K Verbeke

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. doi request reprint Will the 13C-octanoic acid breath test ever replace scintigraphy as the gold standard to assess gastric emptying?
    K Verbeke
    Department of Gastrointestinal Research, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 21:1013-6. 2009
  2. doi request reprint Influence of the type of indigestible carbohydrate on plasma and urine short-chain fatty acid profiles in healthy human volunteers
    K Verbeke
    Department of Gastrointestinal Research and Leuven Food and Nutrition Research Centre LFoRCe, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Clin Nutr 64:678-84. 2010
  3. ncbi request reprint Effect of lactulose and Saccharomyces boulardii administration on the colonic urea-nitrogen metabolism and the bifidobacteria concentration in healthy human subjects
    V De Preter
    Department of Gastrointestinal Research, University Hospital Gasthuisberg, KU Leuven, Belgium
    Aliment Pharmacol Ther 23:963-74. 2006
  4. ncbi request reprint CYP3A5 and CYP3A4 but not MDR1 single-nucleotide polymorphisms determine long-term tacrolimus disposition and drug-related nephrotoxicity in renal recipients
    D R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals of Leuven, Leuven, Belgium
    Clin Pharmacol Ther 82:711-25. 2007
  5. ncbi request reprint Effect of dietary intervention with different pre- and probiotics on intestinal bacterial enzyme activities
    V De Preter
    Department of Gastrointestinal Research, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Clin Nutr 62:225-31. 2008
  6. doi request reprint In vivo CYP3A activity is significantly lower in cyclosporine-treated as compared with tacrolimus-treated renal allograft recipients
    H de Jonge
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Pharmacol Ther 90:414-22. 2011
  7. ncbi request reprint Baseline microbiota activity and initial bifidobacteria counts influence responses to prebiotic dosing in healthy subjects
    V De Preter
    Department of Gastrointestinal Research, University Hospital Gasthuisberg, K U Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 27:504-13. 2008
  8. doi request reprint In vivo CYP3A4 activity, CYP3A5 genotype, and hematocrit predict tacrolimus dose requirements and clearance in renal transplant patients
    H de Jonge
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Pharmacol Ther 92:366-75. 2012
  9. ncbi request reprint Clinical trial: a randomized-controlled crossover study of intrapyloric injection of botulinum toxin in gastroparesis
    J Arts
    Department of Neurogastroenterology, University Hospitals Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 26:1251-8. 2007
  10. ncbi request reprint Combined therapy with atorvastatin and calcineurin inhibitors: no interactions with tacrolimus
    W P D Lemahieu
    Department of Medicine, Division of Nephrology and Laboratory of Gastrointestinal Research, University Hospitals Gasthuisberg, Leuven, Belgium
    Am J Transplant 5:2236-43. 2005

Collaborators

Detail Information

Publications27

  1. doi request reprint Will the 13C-octanoic acid breath test ever replace scintigraphy as the gold standard to assess gastric emptying?
    K Verbeke
    Department of Gastrointestinal Research, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 21:1013-6. 2009
    ..In the current issue of this journal, Keller and her colleagues described the application of different mathematical models for analysis of the 13C-octanoic acid test in a very large patient population...
  2. doi request reprint Influence of the type of indigestible carbohydrate on plasma and urine short-chain fatty acid profiles in healthy human volunteers
    K Verbeke
    Department of Gastrointestinal Research and Leuven Food and Nutrition Research Centre LFoRCe, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Clin Nutr 64:678-84. 2010
    ..In this study, we analysed the short-chain fatty acid profiles in urine and serum derived from the colonic fermentation process of (13)C-barley meals, prepared from barley grown under (13)CO(2) atmosphere...
  3. ncbi request reprint Effect of lactulose and Saccharomyces boulardii administration on the colonic urea-nitrogen metabolism and the bifidobacteria concentration in healthy human subjects
    V De Preter
    Department of Gastrointestinal Research, University Hospital Gasthuisberg, KU Leuven, Belgium
    Aliment Pharmacol Ther 23:963-74. 2006
    ..Protein fermentation products, especially ammonia, are implicated in the pathogenesis of certain diseases...
  4. ncbi request reprint CYP3A5 and CYP3A4 but not MDR1 single-nucleotide polymorphisms determine long-term tacrolimus disposition and drug-related nephrotoxicity in renal recipients
    D R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals of Leuven, Leuven, Belgium
    Clin Pharmacol Ther 82:711-25. 2007
    ....
  5. ncbi request reprint Effect of dietary intervention with different pre- and probiotics on intestinal bacterial enzyme activities
    V De Preter
    Department of Gastrointestinal Research, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Clin Nutr 62:225-31. 2008
    ....
  6. doi request reprint In vivo CYP3A activity is significantly lower in cyclosporine-treated as compared with tacrolimus-treated renal allograft recipients
    H de Jonge
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Pharmacol Ther 90:414-22. 2011
    ..This observation has important implications in the context of drug-drug interactions in transplant recipients...
  7. ncbi request reprint Baseline microbiota activity and initial bifidobacteria counts influence responses to prebiotic dosing in healthy subjects
    V De Preter
    Department of Gastrointestinal Research, University Hospital Gasthuisberg, K U Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 27:504-13. 2008
    ..Dietary intervention with prebiotics can cause changes in the colonic microbiota and their metabolic activities...
  8. doi request reprint In vivo CYP3A4 activity, CYP3A5 genotype, and hematocrit predict tacrolimus dose requirements and clearance in renal transplant patients
    H de Jonge
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Pharmacol Ther 92:366-75. 2012
    ..Furthermore, these data provide a potential basis for a comprehensive approach to predicting tacrolimus dose requirement in individual patients and hence provide a strategy to tailor immunosuppressive therapy in transplant recipients...
  9. ncbi request reprint Clinical trial: a randomized-controlled crossover study of intrapyloric injection of botulinum toxin in gastroparesis
    J Arts
    Department of Neurogastroenterology, University Hospitals Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 26:1251-8. 2007
    ..Uncontrolled studies suggest benefit of intrapyloric injection of botulinum toxin (botox) for the treatment of gastroparesis, but controlled data are lacking...
  10. ncbi request reprint Combined therapy with atorvastatin and calcineurin inhibitors: no interactions with tacrolimus
    W P D Lemahieu
    Department of Medicine, Division of Nephrology and Laboratory of Gastrointestinal Research, University Hospitals Gasthuisberg, Leuven, Belgium
    Am J Transplant 5:2236-43. 2005
    ..Based on these findings treatment with Tac appears a safer option for patients needing a combination of statins and calcineurin inhibitors...
  11. doi request reprint Analysis of the urinary glucose-[¹⁵N, ¹⁵N]-ureide content in the study of the lactose-[¹⁵N, ¹⁵N]-ureide metabolism in healthy humans
    V De Preter
    Department of Gastrointestinal Research and Leuven Food Science and Nutrition Research Centre, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium
    Eur J Clin Nutr 65:959-64. 2011
    ..In addition, urine and faecal samples obtained during a dietary intervention study with the prebiotic lactulose were retrospectively analysed...
  12. ncbi request reprint In vivo evaluation of a colonic delivery system using isotope techniques
    K Verbeke
    Department of Gastrointestinal Research, University Hospital Gasthuisberg, Leuven, Belgium
    Aliment Pharmacol Ther 21:187-94. 2005
    ..This study was repeated after a 2-week lactulose intake period...
  13. ncbi request reprint Further investigations on the role of diet-induced thermogenesis in the regulation of feed intake in chickens: comparison of adult cockerels of lines selected for high or low residual feed intake
    Q Swennen
    Department of Biosystems, Katholieke Universiteit Leuven, 3001 Leuven, Belgium
    Poult Sci 86:1960-71. 2007
    ..Genotype did not influence plasma levels of triglycerides, free fatty acids, glucose, triiodothyronine, or thyroxine after refeeding, whereas plasma leptin levels were significantly higher in the R+ cockerels...
  14. doi request reprint Effect of mianserin on gastric sensorimotor function and gastric emptying: a randomized, placebo-controlled, double-blind, crossover study in healthy volunteers
    P Janssen
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 23:433-8, e174. 2011
    ..Antidepressants such as mianserin can improve symptoms in some functional dyspeptic patients but their mechanism of action remains unclear. We aimed to assess the effects of mianserin on gastric sensorimotor function in man...
  15. ncbi request reprint Superior dialytic clearance of beta(2)-microglobulin and p-cresol by high-flux hemodialysis as compared to peritoneal dialysis
    P Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Kidney Int 70:794-9. 2006
    ..In conclusion, superior dialytic clearance of both water-soluble solutes, beta(2)M, and pcr is achieved by high-flux HD as compared to PD...
  16. ncbi request reprint Influence of delaying gastric emptying on meal-related symptoms in healthy subjects
    J Tack
    Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 24:1045-50. 2006
    ..Although delayed gastric emptying is often found in functional dyspepsia, a causal role for delayed emptying in inducing symptoms has not been demonstrated...
  17. ncbi request reprint Acarbose treatment lowers generation and serum concentrations of the protein-bound solute p-cresol: a pilot study
    P Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Kidney Int 70:192-8. 2006
    ..Although further confirmation is warranted, the data may point to a novel treatment option for chronic kidney disease patients in view of the potential toxic effects of p-cresol and related substances...
  18. doi request reprint Free p-cresol is associated with cardiovascular disease in hemodialysis patients
    B K I Meijers
    Division of Nephrology, Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Kidney Int 73:1174-80. 2008
    ..Our study shows that free p-cresol is a novel cardiovascular risk factor in non-diabetic hemodialysis patients...
  19. ncbi request reprint Influence of intrapyloric botulinum toxin injection on gastric emptying and meal-related symptoms in gastroparesis patients
    J Arts
    Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 24:661-7. 2006
    ..Recent observations in limited numbers of patients suggest a potential benefit of intrapyloric injection of botulinum toxin in the treatment of gastroparesis...
  20. ncbi request reprint Influence of ghrelin on gastric emptying and meal-related symptoms in idiopathic gastroparesis
    J Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Aliment Pharmacol Ther 22:847-53. 2005
    ..Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor, is released from the stomach. Animal studies suggest that ghrelin stimulates gastrointestinal motor activity...
  21. doi request reprint The effects of acute citalopram dosing on gastric motor function and nutrient tolerance in healthy volunteers
    P Janssen
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Belgium
    Aliment Pharmacol Ther 33:395-402. 2011
    ..It is unclear whether endogenous serotonin release is involved in the regulation of gastric motility and food intake...
  22. ncbi request reprint Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients
    B Bammens
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Kidney Int 69:1081-7. 2006
    ..These findings may encourage nephrologists to widen their field of interest beyond the scope of small water-soluble uremic solutes and middle molecules...
  23. doi request reprint Gastric emptying and different types of reflux in adult patients with cystic fibrosis
    A Pauwels
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 34:799-807. 2011
    ..Previous studies showed delayed gastric emptying (GE) and a high prevalence of bile acids in saliva suggesting duodenogastro-oesophageal reflux (DGER)...
  24. ncbi request reprint Inulin is an ideal substrate for a hydrogen breath test to measure the orocaecal transit time
    K P Geboes
    Department of Gastroenterology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 18:721-9. 2003
    ..The recently developed lactose 13C-ureide breath test is reliable, but a hydrogen breath test is preferred, as it allows the simultaneous investigation of the digestion and absorption of nutrients by means of 13C-labelled compounds...
  25. ncbi request reprint The in vivo use of the stable isotope-labelled biomarkers lactose-[15N]ureide and [2H4]tyrosine to assess the effects of pro- and prebiotics on the intestinal flora of healthy human volunteers
    V De Preter
    Department of Gastrointestinal Research, University Hospital Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Br J Nutr 92:439-46. 2004
    ..The present results demonstrate that suppression of the generation and accumulation of potentially toxic fermentation metabolites by pro- and prebiotics can reliably be monitored in vivo by the use of stable isotope-labelled biomarkers...
  26. ncbi request reprint CYP3A4 and P-glycoprotein activity in healthy controls and transplant patients on cyclosporin vs. tacrolimus vs. sirolimus
    W P D Lemahieu
    Division of Nephrology, University Hospitals Gasthuisberg, University of Leuven, Belgium
    Am J Transplant 4:1514-22. 2004
    ..These data suggest that a different pattern of drug interactions might be expected in patients treated with CsA vs. FK506/Rapa...
  27. ncbi request reprint Diet-induced thermogenesis and glucose oxidation in broiler chickens: influence of genotype and diet composition
    Q Swennen
    Laboratory for Livestock Physiology and Immunology, Department of Biosystems, Katholieke Universiteit Leuven, Kasteelpark Arenberg 30, 3001 Leuven, Belgium
    Poult Sci 85:731-42. 2006
    ..Therefore, a model linking feed intake to diet-induced thermogenesis, as postulated for adult mammals, could not be corroborated for growing broiler chickens...