Denis L J Lafontaine

Summary

Country: Belgium

Publications

  1. ncbi request reprint The function and synthesis of ribosomes
    D L Lafontaine
    FNRS, Universite Libre de Bruxelles, Departement de Biologie Moleculaire, IRMW Campus CERIA, Avenue Emile Gryson 1, B 1070 Brussels, Belgium
    Nat Rev Mol Cell Biol 2:514-20. 2001
  2. doi request reprint A 'garbage can' for ribosomes: how eukaryotes degrade their ribosomes
    Denis L J Lafontaine
    Fonds de la Recherche Scientifique FRS F N R S, Institut de Biologie et de Médecine Moléculaire IBMM, Universite Libre de Bruxelles ULB, Charleroi Gosselies, Belgium
    Trends Biochem Sci 35:267-77. 2010
  3. pmc The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2
    Stéphanie Schillewaert
    Fonds de la Recherche Scientifique, Universite Libre de Bruxelles, Charleroi Gosselies, Belgium
    Mol Cell Biol 32:430-44. 2012
  4. pmc TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export
    Emmanuel Vanrobays
    Fonds de la Recherche Scientifique FRS FNRS, Académie Wallonie Bruxelles, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Charleroi Gosselies, B 6041, Belgium
    RNA 14:2061-73. 2008
  5. pmc Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction
    Tran Hoang
    Fonds National de la Recherche Scientifique, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi Gosselies, Belgium
    Mol Cell Biol 25:5523-34. 2005
  6. pmc A functional interface at the rDNA connects rRNA synthesis, pre-rRNA processing and nucleolar surveillance in budding yeast
    Nathalie Leporé
    RNA Metabolism, Fonds de la Recherche Scientifique FRS FNRS, Universite Libre de Bruxelles, Charleroi Gosselies, Belgium
    PLoS ONE 6:e24962. 2011
  7. pmc The nuclear poly(A) polymerase and Exosome cofactor Trf5 is recruited cotranscriptionally to nucleolar surveillance
    Maxime Wery
    Fonds de la Recherche Scientifique FRS FNRS, AcadémieWallonie Bruxelles, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Charleroi Gosselies, B 6041 Belgium
    RNA 15:406-19. 2009
  8. pmc The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology
    Geoffroy Colau
    Fonds National de la Recherche Scientifique, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi Gosselies, Belgium
    Mol Cell Biol 24:7976-86. 2004
  9. pmc Dim2p, a KH-domain protein required for small ribosomal subunit synthesis
    Emmanuel Vanrobays
    F N R S, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi Gosselies, Belgium LBME du CNRS, 31062 Toulouse Cedex 04, France
    RNA 10:645-56. 2004

Collaborators

  • D Tollervey
  • Emmanuel Vanrobays
  • Stéphanie Schillewaert
  • Nathalie Leporé
  • Ludivine Wacheul
  • Maxime Wery
  • Yvonne N Osheim
  • Ann L Beyer
  • Tran Hoang
  • Geoffroy Colau
  • Frédéric Lhommé
  • Sabine Ruidant
  • Alexis Leplus
  • Nevan Krogan
  • Jack Greenblatt
  • Timothy R Hughes
  • Shawna Hiley
  • Wen Tao Peng
  • Michele Caizergues-Ferrer
  • Marc Thiry
  • Rémy Bordonné
  • Jean Paul Gelugne
  • Vivian Leduc

Detail Information

Publications9

  1. ncbi request reprint The function and synthesis of ribosomes
    D L Lafontaine
    FNRS, Universite Libre de Bruxelles, Departement de Biologie Moleculaire, IRMW Campus CERIA, Avenue Emile Gryson 1, B 1070 Brussels, Belgium
    Nat Rev Mol Cell Biol 2:514-20. 2001
    ..The mechanisms that underlie ribosomal synthesis, translocation and catalysis are now being unravelled, with practical implications for the design of antibiotics...
  2. doi request reprint A 'garbage can' for ribosomes: how eukaryotes degrade their ribosomes
    Denis L J Lafontaine
    Fonds de la Recherche Scientifique FRS F N R S, Institut de Biologie et de Médecine Moléculaire IBMM, Universite Libre de Bruxelles ULB, Charleroi Gosselies, Belgium
    Trends Biochem Sci 35:267-77. 2010
    ..This surveillance is active at every step of the ribosome synthesis pathway and on mature ribosomes, involves nearly entirely different mechanisms for the small and large subunits, and requires specialized subcellular organelles...
  3. pmc The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2
    Stéphanie Schillewaert
    Fonds de la Recherche Scientifique, Universite Libre de Bruxelles, Charleroi Gosselies, Belgium
    Mol Cell Biol 32:430-44. 2012
    ..Consistently, we note the conspicuous presence of ~7- or 8-nucleotide extensions on both ends of 5.8S rRNA precursors and at the 5' end of pre-25S RNAs suggestive of a protected spacer fragment of similar length...
  4. pmc TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export
    Emmanuel Vanrobays
    Fonds de la Recherche Scientifique FRS FNRS, Académie Wallonie Bruxelles, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Charleroi Gosselies, B 6041, Belgium
    RNA 14:2061-73. 2008
    ..Strikingly, DIM2 and RRP12 are both involved in the nucleocytoplasmic translocation of pre-ribosomes, suggesting that this step in the ribosome assembly pathway has been selected as a regulatory target for the TOR pathway...
  5. pmc Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction
    Tran Hoang
    Fonds National de la Recherche Scientifique, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi Gosselies, Belgium
    Mol Cell Biol 25:5523-34. 2005
    ..The identification of ABT1 in a large-scale analysis of the human nucleolar proteome indicates that its role may also be conserved in mammals...
  6. pmc A functional interface at the rDNA connects rRNA synthesis, pre-rRNA processing and nucleolar surveillance in budding yeast
    Nathalie Leporé
    RNA Metabolism, Fonds de la Recherche Scientifique FRS FNRS, Universite Libre de Bruxelles, Charleroi Gosselies, Belgium
    PLoS ONE 6:e24962. 2011
    ..Altogether these results indicate that Nrd1-Nab3 contributes to recruiting the nucleolar surveillance to elongating polymerases to survey nascent rRNA transcripts...
  7. pmc The nuclear poly(A) polymerase and Exosome cofactor Trf5 is recruited cotranscriptionally to nucleolar surveillance
    Maxime Wery
    Fonds de la Recherche Scientifique FRS FNRS, AcadémieWallonie Bruxelles, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Charleroi Gosselies, B 6041 Belgium
    RNA 15:406-19. 2009
    ..Trf5 colocalized with nascent pre-rRNPs, indicating that this nucleolar surveillance initiates cotranscriptionally...
  8. pmc The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology
    Geoffroy Colau
    Fonds National de la Recherche Scientifique, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi Gosselies, Belgium
    Mol Cell Biol 24:7976-86. 2004
    ..This conclusion is compatible with a model of self-organization for nucleolar assembly...
  9. pmc Dim2p, a KH-domain protein required for small ribosomal subunit synthesis
    Emmanuel Vanrobays
    F N R S, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi Gosselies, Belgium LBME du CNRS, 31062 Toulouse Cedex 04, France
    RNA 10:645-56. 2004
    ....