Thomas Voets

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint TRP Channels and Thermosensation
    Thomas Voets
    Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, Herestraat 49 bus 802, 3000, Leuven, Belgium
    Handb Exp Pharmacol 223:729-41. 2014
  2. ncbi request reprint TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli
    Thomas Voets
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, Campus Gasthuisberg O and N1, KU Leuven, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Nat Chem Biol 3:174-82. 2007
  3. pmc Modulation of TRPs by PIPs
    Thomas Voets
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, KU Leuven, Onderwijs and Navorsing 1, Herestraat 49 bus 802, 3000 Leuven, Belgium
    J Physiol 582:939-44. 2007
  4. doi request reprint Nicotine activates the chemosensory cation channel TRPA1
    Karel Talavera
    Laboratory for Ion Channel Research, Department of Molecular Cell Biology, KU Leuven, Leuven, Belgium
    Nat Neurosci 12:1293-9. 2009
  5. ncbi request reprint The selectivity filter of the cation channel TRPM4
    Bernd Nilius
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Belgium
    J Biol Chem 280:22899-906. 2005
  6. doi request reprint TRPM3 is a nociceptor channel involved in the detection of noxious heat
    Joris Vriens
    Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, 3000 Leuven, Belgium
    Neuron 70:482-94. 2011
  7. pmc TRPA1 acts as a cold sensor in vitro and in vivo
    Yuji Karashima
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, Campus Gasthuisberg O and N1, Katholieke Universiteit Leuven, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 106:1273-8. 2009
  8. doi request reprint Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators
    Yuji Karashima
    KU Leuven Department of Mol Cell Biology, Lab Ion Channel Research, Campus Gasthuisberg, Herestraat 49, Bus 802, B 3000, Leuven, Belgium
    Pflugers Arch 457:77-89. 2008
  9. ncbi request reprint Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice
    Nina D Ullrich
    Laboratorium voor Fysiologie, Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Cell Calcium 37:267-78. 2005
  10. doi request reprint Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3
    Dieter D'Hoedt
    Department of Physiology, Katholieke Universiteit Leuven, Campus Gasthuisberg, O and N 1, Herestraat 49 bus 802, Leuven, Belgium
    J Biol Chem 283:6272-80. 2008

Detail Information

Publications78

  1. ncbi request reprint TRP Channels and Thermosensation
    Thomas Voets
    Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, Herestraat 49 bus 802, 3000, Leuven, Belgium
    Handb Exp Pharmacol 223:729-41. 2014
    ..In this chapter, I provide a brief critical overview of current knowledge on the role of TRP channels in thermosensing and on the thermodynamic and molecular basis of their steep temperature dependence. ..
  2. ncbi request reprint TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli
    Thomas Voets
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, Campus Gasthuisberg O and N1, KU Leuven, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Nat Chem Biol 3:174-82. 2007
    ..Based on these findings, we present a Monod-Wyman-Changeux-type model explaining the combined effects of voltage, temperature and menthol on TRPM8 gating...
  3. pmc Modulation of TRPs by PIPs
    Thomas Voets
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, KU Leuven, Onderwijs and Navorsing 1, Herestraat 49 bus 802, 3000 Leuven, Belgium
    J Physiol 582:939-44. 2007
    ....
  4. doi request reprint Nicotine activates the chemosensory cation channel TRPA1
    Karel Talavera
    Laboratory for Ion Channel Research, Department of Molecular Cell Biology, KU Leuven, Leuven, Belgium
    Nat Neurosci 12:1293-9. 2009
    ..The identification of TRPA1 as a nicotine target suggests that existing models of nicotine-induced irritation should be revised and may facilitate the development of smoking cessation therapies with less adverse effects...
  5. ncbi request reprint The selectivity filter of the cation channel TRPM4
    Bernd Nilius
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Belgium
    J Biol Chem 280:22899-906. 2005
    ..Our findings delineate the selectivity filter of TRPM channels and provide the first insight into the molecular basis of monovalent cation selectivity...
  6. doi request reprint TRPM3 is a nociceptor channel involved in the detection of noxious heat
    Joris Vriens
    Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, 3000 Leuven, Belgium
    Neuron 70:482-94. 2011
    ..These experiments reveal an unanticipated role for TRPM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat...
  7. pmc TRPA1 acts as a cold sensor in vitro and in vivo
    Yuji Karashima
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, Campus Gasthuisberg O and N1, Katholieke Universiteit Leuven, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 106:1273-8. 2009
    ..Finally, cold plate and tail-flick experiments reveal TRPA1-dependent, cold-induced nociceptive behavior in mice. We conclude that TRPA1 acts as a major sensor for noxious cold...
  8. doi request reprint Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators
    Yuji Karashima
    KU Leuven Department of Mol Cell Biology, Lab Ion Channel Research, Campus Gasthuisberg, Herestraat 49, Bus 802, B 3000, Leuven, Belgium
    Pflugers Arch 457:77-89. 2008
    ....
  9. ncbi request reprint Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice
    Nina D Ullrich
    Laboratorium voor Fysiologie, Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Cell Calcium 37:267-78. 2005
    ..TRPM4 displayed a 10-fold higher affinity for block by flufenamic acid. Importantly, ATP4- blocked TRPM4 with high affinity (IC50 of 0.8+/-0.1 microM), whereas TRPM5 is insensitive to ATP4- at concentrations up to 1 mM...
  10. doi request reprint Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3
    Dieter D'Hoedt
    Department of Physiology, Katholieke Universiteit Leuven, Campus Gasthuisberg, O and N 1, Herestraat 49 bus 802, Leuven, Belgium
    J Biol Chem 283:6272-80. 2008
    ..Taken together, these data suggest that PACSIN 3 acts as an auxiliary protein of TRPV4 channel that not only affects the channel's subcellular localization but also modulates its function in a stimulus-specific manner...
  11. doi request reprint Lack of correlation between the amplitudes of TRP channel-mediated responses to weak and strong stimuli in intracellular Ca(2+) imaging experiments
    Yeranddy A Alpizar
    Laboratory for Ion Channel Research and TRP Research Platform Leuven TRPLe, Department of Molecular Cell Biology, KU Leuven, Belgium
    Cell Calcium 54:362-74. 2013
    ....
  12. pmc Functional characterization of transient receptor potential channels in mouse urothelial cells
    Wouter Everaerts
    Department of Molecular Cell Biology, Laboratory Ion Channel Research, Campus Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Physiol Renal Physiol 298:F692-701. 2010
    ..These channels may contribute to the (mechano)sensory function of the urothelial layer and represent potential targets for the treatment of bladder dysfunction...
  13. doi request reprint Mechanisms of transient receptor potential vanilloid 1 activation and sensitization by allyl isothiocyanate
    Maarten Gees
    Laboratory for Ion Channel Research, Department of Molecular Cell Biology and TRP Research Platform Leuven TRPLe, KU Leuven, Leuven, Belgium
    Mol Pharmacol 84:325-34. 2013
    ....
  14. ncbi request reprint TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and Golgi
    Frank Mahieu
    Department of Molecular Cell Biology, Division of Physiology, Laboratory of Ion Channel Research, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 282:3325-36. 2007
    ..Finally, aequorin-based measurements demonstrate that the TRPM8-independent menthol-induced Ca2+ release originates from both endoplasmic reticulum and Golgi compartments...
  15. ncbi request reprint Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4
    Bernd Nilius
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 280:6423-33. 2005
    ..Thus, the Ca(2+) sensitivity of TRPM4 is regulated by ATP, PKC-dependent phosphorylation, and calmodulin binding at the C terminus...
  16. pmc The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate
    Bernd Nilius
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Leuven, Belgium
    EMBO J 25:467-78. 2006
    ..Our data demonstrate that PIP2 is a strong positive modulator of TRPM4, and implicate the C-terminal PH domain in PIP2 action. PLC-mediated PIP2 breakdown may constitute a physiologically important brake on TRPM4 activity...
  17. ncbi request reprint Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 424:434-8. 2003
    ..Activation of TRPV4 in vascular endothelial cells might therefore contribute to the relaxant effects of endocannabinoids and their P450 epoxygenase-dependent metabolites on vascular tone...
  18. ncbi request reprint Heat activation of TRPM5 underlies thermal sensitivity of sweet taste
    Karel Talavera
    Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 438:1022-5. 2005
    ....
  19. ncbi request reprint The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
    Thomas Voets
    Laboratory of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 430:748-54. 2004
    ..Our results suggest a simple unifying principle that explains both cold and heat sensitivity in TRP channels...
  20. doi request reprint Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole
    Victor Meseguer
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, Campus Gasthuisberg O and N1, KU Leuven, B 3000 Leuven, Belgium
    J Neurosci 28:576-86. 2008
    ..Together, our results identify TRP channels in sensory neurons as molecular targets of CLT, and offer means to develop novel CLT preparations with fewer unwanted sensory side effects...
  21. pmc Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1
    Yuji Karashima
    Department of Molecular Cell Biology, Katholieke Universiteit Leuven, Belgium
    Biophys J 98:773-83. 2010
    ..We conclude that the pore of TRPA1 is dynamic and supports a surprisingly large Ca(2+) influx...
  22. doi request reprint Bimodal effects of cinnamaldehyde and camphor on mouse TRPA1
    Yeranddy A Alpizar
    Laboratory for Ion Channel Research and TRP Channel Research Platform, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium
    Pflugers Arch 465:853-64. 2013
    ..These findings are essential for the understanding of the complex sensory properties of these compounds, as well as their utility when used to study the pathophysiological relevance of TRPA1...
  23. ncbi request reprint The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions
    Karel Talavera
    Laboratory of Ion Channel Research, Dept of Molecular Cell Biology, Herestraat 49, Campus Gasthuisberg, O and N1, KU Leuven, B 3000 Leuven, Belgium
    FASEB J 22:1343-55. 2008
    ..The inhibition of TRPM5 by bitter compounds constitutes the molecular basis of a novel mechanism of taste interactions, whereby the bitter tastant inhibits directly the sweet transduction pathway...
  24. pmc Modulation of the cold-activated cation channel TRPM8 by surface charge screening
    Frank Mahieu
    KU Leuven, Laboratory of Ion Channel Research, Department of Molecular Cell Biology, Leuven, Belgium
    J Physiol 588:315-24. 2010
    ..These results represent the first description of the effects of surface charge screening on a TRP channel and provide a straightforward explanation for the known effects of extracellular Ca(2+) on cold-sensitive neurons...
  25. pmc Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice
    Barbara Colsoul
    Laboratory of Ion Channel Research and Gene Expression Unit, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, B 3001 Louvain, Belgium
    Proc Natl Acad Sci U S A 107:5208-13. 2010
    ..As a consequence, glucose-induced insulin release from Trpm5(-/-) pancreatic islets is significantly reduced, resulting in an impaired glucose tolerance in Trpm5(-/-) mice...
  26. pmc Crucial role of TRPC1 and TRPC4 in cystitis-induced neuronal sprouting and bladder overactivity
    Mathieu Boudes
    Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium
    PLoS ONE 8:e69550. 2013
    ..Since TRP channels have been implicated in the guidance of growth cones and survival of neurons, we investigated their involvement in the increases in bladder innervation and bladder activity in rodent models of cystitis...
  27. doi request reprint The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil
    Wouter Everaerts
    Laboratory for Ion Channel Research, Department of Molecular Cell Biology, KU Leuven, 3000 Leuven, Belgium
    Curr Biol 21:316-21. 2011
    ..We propose that TRPV1 has a generalized role in the detection of irritant botanical defensive traits and in the coevolution of multiple mammalian and plant species...
  28. doi request reprint Increased β-adrenergic inotropy in ventricular myocardium from Trpm4-/- mice
    Ilka Mathar
    From the Department of Molecular and Cellular Medicine, Laboratory of Ion Channel Research, Leuven, Belgium I M, M K, G J, T V, B N, R V Research Unit of Experimental Cardiac Surgery, KU Leuven, Leuven, Belgium G V d M, P H Pharmakologisches Institut, Universitat Heidelberg, Heidelberg, Germany I M, J E C L, S U, M F and Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat des Saarlandes, Homburg, Germany J E C L, V F, M F
    Circ Res 114:283-94. 2014
    ..The physiological function of TRPM4 in the heart remains, however, incompletely understood...
  29. ncbi request reprint Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b
    Bernd Nilius
    Laboratorium voor Fysiologie Campus Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    Pflugers Arch 448:70-5. 2004
    ..Spermine blocked TRPM4 currents with an IC(50) of 61 microM. In conclusion, TRPM4 is a channel that can be effectively modulated by intracellular nucleotides and polyamines...
  30. ncbi request reprint TRPV4 calcium entry channel: a paradigm for gating diversity
    Bernd Nilius
    Laboratorium voor Fysiologie, KU Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium
    Am J Physiol Cell Physiol 286:C195-205. 2004
    ..This review summarizes data on TRPV4 as a paradigm of gating diversity in this subfamily of Ca2+ entry channels...
  31. pmc Gating of TRP channels: a voltage connection?
    Bernd Nilius
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Leuven, Belgium
    J Physiol 567:35-44. 2005
    ..Some structural considerations will be given indicating that, although the voltage sensor is not yet known, the C-terminus may substantially change the voltage dependence of these channels...
  32. ncbi request reprint Outer pore architecture of a Ca2+-selective TRP channel
    Thomas Voets
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 279:15223-30. 2004
    ..However, the selectivity filter of TRPV6 is wider than that of K(+) channels and lined by amino acid side chains rather than main chain carbonyls...
  33. pmc Decavanadate modulates gating of TRPM4 cation channels
    Bernd Nilius
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Physiol 560:753-65. 2004
    ..These results indicate that the C-terminus of TRPM4 is critically involved in mediating the DV effects. In conclusion, decavanadate modulates TRPM4, but not TRPM5, by inhibiting voltage-dependent closure of the channel...
  34. doi request reprint Chronic administration of anticholinergics in rats induces a shift from muscarinic to purinergic transmission in the bladder wall
    Pieter Uvin
    Department of Development and Regeneration, Laboratory of Experimental Urology, Campus Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur Urol 64:502-10. 2013
    ..First-line pharmacotherapy for overactive bladder consists of anticholinergics. However, patient compliance is exceptionally low, which may be due to progressive loss of effectiveness...
  35. ncbi request reprint Voltage dependence of the Ca2+-activated cation channel TRPM4
    Bernd Nilius
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Leuven B 3000, Belgium
    J Biol Chem 278:30813-20. 2003
    ..Voltage dependence of TRPM4 may be functionally important, especially in excitable tissues generating plateau-like or bursting action potentials...
  36. pmc Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding
    Thomas Gevaert
    Department of Urology, University Hospital Gasthuisberg, Leuven, Belgium
    J Clin Invest 117:3453-62. 2007
    ..These data demonstrate a previously unrecognized role for TRPV4 in voiding behavior, raising the possibility that TRPV4 plays a critical role in urothelium-mediated transduction of intravesical mechanical pressure...
  37. pmc Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6
    Thomas Voets
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Belgium
    J Gen Physiol 121:245-60. 2003
    ..The effects of intracellular Mg(2+) on TRPV6 are partially reminiscent of the gating mechanism of inwardly rectifying K(+) channels and may represent a novel regulatory mechanism for TRPV6 function in vivo...
  38. ncbi request reprint Invertebrate TRP proteins as functional models for mammalian channels
    Joris Vriens
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    Pflugers Arch 449:213-26. 2004
    ....
  39. ncbi request reprint Bimodal action of menthol on the transient receptor potential channel TRPA1
    Yuji Karashima
    Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Neurosci 27:9874-84. 2007
    ....
  40. doi request reprint Functional characterization of a chronic cyclophosphamide-induced overactive bladder model in mice
    Mathieu Boudes
    Laboratory of Ion Channel Research, Department of Molecular Cell Biology, KU Leuven, Leuven, Belgium
    Neurourol Urodyn 30:1659-65. 2011
    ..To describe a new mouse model of overactive bladder (OAB) at the histological level, pain, voiding behavior, and urodynamics, while assessing the physiological state of mice...
  41. ncbi request reprint Opening of an alternative ion permeation pathway in a nociceptor TRP channel
    Joris Vriens
    1 Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, Leuven, Belgium 2 Laboratory of Obstetrics and Experimental Gynaecology, KU Leuven, Leuven, Belgium
    Nat Chem Biol 10:188-95. 2014
    ..Our findings indicate that a single sensory TRP channel can encompass two distinct ionotropic chemoreceptors, which may have important ramifications for TRP channel function and pharmacology. ..
  42. doi request reprint TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts
    Ritsuko Masuyama
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, B 3000, Belgium
    Cell Metab 8:257-65. 2008
    ....
  43. doi request reprint Regulation of the murine TRPP3 channel by voltage, pH, and changes in cell volume
    Takahiro Shimizu
    Department of Molecular Cell Biology, Laboratory of Ion Channel Research, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, Bus 802, B 3000, Leuven, Belgium
    Pflugers Arch 457:795-807. 2009
    ..Taken together, our results demonstrate that TRPP3, on its own, can act as a voltage-dependent, pH- and volume-sensitive plasma membrane cation channel...
  44. ncbi request reprint Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4
    Joris Vriens
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 282:12796-803. 2007
    ....
  45. doi request reprint Insulin downregulates the expression of the Ca2+-activated nonselective cation channel TRPM5 in pancreatic islets from leptin-deficient mouse models
    Barbara Colsoul
    Laboratory of Ion Channel Research, KU Leuven, Herestraat 49, Bus 802, Leuven, 3000, Belgium
    Pflugers Arch 466:611-21. 2014
    ..In conclusion, our data show that increased plasma insulin levels downregulate TRPM5 expression in pancreatic islets from leptin-deficient mouse models of type 2 diabetes. ..
  46. doi request reprint Allyl isothiocyanate sensitizes TRPV1 to heat stimulation
    Yeranddy A Alpizar
    Laboratory for Ion Channel Research, Department of Cellular and Molecular Medicine and TRP Research Platform Leuven TRPLe, KU Leuven, 3000, Leuven, Belgium
    Pflugers Arch 466:507-15. 2014
    ..Taken together, these findings demonstrate that TRPV1 is a locus for cross sensitization between AITC and heat in sensory neurons and may help explaining, at least in part, the role of this channel in AITC-induced hyperalgesia to heat. ..
  47. pmc Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis
    Wouter Everaerts
    Laboratory of Ion Channel Research, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 107:19084-9. 2010
    ..HC-067047 did not affect bladder function in Trpv4(-/-) mice, demonstrating that its in vivo effects are on target. These results indicate that TRPV4 antagonists may provide a promising means of treating bladder dysfunction...
  48. pmc Cholesterol loss during glutamate-mediated excitotoxicity
    Alejandro O Sodero
    VIB Center for Biology of Disease, Katholieke Universiteit Leuven, Leuven, Belgium
    EMBO J 31:1764-73. 2012
    ..This study underscores the key role of excitatory neurotransmission in the control of membrane lipid composition, and consequently in neuronal membrane organization and function...
  49. pmc Ligand stoichiometry of the cold- and menthol-activated channel TRPM8
    Annelies Janssens
    Laboratory of Ion Channel Research and TRP Research Platform Leuven, KU Leuven, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    J Physiol 589:4827-35. 2011
    ..These results suggest a fundamentally different ligand stoichiometry in TRP channels, in comparison with other major families of ligand-gated ion channels...
  50. ncbi request reprint Sensing with TRP channels
    Thomas Voets
    Laboratory of Physiology, Campus Gasthuisberg O and N, KU Leuven, B 3000 Leuven, Belgium
    Nat Chem Biol 1:85-92. 2005
    ..Activation of TRP channels is highly sensitive to a variety of chemical and physical stimuli, allowing them to function as dedicated biological sensors that are essential in processes such as vision, taste, tactile sensation and hearing...
  51. ncbi request reprint Diversity of TRP channel activation
    Bernd Nilius
    KU Leuven, Department of Physiology, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Novartis Found Symp 258:140-9; discussion 149-59, 263-6. 2004
    ..Regulation of channel availability by interaction with a protein bound to a site at the C-terminus of both channels will be demonstrated. Functional consequences of these different mechanisms of gating will be discussed...
  52. ncbi request reprint TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption
    Thomas Voets
    Department of Physiology, Campus Gasthuisberg, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Biol Chem 279:19-25. 2004
    ..Our data indicate that TRPM6 comprises all or part of the apical Mg2+ channel of Mg2+-absorbing epithelia...
  53. doi request reprint TRPs in our senses
    Nils Damann
    Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Curr Biol 18:R880-9. 2008
    ....
  54. ncbi request reprint Quantifying and modeling the temperature-dependent gating of TRP channels
    Thomas Voets
    Laboratory of Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, Herestraat 49 bus 802, 3000 Leuven, Belgium
    Rev Physiol Biochem Pharmacol 162:91-119. 2012
    ..This review may form a useful reference for the analysis and interpretation of further biophysical and structure-function studies dissecting the molecular basis of thermosensitivity in TRP channels...
  55. ncbi request reprint TRP channels in disease
    Bernd Nilius
    Department of Physiology, Campus Gasthuisberg Katholieke Universiteit, Leuven, Belgium
    Sci STKE 2005:re8. 2005
    ..An understanding of the genetics of disease may lead to the development of targeted new therapies...
  56. ncbi request reprint Permeation and selectivity of TRP channels
    Grzegorz Owsianik
    Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Annu Rev Physiol 68:685-717. 2006
    ..This review gives an overview of available experimental and theoretical data and discusses the functional impact of pore-structure modifications on TRP channel properties...
  57. ncbi request reprint Differential effects of bitter compounds on the taste transduction channels TRPM5 and IP3 receptor type 3
    Maarten Gees
    Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, Herestraat 49, Campus Gasthuisberg, O and N1 Box 802, KU Leuven, B 3000 Leuven, Belgium
    Chem Senses 39:295-311. 2014
    ..Our results demonstrate that bitter compounds have differential effects on key elements of the sweet taste transduction pathway, suggesting for heterogeneous mechanisms of bitter-sweet taste interactions. ..
  58. doi request reprint Bladder dysfunction in a transgenic mouse model of multiple system atrophy
    Mathieu Boudes
    Laboratory of Biomarkers, Screening and Diagnosis, Department of Development and Regeneration, KU Leuven, Leuven, Belgium
    Mov Disord 28:347-55. 2013
    ..PLP-hαSyn mice recapitulate major urological symptoms of human MSA that may be linked to αSyn-related central and peripheral neuropathology and can be further used as a preclinical model to decipher pathomechanisms of MSA...
  59. pmc Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse
    Ine Vandewauw
    Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine and TRP Research Platform Leuven, KU Leuven, Leuven, Belgium
    BMC Neurosci 14:21. 2013
    ....
  60. doi request reprint TRP channels
    Maarten Gees
    Laboratory Ion Channel Research and TRP Research Platform Leuven TRPLe, KU Leuven, Campus Gasthuisberg, Leuven, Belgium
    Compr Physiol 2:563-608. 2012
    ..In this article, we provide a brief and systematic summary of expression, function, and (patho)physiological role of the mammalian TRP channels...
  61. doi request reprint Trpv5/6 is vital for epithelial calcium uptake and bone formation
    Jo Vanoevelen
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre, Utrecht, The Netherlands
    FASEB J 25:3197-207. 2011
    ..Taken together, this study provides both genetic and functional evidence that transcellular epithelial calcium uptake is vital to sustain life and enable bone formation...
  62. pmc The puzzle of TRPV4 channelopathies
    Bernd Nilius
    KU Leuven, Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, Campus Gasthuisberg, Leuven, Belgium
    EMBO Rep 14:152-63. 2013
    ..Putative mechanisms to explain the puzzle, and how mutations in the same region of the channel cause different diseases, are discussed and experimental approaches to tackle this surprising problem are suggested...
  63. pmc Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein
    Bert Billen
    Laboratory of Structural Neurobiology, KU Leuven, 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 109:9173-8. 2012
    ..Together, this study analyzes molecular recognition of smoking cessation drugs by nAChRs in a structural context...
  64. ncbi request reprint The pore of TRP channels: trivial or neglected?
    Thomas Voets
    Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Cell Calcium 33:299-302. 2003
    ....
  65. doi request reprint Neuronal TRP channels: thermometers, pathfinders and life-savers
    Karel Talavera
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, KU Leuven, Campus Gasthuisberg O and N1, Herestraat 49 bus 802, 3000 Leuven, Belgium
    Trends Neurosci 31:287-95. 2008
    ....
  66. pmc Transient receptor potential channels meet phosphoinositides
    Bernd Nilius
    Department of Molecular Cell Biology, Laboratory of Ion Channel Research, Campus Gasthuisberg, KU Leuven, Belgium
    EMBO J 27:2809-16. 2008
    ..In this review, we summarize current knowledge about the mechanisms of interaction between TRP channels and PIPs, and discuss the possible functional implications of TRP-PIP interactions to human physiology and pathophysiology...
  67. doi request reprint Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice
    Valerie Hox
    Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KULeuven, Leuven, Belgium
    Am J Respir Crit Care Med 187:486-93. 2013
    ..Conclusions: Induction of AHR by exposure to ClO(-)-OVA depends on a neuroimmune interaction that involves TRPA1-dependent stimulation of sensory neurons and mast cell activation...
  68. ncbi request reprint Transient receptor potential cation channels in disease
    Bernd Nilius
    Department of Physiology, Campus Gasthuisberg, KULeuven, Leuven, Belgium
    Physiol Rev 87:165-217. 2007
    ..In this review, we provide an overview of the impact of TRP channels on the pathogenesis of several diseases and identify several TRPs for which a causal pathogenic role might be anticipated...
  69. doi request reprint A TRP channel-steroid marriage
    Bernd Nilius
    Department of Molecular Cell Biology, Laboratory of Ion Channel Research, KU Leuven, Campus Gasthuisberg, Herestraat 49, Bus 802, B 3000 Leuven, Belgium
    Nat Cell Biol 10:1383-4. 2008
    ..A surprising functional association between TRPM3, a mysterious member of the family of transient receptor potential (TRP) cation channels, and the sulphated version of pregnenolone, 'mother' of all steroid hormones, has been identified...
  70. pmc TRP channels in neurogastroenterology: opportunities for therapeutic intervention
    Werend Boesmans
    TARGID Translational Research Center for Gastrointestinal Disorders, KULeuven, Leuven, Belgium
    Br J Pharmacol 162:18-37. 2011
    ..However, their role in gastrointestinal pathophysiology first needs to be further elucidated...
  71. ncbi request reprint TRP channels: a TR(I)P through a world of multifunctional cation channels
    Bernd Nilius
    Laboratorium voor Fysiologie, Department of Physiology, Campus Gasthuisberg, KU Leuven, Leuven 3000, Belgium
    Pflugers Arch 451:1-10. 2005
    ..Hopefully, a better understanding of TRP channel physiology will provide important insight into the relationship between TRP channel dysfunction and human diseases...
  72. ncbi request reprint Molecular determinants of permeation through the cation channel TRPV4
    Thomas Voets
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 277:33704-10. 2002
    ..Our findings delineate the pore region of TRPV4 and give a first insight into the possible architecture of its permeation pathway...
  73. ncbi request reprint CAPS1 regulates catecholamine loading of large dense-core vesicles
    Dina Speidel
    Max Planck Institut fur experimentelle Medizin, Abteilung Molekulare Neurobiologie, D 37075 Gottingen, Germany
    Neuron 46:75-88. 2005
    ..We conclude that CAPS1 is required for an essential step in the uptake or storage of catecholamines in LDCVs...
  74. pmc Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport
    Tim T Lambers
    Department of Physiology, Radboud University Nijmegen Medical Centre, The Netherlands
    EMBO J 25:2978-88. 2006
    ..In summary, CaBP(28K) acts in Ca(2+)-transporting epithelia as a dynamic Ca(2+) buffer, regulating [Ca(2+)] in close vicinity to the TRPV5 pore by direct association with the channel...
  75. pmc Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia
    Matthew J Rock
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Nat Genet 40:999-1003. 2008
    ..This study thus defines a previously unknown mechanism, activation of a calcium-permeable TRP ion channel, in skeletal dysplasia pathogenesis...
  76. ncbi request reprint Additional fluxes of activator Ca2+ accompanying Ca2+ release from the sarcoplasmic reticulum triggered by insP3-mobilizing agonists
    Luc Raeymaekers
    Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Belgium
    Novartis Found Symp 246:71-6; discussion 76-80, 221-7. 2002
    ..The best-characterized SOC current, mainly observed in blood cells, is Icrac Recently, it has been proposed that CaTI (TRPV5) forms at least part of the pore of CRAC. This view is challenged by data from our laboratory...
  77. pmc The SNARE protein SNAP-25 is linked to fast calcium triggering of exocytosis
    Jakob B Sørensen
    Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 99:1627-32. 2002
    ..We conclude that the SNARE complex is linked directly to calcium triggering of exocytosis, most likely in a complex with auxiliary proteins...