Affiliation: Laboratory for Thrombosis Research
- Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytesJean Willems
Interdisciplinary Research Centre, KULAK, B 8500 Kortrijk, Belgium
Toxicon 40:1679-83. 2002..They also strongly inhibit the production of superoxide anions. At higher concentrations they act as pore formers and induce leakage of the cells. These different effects may be related to their amphipathic structure...
- Parabutoporin--an antibiotic peptide from scorpion venom--can both induce activation and inhibition of granulocyte cell functionsJean Willems
Interdisciplinary Research Center, KULAK, University Campus, B 8500 Kortrijk, Belgium
Peptides 25:1079-84. 2004..The unexpected inhibitory effect of PP, despite Rac activation, on superoxide production in granulocytes is explained by the direct interaction of membrane localized PP which prevents the formation of a functional NADPH oxidase complex...
- Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cellsLeentje Moerman
Interdisciplinary Research Center, Catholic University Leuven Campus Kortrijk, Belgium
Biochem Biophys Res Commun 311:90-7. 2003..Ca(2+) release by OP1 was found not to be mediated via interaction with the formyl peptide receptor-like 1. Although some of the results might favor a receptor-like interaction, the receptor involved could not be identified...
- Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern AfricaLeentje Moerman
Interdisciplinary Research Center, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium
Eur J Biochem 269:4799-810. 2002..Furthermore, all peptides inhibited growth of fungi. Experiments with SYTOX green suggested that this effect is related to membrane permeabilization...
- The antimicrobial peptide parabutoporin competes with p47(phox) as a PKC-substrate and inhibits NADPH oxidase in human neutrophilsQuinten F M Remijsen
Laboratory of Biochemistry, IRC, KULAK, B8500 Kortrijk, Belgium
FEBS Lett 580:6206-10. 2006..In contrast, PP affects the PKC-independent activation to a much lesser degree. This indicates that PP inhibits the activation of NADPH oxidase at submicromolar concentrations in a strongly PKC-dependent manner...