Y F Vanrenterghem

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Rifampin induces alterations in mycophenolic acid glucuronidation and elimination: implications for drug exposure in renal allograft recipients
    Maarten Naesens
    Department of Nephrology, Catholic University Leuven, University Hospitals Leuven, Belgium
    Clin Pharmacol Ther 80:509-21. 2006
  2. pmc A multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation
    Zbigniew Wlodarczyk
    Klinika Transplantologii, Szpital Uniwersytecki, Bydgoszcz, Poland
    BMC Nephrol 13:68. 2012
  3. ncbi request reprint Which calcineurin inhibitor is preferred in renal transplantation: tacrolimus or cyclosporine?
    Y F Vanrenterghem
    University Hospital Gasthuisberg, Leuven, Belgium
    Curr Opin Nephrol Hypertens 8:669-74. 1999
  4. ncbi request reprint Anaemia after renal transplantation
    Yves Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Nephrol Dial Transplant 19:V54-58. 2004
  5. ncbi request reprint Post-transplant diabetes mellitus and renal function with tacrolimus: A decade of use, a decade of evidence. Foreword
    Yves Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, KU Leuven, Herestraat 47, B3000 Leuven, Belgium
    Nephrol Dial Transplant 19:vi1-vi2. 2004
  6. ncbi request reprint The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients
    Yves Vanrenterghem
    Inwendige Geneeskunde Nefrologie, Universitaire Ziekenhuizen Gasthuisberg, Leuven, Belgium
    Transplantation 78:9-14. 2004
  7. ncbi request reprint Minimization of immunosuppressive therapy after renal transplantation: results of a randomized controlled trial
    Yves Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Transplant 5:87-95. 2005
  8. ncbi request reprint Prevalence and management of anemia in renal transplant recipients: a European survey
    Yves Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Transplant 3:835-45. 2003
  9. doi request reprint Belatacept-based regimens are associated with improved cardiovascular and metabolic risk factors compared with cyclosporine in kidney transplant recipients (BENEFIT and BENEFIT-EXT studies)
    Yves Vanrenterghem
    Nephrology Department, University Hospital Leuven, Leuven, Belgium
    Transplantation 91:976-83. 2011
  10. ncbi request reprint Prevalence and management of anaemia in transplant patients
    Yves Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Nephrol Dial Transplant 17:47. 2002

Detail Information

Publications80

  1. ncbi request reprint Rifampin induces alterations in mycophenolic acid glucuronidation and elimination: implications for drug exposure in renal allograft recipients
    Maarten Naesens
    Department of Nephrology, Catholic University Leuven, University Hospitals Leuven, Belgium
    Clin Pharmacol Ther 80:509-21. 2006
    ..It can be hypothesized that drugs interfering with glucuronidation and excretion will alter (Ac)MPA(G) exposure...
  2. pmc A multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation
    Zbigniew Wlodarczyk
    Klinika Transplantologii, Szpital Uniwersytecki, Bydgoszcz, Poland
    BMC Nephrol 13:68. 2012
    ..This multicenter phase II study in renal transplantation compared 3 concentration-controlled ranges of FK778 (manitimus) with mycophenolate mofetil (MMF) both given in combination with tacrolimus and corticosteroids...
  3. ncbi request reprint Which calcineurin inhibitor is preferred in renal transplantation: tacrolimus or cyclosporine?
    Y F Vanrenterghem
    University Hospital Gasthuisberg, Leuven, Belgium
    Curr Opin Nephrol Hypertens 8:669-74. 1999
    ..Both drugs are equally nephrotoxic, but tacrolimus induces less hypertension and less pronounced hyperlipidaemia. Especially in some categories of patients, a higher incidence of de-novo diabetes mellitus is seen with tacrolimus therapy...
  4. ncbi request reprint Anaemia after renal transplantation
    Yves Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Nephrol Dial Transplant 19:V54-58. 2004
    ..However, there does not appear to be any reason why anaemic renal transplant recipients should not be treated like any other patients with renal anaemia...
  5. ncbi request reprint Post-transplant diabetes mellitus and renal function with tacrolimus: A decade of use, a decade of evidence. Foreword
    Yves Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, KU Leuven, Herestraat 47, B3000 Leuven, Belgium
    Nephrol Dial Transplant 19:vi1-vi2. 2004
  6. ncbi request reprint The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients
    Yves Vanrenterghem
    Inwendige Geneeskunde Nefrologie, Universitaire Ziekenhuizen Gasthuisberg, Leuven, Belgium
    Transplantation 78:9-14. 2004
    ..We report first efficacy and safety data of FK778 in human kidney transplant recipients at two concentration-controlled ranges...
  7. ncbi request reprint Minimization of immunosuppressive therapy after renal transplantation: results of a randomized controlled trial
    Yves Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Transplant 5:87-95. 2005
    ..A longer follow-up will be needed to confirm the expected advantages for the long-term outcome and to assess the long-term safety of this minimization of immunosuppressive therapy...
  8. ncbi request reprint Prevalence and management of anemia in renal transplant recipients: a European survey
    Yves Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Transplant 3:835-45. 2003
    ..Further studies should be carried out to interpret whether appropriate management of anemia after kidney transplantation may improve long-term outcome...
  9. doi request reprint Belatacept-based regimens are associated with improved cardiovascular and metabolic risk factors compared with cyclosporine in kidney transplant recipients (BENEFIT and BENEFIT-EXT studies)
    Yves Vanrenterghem
    Nephrology Department, University Hospital Leuven, Leuven, Belgium
    Transplantation 91:976-83. 2011
    ..Belatacept, a selective co-stimulation blocker, may provide a better cardiovascular/metabolic risk profile than current immunosuppressants...
  10. ncbi request reprint Prevalence and management of anaemia in transplant patients
    Yves Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Nephrol Dial Transplant 17:47. 2002
  11. ncbi request reprint Tailoring immunosuppressive therapy for renal transplant recipients
    Y F Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Pediatr Transplant 5:467-72. 2001
    ....
  12. ncbi request reprint Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transplantation 82:1074-84. 2006
    ..MPAG is excreted into the bile via the multidrug resistance-associated protein 2 (MRP2/ABCC2), which is essential for enterohepatic (re)circulation (EHC) of MPA(G)...
  13. ncbi request reprint The value of tuberculin skin testing in haemodialysis patients
    Anne Wauters
    Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Nephrol Dial Transplant 19:433-8. 2004
    ..The aim of this prospective multi-centre study was to evaluate the tuberculin skin test (TST) as a screening method for detection of M.tuberculosis infection in haemodialysis patients...
  14. ncbi request reprint The impact of renal allograft function on exposure and elimination of mycophenolic acid (MPA) and its metabolite MPA 7-O-glucuronide
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Catholic University of Leuven, Leuven, Belgium
    Transplantation 84:362-73. 2007
    ..In contrast to these studies, other studies have associated renal impairment with higher MPA exposure. The reason for these inconsistencies is not clear...
  15. ncbi request reprint Impairment of small intestinal protein assimilation in patients with end-stage renal disease: extending the malnutrition-inflammation-atherosclerosis concept
    Bert Bammens
    Department of Medicine, Division of Nephrology and the Laboratory of Digestion and Absorption, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Clin Nutr 80:1536-43. 2004
    ..Protein malnutrition is a common finding in renal disease. Recently, we showed that impaired protein assimilation (digestion and absorption) may contribute to protein malnutrition in nondiabetic patients with chronic renal failure...
  16. ncbi request reprint Time profiles of peritoneal and renal clearances of different uremic solutes in incident peritoneal dialysis patients
    Bert Bammens
    Division of Nephrology, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Kidney Dis 46:512-9. 2005
    ..The beneficial impact of RRF also may be related to the preservation of specific renal elimination mechanisms, such as tubular metabolism or secretion, which are crucial for the removal of some uremic retention solutes...
  17. ncbi request reprint Predicting renal graft failure using multivariate longitudinal profiles
    Steffen Fieuws
    Biostatistical Centre, Katholieke Universiteit Leuven, Leuven, Belgium
    Biostatistics 9:419-31. 2008
    ..These estimates are used in a Bayes rule to obtain, at each point in time, the prognosis for long-term success of the transplant. It is shown that allowing the markers to be correlated can improve this prognosis...
  18. doi request reprint Reduced C0 concentrations and increased dose requirements in renal allograft recipients converted to the novel once-daily tacrolimus formulation
    Hylke de Jonge
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transplantation 90:523-9. 2010
    ..Hence, the package insert advices a 1:1 mg conversion. Here, we report our independent experience with conversion to TacOD according to the manufacturer's instructions...
  19. ncbi request reprint Duffy and Kidd blood group antigens: minor histocompatibility antigens involved in renal allograft rejection?
    Evelyne Lerut
    Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium
    Transfusion 47:28-40. 2007
    ....
  20. ncbi request reprint Prospective study on late consequences of subclinical non-compliance with immunosuppressive therapy in renal transplant patients
    Hans Vlaminck
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Am J Transplant 4:1509-13. 2004
    ..001). Non-compliance in renal transplant patients more than 1-year post transplantation is associated with an increased risk for LAR and a higher increase in serum-creatinine during the following 5 years...
  21. pmc p-Cresol and cardiovascular risk in mild-to-moderate kidney disease
    Bjorn K I Meijers
    Department of Medicine, Division of Nephrology and Laboratory for Gastro Intestinal Research and Leuven Food Science and Nutrition Research Centre LFoRCe, University Hospital Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 5:1182-9. 2010
    ..It is not known if p-cresol is associated with cardiovascular disease in patients with chronic kidney disease not yet on dialysis...
  22. doi request reprint Return to work and social participation: does type of organ transplantation matter?
    Christa De Baere
    Kidney Transplantation Program, University Hospitals of Leuven, Leuven, Belgium
    Transplantation 89:1009-15. 2010
    ..These outcomes have never been compared with the general population...
  23. pmc p-Cresyl sulfate and indoxyl sulfate in hemodialysis patients
    Bjorn K I Meijers
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 4:1932-8. 2009
    ..They share important features such as the albumin-binding site, low dialytic clearance, and both originate from protein fermentation. Whether serum concentrations are related is, however, not known...
  24. ncbi request reprint Cytochrome P450 3A4 and P-glycoprotein activity and assimilation of tacrolimus in transplant patients with persistent diarrhea
    Wim Lemahieu
    Department of Medicine, Division of Nephrology, University Hospital, Gasthuisberg, Leuven, Belgium
    Am J Transplant 5:1383-91. 2005
    ..This pattern was not influenced by the specific cause of diarrhea. These data strongly suggest that persistent diarrhea is associated with an increased oral bioavailability of Tac...
  25. ncbi request reprint Posttransplantation diabetes mellitus in FK-506-treated renal transplant recipients: analysis of incidence and risk factors
    B D Maes
    Department of Medicine, University Hospital Gathuisberg, Leuven, Belgium
    Transplantation 72:1655-61. 2001
    ..Higher trough levels of FK-506 during the first month, acute rejections, and higher BMI were the most obvious risk factors...
  26. ncbi request reprint Prometheus versus molecular adsorbents recirculating system: comparison of efficiency in two different liver detoxification devices
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Artif Organs 30:276-84. 2006
    ..PROM produces higher blood clearances for most toxins, which results in higher delivered treatment doses compared with a matching treatment with MARS...
  27. ncbi request reprint The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, Laboratory of Absorption and Digestion, University Hospitals Leuven, Belgium
    Clin Pharmacol Ther 78:351-61. 2005
    ....
  28. ncbi request reprint Subclinical peritubular capillaritis at 3 months is associated with chronic rejection at 1 year
    Evelyne Lerut
    Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium
    Transplantation 83:1416-22. 2007
    ..Peritubular capillaritis has been associated with chronic rejection, but the characteristics of subclinical lesions in peritubular capillaries are unknown...
  29. pmc Measuring total blood calcium displays a low sensitivity for the diagnosis of hypercalcemia in incident renal transplant recipients
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 5:2085-92. 2010
    ..The performance of total calcium (tCa) in the diagnosis of blood calcium disturbances in renal transplant recipients is unknown...
  30. ncbi request reprint Detoxifying capacity and kinetics of prometheus--a new extracorporeal system for the treatment of liver failure
    Pieter Evenepoel
    Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Blood Purif 23:349-58. 2005
    ..The aim of the present study was to evaluate the removal capacity and selectivity of the different inbuilt dialyzers and adsorption columns during a single 6-hour treatment...
  31. doi request reprint Tacrolimus dose requirements and CYP3A5 genotype and the development of calcineurin inhibitor-associated nephrotoxicity in renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals of Leuven, Leuven, Belgium
    Ther Drug Monit 32:394-404. 2010
    ..Prolonged calcineurin inhibitor maintenance therapy in kidney allograft recipients is complicated by the development of chronic irreversible drug-induced nephrotoxicity (CNIT)...
  32. doi request reprint Calcium requirements after parathyroidectomy in patients with refractory secondary hyperparathyroidism
    Liesbeth Viaene
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Nephron Clin Pract 110:c80-5. 2008
    ..The current study aims to quantify these calcium needs and to identify predictors of a high calcium need present at the time of surgery...
  33. pmc Fibroblast growth factor-23 in early chronic kidney disease: additional support in favor of a phosphate-centric paradigm for the pathogenesis of secondary hyperparathyroidism
    Pieter Evenepoel
    Department of Medicine, University Hos pital Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 5:1268-76. 2010
    ....
  34. doi request reprint Effects of CYP3A5 and MDR1 single nucleotide polymorphisms on drug interactions between tacrolimus and fluconazole in renal allograft recipients
    Dirk R Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, Leuven, Belgium
    Pharmacogenet Genomics 18:861-8. 2008
    ..The aim of this study was to examine the influence of the CYP3A4, CYP3A5, and MDR1 single nucleotide polymorphisms on changes in tacrolimus exposure and dosing in renal allograft recipients treated with fluconazole...
  35. ncbi request reprint Current target ranges of mycophenolic acid exposure and drug-related adverse events: a 5-year, open-label, prospective, clinical follow-up study in renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Ther 30:673-83. 2008
    ..No reduced incidence of MMF-related adverse events (AEs) was observed in either of the 2 trials when MMF concentration-controlled and fixed dosing were compared...
  36. doi request reprint Early clinical assessment of glucose metabolism in renal allograft recipients: diagnosis and prediction of post-transplant diabetes mellitus (PTDM)
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, Belgium
    Nephrol Dial Transplant 23:2033-42. 2008
    ..Post-transplant diabetes mellitus (PTDM) has serious consequences for renal allograft survival, cardiovascular risk and patient survival...
  37. pmc Recovery of hyperphosphatoninism and renal phosphorus wasting one year after successful renal transplantation
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, B 3000 Leuven, Belgium
    Clin J Am Soc Nephrol 3:1829-36. 2008
    ..Transplant recipients were (1:1) matched for estimated GFR with chronic kidney disease (CKD) patients...
  38. doi request reprint Troponin I is a predictor of acute cardiac events in the immediate postoperative renal transplant period
    Kathleen Claes
    Department of Nephrology and Transplantation, University Hospitals Gasthuisberg, Leuven, Belgium
    Transplantation 89:341-6. 2010
    ..Patients on the renal transplant waiting list and renal transplant recipients have an increased risk of premature cardiovascular (CV) disease and death...
  39. ncbi request reprint Acute rejection in non-compliant renal allograft recipients: a distinct morphology
    Evelyne Lerut
    Departments of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium
    Clin Transplant 21:344-51. 2007
    ..Detection of non-compliance is mandatory as it represents an important cause of graft loss. This study describes histologic features of renal allograft biopsies in non-compliant patients that could help identifying this patient profile...
  40. ncbi request reprint Heparin-coated polyacrylonitrile membrane versus regional citrate anticoagulation: a prospective randomized study of 2 anticoagulation strategies in patients at risk of bleeding
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Am J Kidney Dis 49:642-9. 2007
    ..0), and heparin-coated membranes (1.3 m(2); AN69ST; Nephral 300ST, Gambro-Hospal, Meyzieu, France) may represent valid alternatives...
  41. ncbi request reprint Parathyroidectomy after successful kidney transplantation: a single centre study
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Nephrol Dial Transplant 22:1730-7. 2007
    ..To gain insight into the incidence, risk factors and consequences of parathyroidectomy in patients with a functioning renal graft, we performed a retrospective case-controlled study...
  42. ncbi request reprint Recurrence of light chain deposit disease after renal allograft transplantation: potential role of rituximab?
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transpl Int 20:381-5. 2007
    ....
  43. ncbi request reprint Drug interaction between mycophenolate mofetil and rifampin: possible induction of uridine diphosphate-glucuronosyltransferase
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, B 3000 Leuven, Belgium
    Clin Pharmacol Ther 78:81-8. 2005
    ....
  44. ncbi request reprint Adjuvant low-dose cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Am J Transplant 5:1997-2004. 2005
    ..In this selected group of recipients with BKVIN, the use of adjuvant low-dose cidofovir therapy resulted in prolonged graft survival and stabilized graft function...
  45. ncbi request reprint Clinical efficacy and toxicity profile of tacrolimus and mycophenolic acid in relation to combined long-term pharmacokinetics in de novo renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Clin Pharmacol Ther 75:434-47. 2004
    ....
  46. ncbi request reprint Regional citrate anticoagulation for hemodialysis using a conventional calcium-containing dialysate
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Am J Kidney Dis 39:315-23. 2002
    ..Compared with the use of a calcium-free dialysate, the number of analyses can be reduced substantially, making this method financially attractive...
  47. ncbi request reprint Anti-CD20 monoclonal antibody (rituximab) treatment for hepatitis C-negative therapy-resistant essential mixed cryoglobulinemia with renal and cardiac failure
    Erik Ghijsels
    Division of Nephrology and Renal Transplantation, Department of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Kidney Dis 43:e34-8. 2004
    ..In a 24-month follow-up period, our patient remains in remission and free of symptoms...
  48. ncbi request reprint Darbepoetin alfa administered once monthly maintains haemoglobin levels in stable dialysis patients
    Michel Jadoul
    Department of Nephrology, Cliniques Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Nephrol Dial Transplant 19:898-903. 2004
    ..The objective of this study was to explore once-monthly administration in this patient population...
  49. ncbi request reprint Natural history of parathyroid function and calcium metabolism after kidney transplantation: a single-centre study
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Belgium
    Nephrol Dial Transplant 19:1281-7. 2004
    ..Our aim was to evaluate the post-transplant natural history of parathyroid function and calcium metabolism in patients with a functional renal graft and to identify risk factors for persistent HPT...
  50. ncbi request reprint Nephrogenic fibrosing dermopathy: a novel, disabling disorder in patients with renal failure
    Pieter Evenepoel
    Division of Nephrology, Department of Medicine, University Hospital Leuven, Leuven, Belgium
    Nephrol Dial Transplant 19:469-73. 2004
  51. ncbi request reprint Evidence for impaired assimilation of protein in chronic renal failure
    Bert Bammens
    Department of Medicine, Division of Nephrology and Laboratory of Radiopharmaceutical Chemistry, University Hospital Gasthuisberg, Leuven, Belgium
    Kidney Int 64:2196-203. 2003
    ..We hypothesized that besides inadequate dietary protein intake and alterations in metabolism, deficient protein assimilation (digestion and absorption) might contribute to the pathogenesis of protein malnutrition in uremia...
  52. ncbi request reprint Health professionals' perceptions of health status after renal transplantation: a comparison with transplantation candidates' expectations
    Irina Cleemput
    Centre for Health Services and Nursing Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Transplantation 76:176-82. 2003
    ....
  53. ncbi request reprint C3D deposition in peritubular capillaries indicates a variant of acute renal allograft rejection characterized by a worse clinical outcome
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transplantation 76:102-8. 2003
    ....
  54. ncbi request reprint Detoxifying capacity and kinetics of the molecular adsorbent recycling system. Contribution of the different inbuilt filters
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Blood Purif 21:244-52. 2003
    ..Our data suggest that the rate and efficacy of removal of albumin-bound toxins are related to both the strength of the albumin binding and the saturation of the adsorption columns...
  55. ncbi request reprint Influence of SDZ RAD vs. MMF on gastric emptying in renal transplant recipients
    Bart D Maes
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Transplant 17:171-6. 2003
    ..Because of the impact on drug absorption and gastrointestinal symptoms, further studies are indicated to corroborate the potential prokinetic properties of SDZ RAD...
  56. ncbi request reprint Health-related quality of life and symptom experience in tacrolimus-based regimens after renal transplantation: a multicentre study
    Philip Moons
    Centre for Health Services and Nursing Research, Katholieke Universiteit of Leuven, Kapucijnenvoer 35 4, 3000, Leuven, Belgium
    Transpl Int 16:653-64. 2003
    ..Therefore, interventions, including the screening and treatment for depression and the addressing of gender-specific issues, can enhance quality of life...
  57. ncbi request reprint An uncommon tumor in a renal graft recipient: a diagnostic and therapeutic challenge
    Kathleen Claes
    Department of Nephrology and Transplantation, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Kidney Dis 40:E21. 2002
    ..This case report also illustrates the different imaging modalities that can be used for the diagnosis of neuroendocrine tumors...
  58. ncbi request reprint A new acute inflammatory syndrome related to the introduction of mycophenolate mofetil in patients with Wegener's granulomatosis
    Bart Maes
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Nephrol Dial Transplant 17:923-6. 2002
    ..Because this side effect of MMF may also occur after solid organ transplantation and in other immune disorders, pharmacokinetic profiling of MPA and MPA acyl glucuronide is needed in future studies with MMF...
  59. ncbi request reprint A prospective proof of concept study of the efficacy of tacrolimus ointment on uraemic pruritus (UP) in patients on chronic dialysis therapy
    Dirk R Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Nephrol Dial Transplant 19:1895-901. 2004
    ..UP causes skin damage, discomfort, sleeping disorders and diminished quality of life. Since UP is considered to be in part an immune-mediated inflammatory process, immunosuppressive drugs like tacrolimus may be beneficial...
  60. ncbi request reprint Time-related clinical determinants of long-term tacrolimus pharmacokinetics in combination therapy with mycophenolic acid and corticosteroids: a prospective study in one hundred de novo renal transplant recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Pharmacokinet 43:741-62. 2004
    ..The specific characteristics of the inter-relationship between dose, concentration and clinical (side-)effects for tacrolimus have not yet been identified and extensive long-term pharmacokinetic studies are presently lacking...
  61. ncbi request reprint The rate of gastric emptying determines the timing but not the extent of oral tacrolimus absorption: simultaneous measurement of drug exposure and gastric emptying by carbon-14-octanoic acid breath test in stable renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Drug Metab Dispos 32:1421-5. 2004
    ....
  62. ncbi request reprint The construct and concurrent validity of the EQ-5D in a renal transplant population
    Irina Cleemput
    Centre for Health Services and Nursing Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Value Health 7:499-509. 2004
    ..Such instruments should be widely applicable in diverse patient populations and their validity should be established. The aim of this study was to explore the validity of the EQ-5D in renal transplant patients...
  63. ncbi request reprint A simplified strategy for clinical management of late cytomegalovirus infection after oral ganciclovir prophylaxis in renal recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Antimicrob Chemother 55:391-4. 2005
    ..Identifying patients at risk for late infection is clinically difficult; prolonged cytomegalovirus (CMV) monitoring is costly and cumbersome as follow-up intervals lengthen...
  64. ncbi request reprint Impact of parathyroidectomy on renal graft function, blood pressure and serum lipids in kidney transplant recipients: a single centre study
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Nephrol Dial Transplant 20:1714-20. 2005
    ..To evaluate the impact of PTX on blood pressure (BP), renal graft function and serum lipids, we performed a retrospective case-controlled study in renal graft recipients...
  65. ncbi request reprint Impact of gastric acid suppressants on cytochrome P450 3A4 and P-glycoprotein: consequences for FK506 assimilation
    Wim P D Lemahieu
    Division of Nephrology and Laboratory of Digestion and Absorption, Department of Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Kidney Int 67:1152-60. 2005
    ..Cimetidine and omeprazole are known modulators of several CYPs in vitro. In the present study, the impact of cimetidine and omeprazole on tacrolimus exposure and on CYP3A4/PGP activity in vivo was examined...
  66. ncbi request reprint Time to reach tacrolimus maximum blood concentration,mean residence time, and acute renal allograft rejection: an open-label, prospective, pharmacokinetic study in adult recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Clin Ther 26:1834-44. 2004
    ....
  67. pmc Calcium metabolism in the early posttransplantation period
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 4:665-72. 2009
    ..Both the abrupt cessation of calcium-containing phosphorus binders and vitamin D (analogs) at the time of surgery and the recovery of renal function may be hypothesized to affect serum calcium levels in this period...
  68. ncbi request reprint Secondary effects of immunosuppressive drugs after simultaneous pancreas-kidney transplantation
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Nephrol Dial Transplant 20:ii33-9, ii62. 2005
    ..This report examines the early and late secondary effects of tacrolimus, cyclosporin microemulsion (ME), mycophenolate mofetil (MMF) and rabbit anti-thymocyte globulin (rATG) in simultaneous pancreas-kidney (SPK) recipients...
  69. ncbi request reprint Cyclosporine withdrawal from a mycophenolate mofetil-containing immunosuppressive regimen in stable kidney transplant recipients: a randomized, controlled study
    Daniel Abramowicz
    Hopital Erasme, Bruxelles, Belgium
    Transplantation 74:1725-34. 2002
    ..Several nonrandomized studies suggest that CsA might safely be withdrawn from immunosuppressive regimens containing mycophenolate mofetil (MMF; CellCept)...
  70. ncbi request reprint FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation
    Helio Tedesco-Silva
    Hospital do Rim e Hipertensao, Sao Paulo 04038 002, Brazil
    Transplantation 79:1553-60. 2005
    ..Its effect relates to the modulation of lymphocytes trafficking from blood and peripheral tissues to lymph nodes. This is the first study to evaluate the efficacy and safety of FTY720 in de novo renal transplantation...
  71. ncbi request reprint Efficacy and cardiovascular safety of daclizumab, mycophenolate mofetil, tacrolimus, and early steroid withdrawal in renal transplant recipients: a multicenter, prospective, pilot trial
    Daniel Abramowicz
    Nephrology and Renal Transplantation, ULB, Hopital Erasme, Brussels, Belgium
    Clin Transplant 19:475-82. 2005
    ..The regimen appears to be associated with a favorable cardiovascular profile...
  72. ncbi request reprint A prospective randomized multicenter study of tacrolimus in combination with sirolimus in renal-transplant recipients
    Johannes P van Hooff
    Academisch Ziekenhuis Maastricht, Department of Internal Medicine, Maastricht, The Netherlands
    Transplantation 75:1934-9. 2003
    ..Recently, sirolimus (SRL) was introduced as an immunosuppressant in solid-organ transplantation. This study evaluated combinations of SRL and tacrolimus (Tac)...
  73. ncbi request reprint Clinically relevant drug interaction between voriconazole and tacrolimus in a primary renal allograft recipient
    Dirk R Kuypers
    Transplantation 81:1750-2. 2006
  74. ncbi request reprint Nonadherence with immunosuppressive drugs: U.S. compared with European kidney transplant recipients
    Kris Denhaerynck
    University of Basel, Switzerland
    Prog Transplant 16:206-14. 2006
    ..System factors increasingly are suggested as important yet understudied correlates of nonadherence...
  75. ncbi request reprint Expanding the donor pool to increase renal transplantation
    Bernard Cohen
    Eurotransplant International Foundation, Leiden, The Netherlands
    Nephrol Dial Transplant 20:34-41. 2005
    ..New initiatives were taken in order to maximize donor usage while maintaining a successful transplant outcome...
  76. pmc Effects of gastric emptying on oral mycophenolic acid pharmacokinetics in stable renal allograft recipients
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Br J Clin Pharmacol 63:541-7. 2007
    ..Previous studies in healthy subjects and diabetes patients have suggested that MPA pharmacokinetics are influenced by gastric emptying, but this has not been demonstrated directly...
  77. ncbi request reprint MYSS: should we alter clinical practice?
    Bart Maes
    Lancet 364:2016-7; author reply 2017-8. 2004
  78. doi request reprint Association of four DNA polymorphisms with acute rejection after kidney transplantation
    Josep Grinyo
    Department of Nephrology, Hospital de Bellvitge, University of Barcelona, Barcelona, Spain
    Transpl Int 21:879-91. 2008
    ..Variation in genes of immune response and pharmacodynamic/pharmacokinetic relevance may be important in understanding acute rejection after renal transplant...
  79. ncbi request reprint Reduced exposure to calcineurin inhibitors in renal transplantation
    Henrik Ekberg
    Lund University, Malmo, Sweden
    N Engl J Med 357:2562-75. 2007
    ..Immunosuppressive regimens with the fewest possible toxic effects are desirable for transplant recipients. This study evaluated the efficacy and relative toxic effects of four immunosuppressive regimens...
  80. ncbi request reprint Efficacy and safety of tacrolimus compared with cyclosporine microemulsion in primary simultaneous pancreas-kidney transplantation: 1-year results of a large multicenter trial
    Wolf Otto Bechstein
    Department of General Surgery, Charite Campus Virchow Clinic, Berlin, Germany
    Transplantation 77:1221-8. 2004
    ..This open-label, multicenter study compared the efficacy and safety of tacrolimus with the microemulsion (ME) formulation of cyclosporine in a clinical setting. The 1-year results are reported here...