  8. doi request reprint Correlation of tacrolimus levels in peripheral blood mononuclear cells with histological staging of rejection after liver transplantation: preliminary results of a prospective study
    Arnaud Capron
    Clinical Chemistry Department, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Transpl Int 25:41-7. 2012
    ..This finding could represent an additional tool to individualize more precisely early immunosuppressive schemes after liver transplantation...
  9. ncbi request reprint Extension of the adult hepatic allograft pool using split liver transplantation
    Roberto Sampietro
    Liver Transplant Unit, Universite Catholique de Louvain, University Hospital St Luc, Brussels, Belgium
    Acta Gastroenterol Belg 68:369-75. 2005
    ..The ever increasing number of, especially, adults waiting for a liver transplantation necessitates to develop techniques allowing to extend the available donor liver pool...
  10. doi request reprint Liver transplantation for hepatocellular cancer: UCL experience in 137 adult cirrhotic patients. Alpha-foetoprotein level and locoregional treatment as refined selection criteria
    Olga Ciccarelli
    Starzl Unit Abdominal Transplantation, University Hospitals St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Transpl Int 25:867-75. 2012
    ..0001). Immediate pre-LT AFP and aggressive pre-transplant LRT strategy, especially in MC-OUT patients, are both important elements to further expand inclusion criteria without compromising long-term results of HCC liver recipients...
  11. ncbi request reprint Validation of a liquid chromatography-mass spectrometric assay for tacrolimus in liver biopsies after hepatic transplantation: correlation with histopathologic staging of rejection
    Arnaud Capron
    Department of Clinical Chemistry, Laboratory of Toxicology and Therapeutic Drug Monitoring, University Hospital St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Ther Drug Monit 29:340-8. 2007
    ....
  12. ncbi request reprint Long-term medical complications and quality of life in adult recipients surviving 10 years or more after liver transplantation
    Olga Ciccarelli
    Liver Transplant Unit, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Acta Gastroenterol Belg 68:323-30. 2005
    ..This study analyses long-term medical complications, changes of immunosuppression, recurrence of primary disease and quality of life 10 years after liver transplantation...
  13. ncbi request reprint Pediatric liver transplantation using left hepatic segments from living related donors: surgical experience in 100 recipients at Saint-Luc University Clinics
    Ahmed A Darwish
    Pediatric Liver Transplantation Program, Saint Luc University Clinics, Universite Catholique de Louvain, Brussels, Belgium
    Pediatr Transplant 10:345-53. 2006
    ..Donor morbidity was kept to acceptable incidence, and surgical technique in the recipient needs to be tailored to minimize postoperative complications...
  14. ncbi request reprint Comparison of different methods to quantify future liver remnants after preoperative portal vein embolization to predict postoperative liver failure
    Amit Shah
    Department of Abdominal Surgery and Transplantation, Saint Luc University Hospital, Universite Catholique de Louvain, Hippocrate Avenue, 10, 1200 Brussels, Belgium
    Hepatogastroenterology 58:109-14. 2011
    ..The role of the degree of liver hypertrophy (DLH) in this context was also explored...
  15. doi request reprint Validation of a liquid chromatography-mass spectrometric assay for tacrolimus in peripheral blood mononuclear cells
    Arnaud Capron
    Department of Clinical Chemistry, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Ther Drug Monit 31:178-86. 2009
    ..Further studies should be conducted to fully evaluate the benefit of intracellular TAC concentrations in refinement of TDM strategies for TAC to ensure optimal clinical outcomes...
  16. ncbi request reprint Use of anti-HBc positive allografts in adult liver transplantation: toward a safer way to expand the donor pool
    Dino Donataccio
    Liver Transplant Unit, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Transpl Int 19:38-43. 2006
    ..The necessity for IP therapy should be guided by HBV-DNA testing of donor liver tissue and serum. IH of early liver biopsies is an unreliable marker for predicting antiviral treatment requirements...
  17. doi request reprint Liver transplantation and neuroendocrine tumors: lessons from a single centre experience and from the literature review
    Eliano Bonaccorsi-Riani
    Starzl Unit of Abdominal Transplantation, University Hospitals St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Transpl Int 23:668-78. 2010
    ..LT should be considered earlier in the therapeutic algorithm of selected NET patients as it is the only therapy that can offer a cure...
  18. doi request reprint Biotransformation enzymes and drug transporters pharmacogenetics in relation to immunosuppressive drugs: impact on pharmacokinetics and clinical outcome
    Michel Mourad
    Department of Surgery, Surgery and Abdominal Transplantation Division, Universite Catholique de Louvain, Saint Luc University Hospital, Brussels, Belgium
    Transplantation 85:S19-24. 2008
    ..Further studies are needed to provide evidence that a genetic analysis combined with therapeutic drug monitoring has the potential to optimize drug use after transplantation...
  19. ncbi request reprint 1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation
    Laure Elens
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, St Luc Hospital, Brussels, Belgium
    Pharmacogenet Genomics 17:873-83. 2007
    ....
  20. ncbi request reprint Cavocaval adult liver transplantation and retransplantation without venovenous bypass and without portocaval shunting: a prospective feasibility study in adult liver transplantation
    Jan Lerut
    Department of Digestive Surgery, Liver Transplant Program, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Transplantation 75:1740-5. 2003
    ..Refinements in technique permit transplantation to be done with IVC preservation and without VVB use...
  21. ncbi request reprint Response to an experimental HBV vaccine permits withdrawal of HBIg prophylaxis in fulminant and selected chronic HBV-infected liver graft recipients
    Peter Starkel
    Department of Gastroenterology, St Luc University Hospital, Brussels, Belgium
    Liver Transpl 11:1228-34. 2005
    ..Vaccination seems well tolerated and safe and allows long-term discontinuation of HBIg...
  22. ncbi request reprint Stepwise minimization of the immunosuppressive therapy in pediatric liver transplantation. A conceptual approach towards operational tolerance
    Raymond Reding
    Pediatric Liver Transplant Program, Saint Luc University Clinics, Universite Catholique de Louvain, Brussels, Belgium
    Acta Gastroenterol Belg 68:320-2. 2005
    ..We hypothesize that the recent population of liver transplant recipients with low immunosuppression might be more suitable for progressive immunosuppression withdrawal trial, with the aim to reach ultimately operational tolerance...
  23. ncbi request reprint Liver transplantation with preservation of the inferior vena cava in case of symptomatic adult polycystic disease
    Jan Lerut
    Department of Abdominal Transplantation, hepatobiliary and endocrine surgery, Liver Transplant Program, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Transpl Int 18:513-8. 2005
    ..There was minimal morbidity and no mortality. All patients have excellent quality of life with a median follow-up of 41 months (range: 12-58) as testified by a median Karnofsky score of 90% (range: 80-100%)...
  24. doi request reprint Liver transplantation in children with fulminant hepatic failure: The UCL experience
    Parikshat Mahadeb
    Pediatric Liver Transplant Program, St Luc University Clinics, Universite Catholique de Louvain, Brussels, Belgium
    Pediatr Transplant 13:414-20. 2009
    ....
  25. doi request reprint Hepatic hemangiosarcoma: an absolute contraindication to liver transplantation--the European Liver Transplant Registry experience
    Giuseppe Orlando
    Starzl Abdominal Transplant Unit, University Hospitals St Luc, Brussels, Belgium
    Transplantation 95:872-7. 2013
    ..Liver transplantation (LT) is performed for hemangiosarcoma (HAS) despite disappointing results...
  26. pmc Congenital intrahepatic bile duct dilatation is a potentially curable disease: long-term results of a multi-institutional study
    Jean Yves Mabrut
    Department of Abdominal Surgery and Transplantation, Saint Luc University Hospital, Brussels, Belgium
    Ann Surg 246:236-45. 2007
    ..To report clinical presentation, perioperative outcome, and long-term results of surgical management of congenital intrahepatic bile duct (IHBD) dilatations (including Caroli disease) in a multi-institutional setting...
  27. doi request reprint Outcome of patients with hepatocellular carcinoma listed for liver transplantation within the Eurotransplant allocation system
    Michael Adler
    Medico Surgical Department of Gastroenterology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Liver Transpl 14:526-33. 2008
    ..Patients older than 50 years with a stage above the Milan criteria at transplantation have a poorer prognosis after transplantation...
  28. ncbi request reprint The place of liver transplantation in Caroli's disease and syndrome
    Laurent De Kerckhove
    Abdominal Transplantation Unit, Universite Catholique de Louvain, UCL, Brussels, Belgium
    Transpl Int 19:381-8. 2006
    ..In case of associated ARPKD, renal transplantation is often indicated early on because of the more rapid progression of the renal component of the disease...
  29. ncbi request reprint Re-use of a liver allograft; an exceptional opportunity to enlarge the organ donor pool
    Raphaël Rubay
    Department of Digestive Surgery, Cliniques Universitaires St Luc 1400, Universite Catholique de Louvain UCL, Av Hippocrate 10, 1200, Brussels, Belgium
    Transpl Int 16:497-9. 2003
    ..5 h later into a patient with post-viral C cirrhosis and solitary hepatocarcinoma. Both donor and recipient operations were technically successful; liver function after the second use of the graft was normal...
  30. ncbi request reprint Liver transplantation for chronic graft-versus-host disease: case report with 10-year follow-up
    Giuseppe Orlando
    Department of Radiology, Liver Transplant Program, Cliniques Universitaires Saint Luc 1400, Universite Catholique de Louvain, Avenue Hippocrates 10, 1200 Brussels, Belgium
    Transpl Int 18:125-9. 2005
    ..He is now in excellent condition 10 years after the first transplant. This experience and the review of literature indicate that LT can cure GVHD-related chronic liver failure. Recurrent GVHD in the allograft has not yet been reported...
  31. pmc Liver transplantation for hereditary hemorrhagic telangiectasia: Report of the European liver transplant registry
    Jan Lerut
    Liver Transplant Unit, University Hospital St Luc, Brussels, Belgium
    Ann Surg 244:854-62; discussion 862-4. 2006
    ..Hereditary hemorrhagic telangiectasia (HHT) or Rendu-Osler-Weber disease is a rare disease characterized by the presence of arteriovenous malformations. Hepatic involvement can lead to life-threatening conditions...
  32. ncbi request reprint Liver transplantation for nonsteroidal anti-inflammatory drug-induced liver failure: nimesulide as the first implicated compound
    Sergio Negrin Dastis
    Department of Gastroenterology and Hepatology, St Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium
    Eur J Gastroenterol Hepatol 19:919-22. 2007
    ..This has to be taken as a further warning about the potential for this compound to induce liver failure...
  33. doi request reprint Recurrence of hepatocellular cancer after liver transplantation: the role of primary resection and salvage transplantation in East and West
    Quirino Lai
    Department of General Surgery and Organ Transplantation, Sapienza University, Umberto I Hospital, Rome, Italy
    J Hepatol 57:974-9. 2012
    ....
  34. ncbi request reprint Liver segmentation in living liver transplant donors: comparison of semiautomatic and manual methods
    Laurent Hermoye
    Diagnostic Radiology Unit and Center for Anatomical, Functional and Molecular Imaging Research, Universite Catholique de Louvain, Saint Luc University Hospital, Avenue Hippocrate 10, B 1200 Brussels, Belgium
    Radiology 234:171-8. 2005
    ..To compare the accuracy and repeatability of a semiautomatic segmentation algorithm with those of manual segmentation for determining liver volume in living liver transplant donors at magnetic resonance (MR) imaging...
  35. ncbi request reprint Limited lamivudine and long-term hepatitis B immunoglobulin immunoprophylaxis for prevention of hepatitis B recurrence after liver transplantation
    Peter Starkel
    Department of Gastroenterology, St Luc University Hospital, Brussels, Belgium
    Transplantation 74:408-10. 2002
    ..No consensus exists concerning dosage and duration of prophylactic hepatitis B immunoglobulin and lamivudine for prevention of hepatitis B recurrence after liver transplantation (LT)...
  36. ncbi request reprint Left lobe living related liver transplantation in the absence of an extrahepatic left portal vein
    Jan Lerut
    Liver Transplant Program, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain Brussels, Brussels, Belgium
    Transplantation 74:278-9. 2002
    ..This report is of a successful case of living- related liver transplantation using a left lobe procured in a patient presenting with an absent horizontal segment of the left extrahepatic vein...