Fons Verdonck

Summary

Affiliation: Laboratory for Thrombosis Research
Country: Belgium

Publications

  1. ncbi request reprint Increased Na+ concentration and altered Na/K pump activity in hypertrophied canine ventricular cells
    Fons Verdonck
    Interdisciplinary Research Center, University of Leuven Campus Kortrijk, E Sabbelaan 53, B 8500, Kortrijk, Belgium
    Cardiovasc Res 57:1035-43. 2003
  2. ncbi request reprint Intracellular Na+ and altered Na+ transport mechanisms in cardiac hypertrophy and failure
    Fons Verdonck
    Interdisciplinary Research Centre, University of Leuven Campus Kortrijk, E Sabbelaan 53, B 8500, Kortrijk, Belgium
    J Mol Cell Cardiol 35:5-25. 2003
  3. ncbi request reprint Parabutoporin--an antibiotic peptide from scorpion venom--can both induce activation and inhibition of granulocyte cell functions
    Jean Willems
    Interdisciplinary Research Center, KULAK, University Campus, B 8500 Kortrijk, Belgium
    Peptides 25:1079-84. 2004
  4. ncbi request reprint Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes
    Jean Willems
    Interdisciplinary Research Centre, KULAK, B 8500 Kortrijk, Belgium
    Toxicon 40:1679-83. 2002
  5. ncbi request reprint Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cells
    Leentje Moerman
    Interdisciplinary Research Center, Catholic University Leuven Campus Kortrijk, Belgium
    Biochem Biophys Res Commun 311:90-7. 2003
  6. ncbi request reprint [Na(+)] in the subsarcolemmal 'fuzzy' space and modulation of [Ca(2+)](i) and contraction in cardiac myocytes
    Fons Verdonck
    Interdisciplinary Research Center, Katholieke University of Leuven, Campus Kortrijk, Kortrijk, Belgium
    Cell Calcium 35:603-12. 2004
  7. ncbi request reprint Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa
    Leentje Moerman
    Interdisciplinary Research Center, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium
    Eur J Biochem 269:4799-810. 2002
  8. ncbi request reprint The amiodarone derivative KB130015 [2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran] induces an Na+-dependent increase of [Ca2+] in ventricular myocytes
    Virginie Bito
    Laboratory of Experimental Cardiology, Catholic University Leuven, Campus Gasthuisberg O N 7th Floor, Herestraat 49, B 3000 Leuven, Belgium
    J Pharmacol Exp Ther 316:162-8. 2006
  9. ncbi request reprint Determination of species-specific components in the venom of Parabuthus scorpions from southern Africa using matrix-assisted laser desorption time-of-flight mass spectrometry
    Karin Dyason
    Department of Physiology, Potchefstroom University for Christian Higher Education, Private Bag X6001, Potchefstroom 2520, South Africa
    Rapid Commun Mass Spectrom 16:768-73. 2002
  10. ncbi request reprint The antimicrobial peptide parabutoporin competes with p47(phox) as a PKC-substrate and inhibits NADPH oxidase in human neutrophils
    Quinten F M Remijsen
    Laboratory of Biochemistry, IRC, KULAK, B8500 Kortrijk, Belgium
    FEBS Lett 580:6206-10. 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Increased Na+ concentration and altered Na/K pump activity in hypertrophied canine ventricular cells
    Fons Verdonck
    Interdisciplinary Research Center, University of Leuven Campus Kortrijk, E Sabbelaan 53, B 8500, Kortrijk, Belgium
    Cardiovasc Res 57:1035-43. 2003
    ..To investigate whether hypertrophy in the dog with chronic atrioventricular block (CAVB) alters [Na+]i and Na/K-pump function of ventricular myocytes...
  2. ncbi request reprint Intracellular Na+ and altered Na+ transport mechanisms in cardiac hypertrophy and failure
    Fons Verdonck
    Interdisciplinary Research Centre, University of Leuven Campus Kortrijk, E Sabbelaan 53, B 8500, Kortrijk, Belgium
    J Mol Cell Cardiol 35:5-25. 2003
    ....
  3. ncbi request reprint Parabutoporin--an antibiotic peptide from scorpion venom--can both induce activation and inhibition of granulocyte cell functions
    Jean Willems
    Interdisciplinary Research Center, KULAK, University Campus, B 8500 Kortrijk, Belgium
    Peptides 25:1079-84. 2004
    ..The unexpected inhibitory effect of PP, despite Rac activation, on superoxide production in granulocytes is explained by the direct interaction of membrane localized PP which prevents the formation of a functional NADPH oxidase complex...
  4. ncbi request reprint Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytes
    Jean Willems
    Interdisciplinary Research Centre, KULAK, B 8500 Kortrijk, Belgium
    Toxicon 40:1679-83. 2002
    ..They also strongly inhibit the production of superoxide anions. At higher concentrations they act as pore formers and induce leakage of the cells. These different effects may be related to their amphipathic structure...
  5. ncbi request reprint Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cells
    Leentje Moerman
    Interdisciplinary Research Center, Catholic University Leuven Campus Kortrijk, Belgium
    Biochem Biophys Res Commun 311:90-7. 2003
    ..Ca(2+) release by OP1 was found not to be mediated via interaction with the formyl peptide receptor-like 1. Although some of the results might favor a receptor-like interaction, the receptor involved could not be identified...
  6. ncbi request reprint [Na(+)] in the subsarcolemmal 'fuzzy' space and modulation of [Ca(2+)](i) and contraction in cardiac myocytes
    Fons Verdonck
    Interdisciplinary Research Center, Katholieke University of Leuven, Campus Kortrijk, Kortrijk, Belgium
    Cell Calcium 35:603-12. 2004
    ..This has implications for modulation of [Ca(2+)](i) during a single beat as well as during alterations in Na(+) fluxes seen in pathological conditions...
  7. ncbi request reprint Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa
    Leentje Moerman
    Interdisciplinary Research Center, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium
    Eur J Biochem 269:4799-810. 2002
    ..Furthermore, all peptides inhibited growth of fungi. Experiments with SYTOX green suggested that this effect is related to membrane permeabilization...
  8. ncbi request reprint The amiodarone derivative KB130015 [2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran] induces an Na+-dependent increase of [Ca2+] in ventricular myocytes
    Virginie Bito
    Laboratory of Experimental Cardiology, Catholic University Leuven, Campus Gasthuisberg O N 7th Floor, Herestraat 49, B 3000 Leuven, Belgium
    J Pharmacol Exp Ther 316:162-8. 2006
    ..This effect is partially offset by a decrease in I(CaL) resulting in a mild inotropic effect without the signs of Ca(2+) overload and related arrhythmias usually associated with Na(+) channel openers...
  9. ncbi request reprint Determination of species-specific components in the venom of Parabuthus scorpions from southern Africa using matrix-assisted laser desorption time-of-flight mass spectrometry
    Karin Dyason
    Department of Physiology, Potchefstroom University for Christian Higher Education, Private Bag X6001, Potchefstroom 2520, South Africa
    Rapid Commun Mass Spectrom 16:768-73. 2002
    ..MALDI-TOFMS is therefore proposed as a complementary method to morphological and behavioural characteristics for species and ultimately subspecies discrimination...
  10. ncbi request reprint The antimicrobial peptide parabutoporin competes with p47(phox) as a PKC-substrate and inhibits NADPH oxidase in human neutrophils
    Quinten F M Remijsen
    Laboratory of Biochemistry, IRC, KULAK, B8500 Kortrijk, Belgium
    FEBS Lett 580:6206-10. 2006
    ..In contrast, PP affects the PKC-independent activation to a much lesser degree. This indicates that PP inhibits the activation of NADPH oxidase at submicromolar concentrations in a strongly PKC-dependent manner...
  11. ncbi request reprint Evolutionary origin of inhibitor cystine knot peptides
    Shunyi Zhu
    Laboratory of Toxicology, University of Leuven, Belgium
    FASEB J 17:1765-7. 2003
    ..In contrast, ICK peptides from plant and fungus might be independently evolved from another ancestor...
  12. ncbi request reprint Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis
    Steven M Pogwizd
    Department of Medicine, University of Illinois at Chicago, 840 South Wood Street, M C 787, Chicago, IL 60612, USA
    Cardiovasc Res 57:887-96. 2003
  13. ncbi request reprint Evolutionary trace analysis of scorpion toxins specific for K-channels
    Shunyi Zhu
    Laboratory of Toxicology, University of Leuven, Leuven, Belgium
    Proteins 54:361-70. 2004
    ....
  14. ncbi request reprint Role of the Na/Ca exchanger in arrhythmias in compensated hypertrophy
    Karin R Sipido
    Laboratory of Experimental Cardiology, University of Leuven, Leuven, Belgium
    Ann N Y Acad Sci 976:438-45. 2002
    ..However, more than one ionic remodeling process is likely to be present, and different cellular mechanisms of arrhythmias can coexist...
  15. ncbi request reprint Purification, characterization and biosynthesis of parabutoxin 3, a component of Parabuthus transvaalicus venom
    Isabelle Huys
    Laboratory of Toxicology, University of Leuven, Leuven, Belgium
    Eur J Biochem 269:1854-65. 2002
    ..The scaffold of PBTx3 is homologous to most other alpha-KTx scorpion toxins...
  16. ncbi request reprint The poison Dart frog's batrachotoxin modulates Nav1.8
    Frank Bosmans
    Laboratory of Toxicology, University of Leuven, E Van Evenstraat 4, B 3000 Leuven, Belgium
    FEBS Lett 577:245-8. 2004
    ..8 at more negative membrane potentials and the ion selectivity is modified...
  17. ncbi request reprint Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy?
    Karin R Sipido
    Laboratory of Experimental Cardiology, University of Leuven, KUL, Campus Gasthuisberg O N, 7th Floor, Herestraat 49, B 3000 Leuven, Belgium
    Cardiovasc Res 53:782-805. 2002
    ..Development of drugs that target only a specific mode of the exchanger may offer a further advantage...