Jean Willems

Summary

Affiliation: Laboratory for Thrombosis Research
Country: Belgium

Publications

  1. ncbi request reprint Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes
    Jean Willems
    Interdisciplinary Research Centre, KULAK, B 8500 Kortrijk, Belgium
    Toxicon 40:1679-83. 2002
  2. ncbi request reprint Parabutoporin--an antibiotic peptide from scorpion venom--can both induce activation and inhibition of granulocyte cell functions
    Jean Willems
    Interdisciplinary Research Center, KULAK, University Campus, B 8500 Kortrijk, Belgium
    Peptides 25:1079-84. 2004
  3. ncbi request reprint Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cells
    Leentje Moerman
    Interdisciplinary Research Center, Catholic University Leuven Campus Kortrijk, Belgium
    Biochem Biophys Res Commun 311:90-7. 2003
  4. ncbi request reprint Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa
    Leentje Moerman
    Interdisciplinary Research Center, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium
    Eur J Biochem 269:4799-810. 2002
  5. ncbi request reprint The antimicrobial peptide parabutoporin competes with p47(phox) as a PKC-substrate and inhibits NADPH oxidase in human neutrophils
    Quinten F M Remijsen
    Laboratory of Biochemistry, IRC, KULAK, B8500 Kortrijk, Belgium
    FEBS Lett 580:6206-10. 2006

Collaborators

  • Karin Thevissen
  • Leentje Moerman
  • Fons Verdonck
  • Quinten F M Remijsen
  • Liliane Schoofs
  • Elke Clynen
  • Jan Tytgat
  • Suzanne Bosteels
  • Alexandre Fontayne
  • Jurg van der Walt
  • Johan Van Eldere
  • Wim Noppe

Detail Information

Publications5

  1. ncbi request reprint Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes
    Jean Willems
    Interdisciplinary Research Centre, KULAK, B 8500 Kortrijk, Belgium
    Toxicon 40:1679-83. 2002
    ..They also strongly inhibit the production of superoxide anions. At higher concentrations they act as pore formers and induce leakage of the cells. These different effects may be related to their amphipathic structure...
  2. ncbi request reprint Parabutoporin--an antibiotic peptide from scorpion venom--can both induce activation and inhibition of granulocyte cell functions
    Jean Willems
    Interdisciplinary Research Center, KULAK, University Campus, B 8500 Kortrijk, Belgium
    Peptides 25:1079-84. 2004
    ..The unexpected inhibitory effect of PP, despite Rac activation, on superoxide production in granulocytes is explained by the direct interaction of membrane localized PP which prevents the formation of a functional NADPH oxidase complex...
  3. ncbi request reprint Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cells
    Leentje Moerman
    Interdisciplinary Research Center, Catholic University Leuven Campus Kortrijk, Belgium
    Biochem Biophys Res Commun 311:90-7. 2003
    ..Ca(2+) release by OP1 was found not to be mediated via interaction with the formyl peptide receptor-like 1. Although some of the results might favor a receptor-like interaction, the receptor involved could not be identified...
  4. ncbi request reprint Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa
    Leentje Moerman
    Interdisciplinary Research Center, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium
    Eur J Biochem 269:4799-810. 2002
    ..Furthermore, all peptides inhibited growth of fungi. Experiments with SYTOX green suggested that this effect is related to membrane permeabilization...
  5. ncbi request reprint The antimicrobial peptide parabutoporin competes with p47(phox) as a PKC-substrate and inhibits NADPH oxidase in human neutrophils
    Quinten F M Remijsen
    Laboratory of Biochemistry, IRC, KULAK, B8500 Kortrijk, Belgium
    FEBS Lett 580:6206-10. 2006
    ..In contrast, PP affects the PKC-independent activation to a much lesser degree. This indicates that PP inhibits the activation of NADPH oxidase at submicromolar concentrations in a strongly PKC-dependent manner...