P Kolh

Summary

Country: Belgium

Publications

  1. pmc A multi-scale cardiovascular system model can account for the load-dependence of the end-systolic pressure-volume relationship
    Antoine Pironet
    University of Liege ULg, GIGA Cardiovascular Sciences, Liege, Belgium
    Biomed Eng Online 12:8. 2013
  2. pmc Beat-to-beat estimation of the continuous left and right cardiac elastance from metrics commonly available in clinical settings
    David Stevenson
    Department of Mechanical Engineering, Centre for Bio Engineering at the University of Canterbury, Christchurch, New Zealand
    Biomed Eng Online 11:73. 2012
  3. pmc Algorithmic processing of pressure waveforms to facilitate estimation of cardiac elastance
    David Stevenson
    Department of Mechanical Engineering, Centre for Bio Engineering at the University of Canterbury, Christchurch, New Zealand
    Biomed Eng Online 11:28. 2012
  4. pmc Mathematical multi-scale model of the cardiovascular system including mitral valve dynamics. Application to ischemic mitral insufficiency
    Sabine Paeme
    Cardiovascular Research Center, University of Liege, Liege, Belgium
    Biomed Eng Online 10:86. 2011
  5. ncbi request reprint Comparison of the effects of propofol and pentobarbital on left ventricular adaptation to an increased afterload
    Philippe Kolh
    Hemodynamic Research Center HemoLiège, University of Liege, Belgium
    J Cardiovasc Pharmacol 44:294-301. 2004
  6. ncbi request reprint Alteration of left ventriculo-arterial coupling and mechanical efficiency during acute myocardial ischemia
    P Kolh
    Hemodynamic Research Center HemoLiège, University of Liege, Liege, Belgium
    Int Angiol 22:148-58. 2003
  7. ncbi request reprint Evaluation of BM-573, a novel TXA2 synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion
    Philippe Kolh
    Hemodynamic Research Center HemoLiège, University of Liege, Belgium
    Prostaglandins Other Lipid Mediat 79:53-73. 2006
  8. ncbi request reprint Aortic valve surgery in octogenarians: predictive factors for operative and long-term results
    Philippe Kolh
    Cardiothoracic Surgery Department, University Hospital of Liege, Liege, Belgium
    Eur J Cardiothorac Surg 31:600-6. 2007
  9. ncbi request reprint Early stage results after oesophageal resection for malignancy - colon interposition vs. gastric pull-up
    P Kolh
    Department of Cardio Thoracic Surgery, University Hospital of Liege, B35 Sart Tilman, 4000, Liege, Belgium
    Eur J Cardiothorac Surg 18:293-300. 2000
  10. doi request reprint Joint ESC/EACTS guidelines on myocardial revascularization
    Philippe Kolh
    Cardiovascular Surgery Department, University Hospital, CHU, ULg of Liege, Liege, Belgium
    J Cardiovasc Med (Hagerstown) 12:264-7. 2011

Collaborators

Detail Information

Publications45

  1. pmc A multi-scale cardiovascular system model can account for the load-dependence of the end-systolic pressure-volume relationship
    Antoine Pironet
    University of Liege ULg, GIGA Cardiovascular Sciences, Liege, Belgium
    Biomed Eng Online 12:8. 2013
    ....
  2. pmc Beat-to-beat estimation of the continuous left and right cardiac elastance from metrics commonly available in clinical settings
    David Stevenson
    Department of Mechanical Engineering, Centre for Bio Engineering at the University of Canterbury, Christchurch, New Zealand
    Biomed Eng Online 11:73. 2012
    ..This paper presents a method for the estimation of a patient specific FTVE, using only metrics that are currently available in a clinical setting...
  3. pmc Algorithmic processing of pressure waveforms to facilitate estimation of cardiac elastance
    David Stevenson
    Department of Mechanical Engineering, Centre for Bio Engineering at the University of Canterbury, Christchurch, New Zealand
    Biomed Eng Online 11:28. 2012
    ..This paper presents the method to algorithmically process the pressure waveforms...
  4. pmc Mathematical multi-scale model of the cardiovascular system including mitral valve dynamics. Application to ischemic mitral insufficiency
    Sabine Paeme
    Cardiovascular Research Center, University of Liege, Liege, Belgium
    Biomed Eng Online 10:86. 2011
    ..Validated models would offer the ability to better understand these dynamics and thus optimize diagnosis, as well as surgical and other interventions...
  5. ncbi request reprint Comparison of the effects of propofol and pentobarbital on left ventricular adaptation to an increased afterload
    Philippe Kolh
    Hemodynamic Research Center HemoLiège, University of Liege, Belgium
    J Cardiovasc Pharmacol 44:294-301. 2004
    ..These results showed that pentobarbital at 3 mg x kg(-1) x h(-1) has less deleterious hemodynamic effects than propofol at 10 mg x kg(-1) x h(-1)...
  6. ncbi request reprint Alteration of left ventriculo-arterial coupling and mechanical efficiency during acute myocardial ischemia
    P Kolh
    Hemodynamic Research Center HemoLiège, University of Liege, Liege, Belgium
    Int Angiol 22:148-58. 2003
    ....
  7. ncbi request reprint Evaluation of BM-573, a novel TXA2 synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion
    Philippe Kolh
    Hemodynamic Research Center HemoLiège, University of Liege, Belgium
    Prostaglandins Other Lipid Mediat 79:53-73. 2006
    ..To investigate whether BM-573 (N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea), an original combined thromboxane A2 synthase inhibitor and receptor antagonist, prevents reperfusion injury in acutely ischemic pigs...
  8. ncbi request reprint Aortic valve surgery in octogenarians: predictive factors for operative and long-term results
    Philippe Kolh
    Cardiothoracic Surgery Department, University Hospital of Liege, Liege, Belgium
    Eur J Cardiothorac Surg 31:600-6. 2007
    ..To assess factors influencing operative and long-term outcome in octogenarians undergoing aortic valve surgery (AVR)...
  9. ncbi request reprint Early stage results after oesophageal resection for malignancy - colon interposition vs. gastric pull-up
    P Kolh
    Department of Cardio Thoracic Surgery, University Hospital of Liege, B35 Sart Tilman, 4000, Liege, Belgium
    Eur J Cardiothorac Surg 18:293-300. 2000
    ....
  10. doi request reprint Joint ESC/EACTS guidelines on myocardial revascularization
    Philippe Kolh
    Cardiovascular Surgery Department, University Hospital, CHU, ULg of Liege, Liege, Belgium
    J Cardiovasc Med (Hagerstown) 12:264-7. 2011
    ..Given the strong impact that ischaemic heart disease has on the survival and quality of life of the individual as well as the economic implications for society, the importance of the ESC/EACTS guidelines is obvious...
  11. ncbi request reprint Increased aortic compliance maintains left ventricular performance at lower energetic cost
    P Kolh
    Haemodynamic Research Center, University of Liege, Belgium
    Eur J Cardiothorac Surg 17:272-8. 2000
    ..The aim of this study was to investigate left ventricular contractility and energetic cost of cardiac ejection under conditions of acute increase in aortic compliance...
  12. ncbi request reprint Aortic valve replacement in the octogenarians: perioperative outcome and clinical follow-up
    P Kolh
    Cardiothoracic Surgery Department, University Hospital of Liege, Belgium
    Eur J Cardiothorac Surg 16:68-73. 1999
    ..To determine long-term results of aortic valve replacement (AVR) in patients 80 years old or older, and assess the factors influencing perioperative outcome...
  13. ncbi request reprint Analysis of factors influencing long-term survival after surgical resection for oesophageal squamous cell carcinoma
    P Kolh
    Department of Surgery, CHU Sart Tilman, Liege, Belgium
    Acta Chir Belg 99:113-8. 1999
    ..We evaluated prognostic factors in 34 patients discharged from hospital after surgical resection for oesophageal squamous cell carcinoma...
  14. ncbi request reprint Effects of BM-573, a novel thromboxane A2 inhibitor, on pulmonary hemodynamics in endotoxic shock
    B Lambermont
    Hemodynamics Research Laboratory HemoLiege, University of Liege, Belgium
    Arch Physiol Biochem 111:224-31. 2003
    ..Concomitant inhibition of TXA2 synthesis and of TXA2 receptors by BM-573 inhibited the pulmonary vasopressive response during the early phase of endotoxin shock as well as the deterioration in arterial oxygenation...
  15. ncbi request reprint Effects of U-46619 on pulmonary hemodynamics before and after administration of BM-573, a novel thromboxane A2 inhibitor
    B Lambermont
    Hemodynamics Research Laboratory HemoLiege, University of Liege, Belgium
    Arch Physiol Biochem 111:217-23. 2003
    ..Such molecule could be a promising therapeutic approach in TXA2 mediated pulmonary hypertension as it is the case in pulmonary embolism, hyperacute lung rejection and endotoxinic shock...
  16. ncbi request reprint Pharmacology of the thromboxane receptor antagonist and thromboxane synthase inhibitor BM-531
    J M Dogne
    University of Liege, Department of Medicinal Chemistry, Belgium
    Cardiovasc Drug Rev 19:87-96. 2001
    ..These results suggest that BM-531, which is devoid of the diuretic property of torasemide, can be regarded as a promising antiplatelet agent...
  17. ncbi request reprint Comparison between three- and four-element Windkessel models to characterize vascular properties of pulmonary circulation
    B Lambermont
    Hemodynamics Research Center HemoLiège, CHU Sart Tilman, University of Liege, Belgium
    Arch Physiol Biochem 105:625-32. 1997
    ....
  18. ncbi request reprint Effects of inhaled nitric oxide on pulmonary hemodynamics in a porcine model of endotoxin shock
    B Lambermont
    Hemodynamics Research Laboratory HemoLiege, University of Liege, Belgium
    Crit Care Med 27:1953-7. 1999
    ..To evaluate the effects of inhaled nitric oxide (NO) on pulmonary circulation in a porcine endotoxin shock model...
  19. ncbi request reprint Effect of hemodiafiltration on pulmonary hemodynamics in endotoxic shock
    B Lambermont
    Hemodynamics Research Laboratory HemoLiege, University of Liege, Liege, Belgium
    Artif Organs 27:1128-33. 2003
    ..Our results show that HDF must be used cautiously in septic shock since it can precipitate right heart failure by increasing pulmonary vascular resistance...
  20. ncbi request reprint Cardiac surgery in octogenarians; peri-operative outcome and long-term results
    P Kolh
    Cardiothoracic Surgery Department, , B 35 Sart Tilman, , Belgium
    Eur Heart J 22:1235-43. 2001
    ..CONCLUSION: Cardiac operations are successful in most octogenarians with increased hospital mortality, and longer hospital stay. Long-term survival and quality of life are good...
  21. ncbi request reprint Study of ventricular interaction during pulmonary embolism using clinical identification in a minimum cardiovascular system model
    Thomas Desaive
    Institute of Physics, University of Liege, Belgium
    Conf Proc IEEE Eng Med Biol Soc 2007:2976-9. 2007
    ..98% to 261.44% of the initial state. These results are an important first step towards model-based cardiac diagnosis in the Intensive Care Unit...
  22. ncbi request reprint Effects of dobutamine on left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs
    Philippe Kolh
    Hemodynamic Research Center HemoLiège, University of Liege, Liege, Belgium
    J Cardiovasc Pharmacol 45:144-52. 2005
    ..However, myocardial oxygen consumption was increased, and mechanical efficiency impaired...
  23. ncbi request reprint Open surgery for abdominal aortic aneurysm or aorto-iliac occlusive disease--clinical and ultrasonographic long-term results
    R Fontaine
    Cardiovascular Surgery Department, University Hospital of Liege, Liege, Belgium
    Acta Chir Belg 108:393-9. 2008
    ..To determine postoperative and long-term outcome and assess the relevance of abdominal ultrasound (US) after surgery for abdominal aortic aneurysm (AAA) or aortoiliac occlusive disease (AIOD)...
  24. ncbi request reprint Large-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs
    Bernard Lambermont
    Department of Medicine, University of Liege, Liege, Belgium
    Artif Organs 30:560-4. 2006
    ..In this model of porcine endotoxic shock, LPHF was responsible for a significant clearance of IL-6 (20 mL/min) and Il-10 (14 mL/min), and for an improvement in RV-vascular coupling...
  25. doi request reprint Effective arterial elastance as an index of pulmonary vascular load
    Philippe Morimont
    Hemodynamics Research Laboratory HemoLiege, University Hospital of Liege, Liege, Belgium
    Am J Physiol Heart Circ Physiol 294:H2736-42. 2008
    ..Thus Ea * (PV), defined as the ratio of RV Pes minus Pla to SV, provides a convenient, useful, and simple method to assess the pulmonary arterial load and its impact on the RV function...
  26. ncbi request reprint Pharmacological characterization of N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane A2 receptor antagonist and thromboxane synthase inhibitor in a rat model of arterial thrombosis and its effects on blee
    Jean Michel Dogne
    Natural and Synthetic Drug Research Center, University of Liege, Belgium
    J Pharmacol Exp Ther 309:498-505. 2004
    ..Moreover, BM-573 lost the diuretic property of torasemide and has no impact on glycemia...
  27. ncbi request reprint New developments on thromboxane modulators
    Jean Michel Dogne
    Natural and Synthetic Drug Research Centre, Medicinal Chemistry, University of Liege, 1, Av de l Hôpital, B 4000 Liege, Belgium
    Mini Rev Med Chem 4:649-57. 2004
    ..Therefore, TXA(2) modulators have been developed for 20 years. This review will highlight the evolution in the field of TXA(2) modulators...
  28. ncbi request reprint Effects of BM-573, a thromboxane A2 modulator on systemic hemodynamics perturbations induced by U-46619 in the pig
    Vincent Tchana-Sato
    Hemodynamic Research Center HemoLiège, University of Liege, Liege 4000, Belgium
    Prostaglandins Other Lipid Mediat 78:82-95. 2005
    ..In conclusion, BM-573 could therefore be a promising therapeutic approach in pathophysiological states where TXA2 plays a main role in the increase of vascular resistance like in pathologies such as systemic hypertension...
  29. ncbi request reprint Characterization of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig
    Jean Michel Dogne
    Natural and Synthetic Drugs Research Center, University of Liege, Liege, Belgium
    Thromb Res 116:431-42. 2005
    ....
  30. ncbi request reprint Effect of a novel thromboxane A2 inhibitor on right ventricular-arterial coupling in endotoxic shock
    Bernard Lambermont
    Hemodynamics Research Laboratory HemoLiege, Liege University, Belgium
    Shock 21:45-51. 2004
    ..In conclusion, dual TXA2 synthase inhibitor and receptor antagonists such as BM-573 have potential therapeutic applications, improving right ventricular efficiency and arterial oxygenation in endotoxic shock...
  31. ncbi request reprint Effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism
    Alexandre Ghuysen
    Hemodynamics Research Laboratory, University of Liege, Belgium
    J Pharmacol Exp Ther 310:964-72. 2004
    ..We conclude that in this animal model of acute pulmonary embolism, infusion of BM-573 reduced pulmonary vasoconstriction. As a result, right ventricular-vascular coupling values were maintained at a maximal efficiency level...
  32. ncbi request reprint New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators
    Jean Michel Dogne
    Natural and Synthetic Drug Research Center, Medicinal Chemistry, University of Liege, 1, Av de l Hôpital, B 4000 Liege, Belgium
    Curr Med Chem 11:1223-41. 2004
    ..In this review, we will propose a description of the recently described thromboxane modulators of major interest from both a pharmacological and a chemical point of view...
  33. ncbi request reprint Effects of increased afterload on left ventricular performance and mechanical efficiency are not baroreflex-mediated
    Philippe Kolh
    Haemodynamic Research Center HemoLiege, University of Liege, Liege, Belgium
    Eur J Cardiothorac Surg 24:912-9. 2003
    ..To assess baroreflex intervention during increase in left ventricular afterload, we compared the effects of aortic banding on the intact cardiovascular system and under hexamethonium infusion...
  34. ncbi request reprint Alteration of right ventricular-pulmonary vascular coupling in a porcine model of progressive pressure overloading
    Alexandre Ghuysen
    Hemodynamic Research Laboratory Hemoliege, Liege University, Belgium
    Shock 29:197-204. 2008
    ..05). In response to gradual increases in afterload, RV contractility reserve was recruited to a point of optimal coupling but submaximal efficiency. Further afterload increases led to RV-vascular uncoupling and failure...
  35. ncbi request reprint Effects of endotoxic shock on right ventricular systolic function and mechanical efficiency
    Bernard Lambermont
    Hemodynamics Research Laboratory HemoLiege, University of Liege, Liege, Belgium
    Cardiovasc Res 59:412-8. 2003
    ..To investigate the effects of endotoxin infusion on right ventricular (RV) systolic function and mechanical efficiency...
  36. ncbi request reprint Pharmacological profile and therapeutic potential of BM-573, a combined thromboxane receptor antagonist and synthase inhibitor
    Alexandre Ghuysen
    Hemodynamics Research Laboratory HemoLiege, University of Liege, Liege, Belgium
    Cardiovasc Drug Rev 23:1-14. 2005
    ..These results suggest that BM-573 should be viewed as a promising therapeutic agent in the treatment of pulmonary hypertension and syndromes associated with platelet activation...
  37. ncbi request reprint Comparison between single-beat and multiple-beat methods for estimation of right ventricular contractility
    Bernard Lambermont
    Hemodynamic Research Center, University of Liege, Liege, Belgium
    Crit Care Med 32:1886-90. 2004
    ..It was investigated whether pharmacologically induced changes in right ventricular contractility can be detected by a so-called "single-beat" method that does not require preload reduction...
  38. ncbi request reprint Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function
    J M Dogne
    Laboratory of Medicinal Chemistry, Department of Medicinal Chemistry, Natural and Synthetic Drugs Research Center, University of Liege, 1, Avenue de l Hopital, Liege, Belgium
    Prostaglandins Leukot Essent Fatty Acids 68:49-54. 2003
    ..These results indicate that BM-567 is a novel combined TXA(2) receptor antagonist and thromboxane synthase inhibitor characterized by a powerful antiplatelet potency...
  39. ncbi request reprint Prosthetic vascular infection complicated or not by aortoenteric fistula: comparison of treatment with and without cryopreserved allograft (homograft)
    J P Lavigne
    Cardiovascular Surgery Department, University Hospital of Liege, B35 Sart Tilman, 4000 Liege, Belgium
    Eur J Vasc Endovasc Surg 25:416-23. 2003
    ..in patients with vascular prosthesis infection, to compare surgical outcome and long-term results of cryopreserved allograft implantations to conventional surgery...
  40. doi request reprint A simplified model for mitral valve dynamics
    K T Moorhead
    Cardiovascular Research Center, University of Liege, 17 allée du 6 Août, Liege 4000, Belgium
    Comput Methods Programs Biomed 109:190-6. 2013
    ..In particular, the model provides a pathway to capturing these dysfunctions in terms of modeled stiffness or elastance that can be directly related to anatomical, structural defects and dysfunction...
  41. ncbi request reprint Arterial elastance and heart-arterial coupling in aortic regurgitation are determined by aortic leak severity
    Patrick Segers
    Hydraulics Laboratory, Institute Biomedical Technology, Ghent University, Gent, Belgium
    Am Heart J 144:568-76. 2002
    ....
  42. ncbi request reprint Cardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion
    Lieve Lanoye
    Hydraulics Laboratory, Institute Biomedical Technology, St Pietersnieuwstraat 41, 9000 Gent, Belgium
    Exp Physiol 92:127-37. 2007
    ....
  43. ncbi request reprint Determinants of left ventricular preload-adjusted maximal power
    Patrick Segers
    Hydraulics Laboratory, Institute Biomedical Technology, Ghent University, Belgium
    Am J Physiol Heart Circ Physiol 284:H2295-301. 2003
    ..09-1.42 mW/ml(2)) and was highly correlated with E(es) (r = 0.89, P < 0.001). In conclusion, correct preload adjustment of maximal LV power requires incorporation of V(0) and thus of data measured under altered loading conditions...
  44. ncbi request reprint Importance of risk stratification models in cardiac surgery
    Philippe Kolh
    Eur Heart J 27:768-9. 2006
  45. ncbi request reprint Diagnosis and treatment of peripheral arterial disease: recommendations for the medical practice in Belgium
    Denis Clement
    University of Ghent, Belgium
    Acta Chir Belg 107:595-604. 2007