Joris Vriens

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4
    Joris Vriens
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 282:12796-803. 2007
  2. doi request reprint TRPM3 is a nociceptor channel involved in the detection of noxious heat
    Joris Vriens
    Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, 3000 Leuven, Belgium
    Neuron 70:482-94. 2011
  3. ncbi request reprint Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:47044-51. 2002
  4. ncbi request reprint Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 424:434-8. 2003
  5. ncbi request reprint TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells
    Joris Vriens
    Department of Physiology, Campus Gasthuisberg, Katholieke Universiteit, B 3000 Leuven, Belgium
    Cell Calcium 36:19-28. 2004
  6. ncbi request reprint Molecular determinants of permeation through the cation channel TRPV4
    Thomas Voets
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 277:33704-10. 2002
  7. ncbi request reprint TRPV4 calcium entry channel: a paradigm for gating diversity
    Bernd Nilius
    Laboratorium voor Fysiologie, KU Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium
    Am J Physiol Cell Physiol 286:C195-205. 2004
  8. ncbi request reprint Modulation of TRPV4 gating by intra- and extracellular Ca2+
    Hiroyuki Watanabe
    Department of Physiology, Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Cell Calcium 33:489-95. 2003
  9. ncbi request reprint The TRPV4 channel: structure-function relationship and promiscuous gating behaviour
    Bernd Nilius
    Department of Physiology, KU Leuven, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Pflugers Arch 446:298-303. 2003
  10. ncbi request reprint Invertebrate TRP proteins as functional models for mammalian channels
    Joris Vriens
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    Pflugers Arch 449:213-26. 2004

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4
    Joris Vriens
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 282:12796-803. 2007
    ....
  2. doi request reprint TRPM3 is a nociceptor channel involved in the detection of noxious heat
    Joris Vriens
    Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, 3000 Leuven, Belgium
    Neuron 70:482-94. 2011
    ..These experiments reveal an unanticipated role for TRPM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat...
  3. ncbi request reprint Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:47044-51. 2002
    ..The failure to activate TRPV4 channels by heat in inside-out patches, which responded to 4alphaPDD, may indicate that heat activation depends on the presence of an endogenous ligand, which is missing in inside-out patches...
  4. ncbi request reprint Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 424:434-8. 2003
    ..Activation of TRPV4 in vascular endothelial cells might therefore contribute to the relaxant effects of endocannabinoids and their P450 epoxygenase-dependent metabolites on vascular tone...
  5. ncbi request reprint TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells
    Joris Vriens
    Department of Physiology, Campus Gasthuisberg, Katholieke Universiteit, B 3000 Leuven, Belgium
    Cell Calcium 36:19-28. 2004
    ..HGF/SF increases Ca(2+) entry via TRPV1, but not via TRPV4. This rise in [Ca(2+)](i) may constitute an early response of a signalling cascade that gives rise to cell locomotion and the migratory phenotype...
  6. ncbi request reprint Molecular determinants of permeation through the cation channel TRPV4
    Thomas Voets
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 277:33704-10. 2002
    ..Our findings delineate the pore region of TRPV4 and give a first insight into the possible architecture of its permeation pathway...
  7. ncbi request reprint TRPV4 calcium entry channel: a paradigm for gating diversity
    Bernd Nilius
    Laboratorium voor Fysiologie, KU Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium
    Am J Physiol Cell Physiol 286:C195-205. 2004
    ..This review summarizes data on TRPV4 as a paradigm of gating diversity in this subfamily of Ca2+ entry channels...
  8. ncbi request reprint Modulation of TRPV4 gating by intra- and extracellular Ca2+
    Hiroyuki Watanabe
    Department of Physiology, Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Cell Calcium 33:489-95. 2003
    ....
  9. ncbi request reprint The TRPV4 channel: structure-function relationship and promiscuous gating behaviour
    Bernd Nilius
    Department of Physiology, KU Leuven, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Pflugers Arch 446:298-303. 2003
    ..Possible functional roles of this channel will be correlated with its observed expression pattern. Finally, we discuss the structural determinants of TRPV4 channel function...
  10. ncbi request reprint Invertebrate TRP proteins as functional models for mammalian channels
    Joris Vriens
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    Pflugers Arch 449:213-26. 2004
    ....
  11. pmc Functional characterization of transient receptor potential channels in mouse urothelial cells
    Wouter Everaerts
    Department of Molecular Cell Biology, Laboratory Ion Channel Research, Campus Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Physiol Renal Physiol 298:F692-701. 2010
    ..These channels may contribute to the (mechano)sensory function of the urothelial layer and represent potential targets for the treatment of bladder dysfunction...
  12. ncbi request reprint Opening of an alternative ion permeation pathway in a nociceptor TRP channel
    Joris Vriens
    1 Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, Leuven, Belgium 2 Laboratory of Obstetrics and Experimental Gynaecology, KU Leuven, Leuven, Belgium
    Nat Chem Biol 10:188-95. 2014
    ..Our findings indicate that a single sensory TRP channel can encompass two distinct ionotropic chemoreceptors, which may have important ramifications for TRP channel function and pharmacology. ..
  13. pmc Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis
    Wouter Everaerts
    Laboratory of Ion Channel Research, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 107:19084-9. 2010
    ..HC-067047 did not affect bladder function in Trpv4(-/-) mice, demonstrating that its in vivo effects are on target. These results indicate that TRPV4 antagonists may provide a promising means of treating bladder dysfunction...
  14. ncbi request reprint Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:13569-77. 2002
    ..We concluded that the phorbol derivatives activate TRPV4 (VR-OAC, VRL-2, OTRPC4, TRP12) independently from protein kinase C, in a manner consistent with direct agonist gating of the channel...
  15. pmc Herbal Compounds and Toxins Modulating TRP Channels
    Joris Vriens
    Laboratory of Ion Channel Research, Department of Mol Cell Biology, Division of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Curr Neuropharmacol 6:79-96. 2008
    ..For this family, a striking number of empirical views have turned into mechanism-based actions of natural compounds. In this review we will give an overview of herbal compounds and toxins, which modulate TRP channels...
  16. doi request reprint TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts
    Ritsuko Masuyama
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, B 3000, Belgium
    Cell Metab 8:257-65. 2008
    ....
  17. pmc Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding
    Thomas Gevaert
    Department of Urology, University Hospital Gasthuisberg, Leuven, Belgium
    J Clin Invest 117:3453-62. 2007
    ..These data demonstrate a previously unrecognized role for TRPV4 in voiding behavior, raising the possibility that TRPV4 plays a critical role in urothelium-mediated transduction of intravesical mechanical pressure...