Research Topics
Genomes and Genes
| Iwona WlodarskaSummaryAffiliation: Katholieke Universiteit Leuven Country: Belgium Publications
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Detail Information
Publications
FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrationsI Wlodarska
Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium
Leukemia 19:1299-305. 2005..However, over-representation of the FOXP1 locus found in one additional case of DLBCL may represent another potential mechanism underlying an increased expression of this gene...- Variant t(2;11)(p11;q13) associated with the IgK-CCND1 rearrangement is a recurrent translocation in leukemic small-cell B-non-Hodgkin lymphomaI Wlodarska
Center for Human Genetics, Katholieke Universiteit Leuven, Belgium
Leukemia 18:1705-10. 2004..Our findings indicate that variant t(2;11)(p11;q13) does not typify a classical MCL but possibly a more indolent leukemic lymphoma originating from an antigen experienced (mutated) B cell... 
Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomasIwona Wlodarska
Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium
Blood 111:5683-90. 2008..Clinically important is a predisposition of t(11;14)-negative MCLs to the central nervous system involvement...
Telomeric IGH losses detectable by fluorescence in situ hybridization in chronic lymphocytic leukemia reflect somatic VH recombination eventsIwona Wlodarska
Center for Human Genetics, Catholoc University Leuven, Leuven, Belgium
J Mol Diagn 9:47-54. 2007....- ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusionsKatrien Van Roosbroeck
Center for Human Genetics, K U Leuven, Gasthuisberg, Herestraat 49, Box 602, B 3000 Leuven, Belgium
Haematologica 95:509-13. 2010.... - Forkhead box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation to diffuse large B-cell lymphomaXavier Sagaert
Department of Morphology and Molecular Pathology, and the Centre for Human Genetics, Catholic University Leuven, Leuven, Belgium
J Clin Oncol 24:2490-7. 2006..In this study, we investigated FOXP1 expression in its relationship to morphology, genetic features, and prognosis in a series of 70 MALT lymphomas... - Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32)Kim De Keersmaecker
Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
Blood 105:4849-52. 2005..These data further demonstrate the involvement of ABL1 fusions in the pathogenesis of T-ALL and identify EML1-ABL1 as a novel therapeutic target of imatinib... - Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphomaIwona Wlodarska
Center for Human Genetics, Catholic University of Leuven, Belgium
Blood 101:706-10. 2003.... - Heterogeneity of BCL6 rearrangements in nodular lymphocyte predominant Hodgkin's lymphomaIwona Wlodarska
Center for Human Genetics, Katholieke Universiteit Leuven, Belgium
Haematologica 89:965-72. 2004..We present our results of metaphase-FISH analyses aimed at identifying and characterizing BCL6-related chromosomal translocations in NLPHL... - Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemiaMaria Kleppe
Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium
Nat Genet 42:530-5. 2010..Our study provides genetic and functional evidence for a tumor suppressor role of PTPN2 and suggests that expression of PTPN2 may modulate response to treatment... - JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphomaKatrien Van Roosbroeck
Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium
Blood 117:4056-64. 2011..The finding that SEC31A-JAK2 responds to JAK inhibitors indicates that patients with cHL and JAK2 rearrangements may benefit from targeted therapies... - Recurrent breakpoints in 14q32.13/TCL1A region in mature B-cell neoplasms with villous lymphocytesHelena Urbankova
Center for Human Genetics, KU Leuven, Leuven, Belgium
Leuk Lymphoma 53:2449-55. 2012..13/TCL1A-TCL6 region are recurrent in mature B-cell neoplasms with villous lymphocytes. Despite extensive qRT-PCR studies, molecular consequences of these novel aberrations remain elusive... - Fusion of ETV6 to GOT1 in a case with myelodysplastic syndrome and t(10;12)(q24;p13)Hilde Janssen
Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
Haematologica 91:949-51. 2006..This work identifies GOT1 as a novel fusion partner of ETV6 in myelodysplastic syndrome... - Alterations of loci encoding PU.1, BOB1, and OCT2 transcription regulators do not correlate with their suppressed expression in Hodgkin lymphomaFrancesco Cavazzini
Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium
Cancer Genet Cytogenet 158:167-71. 2005..These findings indicate that genomic imbalances or rearrangements are not a cause of PU.1, BOB1, and OCT2 deficiency in cHL and argue for another mechanism underlying this phenomenon... - Duplication of the MYB oncogene in T cell acute lymphoblastic leukemiaIdoya Lahortiga
Human Genome Laboratory, Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
Nat Genet 39:593-5. 2007..Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL... - Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusionIdoya Lahortiga
Human Genome Laboratory, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium
Haematologica 93:49-56. 2008..We report an unusual case of a patient presenting with peripheral basophilia and systemic mastocytosis in whom cytogenetic analysis revealed a t(4;5)(q21.1;q31.3)... - Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell non-Hodgkin's lymphomaMaria Kleppe
Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium
Haematologica 96:1723-7. 2011..These results, together with our own data on T-cell acute lymphoblastic leukemia, demonstrate that PTPN2 is a tumor suppressor gene in T-cell malignancies... - Interphase fluorescence in situ hybridization on selected plasma cells is superior in the detection of cytogenetic aberrations in plasma cell dyscrasiaNatalie Put
Centrum voor Menselijke Erfelijkheid, Katholieke Universiteit Leuven, Leuven, Belgium
Genes Chromosomes Cancer 49:991-7. 2010..001) and identified higher percentages of abnormal nuclei (P < 0.001). This study indicates that FISH on PCs is the preferred technique for routine cytogenetic investigation of MM... - MOHITO, a novel mouse cytokine-dependent T-cell line, enables studies of oncogenic signaling in the T-cell contextMaria Kleppe
Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium
Haematologica 96:779-83. 2011.... - Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignanciesFrancois P Duhoux
Center for Human Genetics, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
PLoS ONE 6:e26311. 2011..It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis... - t(X;14)(p11.4;q32.33) is recurrent in marginal zone lymphoma and up-regulates GPR34Mathijs Baens
Center for Human Genetics, KU Leuven, Leuven, Belgium
Haematologica 97:184-8. 2012..Although functional consequences of t(X;14) have not been identified, our studies suggest that up-regulated GPR34 activate neither nuclear factor-κB nor ELK-related tyrosine kinase... - MALT1 and BCL10 aberrations in MALT lymphomas and their effect on the expression of BCL10 in the tumour cellsXavier Sagaert
Division of Morphology and Molecular Pathology, Katholieke Universiteit Leuven, Leuven, Belgium
Mod Pathol 19:225-32. 2006.... - Comparative expressed sequence hybridization studies of hairy cell leukemia show uniform expression profile and imprint of spleen signatureVera Vanhentenrijk
Division of Morphology and Molecualr Pathology and Center for Human Genetics, Katholieke Universiteit Leuven, Belgium
Blood 104:250-5. 2004..3-q21 were the most significantly overexpressed. These regions possibly harbor genes related to the biology and the pathogenesis of HCL. Their identification warrants further molecular investigations... - Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignanciesBeata Katrincsakova
Center for Human Genetics, Catholic University Leuven, Leuven, Belgium
Epigenetics 4:469-75. 2009..These findings argue against the concept that a TSG/anti-oncomir located in the imprinted region is systematically inactivated by a targeted deletion of its functional allele... - The der(12)t(12;16) breakpoint in an acute leukaemia case targets a Sec7 domain containing proteinAnniek Corveleyn
Human Genome Laboratory, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium
Int J Oncol 26:1111-20. 2005..However, the putative SLAG-MYH11 fusions showed only weak transforming properties in NIH3T3 cells in a focus formation assay... - Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumorJan Cools
Center for Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB, University of Leuven, Campus Gasthuisberg O and N 06, Herestraat 49, B 3000 Leuven, Belgium
Genes Chromosomes Cancer 34:354-62. 2002..These results confirm the recurrent involvement of ALK in IMT and further demonstrate the diversity of ALK fusion partners, with the ability to homodimerize as a common characteristic... - Chronic lymphocytic leukemia and prolymphocytic leukemia with MYC translocations: a subgroup with an aggressive disease courseNatalie Put
Center for Human Genetics, Catholic University of Leuven, Belgium
Ann Hematol 91:863-73. 2012..In conclusion, CLL/PLL with MYC translocations is a rare entity, which seems to be associated with adverse prognostic features and unfavorable outcome... - Accurate determination of copy number variations (CNVs): application to the alpha- and beta-defensin CNVsHilde Nuytten
Department of Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium
J Immunol Methods 344:35-44. 2009..This strategy can be easily transferred to any CNV. With this method we structurally analyzed the alpha- and beta-defensin region in 334 Belgian individuals... - Fluorescence in situ hybridization study of chromosome 7 aberrations in hepatosplenic T-cell lymphoma: isochromosome 7q as a common abnormality accumulating in forms with features of cytologic progressionIwona Wlodarska
Center for Human Genetics, University of Leuven, Leuven, Belgium
Genes Chromosomes Cancer 33:243-51. 2002..An increased number of 7q signals was found in three cases with cytologic features of progression, indicating a tendency of HSTCL to multiply the i(7)(q10) chromosome during evolution... - Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemiaKim De Keersmaecker
1 Center for Human Genetics, KU Leuven, Leuven, Belgium 2 Center for the Biology of Disease, VIB, Leuven, Belgium 3
Nat Genet 45:186-90. 2013..Our data provide insights into the mutational landscape of pediatric versus adult T-ALL and identify the ribosome as a potential oncogenic factor... - Two new translocations involving the 11q23 region map outside the MLL locus in myeloid leukemiasEmilia Giugliano
Medicina Interna II, Dipartimento di Scienze Cliniche e Biologiche, Osp S Luigi Gonzaga, Orbassano, Italy
Haematologica 87:1014-20. 2002..In these two patients, involvement of the MLL gene was analyzed by molecular cytogenetic techniques which also allowed a more precise mapping of the breakpoints... - PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangementsBruce Poppe
Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
Genes Chromosomes Cancer 44:218-23. 2005..In addition, the recurrent incidence of this rearrangement in both HRTR-BCL (4 cases) and PTLD-DLBCL (2 cases) was previously unrecognized and is intriguing... - Leukemic recombinations involving heterochromatin in myeloproliferative disorders with t(1;9)Constantina Sambani
Laboratory of Health Physics and Environmental Hygiene, NCSR Demokritos, 15310 Aghia Paraskevi, Athens, Greece
Cancer Genet Cytogenet 162:45-9. 2005..The molecular event underlying juxtaposition of satellite II of chromosome 1 and the satellite III of chromosome 9 remains to be elucidated... - Validation of an interphase fluorescence in situ hybridization approach for the detection of MLL gene rearrangements and of the MLL/AF9 fusion in acute myeloid leukemiaFrancesco Cavazzini
Dipartimento di Scienze Biomediche e Terapie Avanzate, Sezione di Ematologia, University of Ferrara, Italy
Haematologica 91:381-5. 2006..This is a reliable method for the identification of MLL/AF9 fusion in interphase cells, allowing for a reclassification of cases with suboptimal chromosome morphology. The frequency of deletion surrounding MLL and AF9 breakpoint is low... - PVRL2 is translocated to the TRA@ locus in t(14;19)(q11;q13)-positive peripheral T-cell lymphomasCarole Almire
Groupe d Etude des Proliférations Lymphoides GPL, European Institute for Peptides Research IFRMP23, Centre Henri Becquerel, Rouen, France
Genes Chromosomes Cancer 46:1011-8. 2007..These results suggest that both BCL3 and PVRL2 may participate in the pathogenesis of these PTCLs, but further studies should be undertaken to investigate the precise role of these genes... - Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphomaJose I Martin-Subero
Blood 108:401-2; author reply 402-3. 2006 - Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13)Jan Cools
Human Genome Laboratory, Center for Human Genetics Flanders Interuniversity Institute for Biotechnology VIB, University of Leuven, Belgium
Blood 99:1776-84. 2002.... - A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndromeJan Cools
Brigham and Women s Hospital and Harvard Medical School, Boston, USA
N Engl J Med 348:1201-14. 2003..Recent reports of responses to imatinib in patients with the syndrome suggested that an activated kinase such as ABL, platelet-derived growth factor receptor (PDGFR), or KIT, all of which are inhibited by imatinib, might be the cause... - ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphomaPascale De Paepe
Department of Pathology, Center of Medical Genetics and Pediatric Oncology, Ghent University Hospital, Belgium
Blood 102:2638-41. 2003..Although a similar CLTC-ALK aberration was previously identified in ALK-positive T-/null cell ALCL and inflammatory myofibroblastic tumor, its association with ALK-positive LBCL seems to be specific and intriguing... - Large cleaved and immunoblastic lymphoma may represent two distinct clinicopathologic entities within the group of diffuse large B-cell lymphomasPascale De Paepe
Department of Pathology, Ghent University Hospital, Ghent, Belgium
J Clin Oncol 23:7060-8. 2005..Furthermore, we investigated whether both subgroups could comprise clinicopathologic entities recognized by their morphology and characterized by a distinct phenotype, specific genetic abnormalities, and clinical characteristics... - Comparative genomic hybridization pattern distinguishes T-cell/histiocyte-rich B-cell lymphoma from nodular lymphocyte predominance Hodgkin's lymphomaSabine Franke
Department of Human Genetics, Catholic University of Leuven, Belgium
Am J Pathol 161:1861-7. 2002..Altogether, our CGH findings of shared as well as distinctive cytogenetic features in both diseases suggest that T/HRBCL constitutes a separate lymphoma entity, possibly originating from the same precursor cell as LPHL... - Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosisRoss L Levine
Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Cell 7:387-97. 2005..In vitro analysis demonstrated that JAK2V617F is a constitutively active tyrosine kinase... - Prognostic significance of nuclear and cytoplasmic expression of metallothioneins as related to proliferative activity in squamous cell carcinomas of oral cavityJolanta Szelachowska
Department of Oncology, Wroclaw Medical University, Wroclaw, Poland
Histol Histopathol 23:843-51. 2008..Conclusion: This is relevant evidence that MT overexpression could be related to worse prognosis in patients with oral cancer. We have found no relationship between MT expression and proliferative activity... - NOTCH2 mutations in marginal zone lymphomaGunhild Trøen
Haematologica 93:1107-9. 2008 - Is there a difference in childhood T-cell acute lymphoblastic leukaemia and T-cell lymphoblastic lymphoma?Anne Uyttebroeck
Department of Paediatric Haemato Oncology, University Hospital Leuven, Belgium
Leuk Lymphoma 48:1745-54. 2007....