Steven Laureys

Summary

Country: Belgium

Publications

  1. ncbi Science and society: death, unconsciousness and the brain
    Steven Laureys
    Cyclotron Research Centre and Neurology Department, Universite de Liege, Sart Tilman B30, 4000 Liege, Belgium
    Nat Rev Neurosci 6:899-909. 2005
  2. pmc Assessment of localisation to auditory stimulation in post-comatose states: use the patient's own name
    Lijuan Cheng
    International Vegetative State and Consciousness Science Institute, Hangzhou Normal University, Hangzhou, China
    BMC Neurol 13:27. 2013
  3. pmc Actigraphy assessments of circadian sleep-wake cycles in the Vegetative and Minimally Conscious States
    Damian Cruse
    Brain and Mind Institute, University of Western Ontario, 1151 Richmond Street, London, ON N6A 3K7, Canada
    BMC Med 11:18. 2013
  4. doi Unresponsive wakefulness syndrome
    S Laureys
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege, Belgium
    Arch Ital Biol 150:31-5. 2012
  5. doi Coma and consciousness: paradigms (re)framed by neuroimaging
    Steven Laureys
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, 4000 Liege, Belgium
    Neuroimage 61:478-91. 2012
  6. pmc Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study
    Delphine Magis
    University Neurology Department, Liege, Belgium
    BMC Neurol 11:25. 2011
  7. ncbi What is it like to be vegetative or minimally conscious?
    Steven Laureys
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege, Liege, Belgium
    Curr Opin Neurol 20:609-13. 2007
  8. pmc How should functional imaging of patients with disorders of consciousness contribute to their clinical rehabilitation needs?
    Steven Laureys
    Cyclotron Research Center and Neurology Department, University of Liege, Liege, Belgium
    Curr Opin Neurol 19:520-7. 2006
  9. doi Detecting consciousness in a total locked-in syndrome: an active event-related paradigm
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, Sart Tilman, B30, University of Liege, 4000 Liege, Belgium
    Neurocase 15:271-7. 2009
  10. ncbi Functional neuroimaging of auditory processing
    S Laureys
    Cyclotron Research Center, University of Liege, Belgium
    Acta Otorhinolaryngol Belg 57:267-73. 2003

Detail Information

Publications140 found, 100 shown here

  1. ncbi Science and society: death, unconsciousness and the brain
    Steven Laureys
    Cyclotron Research Centre and Neurology Department, Universite de Liege, Sart Tilman B30, 4000 Liege, Belgium
    Nat Rev Neurosci 6:899-909. 2005
    ....
  2. pmc Assessment of localisation to auditory stimulation in post-comatose states: use the patient's own name
    Lijuan Cheng
    International Vegetative State and Consciousness Science Institute, Hangzhou Normal University, Hangzhou, China
    BMC Neurol 13:27. 2013
    ..We here studied auditory localisation using the patient's own name as compared to a meaningless sound (i.e., ringing bell)...
  3. pmc Actigraphy assessments of circadian sleep-wake cycles in the Vegetative and Minimally Conscious States
    Damian Cruse
    Brain and Mind Institute, University of Western Ontario, 1151 Richmond Street, London, ON N6A 3K7, Canada
    BMC Med 11:18. 2013
    ..However, there is little empirical evidence for true circadian sleep-wake cycling in these patients, and there have been no large-scale investigations of the validity of this diagnostic criterion...
  4. doi Unresponsive wakefulness syndrome
    S Laureys
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege, Belgium
    Arch Ital Biol 150:31-5. 2012
    ....
  5. doi Coma and consciousness: paradigms (re)framed by neuroimaging
    Steven Laureys
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, 4000 Liege, Belgium
    Neuroimage 61:478-91. 2012
    ..We here review these advances in measurement and the scientific and broader implications of this rapidly progressing field of research...
  6. pmc Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study
    Delphine Magis
    University Neurology Department, Liege, Belgium
    BMC Neurol 11:25. 2011
    ..However its mode of action remains elusive. Since the long delay to meaningful effect suggests that ONS induces slow neuromodulation, we have searched for changes in central pain-control areas using metabolic neuroimaging...
  7. ncbi What is it like to be vegetative or minimally conscious?
    Steven Laureys
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege, Liege, Belgium
    Curr Opin Neurol 20:609-13. 2007
    ..Here we review current possibilities and limitations of clinical and para-clinical assessment of chronic disorders of consciousness...
  8. pmc How should functional imaging of patients with disorders of consciousness contribute to their clinical rehabilitation needs?
    Steven Laureys
    Cyclotron Research Center and Neurology Department, University of Liege, Liege, Belgium
    Curr Opin Neurol 19:520-7. 2006
    ..We discuss the problems of evidence-based neurorehabilitation in disorders of consciousness, and recent functional neuroimaging data obtained in the vegetative state and minimally conscious state...
  9. doi Detecting consciousness in a total locked-in syndrome: an active event-related paradigm
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, Sart Tilman, B30, University of Liege, 4000 Liege, Belgium
    Neurocase 15:271-7. 2009
    ..This study shows that our active event-related paradigm allowed to identify voluntary brain activity in a patient who would behaviorally be diagnosed as comatose...
  10. ncbi Functional neuroimaging of auditory processing
    S Laureys
    Cyclotron Research Center, University of Liege, Belgium
    Acta Otorhinolaryngol Belg 57:267-73. 2003
    ..Brain activity is much more complex for words, and different networks can be recruited when phonological, lexical and semantic levels of processing are engaged...
  11. ncbi Cerebral processing in the minimally conscious state
    S Laureys
    Cyclotron Research Center and Department of Neurology, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    Neurology 63:916-8. 2004
    ..Cognitive potentials showed preserved P300 responses to the patient's own name...
  12. doi Dualism persists in the science of mind
    Athena Demertzi
    Coma Science Group, Cyclotron Research Centre, University of Liege, Liege, Belgium
    Ann N Y Acad Sci 1157:1-9. 2009
    ..We suggest that the results are relevant to clinical practice, to the formulation of scientific questions about the nature of consciousness, and to the reception of scientific theories of consciousness by the general public...
  13. ncbi Functional neuroimaging in the vegetative state
    Steven Laureys
    Department of Neurology and Cyclotron Research Center, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    NeuroRehabilitation 19:335-41. 2004
    ..However, this activation is limited to primary cortices and dissociated from higher-order associative cortices, thought to be necessary for conscious perception...
  14. ncbi Brain function in the vegetative state
    Steven Laureys
    Cyclotron Research Center, Department of Neurology, CHU Sart Tilman, University of Liege, Liege, Belgium
    Acta Neurol Belg 102:177-85. 2002
    ....
  15. pmc Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome
    Steven Laureys
    Dept of Neurology, Cyclotron Research Centre, University Hospital and University of Liège, Belgium
    BMC Med 8:68. 2010
    ..This syndrome has been coined vegetative state. We here present a new name for this challenging neurological condition: unresponsive wakefulness syndrome (abbreviated UWS)...
  16. ncbi Self-consciousness in non-communicative patients
    Steven Laureys
    Coma Science Group, Cyclotron Research Center and Neurology Department, CHU Sart Tilman Hospital and University of Liège, 4000 Liege, Belgium
    Conscious Cogn 16:722-41; discussion 742-5. 2007
    ..Based on these results we discuss what we currently do and do not know about the functional significance of the neural network involved in "automatic" and "conscious" self-referential processing...
  17. ncbi The locked-in syndrome : what is it like to be conscious but paralyzed and voiceless?
    Steven Laureys
    Neurology Department and Cyclotron Research Center, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    Prog Brain Res 150:495-511. 2005
    ..In our opinion, there is an urgent need for a renewed ethical and medicolegal framework for our care of locked-in patients...
  18. ncbi Brain function in coma, vegetative state, and related disorders
    Steven Laureys
    Belgian National Funds for Scientific Research Cyclotron Research Center and Department of Neurology, University of Liege, Belgium
    Lancet Neurol 3:537-46. 2004
    ..Neuroimaging techniques remain important tools for clinical research that will extend our understanding of the underlying mechanisms of these disorders...
  19. pmc Tracking the recovery of consciousness from coma
    Steven Laureys
    Cyclotron Research Center and Department of Neurology, University of Liege, Liege, Belgium
    J Clin Invest 116:1823-5. 2006
    ..This case shows that old dogmas need to be oppugned, as recovery with meaningful reduction in disability continued in this case for nearly 2 decades after extremely severe traumatic brain injury...
  20. ncbi Residual cognitive function in comatose, vegetative and minimally conscious states
    Steven Laureys
    Cyclotron Research Centre, University of Liege, Belgium
    Curr Opin Neurol 18:726-33. 2005
    ..In addition to novel behavioural 'consciousness-scales', the role of para-clinical markers of consciousness, such as event related potentials and functional neuroimaging is reviewed...
  21. ncbi Cortical processing of noxious somatosensory stimuli in the persistent vegetative state
    S Laureys
    Cyclotron Research Center, University of Liège B30, Department of Neurology, CHU B35, Sart Tilman, 4000 Liege, Belgium
    Neuroimage 17:732-41. 2002
    ..However, this activation of primary cortex seems to be isolated and dissociated from higher-order associative cortices...
  22. doi Perception of pain in the minimally conscious state with PET activation: an observational study
    Melanie Boly
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Lancet Neurol 7:1013-20. 2008
    ..Therefore, better understanding of cerebral noxious processing in these patients is of clinical, therapeutic, and ethical relevance...
  23. ncbi Cerebral processing of auditory and noxious stimuli in severely brain injured patients: differences between VS and MCS
    Melanie Boly
    University of Liege, Belgium
    Neuropsychol Rehabil 15:283-9. 2005
    ..However, in the absence of a generally accepted neural correlate of consciousness as measured by functional neuroimaging, clinical assessment remains the gold standard for the evaluation and management of severely brain damaged patients...
  24. ncbi Neural substrates of phonological and lexicosemantic representations in Alzheimer's disease
    Frederic Peters
    Cyclotron Research Centre, University of Liege, Belgium
    Hum Brain Mapp 30:185-99. 2009
    ..Overall, the results suggest that AD patients use altered pathways to process phonological and lexicosemantic information, possibly related to a progressive loss of specialization of phonological and lexicosemantic neural networks...
  25. pmc Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and Sart Tilman Hospital, 4000 Liege, Belgium
    J Neurosci 32:7082-90. 2012
    ..These results emphasize the importance of recurrent corticocortical communication in the maintenance of consciousness and suggest a direct effect of propofol on cortical dynamics...
  26. pmc Visual fixation in the vegetative state: an observational case series PET study
    Marie Aurelie Bruno
    Coma Science Group and Cyclotron Research Centre, University of Liege, Liege, Belgium
    BMC Neurol 10:35. 2010
    ..e., represents "automatic" subcortical processing) or is a sufficient sign of consciousness and higher order cortical processing...
  27. ncbi Involvement of both prefrontal and inferior parietal cortex in dual-task performance
    Fabienne Collette
    Department of Neuropsychology, University of Liege, Belgium
    Brain Res Cogn Brain Res 24:237-51. 2005
    ..Moreover, the involvement of a parietal area in the dual task is in keeping with the hypothesis that a parieto-frontal network sustains executive functioning...
  28. pmc Automated EEG entropy measurements in coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state
    Olivia Gosseries
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Funct Neurol 26:25-30. 2011
    ..Future studies are needed before using this tool in routine clinical practice, and these should seek to improve automated EEG quantification paradigms in order to reduce the remaining false negative and false positive findings...
  29. doi A French validation study of the Coma Recovery Scale-Revised (CRS-R)
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Liege, Belgium
    Brain Inj 22:786-92. 2008
    ....
  30. doi Thalamus, brainstem and salience network connectivity changes during propofol-induced sedation and unconsciousness
    Pieter Guldenmund
    Coma Science Group, Cyclotron Research Center, University of Liege, Liege, Belgium
    Brain Connect 3:273-85. 2013
    ..It furthermore stresses the necessity of also examining resting state connectivity in networks representing arousal, not only those associated with awareness...
  31. doi Preserved feedforward but impaired top-down processes in the vegetative state
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, 4000 Liege, Belgium
    Science 332:858-62. 2011
    ..This result emphasizes the importance of top-down projections in recurrent processing that involve high-order associative cortices for conscious perception...
  32. doi Cognitive function in the locked-in syndrome
    Caroline Schnakers
    Cyclotron Research Center, University of Liege, Belgium
    J Neurol 255:323-30. 2008
    ..Classically, communication remains possible by means of spared vertical eye movements and/or blinking. To allow assessing cognitive functions in LIS patients, we propose here a neuropsychological testing based on eye-coded communication...
  33. ncbi Auditory processing in severely brain injured patients: differences between the minimally conscious state and the persistent vegetative state
    Melanie Boly
    Cyclotron Research Center, University of Liege, Liege, Belgium
    Arch Neurol 61:233-8. 2004
    ..The minimally conscious state (MCS) is a recently defined clinical condition; it differs from the persistent vegetative state (PVS) by the presence of inconsistent, but clearly discernible, behavioral evidence of consciousness...
  34. ncbi Exploring the unity and diversity of the neural substrates of executive functioning
    Fabienne Collette
    Neuropsychology Unit, University of Liege, Liege, Belgium
    Hum Brain Mapp 25:409-23. 2005
    ..The results of this neuroimaging study are in agreement with cognitive studies demonstrating that executive functioning is characterized by both unity and diversity of processes...
  35. doi Metabolic activity in external and internal awareness networks in severely brain-damaged patients
    Aurore Thibaut
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, 4000 Liege, Belgium
    J Rehabil Med 44:487-94. 2012
    ..This study measured brain metabolism in both networks in patients with severe brain damage...
  36. ncbi A prominent role for amygdaloid complexes in the Variability in Heart Rate (VHR) during Rapid Eye Movement (REM) sleep relative to wakefulness
    Martin Desseilles
    Cyclotron Research Centre, Liege University, Belgium
    Neuroimage 32:1008-15. 2006
    ..This suggests a functional reorganization of central cardiovascular regulation during REMS...
  37. doi [Neuroimaging technique: a diagnostic tool to detect altered states of consciousness]
    Marie Thonnard
    Coma Science Group, Centre de Recherches du Cyclotron, Université et Centre Hospitalier Universitaire de Liège, Sart Tilman, B30, 4000 Liege, Belgique
    Med Sci (Paris) 27:77-81. 2011
    ..The implementation of these methods in clinical routine could permit to reduce the current high rate of misdiagnosis (40%)...
  38. ncbi Are spatial memories strengthened in the human hippocampus during slow wave sleep?
    Philippe Peigneux
    Cyclotron Research Center, University of Liege, B 4000 Liege, Belgium
    Neuron 44:535-45. 2004
    ....
  39. ncbi Cerebral correlates of delta waves during non-REM sleep revisited
    Thien Thanh Dang-Vu
    Cyclotron Research Centre, University of Liege, Belgium
    Neuroimage 28:14-21. 2005
    ..Consequently, this rCBF distribution might preferentially reflect a particular modulation of the cellular processes involved in the generation of cortical delta waves during NREM sleep...
  40. doi Is there anybody in there? Detecting awareness in disorders of consciousness
    Athena Demertzi
    Coma Science Group, Neurology Department, Cyclotron Research Centre, University of Liege, Liege, Belgium
    Expert Rev Neurother 8:1719-30. 2008
    ....
  41. doi Reaching across the abyss: recent advances in functional magnetic resonance imaging and their potential relevance to disorders of consciousness
    Andrea Soddu
    Coma Science Group, Cyclotron Research Centre, University of Liege, Belgium
    Prog Brain Res 177:261-74. 2009
    ..In particular, we discuss the potential provided by assessment of these slow spontaneous BOLD fluctuations as a novel tool in assessing the cognitive state and chances of recovery from brain pathologies underlying DOCs...
  42. ncbi Imaging a cognitive model of apraxia: the neural substrate of gesture-specific cognitive processes
    Philippe Peigneux
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Hum Brain Mapp 21:119-42. 2004
    ..s proposal. Based on the above considerations, we suggest and discuss a revised model for upper limb apraxia that might best account for both brain imaging findings and neuropsychological dissociations reported in the apraxia literature...
  43. pmc Resting-state EEG study of comatose patients: a connectivity and frequency analysis to find differences between vegetative and minimally conscious states
    Rémy Lehembre
    Cyclotron Research Centre and Neurology Department, University Hospital of Liege, Belgium
    Funct Neurol 27:41-7. 2012
    ..Standard EEG recorded in clinical conditions could be used as a tool to help the clinician in the diagnosis of disorders of consciousness...
  44. doi Comparison of the Full Outline of UnResponsiveness and Glasgow Liege Scale/Glasgow Coma Scale in an intensive care unit population
    Marie Aurelie Bruno
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, Sart Tilman B30, 4000 Liege, Belgium
    Neurocrit Care 15:447-53. 2011
    ..We compared the FOUR and GLS/GCS in intensive care unit patients who were admitted in a comatose state...
  45. ncbi Mapping the updating process: common and specific brain activations across different versions of the running span task
    Fabienne Collette
    Neuropsychology Unit, University of Liege, Liege, Belgium
    Cortex 43:146-58. 2007
    ....
  46. doi The effect of clonidine infusion on distribution of regional cerebral blood flow in volunteers
    Vincent Bonhomme
    University Department of Anesthesia and Intensive Care Medicine, CHU de Liege and CHR de la Citadelle, 4000 Liege, Belgium
    Anesth Analg 106:899-909, table of contents. 2008
    ..Our goal in this observational study was to map brain regions whose activity is modified by clonidine infusion so as to better understand its loci of action, especially in relation to sedation...
  47. doi The Nociception Coma Scale: a new tool to assess nociception in disorders of consciousness
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Sart Tilman, Liege, Belgium
    Pain 148:215-9. 2010
    ..e., VS or MCS). The NCS constitutes a sensitive clinical tool for assessing nociception in severely brain-injured patients. This scale constitutes the first step to a better management of patients recovering from coma...
  48. pmc Resting state activity in patients with disorders of consciousness
    Andrea Soddu
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Funct Neurol 26:37-43. 2011
    ....
  49. doi Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness
    Pierre Boveroux
    Department of Anesthesia and Intensive Care Medicine, University of Liege, Liege, Belgium
    Anesthesiology 113:1038-53. 2010
    ..Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness...
  50. ncbi The neural correlate of (un)awareness: lessons from the vegetative state
    Steven Laureys
    Cyclotron Research Center and Department of Neurology, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    Trends Cogn Sci 9:556-9. 2005
    ..Such studies are disentangling the neural correlates of the vegetative state from the minimally conscious state, and have major clinical consequences in addition to empirical importance for the understanding of consciousness...
  51. doi Two distinct neuronal networks mediate the awareness of environment and of self
    Audrey Vanhaudenhuyse
    University of Liege, Liege, Belgium
    J Cogn Neurosci 23:570-8. 2011
    ....
  52. pmc Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients
    Audrey Vanhaudenhuyse
    Coma Science Group, Cyclotron Research Centre, University of Liege, Allee du 6 Aout, B30, Liege, Belgium
    Brain 133:161-71. 2010
    ..Future prospective studies in a larger patient population are needed in order to evaluate the prognostic value of the presented methodology...
  53. doi Probing command following in patients with disorders of consciousness using a brain-computer interface
    Dorothee Lule
    Coma Science Group, Cyclotron Research Centre, University and University Hospital of Liège, Liege, Belgium
    Clin Neurophysiol 124:101-6. 2013
    ..To determine if brain-computer interfaces (BCIs) could serve as supportive tools for detecting consciousness in patients with disorders of consciousness by detecting response to command and communication...
  54. doi Consciousness and cerebral baseline activity fluctuations
    Melanie Boly
    Coma Science Group, Cyclotron Research Center, University of Liege, Liege, Belgium
    Hum Brain Mapp 29:868-74. 2008
    ..We place these findings in light of recent findings on the architecture of spontaneous BOLD fluctuations in the awake human brain, and discuss the possible origins of the observed baseline brain activity fluctuations...
  55. ncbi Cognitive event-related potentials in comatose and post-comatose states
    Audrey Vanhaudenhuyse
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege, Liege, Belgium
    Neurocrit Care 8:262-70. 2008
    ..In coma-survivors, cognitive potentials are more frequently obtained when using stimuli that are more ecologic or have an emotional content (such as the patient's own name) than when using classical sine tones...
  56. pmc Offline persistence of memory-related cerebral activity during active wakefulness
    Philippe Peigneux
    Cyclotron Research Center, University of Liege, Liege, Belgium
    PLoS Biol 4:e100. 2006
    ..Results indicate that the human brain has already extensively processed recent memories during the first hours of post-training wakefulness, even when simultaneously coping with unrelated cognitive demands...
  57. doi Locked-in syndrome in children: report of five cases and review of the literature
    Marie Aurelie Bruno
    Coma Science Group, Cyclotron Research Center and Neurology Department, University of Liege, 4000 Luik, Belgium
    Pediatr Neurol 41:237-46. 2009
    ..These findings raise important ethical considerations in terms of quality of life and end-of-life decisions in such challenging cases...
  58. doi Brain functional integration decreases during propofol-induced loss of consciousness
    Jessica Schrouff
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Neuroimage 57:198-205. 2011
    ..They stress the important role played by parietal and frontal areas in the generation of consciousness...
  59. ncbi Bispectral analysis of electroencephalogram signals during recovery from coma: preliminary findings
    Caroline Schnakers
    University of Liege, Liege, Belgium
    Neuropsychol Rehabil 15:381-8. 2005
    ..These preliminary findings are encouraging in the search for electrophysiological correlates of consciousness in severe acute brain damage...
  60. doi Brain connectivity in disorders of consciousness
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, Liege, Belgium
    Brain Connect 2:1-10. 2012
    ..We will also discuss the relevance of the study of the level versus the contents of consciousness in this context...
  61. doi Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness
    Andrea Soddu
    Coma Science Group, Cyclotron Research Centre, University of Liege, Liege, Belgium
    Hum Brain Mapp 33:778-96. 2012
    ..We here aimed to identify the DMN in the challenging patient population of disorders of consciousness encountered following coma...
  62. ncbi Response to comment on "preserved feedforward but impaired top-down processes in the vegetative state"
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, Liege, Belgium
    Science 334:1203. 2011
    ..We welcome the opportunity to provide more details about our methods and results and to resolve their concerns. We substantiate our interpretation of the results and provide a point-by-point response to the issues raised...
  63. ncbi Nonvisual responses to light exposure in the human brain during the circadian night
    Fabien Perrin
    Centre de Recherches du Cyclotron B30, Universite de Liege, Sart Tilman, 4000 Liege, Belgium
    Curr Biol 14:1842-6. 2004
    ..Activity in the hypothalamus decreased in proportion to previous illumination. These findings have important implications for understanding the effects of light on human behavior...
  64. doi Brain function in physiologically, pharmacologically, and pathologically altered states of consciousness
    Pierre Boveroux
    Department of Neurology, Coma Science Group, University of Liege, Liege, Belgium
    Int Anesthesiol Clin 46:131-46. 2008
  65. ncbi Human cognition during REM sleep and the activity profile within frontal and parietal cortices: a reappraisal of functional neuroimaging data
    Pierre Maquet
    Cyclotron Research Centre, University of Lièege Sart Tilman, 4000 Liege, Belgium
    Prog Brain Res 150:219-27. 2005
    ....
  66. doi "Relevance vector machine" consciousness classifier applied to cerebral metabolism of vegetative and locked-in patients
    Christophe L Phillips
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Neuroimage 56:797-808. 2011
    ..Therefore, RVM classification of cerebral metabolic images obtained in coma survivors could become a useful tool for the automated PET-based diagnosis of altered states of consciousness...
  67. ncbi Self-referential reflective activity and its relationship with rest: a PET study
    Arnaud D'Argembeau
    Department of Cognitive Sciences, University of Liege, Boulevard du Rectorat, 3 B33, 4000 Liege, Belgium
    Neuroimage 25:616-24. 2005
    ..It is suggested that the VMPFC is crucial for representing knowledge pertaining to the self and that this is an important function of the resting state...
  68. doi The problem of aphasia in the assessment of consciousness in brain-damaged patients
    Steve Majerus
    Center for Cognitive and Behavioral Neuroscience and Coma Science Group, University of Liege, Belgium
    Prog Brain Res 177:49-61. 2009
    ..The combined use of behavioral and neuroimaging assessment techniques appears to be particularly promising for disentangling impaired consciousness and aphasia...
  69. doi Magnetic resonance spectroscopy and diffusion tensor imaging in coma survivors: promises and pitfalls
    Luaba Tshibanda
    Coma Science Group, Cyclotron Research Center and Neurology Department, University and University Hospital of Liège, Belgium
    Prog Brain Res 177:215-29. 2009
    ..This review will focus on the interest of comatose patients MRI multimodal assessment with MRS and DTI. It will emphasize the advantages and pitfalls of these techniques in particular in predicting the coma survivors' outcome...
  70. pmc Hierarchical clustering of brain activity during human nonrapid eye movement sleep
    Melanie Boly
    Cyclotron Research Centre, University of Liege, 4000 Liege, Belgium
    Proc Natl Acad Sci U S A 109:5856-61. 2012
    ..Such modifications in brain connectivity, possibly driven by sleep ultraslow oscillations, could hinder the brain's ability to integrate information and account for decreased consciousness during NREM sleep...
  71. doi Neuroimaging after coma
    Luaba Tshibanda
    Coma Science Group, Cyclotron Research Center, University and University Hospital of Liège, Sart Tilman, B30 Liège, Belgium
    Neuroradiology 52:15-24. 2010
    ....
  72. doi Assessment and detection of pain in noncommunicative severely brain-injured patients
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, Sart Tilman, B30, University of Liege, 4000 Liege, Belgium
    Expert Rev Neurother 10:1725-31. 2010
    ..Pain monitoring in these patients is hence of medical and ethical importance. In this article, we will focus on the possible use of behavioral scales for the assessment and detection of pain in noncommunicative patients...
  73. ncbi Neuroimaging activation studies in the vegetative state: predictors of recovery?
    Haibo Di
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege, Belgium
    Clin Med 8:502-7. 2008
    ..The clinical application of these functional neuroimaging techniques awaits validation from ongoing multi-centric cohort studies in these challenging patients with chronic disorders of consciousness...
  74. ncbi Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep
    Philippe Peigneux
    Cyclotron Research Center and Department of Neuropsychology, Universite de Liege, Belgium
    Neuroimage 20:125-34. 2003
    ..Our data provide the first experimental evidence for a link between behavioral performance and cerebral reactivation during REM sleep...
  75. pmc Sleep in disorders of consciousness
    Victor Cologan
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Sleep Med Rev 14:97-105. 2010
    ..At the present time the interactions of sleep and consciousness in brain-injured patients are a little studied subject but, the authors suggest, a potentially very interesting field of research...
  76. pmc Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    BMC Neurol 9:35. 2009
    ..In this study, we compared consensus-based diagnoses of VS and MCS to those based on a well-established standardized neurobehavioral rating scale, the JFK Coma Recovery Scale-Revised (CRS-R)...
  77. doi From unresponsive wakefulness to minimally conscious PLUS and functional locked-in syndromes: recent advances in our understanding of disorders of consciousness
    Marie Aurelie Bruno
    Coma Science Group, Neurology Department and Cyclotron Research Centre, University Hospital and University of Liège, Liege, Belgium
    J Neurol 258:1373-84. 2011
    ....
  78. ncbi Festina lente: evidences for fast and slow learning processes and a role for sleep in human motor skill learning
    Pierre Maquet
    Cyclotron Research Centre, University of Liege, Belgium
    Learn Mem 10:237-9. 2003
  79. ncbi Eyes open, brain shut
    Steven Laureys
    Coma Research Group, Cyclotron Research Center, University of Liege, Belgium
    Sci Am 296:84-9. 2007
  80. ncbi Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine
    Arnaud Fumal
    Department of Neurology, University of Liege, Liege, Belgium
    Brain 129:543-50. 2006
    ..The latter is known to occur in drug dependence and could predispose subgroups of migraineurs to recurrent analgesic overuse...
  81. pmc Neural plasticity lessons from disorders of consciousness
    Athena Demertzi
    Coma Science Group, Cyclotron Research Centre and Neurology Department, Sart Tilman, University and University Hospital of Liège Liège, Belgium
    Front Psychol 1:245. 2010
    ..e., medical management and rehabilitation) but also from a scientific-theoretical perspective (i.e., the brain's plastic abilities and the pursuit of the neural correlate of consciousness)...
  82. ncbi Increased cerebral functional connectivity underlying the antinociceptive effects of hypnosis
    Marie Elisabeth Faymonville
    Department of Anesthesiology and Intensive Care Medicine, CHU Sart Tilman, University of Liege, 4000 Liege, Belgium
    Brain Res Cogn Brain Res 17:255-62. 2003
    ....
  83. ncbi Bispectral index correlates with regional cerebral blood flow during sleep in distinct cortical and subcortical structures in humans
    Q Noirhomme
    Coma Science Group, Cyclotron Research Centre, University of Liege, Liege, Belgium
    Arch Ital Biol 147:51-7. 2009
    ..Thus, although mainly derived from frontal EEG, BIS could represent a wider index of cerebral activity...
  84. ncbi Experience-dependent changes in cerebral functional connectivity during human rapid eye movement sleep
    S Laureys
    Cyclotron Research Center, , Belgium
    Neuroscience 105:521-5. 2001
    ..The optimization of this visuo-motor network during sleep could explain the gain in performance observed during the following day...
  85. ncbi Eye gaze and conscious processing in severely brain-injured patients
    Camille Chatelle
    Coma Science Group, Cyclotron Research Centre, University of Liege, 4000 Liege, Belgium http www ulg ac be www coma ulg ac be
    Behav Brain Sci 33:442-3. 2010
    ..In this commentary, we illustrate the relationship between oriented eye movements, consciousness, and emotion by using the case of severely brain-injured patients recovering from coma (i.e., vegetative and minimally conscious patients)...
  86. doi Influence of anesthesia on cerebral blood flow, cerebral metabolic rate, and brain functional connectivity
    Vincent Bonhomme
    University Department of Anesthesia and ICM, CHR Citadelle, Belgium
    Curr Opin Anaesthesiol 24:474-9. 2011
    ..To describe recent studies exploring brain function under the influence of hypnotic anesthetic agents, and their implications on the understanding of consciousness physiology and anesthesia-induced alteration of consciousness...
  87. ncbi Phonological short-term memory networks following recovery from Landau and Kleffner syndrome
    Steve Majerus
    Department of Cognitive Sciences, University of Liege, Liege, Belgium
    Hum Brain Mapp 19:133-44. 2003
    ..These data suggest that impaired verbal STM at late outcome of LKS might indeed be related to a persistent decrease of activity in those posterior superior temporal gyri that were involved in the epileptic focus during the active phase...
  88. ncbi Short article one's own face is hard to ignore
    Serge Bredart
    Department of Cognitive Science, University of Liege, Liege, Belgium
    Q J Exp Psychol (Hove) 59:46-52. 2006
    ..We argue that the emotional value or the high familiarity of one's own face may explain its attention-grabbing property...
  89. ncbi Two aspects of impaired consciousness in Alzheimer's disease
    Eric Salmon
    Cyclotron Research Centre and Department of Neurology, University of Liege, B35 Sart Tilman, B4000 Liege, Belgium
    Prog Brain Res 150:287-98. 2005
    ..g., the temporoparietal junction). We hypothesize that these patients are impaired in the ability to see themselves with a third-person perspective (i.e., being able to see themselves as other people see them)...
  90. ncbi [(18)F]p-MPPF: aA radiolabeled antagonist for the study of 5-HT(1A) receptors with PET
    A Plenevaux
    Cyclotron Research Center, Liege University, Sart Tilman B 30, B 4000 Liege, Belgium
    Nucl Med Biol 27:467-71. 2000
    ..This includes chemistry, radiochemistry, animal data (rats, cats, and monkeys) with autoradiography and PET, human data with PET, toxicity, and metabolism...
  91. ncbi Striatum forever, despite sequence learning variability: a random effect analysis of PET data
    P Peigneux
    Centre de Recherches du Cyclotron, Universite de Liege, Belgium
    Hum Brain Mapp 10:179-94. 2000
    ....
  92. ncbi Fluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration
    S Laureys
    Cyclotron Research Center, and Department of Neurology, University of Liege, Belgium
    J Neurol 246:1151-8. 1999
    ..In early stages of CBD, FDOPA and FDG PET patterns differed from those observed in PD. In CBD the asymmetry in FDOPA uptake was less pronounced than that of clinical signs or metabolic impairment...
  93. ncbi [Contribution of functional neuroimaging studies to the understanding of the mechanisms of general anesthesia]
    P Boveroux
    Centre de Recherches du Cyclotron et Département d Anesthésie Réanimation, CHU et Université de Liège, Liege, Belgique
    Rev Med Liege 64:36-41. 2009
    ..All these aspects are reviewed in this paper, at the light of the most recent literature...
  94. ncbi Neural mechanisms of antinociceptive effects of hypnosis
    M E Faymonville
    Departments of Anesthesiology and Intensive Care Medicine and Neurology, and the Cyclotron Research Centre, University Hospital of Liege, Liege, Belgium
    Anesthesiology 92:1257-67. 2000
    ..In this study, we used positron emission tomography in 11 healthy volunteers to identify the brain areas in which hypnosis modulates cerebral responses to a noxious stimulus...
  95. ncbi Neural and cognitive bases of upper limb apraxia in corticobasal degeneration
    P Peigneux
    Centre de Recherches du Cyclotron, Service de Neuropsychologie, Universite de Liege, Belgium
    Neurology 57:1259-68. 2001
    ..To investigate the neural and cognitive bases of upper limb apraxia in corticobasal degeneration (CBD)...
  96. ncbi Regional organisation of brain activity during paradoxical sleep (PS)
    P Maquet
    Cyclotron Research Centre, University of Liege, Belgium
    Arch Ital Biol 142:413-9. 2004
    ....
  97. ncbi Memory processing during human sleep as assessed by functional neuroimaging
    P Maquet
    Cyclotron Research Centre, University of Liege, Belgium
    Rev Neurol (Paris) 159:6S27-9. 2003
    ..These changes do not involve isolated brain areas but entire macroscopic cerebral networks. These data suggest a role for sleep in the processing of recent memory traces...
  98. ncbi Generation of rapid eye movements during paradoxical sleep in humans
    P Peigneux
    Cyclotron Research Center, , Belgium
    Neuroimage 14:701-8. 2001
    ..The interest in the presence of PGO waves in humans is outstanding because the cellular processes involved in, or triggered by, PGO waves might favor brain plasticity during PS...
  99. ncbi Experience-dependent changes in cerebral activation during human REM sleep
    P Maquet
    Cyclotron Research Centre, University of Liege, Belgium
    Nat Neurosci 3:831-6. 2000
    ..These results support the hypothesis that memory traces are processed during REM sleep in humans...
  100. pmc Baseline brain activity fluctuations predict somatosensory perception in humans
    M Boly
    Coma Science Group, Cyclotron Research Center, B30, Allee du 6 Aout, Sart Tilman, University of Liege, B 4000 Liege, Belgium
    Proc Natl Acad Sci U S A 104:12187-92. 2007
    ..These results suggest that baseline brain-activity fluctuations may profoundly modify our conscious perception of the external world...
  101. doi Diagnostic and prognostic use of bispectral index in coma, vegetative state and related disorders
    C Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Belgium
    Brain Inj 22:926-31. 2008
    ....