G M Verleden

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Assessment of asthma severity and treatment by GPs in Belgium: an Asthma Drug Utilization Research Study (ADUR)
    G M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    Respir Med 96:170-7. 2002
  2. pmc Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD
    Geert R Van Pottelberge
    Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    Respir Res 11:35. 2010
  3. ncbi request reprint Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome
    Geert M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Respir Crit Care Med 174:566-70. 2006
  4. ncbi request reprint Effect of azithromycin on bronchiectasis and pulmonary function in a heart-lung transplant patient with severe chronic allograft dysfunction: a case report
    Geert M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    J Heart Lung Transplant 24:1155-8. 2005
  5. ncbi request reprint Is it bronchiolitis obliterans syndrome or is it chronic rejection: a reappraisal?
    G M Verleden
    University Hospital Gasthuisberg, Dept of Respiratory Diseases and Lung Transplantation Unit 49, Herestraat, B 3000 Leuven, Belgium
    Eur Respir J 25:221-4. 2005
  6. ncbi request reprint Accuracy of exhaled nitric oxide measurements for the diagnosis of bronchiolitis obliterans syndrome after lung transplantation
    Geert M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, 49 Herestraat, B 3000 Leuven
    Transplantation 78:730-3. 2004
  7. ncbi request reprint Azithromycin therapy for patients with bronchiolitis obliterans syndrome after lung transplantation
    Geert M Verleden
    University Hospital Gasthuisberg, Department of Respiratory Medicine and Lung Transplantation Unit, Leuven, Belgium
    Transplantation 77:1465-7. 2004
  8. ncbi request reprint Effect of switching from cyclosporine to tacrolimus on exhaled nitric oxide and pulmonary function in patients with chronic rejection after lung transplantation
    Geert M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    J Heart Lung Transplant 22:908-13. 2003
  9. ncbi request reprint Exhaled nitric oxide after lung transplantation: impact of the native lung
    G M Verleden
    Dept of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    Eur Respir J 21:429-32. 2003
  10. ncbi request reprint Cyclophosphamide rescue therapy for chronic rejection after lung transplantation
    G M Verleden
    Department of Respiratory Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    J Heart Lung Transplant 18:1139-42. 1999

Collaborators

Detail Information

Publications84

  1. ncbi request reprint Assessment of asthma severity and treatment by GPs in Belgium: an Asthma Drug Utilization Research Study (ADUR)
    G M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    Respir Med 96:170-7. 2002
    ..Improvement of the assessment of asthma severity is definitely needed and may lead to more appropriate use of asthma medication...
  2. pmc Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD
    Geert R Van Pottelberge
    Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    Respir Res 11:35. 2010
    ..The aim of this study is to characterize and quantify pulmonary myeloid DC subsets in small airways of current and ex-smokers with or without COPD...
  3. ncbi request reprint Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome
    Geert M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Respir Crit Care Med 174:566-70. 2006
    ..Bronchiolitis obliterans syndrome (BOS) remains the leading cause of death after lung transplantation. Treatment is difficult, although azithromycin has recently been shown to improve FEV(1). The exact mechanism of action is unclear...
  4. ncbi request reprint Effect of azithromycin on bronchiectasis and pulmonary function in a heart-lung transplant patient with severe chronic allograft dysfunction: a case report
    Geert M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    J Heart Lung Transplant 24:1155-8. 2005
    ..This case report illustrates that bronchiectasis may greatly improve after treatment with azithromycin and no longer needs to be considered an endstage finding in patients with severe BOS...
  5. ncbi request reprint Is it bronchiolitis obliterans syndrome or is it chronic rejection: a reappraisal?
    G M Verleden
    University Hospital Gasthuisberg, Dept of Respiratory Diseases and Lung Transplantation Unit 49, Herestraat, B 3000 Leuven, Belgium
    Eur Respir J 25:221-4. 2005
    ....
  6. ncbi request reprint Accuracy of exhaled nitric oxide measurements for the diagnosis of bronchiolitis obliterans syndrome after lung transplantation
    Geert M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, 49 Herestraat, B 3000 Leuven
    Transplantation 78:730-3. 2004
    ..Exhaled nitric oxide (eNO) is increased in patients with bronchiolitis obliterans syndrome (BOS) after lung transplantation. However, the accuracy of eNO measurements in diagnosing BOS is unknown...
  7. ncbi request reprint Azithromycin therapy for patients with bronchiolitis obliterans syndrome after lung transplantation
    Geert M Verleden
    University Hospital Gasthuisberg, Department of Respiratory Medicine and Lung Transplantation Unit, Leuven, Belgium
    Transplantation 77:1465-7. 2004
    ..Bronchiolitis obliterans syndrome (BOS) is the leading cause of late mortality after lung transplantation...
  8. ncbi request reprint Effect of switching from cyclosporine to tacrolimus on exhaled nitric oxide and pulmonary function in patients with chronic rejection after lung transplantation
    Geert M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    J Heart Lung Transplant 22:908-13. 2003
    ..We report the concomitant stabilization of FEV(1) and decrease in eNO after changing from CyA to FK therapy in patients with chronic rejection after lung transplantation...
  9. ncbi request reprint Exhaled nitric oxide after lung transplantation: impact of the native lung
    G M Verleden
    Dept of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    Eur Respir J 21:429-32. 2003
    ..The diseased native lung after single lung transplantation probably does not contribute much to the exhaled nitric oxide values, either in stable lung transplant patients or in lung transplant patients with chronic rejection...
  10. ncbi request reprint Cyclophosphamide rescue therapy for chronic rejection after lung transplantation
    G M Verleden
    Department of Respiratory Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    J Heart Lung Transplant 18:1139-42. 1999
    ..We therefore conducted an open, uncontrolled study to look at the effect of cyclophosphamide rescue therapy in the treatment of chronic rejection in lung transplant recipients...
  11. ncbi request reprint The effect of cigarette smoking on exhaled nitric oxide in mild steroid-naive asthmatics
    G M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    Chest 116:59-64. 1999
    ..We hypothesized that cigarette smoking would reduce the eNO level in steroid-naive asthmatics and might, therefore, affect the correlation between eNO and airway hyperresponsiveness...
  12. doi request reprint The role of the IL23/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation
    B M Vanaudenaerde
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Transplant 8:1911-20. 2008
    ..IL6, IL1beta and IL23 seem to be skewing cytokines and IL2 a counteracting cytokine for T(H)17 alignment. The involvement of TGF-beta could not be confirmed, either as T(H)17 steering or as counteracting cytokine...
  13. doi request reprint A dichotomy in bronchiolitis obliterans syndrome after lung transplantation revealed by azithromycin therapy
    B M Vanaudenaerde
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur Respir J 32:832-43. 2008
    ....
  14. doi request reprint C-reactive protein in bronchoalveolar lavage fluid is associated with markers of airway inflammation after lung transplantation
    R Vos
    Lung Transplantation Unit, Katholieke Universiteit Leuven and University Hospital Gasthuisberg, B 3000 Leuven, Belgium
    Transplant Proc 41:3409-13. 2009
    ..We hypothesized that CRP in bronchoalveolar lavage (BAL) fluid might be associated with airway inflammation or remodeling. Therefore, it could play a role in the development of bronchiolitis obliterans syndrome (BOS)...
  15. doi request reprint A randomised controlled trial of azithromycin to prevent chronic rejection after lung transplantation
    R Vos
    Laboratory of Pneumology, Lung Transplantation Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Eur Respir J 37:164-72. 2011
    ..050) over time. Open-label azithromycin for BOS improved FEV₁ in 52.2% patients. No serious adverse events were noted. Azithromycin prophylaxis attenuates local and systemic inflammation, improves FEV₁ and reduces BOS 2 yrs after LTx...
  16. doi request reprint Plasma C-reactive protein levels correlate with markers of airway inflammation after lung transplantation: a role for systemic inflammation in bronchiolitis obliterans syndrome?
    R Vos
    Lung Transplantation Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Transplant Proc 41:595-8. 2009
    ..We hypothesized that in Ltx, systemic inflammation may be associated with airway inflammation, which has an important role in the development of chronic allograft dysfunction or bronchiolitis obliterans syndrome after LTx...
  17. ncbi request reprint Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells
    B M Vanaudenaerde
    Laboratorium of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Transplant 7:76-82. 2007
    ..In BOS patients, these phenomena may explain the anti-inflammatory effects of azithromycin...
  18. doi request reprint Azithromycin reduces pulmonary fibrosis in a bleomycin mouse model
    W A Wuyts
    Laboratory of Pneumology, Katholieke Universiteit Leuven and University Hospitals Leuven, Leuven, Belgium
    Exp Lung Res 36:602-14. 2010
    ..A possible mechanism could be a modulation of both innate immunity and adaptive immunity. These findings might suggest a potential role for azithromycin in the treatment of IPF...
  19. ncbi request reprint The role of interleukin-17 during acute rejection after lung transplantation
    B M Vanaudenaerde
    Laboratory of Pneumology, Katholieke Universiteit, and Lung Transplantation Unit, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Respir J 27:779-87. 2006
    ..These findings suggest that interleukin-17 is important in the pathophysiology of acute lung rejection...
  20. ncbi request reprint 5-HT modulates noncholinergic contraction in guinea pig airways in vitro by prejunctional 5-HT1-like receptor
    J L Pype
    Laboratory of Pneumology, Pulmonary Pharmacology Unit, Leuven, Belgium
    J Appl Physiol (1985) 77:1135-41. 1994
    ..This effect is probably mediated through a 5-HT1-like receptor; however, the exact subtype remains to be elucidated...
  21. ncbi request reprint The pH of exhaled breath condensate of patients with allograft rejection after lung transplantation
    L J Dupont
    Lung Transplantation Unit, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Am J Transplant 6:1486-92. 2006
    ..Measuring condensate pH might thus be a new tool for the evaluation of rejection in lung transplant patients...
  22. ncbi request reprint Follicular bronchiolitis: a rare cause of bronchiolitis obliterans syndrome after lung transplantation: a case report
    R Vos
    Laboratory of Pneumology, Katholieke Universiteit Leuven and University Hospital Gasthuisberg, Leuven, Belgium
    Am J Transplant 9:644-50. 2009
    ..It is to our knowledge, the first publication describing FB after lung transplantation (LTx), presenting as chronic allograft dysfunction or bronchiolitis obliterans syndrome (BOS)...
  23. doi request reprint Diagnostic value of antibodies against Pseudomonas aeruginosa in bronchoalveolar lavage fluid after lung transplantation
    R Vos
    Pneumology Laboratory and the Lung Transplantation Unit, K U Leuven and University Hospital Gasthuisberg, Leuven, Belgium
    Transplant Proc 42:4415-20. 2010
    ..Pseudomonas aeruginosa exoproteases are involved in initiating colonization, and immune complexes directed against these proteases may activate innate immune responses...
  24. ncbi request reprint Pirfenidone: a potential new therapy for restrictive allograft syndrome?
    R Vos
    Lung Transplantation Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Transplant 13:3035-40. 2013
    ..Furthermore, we herein report hypermetabolic activity on (18) F-FDG PET imaging in this setting, which could indicate active fibroproliferation and pleuroparenchymal remodeling. These findings may warrant further investigation. ..
  25. ncbi request reprint Efficacy of total lymphoid irradiation in azithromycin nonresponsive chronic allograft rejection after lung transplantation
    G M Verleden
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    Transplant Proc 41:1816-20. 2009
    ..We conclude that patients who do not or no longer respond to azithromycin may benefit from TLI, as suggested by a decreased rate in decline of the FEV(1)...
  26. ncbi request reprint Transient airway colonization is associated with airway inflammation after lung transplantation
    R Vos
    Laboratorium of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Transplant 7:1278-87. 2007
    ..Transient airway colonization, especially with Pseudomonas-like GN bacteria, in stable LTx patients may be associated with IL8-dependent neutrophilic airway inflammation and a, albeit subtle, decrease in FEV(1)...
  27. ncbi request reprint Gastro-oesophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection
    K Blondeau
    Centre for Gastroenterological Research, University Hospital Gasthuisberg, Katholieke Universiteit, Leuven, Belgium
    Eur Respir J 31:707-13. 2008
    ..Pepsin was a more general marker and bile acids a more specific marker that might be associated with bronchiolitis obliterans syndrome. Proton pump inhibitor treatment did not prevent nonacid reflux and gastric aspiration...
  28. ncbi request reprint Modulation by cAMP of IL-1beta-induced eotaxin and MCP-1 expression and release in human airway smooth muscle cells
    W A Wuyts
    Laboratory of Pneumology, Unit of Respiratory Pharmacology, Leuven, Belgium
    Eur Respir J 22:220-6. 2003
    ..These findings may be important for the further development of new anti-inflammatory drugs...
  29. ncbi request reprint Mechanisms of interleukin 1beta-induced human airway smooth muscle hyporesponsiveness to histamine. Involvement of p38 MAPK NF-kappaB
    J L Pype
    Katholieke Universiteit Leuven, Laboratory of Pneumology, Leuven, Belgium
    Am J Respir Crit Care Med 163:1010-7. 2001
    ....
  30. doi request reprint The lectin-like domain of thrombomodulin protects against ischaemia-reperfusion lung injury
    N Geudens
    Laboratory of Experimental Thoracic Surgery, University of Leuven, Leuven, Belgium
    Eur Respir J 32:862-70. 2008
    ..These novel findings support further evaluation of recombinant lectin-like domain of thrombomodulin to protect the lung against tissue-damaging pro-inflammatory responses following ischaemia-reperfusion...
  31. doi request reprint Lymphocytic bronchiolitis after lung transplantation is associated with daily changes in air pollution
    S E Verleden
    Lung Transplantation Unit, KU Leuven and UZ Gasthuisberg, Leuven, Belgium
    Am J Transplant 12:1831-8. 2012
    ..0001). The risk for LB after lung transplantation increased with temporal changes in particulate air pollution, and this was associated with BAL neutrophilia and lymphocytosis. Azithromycin was protective against this PM effect...
  32. ncbi request reprint Body Mass Index in Lung Transplant Candidates: A Contra-indication to Transplant or Not?
    D Ruttens
    Lung Transplant Unit, Lab of Pneumology, Katholieke Universiteit Leuven, University Hospital Gasthuisberg Leuven, Leuven, Belgium
    Transplant Proc 46:1506-10. 2014
    ..On the other hand, low BMI may be associated with worse outcome. We investigated the influence of pre-LT BMI on survival after LT in a single-center study...
  33. doi request reprint Acute liver failure due to Varicella zoster virus infection after lung transplantation: a case report
    G M Verleden
    Lung Transplantation Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Transplant Proc 44:1457-9. 2012
    ..Despite a rapid diagnosis of VZV infection and treatment with acyclovir, his situation deteriorated within 24 hours and while awaiting an urgent liver transplantation, he developed multiple organ failure and died...
  34. doi request reprint Neutrophilic reversible airways dysfunction after liver transplantation: a case report
    G M Verleden
    Lung Transplantation Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Transplant Proc 43:2078-81. 2011
    ..Moreover, it demonstrates that this condition is not always related to allograft rejection, but rather may be induced by non-immunologic factors, which remain to be further investigated...
  35. ncbi request reprint Genetic variation in immunoglobulin g receptor affects survival after lung transplantation
    D Ruttens
    Lung Transplant Unit, Laboratory of Pneumology, KU Leuven, University Hospital Gasthuisberg Leuven, Leuven, Belgium
    Am J Transplant 14:1672-7. 2014
    ..0022) compared with the other genotypes. A genetic variant in the IgGR is associated with higher mortality and more respiratory infections, although not with increased prevalence of chronic rejection, after LTx. ..
  36. ncbi request reprint The effects of 5-HT on cholinergic contraction in human airways in vitro
    L J Dupont
    Pulmonary Pharmacology Unit, Laboratory of Pneumology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 14:642-9. 1999
    ..These findings suggest that 5-HT facilitates cholinergic contraction in human airways in vitro through stimulation of both prejunctional 5-HT3 and 5-HT4 receptors. This may implicate a role of 5-HT in asthma...
  37. doi request reprint Determinants of physical activity in daily life in candidates for lung transplantation
    D Langer
    Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Belgium
    Respir Med 106:747-54. 2012
    ..The main research questions were: 1) How active are LTx-candidates in daily life? 2) What are determinants of activity behavior before LTX?..
  38. ncbi request reprint Listeria pleuritis 1 week after lung transplantation
    W Janssens
    Department of Pneumology, University Hospital of Leuven, Leuven, Belgium
    J Heart Lung Transplant 25:734-7. 2006
    ..This case highlights the increased risk for uncommon respiratory infections in lung transplant patients and examines the specific management of listeria pleuritis...
  39. doi request reprint Long-term azithromycin therapy for bronchiolitis obliterans syndrome: divide and conquer?
    Robin Vos
    Laboratory of Pneumology, Katholieke Universiteit Leuven and University Hospital Gasthuisberg, Leuven, Belgium
    J Heart Lung Transplant 29:1358-68. 2010
    ..Azithromycin may reverse or halt the decline of pulmonary function (FEV(1)) in bronchiolitis obliterans syndrome (BOS). In this study we investigated the effects of long-term azithromycin treatment in lung transplant recipients with BOS...
  40. doi request reprint Airway colonization and gastric aspiration after lung transplantation: do birds of a feather flock together?
    Robin Vos
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Heart Lung Transplant 27:843-9. 2008
    ..We investigated whether gastric aspiration and airway colonization with P aeruginosa after LTx are associated...
  41. ncbi request reprint Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma
    Lieven J Dupont
    Department of Respiratory Medicine, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Chest 123:751-6. 2003
    ..The aim of this study was to assess the accuracy of exhaled NO levels for the diagnosis of asthma...
  42. ncbi request reprint Paecilomyces lilacinus and alternaria infectoria cutaneous infections in a sarcoidosis patient after double-lung transplantation
    V S M Saegeman
    Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium
    Acta Clin Belg 67:219-21. 2012
    ..Antifungal treatment and surgery of residual skin lesions was necessary to cure the infections. With this report, we aim at highlighting the importance of dermatological control of patients post lung transplantation...
  43. ncbi request reprint How invasive aspergillosis may have a beneficial effect after single lung transplantation
    J Wynants
    University Hospital Gasthuisberg, Lung Transplantation Unit, Leuven, Belgium
    Acta Clin Belg 64:239-41. 2009
    ..After resolution of the infection, both FVC (forced vital capacity) and FEV1 became surprisingly better, due to fibrosis of the affected lobe, compatible with infection-induced volume reduction of the native lung...
  44. ncbi request reprint Activity related increase of exhaled nitric oxide in Crohn's disease and ulcerative colitis: a manifestation of systemic involvement?
    G H Koek
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Respir Med 96:530-5. 2002
    ..These observations strengthen the arguments that IBD is a systemic disease. Further research is needed to try to explain the significance of an increased eNO in IBD...
  45. ncbi request reprint N-acetylcysteine reduces chemokine release via inhibition of p38 MAPK in human airway smooth muscle cells
    W A Wuyts
    KU Leuven, Laboratory of Pneumology, Leuven, Belgium
    Eur Respir J 22:43-9. 2003
    ..This study has also shown that N-acetylcysteine decreases the interleukin-1beta-induced production of reactive oxygen species, as suggested by a reduction in the 8-isoprostane production...
  46. ncbi request reprint Effects of a shortened asthma self-management group program
    V Lemaigre
    Dienst Longziekten, Universitaire Ziekenhuizen Leuven, Campus Gasthuisberg, Leuven, Belgium
    Acta Clin Belg 65:29-36. 2010
    ..We evaluated the effects of a shortened asthma self-management program on asthma knowledge, morbidity and asthma-related behaviour in a group of moderate to severe adult asthmatics...
  47. ncbi request reprint Broncho-alveolar lavage fluid recovery correlates with airway neutrophilia in lung transplant patients
    Bart M Vanaudenaerde
    Laboratorium of Pneumology, Katholieke Universiteit Leuven, and Lung Transplantation Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Respir Med 102:339-47. 2008
    ..Airway colonization in stable patients had no effect on airway inflammatory parameters, BFR and FEV1...
  48. doi request reprint Obliterative bronchiolitis following lung transplantation: from old to new concepts?
    Geert M Verleden
    Department of Respiratory Medicine, University Hospital Gasthuisberg, 49 Herestraat, Leuven, Belgium
    Transpl Int 22:771-9. 2009
    ..The present review intends to give the scientific evidence for these two subtypes, and to clarify the role of azithromycin in the treatment of BOS...
  49. doi request reprint Exhaled carbon monoxide as a noninvasive marker of airway neutrophilia after lung transplantation
    Robin Vos
    Laboratory of Pneumology, Katholieke Universiteit Leuven, University Hospital Gasthuisberg, Leuven, Belgium
    Transplantation 87:1579-83. 2009
    ..Exhaled carbon monoxide (eCO) reflects heme oxygenase-1 activity in response to oxidative stress. We investigated whether airway neutrophilia and eCO levels are associated in stable LTx recipients...
  50. ncbi request reprint Successful conversion from cyclosporine to tacrolimus for gastric motor dysfunction in a lung transplant recipient
    Geert M Verleden
    Department of Respiratory Disease, University Hospital Gasthuisberg, Leuven, Belgium geert verleden uz kuleuven ac be
    Transplantation 73:1974-6. 2002
    ....
  51. ncbi request reprint Circulating and intrapulmonary C-reactive protein: a predictor of bronchiolitis obliterans syndrome and pulmonary allograft outcome
    Robin Vos
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Heart Lung Transplant 28:799-807. 2009
    ..Data in lung transplantation (LTx) are lacking. We hypothesized that baseline plasma or bronchoalveolar lavage (BAL) CRP might be prognostic for the long-term outcome after LTx...
  52. ncbi request reprint N-acetylcysteine inhibits interleukin-17-induced interleukin-8 production from human airway smooth muscle cells: a possible role for anti-oxidative treatment in chronic lung rejection?
    Wim A Wuyts
    Laboratory of Pneumology, Katholieke University Leuven, Leuven, Belgium
    J Heart Lung Transplant 23:122-7. 2004
    ..Recently, it has been suggested that reactive oxygen species may also play an important role in the pathogenesis because they are known to induce smooth muscle proliferation...
  53. doi request reprint Nocturnal weakly acidic reflux promotes aspiration of bile acids in lung transplant recipients
    Kathleen Blondeau
    Centre for Gastroenterological Research, Katholieke Universiteit Leuven, Leuven, Belgium
    J Heart Lung Transplant 28:141-8. 2009
    ....
  54. ncbi request reprint Fatal Scopulariopsis infection in a lung transplant recipient: a case report
    Wim A Wuyts
    Department of Respiratory Disease, Lung Transplantation Unit, University Hospital Gasthuisberg, Herestraat, Leuven, Belgium
    J Heart Lung Transplant 24:2301-4. 2005
    ....
  55. ncbi request reprint IL-1beta in bronchial lavage fluid is a non-invasive marker that predicts the viability of the pulmonary graft from the non-heart-beating donor
    Filip R Rega
    Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Heart Lung Transplant 24:20-8. 2005
    ....
  56. ncbi request reprint N-acetyl cysteine pre-treatment attenuates inflammatory changes in the warm ischemic murine lung
    Nele Geudens
    Laboratory of Experimental Thoracic Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
    J Heart Lung Transplant 26:1326-32. 2007
    ..We investigated the impact and timing of administration of N-acetyl cysteine (NAC) on inflammatory parameters...
  57. ncbi request reprint How long can we preserve the pulmonary graft inside the nonheart-beating donor?
    Filip R Rega
    Center for Experimental Surgery and Anesthesiology, Catholic University of Leuven, Leuven, Belgium
    Ann Thorac Surg 77:438-44; discussion 444. 2004
    ..Extending the preharvest interval in NHBD would facilitate distant organ retrieval. We hypothesized that prolonged topical cooling inside NHBD after 60 minutes of initial warm ischemia would not affect the pulmonary graft...
  58. ncbi request reprint Interleukin-17 stimulates release of interleukin-8 by human airway smooth muscle cells in vitro: a potential role for interleukin-17 and airway smooth muscle cells in bronchiolitis obliterans syndrome
    Bart M Vanaudenaerde
    Laboratory of Pneumology, Catholic University Leuven, Leuven, Belgium
    J Heart Lung Transplant 22:1280-3. 2003
    ....
  59. ncbi request reprint Effects of long-acting bronchodilators and placebo on histamine-induced asthma symptoms and mild bronchusobstruction
    Valentine Lemaigre
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Respir Med 100:348-53. 2006
    ..In the present study, we compared the effects of salmeterol, formoterol and placebo on relief of histamine-induced asthma symptoms and mild bronchusobstruction...
  60. doi request reprint The number of lung transplants can be safely doubled using extended criteria donors; a single-center review
    Caroline Meers
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium
    Transpl Int 23:628-35. 2010
    ..1%) in our donor network is 10-20% higher than reported figures. The number of lung transplants in our center doubled by accepting extended criteria donors. This policy did not negatively influence our results after lung transplantation...
  61. pmc Long-term preservation with interim evaluation of lungs from a non-heart-beating donor after a warm ischemic interval of 90 minutes
    Filip R Rega
    Center for Experimental Surgery and Anesthesiology, University Hospital Gasthuisberg, Leuven, Belgium
    Ann Surg 238:782-92; discussion 792-3. 2003
    ..To investigate the value of in situ preservation and ex vivo evaluation of lungs from a non-heart-beating donor (NHBD) prior to long-term cold storage...
  62. ncbi request reprint Retrograde flush following topical cooling is superior to preserve the non-heart-beating donor lung
    Caroline van de Wauwer
    Laboratory for Experimental Thoracic Surgery, University Hospital Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Cardiothorac Surg 31:1125-32; discussion 1132-3. 2007
    ..Formation of microthrombi after circulatory arrest, however, is a major concern for the development of reperfusion injury. We looked at the effect and the best route of pulmonary flush following topical cooling in NHBD...
  63. ncbi request reprint Should we ventilate or cool the pulmonary graft inside the non-heart-beating donor?
    Filip R Rega
    Center for Experimental Surgery and Anesthesiology, Catholic University of Leuven, Leuven, Belgium
    J Heart Lung Transplant 22:1226-33. 2003
    ..The ideal preservation method during the warm ischemic period in the non-heart-beating donor (NHBD) remains unclear. In this study we compare the protective effect of ventilation vs cooling of the non-perfused pulmonary graft...
  64. ncbi request reprint N-acetyl cysteine attenuates the inflammatory response in warm ischemic pig lungs
    Nele Geudens
    Laboratory for Experimental Thoracic Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
    J Surg Res 146:177-83. 2008
    ..We investigated the possible therapeutic effect of N-acetyl cysteine (NAC), a potent anti-oxidative agent on IRI in a porcine ex vivo lung reperfusion model...
  65. ncbi request reprint Impact of warm ischemia on different leukocytes in bronchoalveolar lavage from mouse lung: possible new targets to condition the pulmonary graft from the non-heart-beating donor
    Nele Geudens
    Laboratory for Experimental Thoracic Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
    J Heart Lung Transplant 25:839-46. 2006
    ..A better understanding of the role of inflammatory cells during the warm ischemic interval may be useful for developing new therapeutic strategies against IRI...
  66. ncbi request reprint Primary cryptococcal cellulitis in a lung transplant recipient
    Sofie A H Van Grieken
    Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium
    J Heart Lung Transplant 26:285-9. 2007
    ..In this study we review cryptococcosis, which should always be considered in the differential diagnosis of cellulitis in transplant recipients...
  67. ncbi request reprint Non-heart-beating donors
    Dirk E M Van Raemdonck
    Thoracic Surgical Research Unit, Center for Experimental Surgery and Anaesthesiology, Catholic University, Leuven, Belgium
    Semin Thorac Cardiovasc Surg 16:309-21. 2004
    ..Techniques for NHBD lung preservation and pretransplant functional assessment are reviewed. Ethical issues involved in transplanting lungs from asystolic donors are discussed...
  68. doi request reprint Lung donor selection and management
    Dirk Van Raemdonck
    Department of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium
    Proc Am Thorac Soc 6:28-38. 2009
    ..This article aims to update the current evidence from the literature to identify and select potential lung donors and to manage cadaveric donors to maximally increase the organ yield for lung transplantation...
  69. doi request reprint Azithromycin reduces airway inflammation in a murine model of lung ischaemia reperfusion injury
    Nele Geudens
    Laboratory of Experimental Thoracic Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
    Transpl Int 21:688-95. 2008
    ..Azithromycin should be further investigated as a novel drug to prevent lung ischaemia-reperfusion injury...
  70. ncbi request reprint Macrolide therapy targets a specific phenotype in respiratory medicine: from clinical experience to basic science and back
    Bart M Vanaudenaerde
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    Inflamm Allergy Drug Targets 7:279-87. 2008
    ....
  71. ncbi request reprint Involvement of p38 MAPK, JNK, p42/p44 ERK and NF-kappaB in IL-1beta-induced chemokine release in human airway smooth muscle cells
    Wim A Wuyts
    Lung Transplantation Unit, Department of Respiratory Diseases, University Hospital Gasthuisberg, 49 Herestraat, Leuven B 3000, Belgium
    Respir Med 97:811-7. 2003
    ..05, n = 10 and 23 +/- 7%, P < 0.05, n = 12). We conclude that p38 MAPK, JNK kinase, ERK and NF-kappaB are involved in the IL-1beta-induced eotaxin, MCP-1, and MCP-3 expression and release in HASMC...
  72. ncbi request reprint Nebulized N-acetyl cysteine protects the pulmonary graft inside the non-heart-beating donor
    Filip R Rega
    Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Heart Lung Transplant 24:1369-77. 2005
    ..If the lung could be safely protected inside the cadaver, this time period may be prolonged. This would help to obtain family consent and to organize organ retrieval...
  73. doi request reprint Retrograde flush following warm ischemia in the non-heart-beating donor results in superior graft performance at reperfusion
    Caroline van de Wauwer
    Laboratory for Experimental Thoracic Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
    J Surg Res 154:118-25. 2009
    ..The presence of postmortem thrombi, however, is a concern for the development of primary graft dysfunction. In this isolated lung reperfusion study, we looked at the need and the best route of preharvest pulmonary flush...
  74. ncbi request reprint The mode of death in the non-heart-beating donor has an impact on lung graft quality
    Caroline van de Wauwer
    Laboratory for Experimental Thoracic Surgery, KU Leuven, Leuven, Belgium
    Eur J Cardiothorac Surg 36:919-26. 2009
    ..We hypothesised that the agonal phase prior to cardiac death may negatively influence the quality of the pulmonary graft recovered from non-heart-beating donors (NHBDs). Different modes of death were compared in an experimental model...
  75. ncbi request reprint Interleukin-17--induced interleukin-8 release in human airway smooth muscle cells: role for mitogen-activated kinases and nuclear factor-kappaB
    Wim A Wuyts
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Heart Lung Transplant 24:875-81. 2005
    ....
  76. ncbi request reprint Comparative study of donor lung injury in heart-beating versus non-heart-beating donors
    Arne P Neyrinck
    Laboratory for Experimental Thoracic Surgery, Katholieke Universiteit Leuven, Belgium
    Eur J Cardiothorac Surg 30:628-36. 2006
    ..In this study we compared the quality of lungs from HBD versus NHBD in an isolated reperfusion model...
  77. ncbi request reprint Azithromycin: a plea for multicenter randomized studies in lung transplantation
    Trevor J Williams
    Am J Respir Crit Care Med 172:657-9. 2005
  78. ncbi request reprint Inhaled cyclosporine in lung transplantation
    Geert M Verleden
    N Engl J Med 354:1752-3; author reply 1752-3. 2006
  79. ncbi request reprint Interleukin-17 and neutrophils are increased in BAL fluid during acute lung rejection
    Geert M Verleden
    Chest 131:1988-9; author reply 1989. 2007
  80. ncbi request reprint The role of leukocyte depletion in ex vivo evaluation of pulmonary grafts from (non-)heart-beating donors
    Filip R Rega
    Centre for Experimental Surgery and Anaesthesiology, Catholic University of Leuven, Belgium
    Perfusion 18:13-21. 2003
    ....
  81. ncbi request reprint Risk factors for airway complications within the first year after lung transplantation
    Caroline van de Wauwer
    Department of Thoracic Surgery, UZ Leuven, Belgium
    Eur J Cardiothorac Surg 31:703-10. 2007
    ..Nevertheless, airway anastomotic complications (AC) are still a potential cause of early morbidity and mortality. In this retrospective cohort study we looked at possible predictors of AC within the first year after LTx...
  82. ncbi request reprint Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part III: donor-related risk factors and markers
    Marc de Perrot
    Toronto General Hospital, Toronto, Ontario, Canada
    J Heart Lung Transplant 24:1460-7. 2005
  83. ncbi request reprint De novo or persistent pseudomonal airway colonization after lung transplantation: importance for bronchiolitis obliterans syndrome?
    Robin Vos
    Transplantation 86:624-5; author reply 635-6. 2008
  84. ncbi request reprint An algorithm to tackle acute exacerbations in idiopathic pulmonary fibrosis
    Wim A Wuyts
    Am J Respir Crit Care Med 177:1397; author reply 1398. 2008