Denis L J Lafontaine

Summary

Country: Belgium

Publications

  1. pmc A functional interface at the rDNA connects rRNA synthesis, pre-rRNA processing and nucleolar surveillance in budding yeast
    Nathalie Leporé
    RNA Metabolism, Fonds de la Recherche Scientifique FRS FNRS, Universite Libre de Bruxelles, Charleroi Gosselies, Belgium
    PLoS ONE 6:e24962. 2011
  2. ncbi request reprint The function and synthesis of ribosomes
    D L Lafontaine
    FNRS, Universite Libre de Bruxelles, Departement de Biologie Moleculaire, IRMW Campus CERIA, Avenue Emile Gryson 1, B 1070 Brussels, Belgium
    Nat Rev Mol Cell Biol 2:514-20. 2001
  3. doi request reprint A 'garbage can' for ribosomes: how eukaryotes degrade their ribosomes
    Denis L J Lafontaine
    Fonds de la Recherche Scientifique FRS F N R S, Institut de Biologie et de Médecine Moléculaire IBMM, Universite Libre de Bruxelles ULB, Charleroi Gosselies, Belgium
    Trends Biochem Sci 35:267-77. 2010
  4. pmc TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export
    Emmanuel Vanrobays
    Fonds de la Recherche Scientifique FRS FNRS, Académie Wallonie Bruxelles, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Charleroi Gosselies, B 6041, Belgium
    RNA 14:2061-73. 2008
  5. pmc Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction
    Tran Hoang
    Fonds National de la Recherche Scientifique, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi Gosselies, Belgium
    Mol Cell Biol 25:5523-34. 2005
  6. pmc The nuclear poly(A) polymerase and Exosome cofactor Trf5 is recruited cotranscriptionally to nucleolar surveillance
    Maxime Wery
    Fonds de la Recherche Scientifique FRS FNRS, AcadémieWallonie Bruxelles, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Charleroi Gosselies, B 6041 Belgium
    RNA 15:406-19. 2009
  7. doi request reprint The complexity of human ribosome biogenesis revealed by systematic nucleolar screening of Pre-rRNA processing factors
    Lionel Tafforeau
    Fonds de la Recherche Scientifique FRS FNRS, Universite Libre de Bruxelles, 1050 Bruxelles, Belgium
    Mol Cell 51:539-51. 2013
  8. pmc The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2
    Stéphanie Schillewaert
    Fonds de la Recherche Scientifique, Universite Libre de Bruxelles, Charleroi Gosselies, Belgium
    Mol Cell Biol 32:430-44. 2012
  9. pmc The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology
    Geoffroy Colau
    Fonds National de la Recherche Scientifique, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi Gosselies, Belgium
    Mol Cell Biol 24:7976-86. 2004
  10. doi request reprint [<< Catch me if you can >>: how the structural and functional integrity of eukaryotic RNA molecules is monitored by surveillance mechanisms]
    Nathalie Leporé
    Fonds de la Recherche Scientifique FRS FNRS, Métabolisme de l ARN, Institut de Biologie et de Médecine Moléculaires IBMM, Universite Libre de Bruxelles ULB, avenue des Professeurs Jeener et Brachet, 12, B 6041 Gosselies, Belgique
    Med Sci (Paris) 26:259-66. 2010

Collaborators

  • D Tollervey
  • Nathalie Leporé
  • Emmanuel Vanrobays
  • Sahra Taylor Mullineux
  • Stéphanie Schillewaert
  • Ludivine Wacheul
  • Lionel Tafforeau
  • Maxime Wery
  • Yvonne N Osheim
  • Ann L Beyer
  • Tran Hoang
  • Geoffroy Colau
  • Jean Louis Langhendries
  • Vassiliki Stamatopoulou
  • Romain Mullier
  • Christiane Zorbas
  • Frédéric Lhommé
  • Sabine Ruidant
  • Alexis Leplus
  • Shawna Hiley
  • Nevan Krogan
  • Timothy R Hughes
  • Jack Greenblatt
  • Wen Tao Peng
  • Vivian Leduc
  • Jean Paul Gelugne
  • Michele Caizergues-Ferrer
  • Marc Thiry
  • Rémy Bordonné

Detail Information

Publications12

  1. pmc A functional interface at the rDNA connects rRNA synthesis, pre-rRNA processing and nucleolar surveillance in budding yeast
    Nathalie Leporé
    RNA Metabolism, Fonds de la Recherche Scientifique FRS FNRS, Universite Libre de Bruxelles, Charleroi Gosselies, Belgium
    PLoS ONE 6:e24962. 2011
    ..Altogether these results indicate that Nrd1-Nab3 contributes to recruiting the nucleolar surveillance to elongating polymerases to survey nascent rRNA transcripts...
  2. ncbi request reprint The function and synthesis of ribosomes
    D L Lafontaine
    FNRS, Universite Libre de Bruxelles, Departement de Biologie Moleculaire, IRMW Campus CERIA, Avenue Emile Gryson 1, B 1070 Brussels, Belgium
    Nat Rev Mol Cell Biol 2:514-20. 2001
    ..The mechanisms that underlie ribosomal synthesis, translocation and catalysis are now being unravelled, with practical implications for the design of antibiotics...
  3. doi request reprint A 'garbage can' for ribosomes: how eukaryotes degrade their ribosomes
    Denis L J Lafontaine
    Fonds de la Recherche Scientifique FRS F N R S, Institut de Biologie et de Médecine Moléculaire IBMM, Universite Libre de Bruxelles ULB, Charleroi Gosselies, Belgium
    Trends Biochem Sci 35:267-77. 2010
    ..This surveillance is active at every step of the ribosome synthesis pathway and on mature ribosomes, involves nearly entirely different mechanisms for the small and large subunits, and requires specialized subcellular organelles...
  4. pmc TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export
    Emmanuel Vanrobays
    Fonds de la Recherche Scientifique FRS FNRS, Académie Wallonie Bruxelles, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Charleroi Gosselies, B 6041, Belgium
    RNA 14:2061-73. 2008
    ..Strikingly, DIM2 and RRP12 are both involved in the nucleocytoplasmic translocation of pre-ribosomes, suggesting that this step in the ribosome assembly pathway has been selected as a regulatory target for the TOR pathway...
  5. pmc Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction
    Tran Hoang
    Fonds National de la Recherche Scientifique, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi Gosselies, Belgium
    Mol Cell Biol 25:5523-34. 2005
    ..The identification of ABT1 in a large-scale analysis of the human nucleolar proteome indicates that its role may also be conserved in mammals...
  6. pmc The nuclear poly(A) polymerase and Exosome cofactor Trf5 is recruited cotranscriptionally to nucleolar surveillance
    Maxime Wery
    Fonds de la Recherche Scientifique FRS FNRS, AcadémieWallonie Bruxelles, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Charleroi Gosselies, B 6041 Belgium
    RNA 15:406-19. 2009
    ..Trf5 colocalized with nascent pre-rRNPs, indicating that this nucleolar surveillance initiates cotranscriptionally...
  7. doi request reprint The complexity of human ribosome biogenesis revealed by systematic nucleolar screening of Pre-rRNA processing factors
    Lionel Tafforeau
    Fonds de la Recherche Scientifique FRS FNRS, Universite Libre de Bruxelles, 1050 Bruxelles, Belgium
    Mol Cell 51:539-51. 2013
    ....
  8. pmc The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2
    Stéphanie Schillewaert
    Fonds de la Recherche Scientifique, Universite Libre de Bruxelles, Charleroi Gosselies, Belgium
    Mol Cell Biol 32:430-44. 2012
    ..Consistently, we note the conspicuous presence of ~7- or 8-nucleotide extensions on both ends of 5.8S rRNA precursors and at the 5' end of pre-25S RNAs suggestive of a protected spacer fragment of similar length...
  9. pmc The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology
    Geoffroy Colau
    Fonds National de la Recherche Scientifique, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi Gosselies, Belgium
    Mol Cell Biol 24:7976-86. 2004
    ..This conclusion is compatible with a model of self-organization for nucleolar assembly...
  10. doi request reprint [<< Catch me if you can >>: how the structural and functional integrity of eukaryotic RNA molecules is monitored by surveillance mechanisms]
    Nathalie Leporé
    Fonds de la Recherche Scientifique FRS FNRS, Métabolisme de l ARN, Institut de Biologie et de Médecine Moléculaires IBMM, Universite Libre de Bruxelles ULB, avenue des Professeurs Jeener et Brachet, 12, B 6041 Gosselies, Belgique
    Med Sci (Paris) 26:259-66. 2010
    ..The actual mechanisms that discriminate aberrant RNAs from normal RNAs are still loosely defined. Surveillance is essential to cellular homeostasis and has been linked to several human diseases...
  11. pmc Dim2p, a KH-domain protein required for small ribosomal subunit synthesis
    Emmanuel Vanrobays
    F N R S, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Charleroi Gosselies, Belgium LBME du CNRS, 31062 Toulouse Cedex 04, France
    RNA 10:645-56. 2004
    ....
  12. doi request reprint Mapping the cleavage sites on mammalian pre-rRNAs: where do we stand?
    Sahra Taylor Mullineux
    Fonds de la Recherche Scientifique FRS FNRS, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Belgium
    Biochimie 94:1521-32. 2012
    ..These features might have been selected because they increase the robustness of pre-rRNA processing by acting as "back-up" mechanisms to ensure the proper maturation of rRNA...