Rik Vandenberghe

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..In this sample the specificity of (18)F-flutemetamol based SVM for distinguishing AD from controls is higher than that of gray matter volume-based SVM...

..Functional imaging has also provided hints about the differences in functional contribution between inferior and superior parietal cortex. These hypotheses await further confirmation based on lesion evidence...

..Its availability, however, is limited by the need for an on-site cyclotron. Validation of the (18)F-labeled PIB derivative (18)F-flutemetamol could significantly enhance access to this novel technology...

..The advances at the clinical and at the basic research levels are necessary if we wish to meet the formidable challenge that the increasing prevalence of Alzheimer's disease poses to the medical community...

..Functional imaging in neglect patients will be necessary to assess IPS function in those cases where the structural lesion spares the middle IPS segment...

..Selection among competing word forms sharing a same semantic field is abnormal in PPA. The semantic interference effect constitutes a positive distinguishing feature between PPA and PRAD...

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..Functional reorganization of the language system in response to Abeta amyloid-related brain injury exists in early-stage AD and determines the degree of anomia more than Abeta amyloid load per se does...

..Omissions and reaction time variability had less localising value in our sample. To conclude, commission errors and post-error slowing in the SART mainly probe right inferior frontal integrity...

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..Our findings demonstrate that the human superior parietal cortex critically contributes to spatially selective attention...

..We have characterized the biodistribution and dosimetry of (18)F-3'-F-6-OH-BTA1 ((18)F-GE067), a newly developed radioligand to visualize and quantify amyloid burden, in healthy elderly human subjects...

..Thus, the left perisylvian temporoparietal area may underpin verbal imitative behavior, gesture imitation, and gesture discrimination indicative of a partly shared neural substrate for language and gesture resonance...

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..34; SE, 0.19), with an intermediate pattern in PPA without comprehension deficit (LI, +0.23; SE, 0.14). The rightward laterality shift previously reported in aphasic stroke extends to PPA, in particular, when comprehension is deficient...

..Right-hemispheric recruitment and disconnections within the right temporal lobe may affect the degree of aphasia in cortical neurodegenerative disease...

..Therefore, right fusiform gyrus critically contributes to the conscious recollection of visual attributes of familiar entities...

..Our data provide converging evidence for a critical contribution of the lower bank of the left posterior STS to mapping word form onto word meaning (lexical-semantic retrieval)...

..Our findings are in line with a model where the initial stages of perceptual identification and visual short-term memory access rely on long-distance connections that are shared between written words and pictures...

..Our study reconciles the role of middle IPS in attentional selection and biased competition with its role in VSTM access...

..The amodal nature of left OTS and IFS involvement in word and picture processing extends to tasks with minimal semantic executive demands...

..The current experiment confirms that left frontal convexity is sensitive to manipulations of the direction of visuospatial attention. The results do not indicate a specific role of parietal cortex in attentional shifting...

..Furthermore, the study demonstrated within a same experiment a functional dissociation between reorienting and selection in parietal cortex...

..Placement of a coronary stent-graft resulted in immediate complete resolution of clinical symptoms and radiologic restoration of normal flow...

..These results confirm that processing in the human visual cortex is task dependent and underscore the role of the middle fusiform gyrus in temporal comparison of simple attributes...

..Its relatively equal activation for leftward and rightward attentional shifts is also consistent with models of right hemispheric dominance of spatial attention...

..This report is based on a review of the literature (except the literature in Japanese) and own findings in patients with autoimmune-mediated encephalitis...

..The response to spatial shifts and the correlation with the distance between the original and the new location points to a specific role of the superior parietal gyrus in shifting the locus of spatial attention...

..The degree to which brain systems adapt in a plastic way to pathogenetic processes at multiple levels, is a determinant of disease manifestation and an important target for current and future therapies...

..Furthermore, in a Belgian series of familial FTD patients, PGRN mutations were 3.5 times more frequent than mutations in MAPT, underscoring a principal involvement of PGRN in FTD pathogenesis...

..Our findings extend the mutation spectrum in PGRN leading to loss of functional PGRN as the basis for FTD...

..Progranulin gene (PGRN) haploinsufficiency was recently associated with ubiquitin-positive frontotemporal lobar degeneration linked to chromosome 17q21 (FTLDU-17)...