I Vergote

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Neoadjuvant chemotherapy for ovarian cancer
    Ignace Vergote
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals, Leuven, Belgium
    Oncology (Williston Park) 19:1615-22; discussion 1623-30. 2005
  2. pmc Role of TRAP1 and estrogen receptor alpha in patients with ovarian cancer -a study of the OVCAD consortium
    Stefanie Aust
    Department of Obstetrics and Gynecology Molecular Oncology Group, Medical University of Vienna, Vienna, Austria
    Mol Cancer 11:69. 2012
  3. pmc A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium
    Dietmar Pils
    Department of Obstetrics and Gynecology, Molecular Oncology Group, Medical University of Vienna, European Union, Vienna, Austria
    BMC Cancer 13:178. 2013
  4. pmc High-grade endometrial stromal sarcoma presenting in a 28-year-old woman during pregnancy: a case report
    Frederic Amant
    Gynecologic Oncology, Leuven Cancer Institute LKI, Katholieke Universiteit Leuven, Belgium
    J Med Case Reports 4:243. 2010
  5. pmc Expression profiling to predict the clinical behaviour of ovarian cancer fails independent evaluation
    Olivier Gevaert
    Department of Electrical Engineering ESAT SCD SISTA, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Leuven, Belgium
    BMC Cancer 8:18. 2008
  6. ncbi request reprint Port-site metastases after open laparoscopy: a study in 173 patients with advanced ovarian carcinoma
    I Vergote
    Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium
    Int J Gynecol Cancer 15:776-9. 2005
  7. doi request reprint Carboplatin and paclitaxel in combination with oral enzastaurin in advanced ovarian or primary peritoneal cancer: results from a safety lead-in study
    Ignace Vergote
    Department of Gynaecological Oncology, Division Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium
    Int J Gynecol Cancer 19:1505-10. 2009
  8. doi request reprint Timing of debulking surgery in advanced ovarian cancer
    I Vergote
    Department of Obstetrics and Gynaecology, Division of Gynaecological Oncology, University Hospitals, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Gynecol Cancer 18:11-9. 2008
  9. ncbi request reprint Treatment of patients with early epithelial ovarian cancer
    Ignace Vergote
    Department of Gynaecological Oncology, University Hospital Leuven, Belgium
    Curr Opin Oncol 15:452-5. 2003
  10. ncbi request reprint Role of surgery in ovarian cancer: an update
    I Vergote
    University Hospitals Leuven, Dept Gynaecological Oncology, Leuven, Belgium
    Acta Chir Belg 104:246-56. 2004

Detail Information

Publications165 found, 100 shown here

  1. ncbi request reprint Neoadjuvant chemotherapy for ovarian cancer
    Ignace Vergote
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals, Leuven, Belgium
    Oncology (Williston Park) 19:1615-22; discussion 1623-30. 2005
    ..Open laparoscopy is probably the most valuable tool for evaluating the operability primarily or at the time of interval debulking surgery...
  2. pmc Role of TRAP1 and estrogen receptor alpha in patients with ovarian cancer -a study of the OVCAD consortium
    Stefanie Aust
    Department of Obstetrics and Gynecology Molecular Oncology Group, Medical University of Vienna, Vienna, Austria
    Mol Cancer 11:69. 2012
    ..Therefore, we investigated the importance of TRAP1 together with ERα in regard to clinicopathological parameters, chemotherapy response, and survival...
  3. pmc A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium
    Dietmar Pils
    Department of Obstetrics and Gynecology, Molecular Oncology Group, Medical University of Vienna, European Union, Vienna, Austria
    BMC Cancer 13:178. 2013
    ....
  4. pmc High-grade endometrial stromal sarcoma presenting in a 28-year-old woman during pregnancy: a case report
    Frederic Amant
    Gynecologic Oncology, Leuven Cancer Institute LKI, Katholieke Universiteit Leuven, Belgium
    J Med Case Reports 4:243. 2010
    ..To the best of our knowledge, soft tissue sarcomas have not prevously been reported as a complication during pregnancy...
  5. pmc Expression profiling to predict the clinical behaviour of ovarian cancer fails independent evaluation
    Olivier Gevaert
    Department of Electrical Engineering ESAT SCD SISTA, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Leuven, Belgium
    BMC Cancer 8:18. 2008
    ..92% accuracy using leave-one-out cross validation techniques in combination with Least Squares Support Vector Machines (LS-SVMs)...
  6. ncbi request reprint Port-site metastases after open laparoscopy: a study in 173 patients with advanced ovarian carcinoma
    I Vergote
    Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium
    Int J Gynecol Cancer 15:776-9. 2005
    ..However, prognosis was not worse in this group of patients. Laparoscopy is a convenient technique to diagnose advanced ovarian carcinoma, to exclude other primary tumors, and to refer patients to a tertiary center...
  7. doi request reprint Carboplatin and paclitaxel in combination with oral enzastaurin in advanced ovarian or primary peritoneal cancer: results from a safety lead-in study
    Ignace Vergote
    Department of Gynaecological Oncology, Division Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium
    Int J Gynecol Cancer 19:1505-10. 2009
    ....
  8. doi request reprint Timing of debulking surgery in advanced ovarian cancer
    I Vergote
    Department of Obstetrics and Gynaecology, Division of Gynaecological Oncology, University Hospitals, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Gynecol Cancer 18:11-9. 2008
    ..Open laparoscopy is probably the most valuable tool for evaluating the operability primarily or at the time of interval debulking surgery...
  9. ncbi request reprint Treatment of patients with early epithelial ovarian cancer
    Ignace Vergote
    Department of Gynaecological Oncology, University Hospital Leuven, Belgium
    Curr Opin Oncol 15:452-5. 2003
    ..During 2003, the first randomized trials were published comparing adjuvant platin-based chemotherapy versus no treatment in early epithelial ovarian cancer...
  10. ncbi request reprint Role of surgery in ovarian cancer: an update
    I Vergote
    University Hospitals Leuven, Dept Gynaecological Oncology, Leuven, Belgium
    Acta Chir Belg 104:246-56. 2004
    ..g. more than 12 months), and resectable disease (without diffuse carcinomatosis)...
  11. doi request reprint Phase 3 randomised study of canfosfamide (Telcyta, TLK286) versus pegylated liposomal doxorubicin or topotecan as third-line therapy in patients with platinum-refractory or -resistant ovarian cancer
    I Vergote
    University Hospitals, Leuven, European Union, Gynecologic Oncology, Gasthuisberg, B 3000 Leuven, Belgium
    Eur J Cancer 45:2324-32. 2009
    ..Canfosfamide HCl (CAN) is a glutathione analogue prodrug that is activated by glutathione S-transferase P1-1 and induces apoptosis. CAN is synergistic in vitro with carboplatin, paclitaxel and anthracyclines...
  12. ncbi request reprint Postmenopausal women who progress on fulvestrant ('Faslodex') remain sensitive to further endocrine therapy
    I Vergote
    Department of Gynecologic Oncology, University Hospitals, Leuven, Belgium
    Breast Cancer Res Treat 79:207-11. 2003
    ....
  13. ncbi request reprint Positron emission tomography with FDG in the detection of peritoneal and retroperitoneal metastases of ovarian cancer
    O Drieskens
    Department of Nuclear Medicine, University Hospital Leuven, Leuven, Belgium
    Gynecol Obstet Invest 55:130-4. 2003
    ..The aim of this prospective study was to evaluate (18)F-FDG-PET, in comparison with CT, for the detection of peritoneal and retroperitoneal metastases of ovarian cancer...
  14. ncbi request reprint Randomized phase III study of canfosfamide in combination with pegylated liposomal doxorubicin compared with pegylated liposomal doxorubicin alone in platinum-resistant ovarian cancer
    Ignace Vergote
    University Hospitals, Leuven, European Union
    Int J Gynecol Cancer 20:772-80. 2010
    ..To evaluate the safety and efficacy of canfosfamide in combination with pegylated liposomal doxorubicin (PLD) in platinum-resistant ovarian cancer (OC)...
  15. ncbi request reprint Fulvestrant versus anastrozole as second-line treatment of advanced breast cancer in postmenopausal women
    I Vergote
    Department of Gynecologic Oncology, University Hospitals Leuven, Leuven, Belgium
    Eur J Cancer 38:S57-8. 2002
  16. ncbi request reprint Fulvestrant, a new treatment option for advanced breast cancer: tolerability versus existing agents
    I Vergote
    University Hospitals, Leuven, Belgium
    Ann Oncol 17:200-4. 2006
    ..The overall safety profiles of newer agents such as fulvestrant will become increasingly clear with their ongoing use...
  17. ncbi request reprint Prognostic importance of degree of differentiation and cyst rupture in stage I invasive epithelial ovarian carcinoma
    I Vergote
    Department of Gynaecological Oncology, University Hospitals Leuven, Belgium
    Lancet 357:176-82. 2001
    ..We undertook a retrospective study in a large international database to identify the most important prognostic variables...
  18. ncbi request reprint Interval debulking surgery: an alternative for primary surgical debulking?
    I Vergote
    Department of Gynaecological Oncology University Hospital, Leuven, Belgium
    Semin Surg Oncol 19:49-53. 2000
    ..We will review the studies on primary chemotherapy, interval debulking surgery, and the indications for primary chemotherapy followed by interval debulking surgery, and ongoing trials...
  19. pmc Fulvestrant is an effective and well-tolerated endocrine therapy for postmenopausal women with advanced breast cancer: results from clinical trials
    I Vergote
    Department of Gynaecology and Gynaecological Oncology, University Hospitals, Herestraat 49, B 3000 Leuven, Belgium
    Br J Cancer 90:S11-4. 2004
    ..This paper reviews the efficacy and tolerability results from these trials...
  20. ncbi request reprint Laparoscopic lower para-aortic staging lymphadenectomy in stage IB2, II, and III cervical cancer
    Ignace Vergote
    Department of Gynaecological Oncology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Int J Gynecol Cancer 12:22-6. 2002
    ..Laparoscopic para-aortic staging in cervical carcinoma is feasible with low morbidity. Eighteen percent of the patients, without suspicion of para-aortic metastases on CT, proved to have metastases in the lower para-aortic region...
  21. ncbi request reprint Metastatic breast cancer: sequencing hormonal therapy and positioning of fulvestrant
    I Vergote
    Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, University Hospitals, Katholieke Universiteit Leuven, Belgium
    Int J Gynecol Cancer 16:524-6. 2006
    ..In conclusion, fulvestrant provides us with an additional endocrine treatment option making it possible to prolong the time that patients with ABC can be treated with endocrine therapy...
  22. doi request reprint Intraperitoneal chemotherapy in patients with advanced ovarian cancer: the con view
    Ignace Vergote
    Department of Gynaecological Oncology, Division Obstetrics and Gynaecology, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium
    Oncologist 13:410-4. 2008
    ..In this paper we wish to present the reasons why i.p. chemotherapy cannot be accepted as standard of care for first-line systemic treatment of advanced ovarian carcinoma...
  23. doi request reprint Prospective study to assess fluid accumulation and tenosynovial changes in the aromatase inhibitor-induced musculoskeletal syndrome: 2-year follow-up data
    A Lintermans
    Department of Obstetrics and Gynecology, KU Leuven, Leuven, Belgium
    Ann Oncol 24:350-5. 2013
    ..Looking into its pathophysiology, 6 months of AI therapy thickens the tendon sheath with intra-articular fluid (IAF) retention and loss of grip strength. We here report 24-month follow-up data...
  24. pmc Neoadjuvant chemotherapy followed by interval debulking surgery in patients with serous endometrial cancer with transperitoneal spread (stage IV): a new preferred treatment?
    I Vandenput
    Leuven Cancer Institute, Gynecologic Oncology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Br J Cancer 101:244-9. 2009
    ..To investigate the value of neoadjuvant chemotherapy (NACT), followed by interval debulking surgery (IDS), in endometrial cancer with transperitoneal spread (stage IV)...
  25. pmc Clinical study investigating the role of lymphadenectomy, surgical castration and adjuvant hormonal treatment in endometrial stromal sarcoma
    F Amant
    Division of Gynecological Oncology, Leuven Cancer Institute LKI, Department of Obstetrics and Gynecology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Br J Cancer 97:1194-9. 2007
    ..The data support the current practice in some centres to administer adjuvant hormonal treatment...
  26. doi request reprint Effect of laparoscopic surgery for moderate and severe endometriosis on depression, relationship satisfaction and sexual functioning: comparison of patients with and without bowel resection
    U Van den Broeck
    Department of Gynaecology and Obstetrics, University Hospital Leuven, Campus Gasthuisberg, Leuven, Belgium
    Hum Reprod 28:2389-97. 2013
    ..Is there a difference between women with endometriosis who underwent laparoscopic surgery with bowel resection or without bowel resection regarding depressive symptoms, relational adjustment and sexual functioning?..
  27. ncbi request reprint Is there a role for neoadjuvant chemotherapy in the treatment of stage IV serous endometrial carcinoma?
    E Despierre
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Gynecol Cancer 16:273-7. 2006
    ..The documentation of chemosensitivity might enable the clinician to select a subpopulation of patients with widespread SEC that might benefit from interval debulking surgery...
  28. doi request reprint Aromatase inhibitor-induced loss of grip strength is body mass index dependent: hypothesis-generating findings for its pathogenesis
    A Lintermans
    Department of Obstetrics and Gynecology, Division of Gynecological Oncology, University Hospitals Leuven, Belgium
    Ann Oncol 22:1763-9. 2011
    ..Here, we report the final results and assess the relationship between grip strength and body mass index (BMI)...
  29. doi request reprint Simple ultrasound-based rules for the diagnosis of ovarian cancer
    D Timmerman
    Department of Obstetrics and Gynecology, University Hospitals KU Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 31:681-90. 2008
    ..To derive simple and clinically useful ultrasound-based rules for discriminating between benign and malignant adnexal masses...
  30. doi request reprint Limited clinical benefit from trastuzumab in recurrent endometrial cancer: two case reports
    I Vandenput
    Leuven Cancer Institute, Division of Gynecological Oncology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Gynecol Obstet Invest 67:46-8. 2009
    ..It is hypothesized that the HER-2/neu receptor could be used for targeted therapy in recurrent endometrial cancer...
  31. doi request reprint PET/CT in the staging of patients with a pelvic mass suspicious for ovarian cancer
    H Dauwen
    Division of Gynaecological Oncology, Department of Gynaecology Obstetrics, Cancer Institute, University Hospital Leuven, Leuven, Belgium
    Gynecol Oncol 131:694-700. 2013
    ..To prospectively assess the value of PET/CT for staging, diagnosis and operability of ovarian cancer, with special attention to the peritoneal spread...
  32. doi request reprint Improving strategies for diagnosing ovarian cancer: a summary of the International Ovarian Tumor Analysis (IOTA) studies
    J Kaijser
    Department of Obstetrics and Gynecology, University Hospitals KU Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 41:9-20. 2013
    ..An evidence-based approach to the preoperative characterization of ovarian and other adnexal masses should include the use of LR1, LR2 or IOTA simple rules and subjective assessment by an experienced examiner...
  33. ncbi request reprint Body mass index and HER-2 overexpression in breast cancer patients over 50 years of age
    T Van Mieghem
    Department of Obstetrics and Gynaecology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium
    Breast Cancer Res Treat 106:127-33. 2007
    ..It is unknown whether circulating estrogens affect HER-2 expression. We hypothesize that the postmenopausal body mass index (BMI) as a surrogate marker for bio-available estrogens, is inversely associated with HER-2 over-expression...
  34. ncbi request reprint Neoadjuvant chemotherapy followed by radical hysterectomy for invasive cervical cancer diagnosed during pregnancy: report of a case and review of the literature
    S Caluwaerts
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium
    Int J Gynecol Cancer 16:905-8. 2006
    ..The use of neoadjuvant chemotherapy enabled us to continue this pregnancy until the fetus was viable. Cisplatin did not influence the short-term outcome, but only a long-term follow-up will inform us on its safety during pregnancy...
  35. doi request reprint Ovarian cancer prediction in adnexal masses using ultrasound-based logistic regression models: a temporal and external validation study by the IOTA group
    D Timmerman
    Department of Obstetrics and Gynecology, University Hospitals, Leuven, Belgium
    Ultrasound Obstet Gynecol 36:226-34. 2010
    ....
  36. ncbi request reprint Applying the 2011 St Gallen panel of prognostic markers on a large single hospital cohort of consecutively treated primary operable breast cancers
    O Brouckaert
    Multidisciplinary Breast Centre, University Hospital Leuven, Leuven, Belgium
    Ann Oncol 23:2578-84. 2012
    ..We here applied the 2011 St Gallen surrogate definition for breast cancer subclassification using tumor grade instead of Ki67...
  37. ncbi request reprint Laparoscopic para-aortic lymphadenectomy and positron emission tomography scan as staging procedures in patients with cervical carcinoma stage IB2-IIIB
    D G Mortier
    Department of Obstetrics and Gynaecology, Division of Gynaecological Oncology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Gynecol Cancer 18:723-9. 2008
    ..Laparoscopic para-aortic lymphadenectomy showed metastases in 13% of the patients. In the subgroup with negative PET scan, 11% had metastases. The procedure had a low morbidity and identified a group with an extremely poor prognosis...
  38. ncbi request reprint Gemcitabine-carboplatin-paclitaxel combination as first-line therapy in advanced ovarian carcinoma: a single institution phase II study in 24 patients
    L Fuso
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Katholieke Universiteit, Leuven, Belgium
    Int J Gynecol Cancer 16:60-7. 2006
    ..Median overall survival was 28 months, and the 2-year actuarial survival was 73%. The gemcitabine, carboplatin, paclitaxel triplet has an acceptable toxicity with high response rates as first-line therapy in advanced ovarian cancer...
  39. doi request reprint The prognostic role of preoperative and (early) postoperatively change in CA15.3 serum levels in a single hospital cohort of primary operable breast cancers
    O Brouckaert
    Multidisciplinary Breast Centre, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium
    Breast 22:254-62. 2013
    ..0291). Change in CA15.3 impacts on prognosis (distant metastasis) differently in different breast cancer phenotypes. A decrease in CA15.3 may be informative of improved prognosis in basal like and HER2 like breast cancer...
  40. ncbi request reprint Adjuvant therapy for postmenopausal ER-positive breast cancer. Why tamoxifen still has a future? The Leuven point of view
    P Neven
    Multidisciplinary Breast Center Department of Obstetrics and Gynecology, UZ Leuven, Catholic University Leuven, Leuven, Belgium
    Int J Gynecol Cancer 16:505-10. 2006
  41. doi request reprint Diaphragmatic surgery during primary debulking in 89 patients with stage IIIB-IV epithelial ovarian cancer
    D Tsolakidis
    Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Gynecol Oncol 116:489-96. 2010
    ..The aim of this study was to describe the role of diaphragmatic surgery in achieving optimal debulking in patients with advanced ovarian cancer and the assessment of the relative post-operative complications...
  42. doi request reprint Prevalent breast cancer patients with a homozygous mutant status for CYP2D6*4: response and biomarkers in tamoxifen users
    A S Dieudonné
    Department of Obstetrics and Gynecology, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Breast Cancer Res Treat 118:531-8. 2009
    ..They support clinical trials prospectively testing the effect of CYP2D6 genetic variability in response to tamoxifen before denying this drug to breast cancer patients only based on their CYP2D6*4 status...
  43. ncbi request reprint Age interacts with the expression of steroid and HER-2 receptors in operable invasive breast cancer
    P Neven
    Department of Obstetrics and Gynaecology, Multidisciplinary Breast Centre, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Breast Cancer Res Treat 110:153-9. 2008
    ..The negative association between the oestrogen receptor (ER) and the human epidermal growth factor receptor 2 (HER-2) in breast cancer travels in both directions. ER+ tumours are less likely HER-2+ and HER-2+ tumours are less likely ER+...
  44. ncbi request reprint Effectiveness of weekly topotecan in patients with recurrent epithelial ovarian cancer
    I Vandenput
    Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Int J Gynecol Cancer 17:83-7. 2007
    ..The response rate of 10% is low but was not expected to be higher as these patients were heavily pretreated...
  45. doi request reprint Breast cancer phenotype, nodal status and palpability may be useful in the detection of overdiagnosed screening-detected breast cancers
    O Brouckaert
    Multidisciplinary Breast Center, University Hospital Leuven, Leuven
    Ann Oncol 24:1847-52. 2013
    ..Screening is often criticized for leading to overdiagnosis and overtreatment. However, few have attempted to identify overdiagnosed cases...
  46. doi request reprint Folate receptor alpha (FRA) expression remains unchanged in epithelial ovarian and endometrial cancer after chemotherapy
    E Despierre
    Gynecologic Oncology and Leuven Cancer Institute, University Hospitals Leuven, Department of Oncology, KU Leuven, Belgium
    Gynecol Oncol 130:192-9. 2013
    ..We evaluated whether chemotherapy modified FRA expression in non-mucinous epithelial ovarian (EOC) and endometrial carcinoma (EC)...
  47. doi request reprint Primary invasive mucinous ovarian carcinoma of the intestinal type: importance of the expansile versus infiltrative type in predicting recurrence and lymph node metastases
    K Muyldermans
    Division of Gynecologic Oncology, Leuven Cancer Institute and Department of Obstetrics and Gynaecology, University Hospital Leuven, Leuven, Belgium
    Eur J Cancer 49:1600-8. 2013
    ..Investigate the role of expansile versus infiltrative type of primary invasive intestinal type mucinous epithelial ovarian carcinoma (mEOC) in predicting recurrence and lymph node metastases...
  48. doi request reprint Stellate ganglion block for the management of hot flashes and sleep disturbances in breast cancer survivors: an uncontrolled experimental study with 24 weeks of follow-up
    K Haest
    Department of Obstetrics and Gynecology, University Hospitals Leuven and Katholieke Universiteit Leuven, Belgium
    Ann Oncol 23:1449-54. 2012
    ..Efficacy data were analyzed using longitudinal regression models...
  49. ncbi request reprint The position of neoadjuvant chemotherapy within the treatment of ovarian cancer
    T Van Gorp
    Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology University Hospitals, Katholieke Universiteit Leuven, Belgium
    Minerva Ginecol 58:393-403. 2006
    ..However, we will have to wait for the results of future randomized trials to know whether neoadjuvant chemotherapy followed by interval debulking surgery is a good alternative to primary debulking surgery in stage IIIc and IV patients...
  50. pmc HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the Risk of Ovarian Malignancy Algorithm
    T Van Gorp
    Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, Universitaire Ziekenhuizen Leuven, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Br J Cancer 104:863-70. 2011
    ..We validated this algorithm in an independent prospective study...
  51. ncbi request reprint Preoperative diagnosis of ovarian tumors using Bayesian kernel-based methods
    B Van Calster
    Department of Electrical Engineering ESAT SCD, Katholieke Universiteit Leuven, and Department of Obstetrics and Gynecology, University Hospitals K U Leuven, Belgium
    Ultrasound Obstet Gynecol 29:496-504. 2007
    ..To develop flexible classifiers that predict malignancy in adnexal masses using a large database from nine centers...
  52. ncbi request reprint The role of neoadjuvant chemotherapy versus primary surgery in the management of stage III ovarian cancer
    T Van Gorp
    Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, University Hospitals, Katholieke Universiteit, Leuven, Belgium
    Cancer Treat Res 134:387-402. 2007
  53. ncbi request reprint Prognostic implications of lobular breast cancer histology: New insights from a single hospital cross-sectional study and SEER data
    O Brouckaert
    Multidisciplinary Breast Centre, University Hospital Leuven, Leuven, Belgium Electronic address
    Breast 23:371-7. 2014
    ..We hypothesize that nodal status may influence the hazard of relapse since time of diagnosis differently in invasive ductal carcinoma (IDC) and ILC...
  54. ncbi request reprint Prophylactic salpingo-oophorectomy in 51 women with familial breast-ovarian cancer: importance of fallopian tube dysplasia
    K Leunen
    Department of Obstetrics and Gynaecology, Division of Gynaecologic Oncology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Int J Gynecol Cancer 16:183-8. 2006
    ..Peritoneal cytology specimens (n= 28) were all negative. Laparoscopic pBSO is well tolerated. Concomitant hysterectomy should be considered, given the observed fallopian tube dysplasia and the possibility of a tubal remnant after pBSO...
  55. ncbi request reprint Third generation aromatase inhibitors may prevent endometrial growth and reverse tamoxifen-induced uterine changes in postmenopausal breast cancer patients
    L Morales
    Department of Medical Oncology, University Hospitals Leuven, Belgium
    Ann Oncol 16:70-4. 2005
    ..We also assessed the effect of aromatase inhibitors on tamoxifen-induced uterine changes...
  56. ncbi request reprint Absence of correlation between risk factors for endometrial cancer and the presence of tamoxifen-associated endometrial polyps in postmenopausal patients with breast cancer
    D Timmerman
    Departments of Obstetrics and Gynaecology, University Hospitals Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Eur J Cancer 36:S40-2. 2000
    ..So far there is no evidence that these polyps are premalignant lesions...
  57. ncbi request reprint New models to predict depth of infiltration in endometrial carcinoma based on transvaginal sonography
    F De Smet
    Department of Electrical Engineering ESAT SCD, Katholieke Universiteit Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 27:664-71. 2006
    ....
  58. ncbi request reprint Randomised study of anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women
    I Vergote
    Department Gynaecological Oncology, University Hospitals Leuven, Herestraat 49, B3000, Leuven, Belgium
    Eur J Cancer 36:S84-5. 2000
    ..In conclusion, these findings indicate that anastrozole can be considered as first-line therapy for postmenopausal women with advanced breast cancer...
  59. doi request reprint A scoring system to differentiate malignant from benign masses in specific ultrasound-based subgroups of adnexal tumors
    L Ameye
    Department of Electrical Engineering ESAT SCD, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 33:92-101. 2009
    ....
  60. doi request reprint The use of lymph vessel markers to predict endometrial cancer outcome
    Ingrid Vandenput
    Leuven Cancer Institute, Gynecologic Oncology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Gynecol Cancer 20:363-7. 2010
    ..To evaluate lymphangiogenesis and lymph vessel space involvement in different subsets of endometrial cancer using podoplanin, a specific marker for lymphatic endothelium...
  61. doi request reprint Are serum HE4 or ROMA scores useful to experienced examiners for improving characterization of adnexal masses after transvaginal ultrasonography?
    J Kaijser
    KU Leuven Department of Development and Regeneration, Leuven, Belgium Department of Obstetrics and Gynecology and Leuven Cancer Institute, University Hospitals, KU Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 43:89-97. 2014
    ....
  62. ncbi request reprint Pitfall in the diagnosis of endometrial cancer: case report of an endometrioid adenocarcinoma arising from uterine adenomyosis
    A S Boes
    Department of Obstetrics and Gynecology, UZ Gasthuisberg, Katholieke Universiteit, Leuven, Belgium
    Eur J Gynaecol Oncol 32:431-4. 2011
    ..The development of cancer from adenomyotic foci is a rare occurrence. The diagnosis is frequently delayed because of the absence of tumor in the eutopic endometrium...
  63. doi request reprint Triaging women with ovarian masses for surgery: observational diagnostic study to compare RCOG guidelines with an International Ovarian Tumour Analysis (IOTA) group protocol
    B Van Calster
    Department of Development and Regeneration, KU Leuven University of Leuven, Leuven, Belgium
    BJOG 119:662-71. 2012
    ....
  64. doi request reprint Improving the preoperative classification of adnexal masses as benign or malignant by second-stage tests
    A Daemen
    Department of Electrical Engineering ESAT SCD, Katholieke Universiteit Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 37:100-6. 2011
    ..The aim of this study was to establish when a second-stage diagnostic test may be of value in cases where a primary diagnostic test has given an uncertain diagnosis of the benign or malignant nature of an adnexal mass...
  65. doi request reprint Role of diaphragmatic surgery in 69 patients with ovarian carcinoma
    K Devolder
    Department of Obstetrics and Gynaecology, Division of Gynaecological Oncology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Gynecol Cancer 18:363-8. 2008
    ..We conclude that diaphragmatic resection is an important part of optimal debulking surgery with an acceptable morbidity...
  66. doi request reprint Clinical outcome after CO₂ laser laparoscopic radical excision of endometriosis with colorectal wall invasion combined with laparoscopic segmental bowel resection and reanastomosis
    C Meuleman
    Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, Leuven, Belgium
    Hum Reprod 26:2336-43. 2011
    ..This study was performed to test the hypothesis that this high complication rate can be prevented and combined with a good clinical outcome, following a multidisciplinary surgical approach...
  67. ncbi request reprint Endocrine Treatment and Prevention of Breast and Gynecological Cancers Vth International Symposium of the Flemish Gynecological Oncology Group, January 26-28, 2006
    P Neven
    Department of Obstetrics and Gynecology and Multidisciplinary Breast Center, UZ Leuven, Leuven, Belgium
    Int J Gynecol Cancer 16:479-91. 2006
  68. ncbi request reprint Uterine carcinosarcoma with melanocytic differentiation
    F Amant
    Department of Obstetrics and Gynecology, Division Gynecological Oncology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Int J Gynecol Pathol 20:186-90. 2001
    ..Electron-microscopic studies showed large tumor cells with an irregularly indented nucleus and abnormal giant cytoplasmic melanosomes. Only one case of uterine carcinosarcoma with melanocytic differentiation has been previously reported...
  69. doi request reprint The molecular genetic basis of ovarian cancer and its roadmap towards a better treatment
    E Despierre
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium
    Gynecol Oncol 117:358-65. 2010
    ..Recently, high-resolution genomic maps generated by genome-wide SNP analyses and novel sequencing technologies, have started to dissect the genetic basis of ovarian cancer...
  70. ncbi request reprint Endometrial cancer: predictors of response and preferred endocrine therapy
    F Amant
    Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, UZ Gasthuisberg, Katholieke Universiteit, Leuven, Belgium
    Int J Gynecol Cancer 16:527-8. 2006
  71. ncbi request reprint A thin and regular endometrium on ultrasound is very unlikely in patients with endometrial malignancy
    T van den Bosch
    Department of Obstetrics and Gynecology, University Hospitals Leuven, K U Leuven, Belgium
    Ultrasound Obstet Gynecol 29:674-9. 2007
    ..To evaluate the clinical and sonographic features in patients with endometrial malignancy in whom endometrial thickness on ultrasound examination had been recorded in our database to be < 5 mm...
  72. ncbi request reprint HPV induced ovarian squamous cell carcinoma: case report and review of the literature
    J Verguts
    Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
    Arch Gynecol Obstet 276:285-9. 2007
    ..Ovarian squamous cell carcinoma is usually derived from a teratoma, a Brenner tumour or endometriosis. Association with an HPV infection is rare...
  73. ncbi request reprint Role of lymphadenectomy and pelvic radiotherapy in patients with clinical FIGO stage I endometrial adenocarcinoma: An analysis of 208 patients
    I Kalogiannidis
    Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Gynecol Cancer 16:1885-93. 2006
    ..In conclusion, lymphadenectomy remains indicated to better select patients at high risk of pelvic recurrence that may benefit from postoperative radiotherapy...
  74. ncbi request reprint Second case of uterine mesonephric adenocarcinoma
    A Marquette
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Int J Gynecol Cancer 16:1450-4. 2006
    ..A second report of an intramural mesonephric adenocarcinoma of the uterus is presented. The histogenesis and clinicopathologic outcome of a surgically staged malignancy add to the insights and experience of this uncommon disorder...
  75. ncbi request reprint Endometrial carcinosarcoma with osteoclast-like giant cells
    F Amant
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Catholic University of Leuven, Leuven, Belgium
    Eur J Gynaecol Oncol 27:92-4. 2006
    ..The description of osteoclast-like giant cells adds to the knowledge of endometrial carcinosarcoma tumor biology...
  76. doi request reprint Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer
    Ignace Vergote
    University Hospitals, K U Leuven Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Herestraat 49, B 3000 Leuven, Belgium
    N Engl J Med 363:943-53. 2010
    ..Primary debulking surgery before initiation of chemotherapy has been the standard of care for patients with advanced ovarian cancer...
  77. ncbi request reprint External validation of mathematical models to distinguish between benign and malignant adnexal tumors: a multicenter study by the International Ovarian Tumor Analysis Group
    Caroline Van Holsbeke
    Department of Obstetrics and Gynecology, University Hospitals KU Leuven, Belgium
    Clin Cancer Res 13:4440-7. 2007
    ..However, few of them have been externally validated in new populations. Our aim was to compare their performance on a prospectively collected large multicenter data set...
  78. doi request reprint Leuven dose-dense paclitaxel/carboplatin regimen in patients with primary advanced or recurrent endometrial carcinoma
    Ingrid Vandenput
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Leuven Cancer Institute, University Hospitals Leuven, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    Int J Gynecol Cancer 19:1147-51. 2009
    ..To evaluate the response of dose-dense paclitaxel/carboplatin (TC) patients with primarily advanced or recurrent endometrial cancer...
  79. doi request reprint Qualitative assessment of the progesterone receptor and HER2 improves the Nottingham Prognostic Index up to 5 years after breast cancer diagnosis
    Vanya Van Belle
    Department of Electrical Engineering, Katholieke Universiteit Leuven, Kasteelpark Arenber, 10 2446, B 3001 Leuven, Belgium
    J Clin Oncol 28:4129-34. 2010
    ....
  80. ncbi request reprint Ineffective attempt to preserve fertility with a levonorgestrel-releasing intrauterine device in a young woman with endometrioid endometrial carcinoma: a case report and review of the literature
    I Vandenput
    Leuven Cancer Institute LKI, Division of Gynecological Oncology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Eur J Gynaecol Oncol 30:313-6. 2009
    ..The treatment of endometrial cancer in young women who want to preserve their fertility is challenging...
  81. ncbi request reprint Sexual and psychological functioning in women after pelvic surgery for gynaecological cancer
    L Aerts
    Department of Obstetrics and Gynecology, Institute of Family and Sexuality Studies, UZ Gasthuisberg Katholieke Universiteit Leuven, Belgium
    Eur J Gynaecol Oncol 30:652-6. 2009
    ..These results indicate that although the psychological adjustment of women who underwent pelvic surgery seems to be satisfactory, they seem to be at risk for sexual dysfunctions...
  82. ncbi request reprint Cumulative dosage effect of a RAD51L1/HMGA2 fusion and RAD51L1 loss in a case of pseudo-Meigs' syndrome
    F Amant
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium
    Genes Chromosomes Cancer 32:324-9. 2001
    ....
  83. ncbi request reprint Tamoxifen, screening and new oestrogen receptor modulators
    P Neven
    Department of Obstetrics and Gynaecology, Algemene Kliniek St.-Jan, Broekstraat 104, Brussels, B-1000, Belgium
    Best Pract Res Clin Obstet Gynaecol 15:365-80. 2001
    ..Longer endometrial safety will hopefully confirm these early findings. Whether other SERMs in development are better, and which of them is better for the breast, is to be demonstrated in ongoing studies...
  84. ncbi request reprint Pseudo-Meigs' syndrome caused by a hydropic degenerating uterine leiomyoma with elevated CA 125
    F Amant
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium
    Gynecol Oncol 83:153-7. 2001
    ..Uterine leiomyomas rarely cause pseudo-Meigs' syndrome with elevated serum CA 125 levels...
  85. ncbi request reprint Report of an unusual problematic uterine smooth muscle neoplasm, emphasizing the prognostic importance of coagulative tumor cell necrosis
    F Amant
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, and Department of Anatomic Pathology, University Hospitals Leuven, Leuven, Belgium
    Int J Gynecol Cancer 15:1210-2. 2005
    ..This case adds to the limited experience of the clinical behavior of problematic uterine smooth muscle cell neoplasms and underscores the prognostic importance of CTCN...
  86. doi request reprint The role of diaphragmatic surgery during interval debulking after neoadjuvant chemotherapy: an analysis of 74 patients with advanced epithelial ovarian cancer
    Dimitris Tsolakidis
    Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Gynecol Cancer 20:542-51. 2010
    ..The purpose of this retrospective study was to evaluate diaphragmatic surgery in achieving optimal cytoreductive results and its associated complications during interval debulking surgery in patients with advanced ovarian cancer...
  87. doi request reprint Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive
    Ben Van Calster
    Multidisciplinary Breast Centre, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium
    Breast Cancer Res Treat 113:181-7. 2009
    ..To examine the frequency of axillary lymph node (ALN) invasion of operable breast cancers by their combined oestrogen receptor (ER), progesterone receptor (PR) and HER-2 status...
  88. ncbi request reprint Laparoscopy-assisted vaginal hysterectomy compared with abdominal hysterectomy in clinical stage I endometrial cancer: safety, recurrence, and long-term outcome
    Ioannis Kalogiannidis
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Obstet Gynecol 196:248.e1-8. 2007
    ..To determine the feasibility of laparoscopic-assisted vaginal hysterectomy (LAVH) in the treatment of clinical FIGO stage I endometrial adenocarcinoma and long-term survival outcome...
  89. doi request reprint Wilms' tumor gene 1 (WT1) in endometrial carcinoma
    An Coosemans
    Laboratory of Experimental Gynaecology, Katholieke Universiteit Leuven, Leuven, Belgium
    Gynecol Oncol 111:502-8. 2008
    ..To expand the knowledge on the biological role of WT1 in other uterine cancers, we focused on its detection in endometrial carcinoma...
  90. ncbi request reprint Management of borderline ovarian neoplasms
    Isabelle Cadron
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Oncol 25:2928-37. 2007
    ....
  91. doi request reprint V-Y Bilateral gluteus maximus myocutaneous advancement flap in the reconstruction of large perineal defects after resection of pelvic malignancies
    D Di Mauro
    Department of Abdominal Surgery, University Hospital Gasthuisberg, Leuven, Belgium
    Colorectal Dis 11:508-12. 2009
    ..To evaluate the role of the V-Y bilateral gluteus maximus myocutaneous flap (GLM) in the reconstruction of large perineal defects after wide surgical resections for pelvic malignancies...
  92. pmc Balancing false positives and false negatives for the detection of differential expression in malignancies
    F De Smet
    Department of Electrical Engineering, ESAT SCD, K U Leuven, Kasteelpark Arenberg 10, 3001 Leuven Heverlee, Belgium
    Br J Cancer 91:1160-5. 2004
    ..As an example, we apply our method to data sets studying acute leukaemia...
  93. ncbi request reprint Microsatellite instability in uterine sarcomas
    F Amant
    Department of Obstetrics and Gynaecology, Pretoria Academic Hospital, Pretoria, South Africa
    Int J Gynecol Cancer 11:218-23. 2001
    ..In conclusion, it is suggested that tumor suppressor genes may play a role in the tumorigenesis of uterine mesenchymal cells, whereas mismatch repair genes contribute to the carcinogenesis of endometrial cancer...
  94. ncbi request reprint Immunohistochemical expression of CD10 antigen in uterine adenosarcoma
    F Amant
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium
    Int J Gynecol Cancer 14:1118-21. 2004
    ..Furthermore, CD10 positivity in recurrent UAS might guide the pathologist toward an endometrial stromal origin...
  95. ncbi request reprint PTEN mutations in uterine sarcomas
    F Amant
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, UZ Gasthuisberg, Leuven, Belgium
    Gynecol Oncol 85:165-9. 2002
    ..Since little is known about the molecular pathobiology, our goal was to investigate the potential role of the PTEN gene in the carcinogenesis of uterine sarcomas...
  96. doi request reprint Recurrent copy number alterations in BRCA1-mutated ovarian tumors alter biological pathways
    Karin Leunen
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Katholieke Universiteit Leuven, Belgium
    Hum Mutat 30:1693-702. 2009
    ..Moreover, important biological pathways are altered differentially when compared to the sporadic group...
  97. ncbi request reprint Endometrial stromal sarcoma with a sole t(X;17) chromosome change: report of a case and review of the literature
    Frederic Amant
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, 3000, Leuven, Belgium
    Gynecol Oncol 88:459-62. 2003
    ..Endometrial stromal sarcomas (ESSs) exhibit varying degrees of malignancy and heterogeneity at the karyotypic level. The biological mechanisms that contribute to tumorigenesis of ESS are still largely unknown...
  98. doi request reprint Application of proteomics in ovarian cancer: which sample should be used?
    Isabelle Cadron
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Gynecol Oncol 115:497-503. 2009
    ..This review gives an overview of proteomic studies performed in ovarian cancer focusing on the nature of samples that have been used...
  99. ncbi request reprint Transition of epithelial toward mesenchymal differentiation during ovarian carcinosarcoma tumorigenesis
    Frederic Amant
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium
    Gynecol Oncol 90:372-7. 2003
    ..It was the purpose of this study to test the monoclonal theory in ovarian carcinosarcoma...
  100. ncbi request reprint The use of laser microdissection and SELDI-TOF MS in ovarian cancer tissue to identify protein profiles
    Isabelle Cadron
    University Hospitals Leuven, Campus Gasthuisberg, Division of Gynecologic Oncology, Herestraat 49, B 3000 Leuven, Belgium
    Anticancer Res 29:1039-45. 2009
    ..There is a strong need for prognostic biomarkers in ovarian cancer patients due to the heterogeneous responses on current treatment modalities...
  101. ncbi request reprint Ethnic variations in uterine leiomyoma biology are not caused by differences in myometrial estrogen receptor alpha levels
    Frederic Amant
    Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium
    J Soc Gynecol Investig 10:105-9. 2003
    ..The present study was designed to investigate a possible physiologic role of racial differences in the myometrial estrogen receptor alpha in this phenomenon...