A M Vandamme

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc HIV-1 gp120 N-linked glycosylation differs between plasma and leukocyte compartments
    Yung Shwen Ho
    Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Westmead NSW, 2145 Sydney, Australia
    Virol J 5:14. 2008
  2. pmc Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach
    Dimitrios Paraskevis
    Katholieke Universiteit Leuven, Rega Institute for Medical Research, Minderbroederstraat 10, B 3000 Leuven, Belgium
    Retrovirology 6:49. 2009
  3. pmc Estimating the individualized HIV-1 genetic barrier to resistance using a nelfinavir fitness landscape
    Kristof Theys
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    BMC Bioinformatics 11:409. 2010
  4. ncbi request reprint Anti-human immunodeficiency virus drug combination strategies
    A M Vandamme
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antivir Chem Chemother 9:187-203. 1998
  5. ncbi request reprint Managing resistance to anti-HIV drugs: an important consideration for effective disease management
    A M Vandamme
    Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Belgium
    Drugs 57:337-61. 1999
  6. ncbi request reprint Updated European recommendations for the clinical use of HIV drug resistance testing
    A M Vandamme
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antivir Ther 9:829-48. 2004
  7. ncbi request reprint Laboratory guidelines for the practical use of HIV drug resistance tests in patient follow-up
    A M Vandamme
    AIDS Reference Laboratory, Rega Institute and University Hospitals, KU Leuven, Belgium
    Antivir Ther 6:21-39. 2001
  8. pmc African origin of human T-lymphotropic virus type 2 (HTLV-2) supported by a potential new HTLV-2d subtype in Congolese Bambuti Efe Pygmies
    A M Vandamme
    Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Belgium
    J Virol 72:4327-40. 1998
  9. pmc Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues
    K Van Vaerenbergh
    Rega Institute for Medical Research and University Hospitals, Leuven, Belgium
    Antimicrob Agents Chemother 44:2109-17. 2000
  10. pmc A primate T-lymphotropic virus, PTLV-L, different from human T-lymphotropic viruses types I and II, in a wild-caught baboon (Papio hamadryas)
    P Goubau
    Department of Microbiology, Rega Institute and University Hospitals, Katholieke Universiteit Leuven, Belgium
    Proc Natl Acad Sci U S A 91:2848-52. 1994

Detail Information

Publications58

  1. pmc HIV-1 gp120 N-linked glycosylation differs between plasma and leukocyte compartments
    Yung Shwen Ho
    Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Westmead NSW, 2145 Sydney, Australia
    Virol J 5:14. 2008
    ..Although it is known that glycosylation changes can dramatically influence virus recognition by the host antibody, the actual contribution of compartmental differences in N-linked glycosylation patterns remains unclear...
  2. pmc Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach
    Dimitrios Paraskevis
    Katholieke Universiteit Leuven, Rega Institute for Medical Research, Minderbroederstraat 10, B 3000 Leuven, Belgium
    Retrovirology 6:49. 2009
    ..However the spatial diffusion of the epidemic from the perspective of the virus has not previously been traced...
  3. pmc Estimating the individualized HIV-1 genetic barrier to resistance using a nelfinavir fitness landscape
    Kristof Theys
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    BMC Bioinformatics 11:409. 2010
    ..By simulation of evolution over this landscape, the individualized genetic barrier to NFV resistance may be estimated for an isolate...
  4. ncbi request reprint Anti-human immunodeficiency virus drug combination strategies
    A M Vandamme
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antivir Chem Chemother 9:187-203. 1998
    ..HIV drug resistance testing to guide this salvage therapy and the development of new drugs to allow new options will therefore remain priorities in anti-HIV drug research...
  5. ncbi request reprint Managing resistance to anti-HIV drugs: an important consideration for effective disease management
    A M Vandamme
    Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Belgium
    Drugs 57:337-61. 1999
    ..The development of new drugs will remain necessary for those patients who have failed to respond to all currently available drugs, as will be the institution of more effective and less toxic HAART regimens...
  6. ncbi request reprint Updated European recommendations for the clinical use of HIV drug resistance testing
    A M Vandamme
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antivir Ther 9:829-48. 2004
    ..The panel also encourages the timely collection of epidemiological information to estimate the impact of transmission of resistant HIV and the prevalence of HIV-1 non-B subtypes in the different European countries...
  7. ncbi request reprint Laboratory guidelines for the practical use of HIV drug resistance tests in patient follow-up
    A M Vandamme
    AIDS Reference Laboratory, Rega Institute and University Hospitals, KU Leuven, Belgium
    Antivir Ther 6:21-39. 2001
    ....
  8. pmc African origin of human T-lymphotropic virus type 2 (HTLV-2) supported by a potential new HTLV-2d subtype in Congolese Bambuti Efe Pygmies
    A M Vandamme
    Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Belgium
    J Virol 72:4327-40. 1998
    ..When the STLV-2 bonobo viruses PP1664 and PanP were used as an outgroup, it was clear that the Pygmy HTLV-2 Efe2 strain had the longest independent evolution and that HTLV-2 evolution is consistent with an African origin...
  9. pmc Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues
    K Van Vaerenbergh
    Rega Institute for Medical Research and University Hospitals, Leuven, Belgium
    Antimicrob Agents Chemother 44:2109-17. 2000
    ..MNR HIV-1 is found only among multinucleoside-experienced patients. Its prevalence is low in Europe, but it should be closely monitored since it seriously limits treatment options...
  10. pmc A primate T-lymphotropic virus, PTLV-L, different from human T-lymphotropic viruses types I and II, in a wild-caught baboon (Papio hamadryas)
    P Goubau
    Department of Microbiology, Rega Institute and University Hospitals, Katholieke Universiteit Leuven, Belgium
    Proc Natl Acad Sci U S A 91:2848-52. 1994
    ..Whether PTLV-L resembles PTLV-I and PTLV-II in the extension of its host range to other primates, including humans, remains to be seen...
  11. ncbi request reprint S-adenosylhomocysteine hydrolase inhibitors interfere with the replication of human immunodeficiency virus type 1 through inhibition of the LTR transactivation
    D Daelemans
    Rega Institute for Medical Research, Katholieke Universtiteit Leuven, Belgium
    Mol Pharmacol 52:1157-63. 1997
    ..Our results suggest that AdoHcy hydrolase and the associated S-adenosylmethionine-dependent methylation mechanism play a role in the process of long terminal repeat transactivation and, hence, HIV replication...
  12. ncbi request reprint Use of a generic polymerase chain reaction assay detecting human T-lymphotropic virus (HTLV) types I, II and divergent simian strains in the evaluation of individuals with indeterminate HTLV serology
    A M Vandamme
    Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Belgium
    J Med Virol 52:1-7. 1997
    ..This new assay can identify otherwise undetected HTLV-I or HTLV-II infections and is a useful tool of screening for new types of HTLV among seroindeterminate samples...
  13. ncbi request reprint Comparison of the LiPA HIV-1 RT test, selective PCR and direct solid phase sequencing for the detection of HIV-1 drug resistance mutations
    J C Schmit
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    J Virol Methods 73:77-82. 1998
    ..Overall, there was a 73 to 100% concordance between the three methods. In this study, LiPA HIV-1 RT proved to be an accurate and reliable alternative to DNA sequencing for the detection of drug resistance mutations in patient samples...
  14. ncbi request reprint SlidingBayes: exploring recombination using a sliding window approach based on Bayesian phylogenetic inference
    D Paraskevis
    Laboratory for Clinical and Epidemiological Virology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Bioinformatics 21:1274-5. 2005
    ..The tool can be used for nucleotide and amino acid sequences and combines all the modeling possibilities of MrBayes with the ability to plot the posterior probability support for clustering of various combinations of taxa...
  15. pmc SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus
    M Witvrouw
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antimicrob Agents Chemother 41:262-8. 1997
    ..Time-of-addition experiments indicated that SRR-SB3 acts at a late stage of the HIV-1 replicative cycle...
  16. pmc Complete nucleotide sequence of the new simian T-lymphotropic virus, STLV-PH969 from a Hamadryas baboon, and unusual features of its long terminal repeat
    M van Brussel
    Rega Institute for Medical Research and University Hospitals, Leuven, Belgium
    J Virol 71:5464-72. 1997
    ..We conclude that STLV-PH969 has all the genes and genomic regions to suggest a replication cycle comparable to that of HTLV-1 and HTLV-2...
  17. ncbi request reprint Evolutionary rate and genetic heterogeneity of human T-cell lymphotropic virus type II (HTLV-II) using isolates from European injecting drug users
    M Salemi
    Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Mol Evol 46:602-11. 1998
    ..This is the lowest fixation rate so far reported for RNA viruses, including for HIV, which typically range between 10(-2) and 10(-4)...
  18. ncbi request reprint Optimization of a genotypic assay applicable to all human immunodeficiency virus type 1 protease and reverse transcriptase subtypes
    J Snoeck
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium
    J Virol Methods 128:47-53. 2005
    ..The detection limit for these samples was 5000 copies/ml. A sequence could be obtained in both directions for most of the samples...
  19. ncbi request reprint The presence of a divergent T-lymphotropic virus in a wild-caught pygmy chimpanzee (Pan paniscus) supports an African origin for the human T-lymphotropic/simian T-lymphotropic group of viruses
    A M Vandamme
    Rega Institute for Medical Research, Leuven, Belgium
    J Gen Virol 77:1089-99. 1996
    ..Thus, as for the other primate retroviruses HIV and SIV, PTLV most probably has its origins in Africa...
  20. ncbi request reprint Failure to quantify viral load with two of the three commercial methods in a pregnant woman harboring an HIV type 1 subtype G strain
    Z Debyser
    Department of Microbiology and Immunology, Rega Institute and University Hospitals, Katholieke Universiteit Leuven, Belgium
    AIDS Res Hum Retroviruses 14:453-9. 1998
    ..In the case of discrepant low viral loads determined by one amplification technique in patients with advanced clinical stage one should use an alternative quantification technique for confirmation...
  21. ncbi request reprint Analysis of HIV-1 pol sequences using Bayesian Networks: implications for drug resistance
    K Deforche
    Rega Institute for Medical Research, Katholieke Universiteit Leuven Leuven, Belgium
    Bioinformatics 22:2975-9. 2006
    ....
  22. doi request reprint Resistance pathways of human immunodeficiency virus type 1 against the combination of zidovudine and lamivudine
    K Theys
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    J Gen Virol 91:1898-908. 2010
    ..Moreover, a model to predict resistance evolution during AZT and 3CT treatment has been built and validated...
  23. ncbi request reprint The discovery of two new divergent STLVs has implications for the evolution and epidemiology of HTLVs
    M van Brussel
    Rega Institute for Medical Research and University Hospitals, Leuven, Belgium
    Rev Med Virol 9:155-70. 1999
    ..Considering the growing interest in xenotransplantations, more epidemiological and biological knowledge of simian and human T-lymphotropic viruses is necessary to estimate the risk of interspecies transmissions...
  24. ncbi request reprint The three human T-lymphotropic virus type I subtypes arose from three geographically distinct simian reservoirs
    H F Liu
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    J Gen Virol 77:359-68. 1996
    ..In the rooted env trees obtained using the STLV strain PH969 as an outgroup, the Asian strains branched off before the African strains, implying an Asian origin for HTLV/STLV type I based on presently available strains...
  25. ncbi request reprint Analysis of the evolutionary relationships of HIV-1 and SIVcpz sequences using bayesian inference: implications for the origin of HIV-1
    D Paraskevis
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Mol Biol Evol 20:1986-96. 2003
    ..The discordant phylogenetic relationships between the HIV-1/SIVcpz sequences may have been caused by ancient recombination events, but they are also due, at least in part, to altered rates of evolution between parental SIVcpz lineages...
  26. ncbi request reprint The genomic structure of a new simian T-lymphotropic virus, STLV-PH969, differs from that of human T-lymphotropic virus types I and II
    M van Brussel
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    J Gen Virol 77:347-58. 1996
    ..Therefore, the distinct classification of this virus can be justified, not only in terms of sequence divergence but also in terms of its different genomic structure...
  27. ncbi request reprint Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype
    K Van Laethem
    Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Belgium
    AIDS 15:553-61. 2001
    ..CONCLUSION: Changes in the non-nucleoside binding pocket must affect the conformation of residues at the dNTP binding site, and can result in a partial phenotypic reversal of the multi-nucleoside resistance phenotype...
  28. pmc Different population dynamics of human T cell lymphotropic virus type II in intravenous drug users compared with endemically infected tribes
    M Salemi
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 96:13253-8. 1999
    ..We also noted a sharp increase in the population size of the virus among IDUs during the last decades probably caused by the worldwide increase in intravenous drug use...
  29. pmc 1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity
    M Witvrouw
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antimicrob Agents Chemother 42:618-23. 1998
    ..Modelling studies suggest that in contrast to most other NNRTIs, but akin to nevirapine, QM96521 does not act as a hydrogen bond donor in the RT-drug complex...
  30. ncbi request reprint Long-term stability of human immunodeficiency virus viral load and infectivity in whole blood
    A M Vandamme
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Eur J Clin Invest 29:445-52. 1999
    ..We intended to evaluate the stability of human immunodeficiency virus (HIV) type 1 virions in whole blood and in culture medium...
  31. ncbi request reprint Two new human T-lymphotropic virus type I phylogenetic subtypes in seroindeterminates, a Mbuti pygmy and a Gabonese, have closest relatives among African STLV-I strains
    M Salemi
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Virology 246:277-87. 1998
    ..In addition, present day serological tests do not reliably type strains within the HTLV-Ib Central African subtype...
  32. ncbi request reprint The simian T-lymphotropic virus STLV-PP1664 from Pan paniscus is distinctly related to HTLV-2 but differs in genomic organization
    M van Brussel
    Rega Institute for Medical Research, Louvain, Belgium
    Virology 243:366-79. 1998
    ..Although arguments pro and contra a distinct classification are nearly equally balanced, we propose to classify this virus as an STLV-2, designated STLV-2PP1664...
  33. ncbi request reprint Analysis of complex HIV-1 intersubtype recombinants using a Bayesian scanning method
    D Paraskevis
    Laboratory for Clinical and Epidemiological Virology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Infect Genet Evol 5:219-24. 2005
    ..Thus, a recently developed Bayesian scanning tool can facilitate the analysis and classification of HIV-1 mosaic sequences...
  34. ncbi request reprint A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibition of human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry
    D Daelemans
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Mol Pharmacol 57:116-24. 2000
    ..Mechanism of action studies revealed that CGP64222 can inhibit the HIV replicative cycle, also through a selective interaction with the CXC-chemokine receptor 4 coreceptor...
  35. ncbi request reprint Development of resistance of human immunodeficiency virus type 1 to dextran sulfate associated with the emergence of specific mutations in the envelope gp120 glycoprotein
    J A Este
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Mol Pharmacol 52:98-104. 1997
    ....
  36. ncbi request reprint The origin and evolution of human T-cell lymphotropic virus type II (HTLV-II) and the relationship with its replication strategy
    M Salemi
    Rega Institute for Medical Research, KULeuven, B 3000, Leuven, Belgium
    Gene 234:11-21. 1999
    ..It might be speculated that at least two separate introductions of HTLV-II in European IDUs from US IDUs have occurred, due to the practice of needle-sharing among IDUs...
  37. ncbi request reprint Tempo and mode of human and simian T-lymphotropic virus (HTLV/STLV) evolution revealed by analyses of full-genome sequences
    M Salemi
    Rega Institute for Medical Research, KULeuven, Belgium
    Mol Biol Evol 17:374-86. 2000
    ..In particular, the HTLV-I/STLV-I history might suggest a simian migration from Asia to Africa not much earlier than 19,500-60,000 years ago...
  38. ncbi request reprint Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138
    H Pelemans
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, B-3000, Belgium
    Virology 280:97-106. 2001
    ....
  39. ncbi request reprint The simian origins of the pathogenic human T-cell lymphotropic virus type I
    A M Vandamme
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Trends Microbiol 6:477-83. 1998
    ..Molecular epidemiology suggests that all subtypes arose from separate interspecies transmissions from simians to humans...
  40. ncbi request reprint Initiation of HAART in drug-naive HIV type 1 patients prevents viral breakthrough for a median period of 35.5 months in 60% of the patients
    K Van Vaerenbergh
    Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    AIDS Res Hum Retroviruses 18:419-26. 2002
    ..Virologic failure was associated with the development of resistance-related mutations, a later stage of disease at start of therapy and lower PI drug levels...
  41. ncbi request reprint Human immunodeficiency virus gene regulation as a target for antiviral chemotherapy
    D Daelemans
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antivir Chem Chemother 10:1-14. 1999
    ..Although a promising lead, considerable research is still required before gene regulation inhibitors may come of age as clinically useful agents...
  42. ncbi request reprint Dating the origin of the African human T-cell lymphotropic virus type-i (HTLV-I) subtypes
    S Van Dooren
    Rega Institute for Medical Research, Kotholieke Universiteit Leuven, Leuven, Belgium
    Mol Biol Evol 18:661-71. 2001
    ..Due to the small number of strains in some of the investigated groups, these data on selective pressure should be taken with caution...
  43. ncbi request reprint Bayesian network analysis of resistance pathways against HIV-1 protease inhibitors
    K Deforche
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Infect Genet Evol 7:382-90. 2007
    ..We successfully applied the method to three protease inhibitors. The analysis shows differences with current knowledge especially concerning resistance development in several non-B subtypes...
  44. pmc Decreasing population selection rates of resistance mutation K65R over time in HIV-1 patients receiving combination therapy including tenofovir
    K Theys
    Rega Institute for Medical Research, KU Leuven, Leuven, Belgium
    J Antimicrob Chemother 68:419-23. 2013
    ....
  45. ncbi request reprint Estimation of an in vivo fitness landscape experienced by HIV-1 under drug selective pressure useful for prediction of drug resistance evolution during treatment
    K Deforche
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Bioinformatics 24:34-41. 2008
    ..The method was evaluated for recovering 10 random fictive selective pressures in simulation experiments, and for modeling the selective pressure under treatment with the protease inhibitor nelfinavir...
  46. ncbi request reprint Evolutionary strategies of human T-cell lymphotropic virus type II
    A M Vandamme
    Rega Institute for Medical Research, KULeuven, Minderbroedersstraat 10 B 3000 Leuven, Belgium
    Gene 261:171-80. 2000
    ..These contrasting evolutionary rates correlate with an endemic spread of HTLV-II in infected tribes compared to an epidemic spread in IDUs...
  47. ncbi request reprint The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains
    S Van Dooren
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Mol Biol Evol 21:603-11. 2004
    ..06 x 10(-7)-1.38 x 10(-5)substitutions per site per year. We also note an interesting correlation between the occurrence of mutations in HTLV-1 and the age of the individual infected...
  48. pmc HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir
    K Theys
    Rega Institute for Medical Research, KU Leuven, Leuven, Belgium
    Antimicrob Agents Chemother 57:1053-6. 2013
    ..K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways...
  49. ncbi request reprint Prevalence of genotypic resistance among antiretroviral drug-naive HIV-1-infected patients in Belgium
    K Van Vaerenbergh
    Rega Institute for Medical Research, University of Leuven, Belgium
    Antivir Ther 6:63-70. 2001
    ..3% and 22%, which were based on sequencing methods. According to the European guidelines for resistance testing, resistance testing in Belgium before starting antiviral therapy should be considered...
  50. ncbi request reprint Stereospecificity of 6'-C-neplanocin A analogues as inhibitors of S-adenosylhomocysteine hydrolase activity and human immunodeficiency virus replication
    D Daelemans
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Nucleosides Nucleotides 17:479-86. 1998
    ..The R-isomers showed much greater activity against AdoHcy hydrolase than the S-isomers. The same differential activity was observed against the HIV-1 replication and the Tat transactivation...
  51. ncbi request reprint Complete nucleotide sequence of the Italian human T-cell lymphotropic virus type II isolate Gu and phylogenetic identification of a possible origin of South European epidemics
    M Salemi
    Istituto di Genetica Biochimica ed Evoluzionistica del C N R, Pavia, Italy
    J Gen Virol 77:1193-201. 1996
    ..The results suggest that HTLV-II-Gu and other IIb South European isolates were probably derived from North American IIb isolates. The data also indicate that sequence analysis is necessary to further classify IIa and IIb subtypes...
  52. doi request reprint The epidemic history of hepatitis C among injecting drug users in Flanders, Belgium
    C Mathei
    Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium
    J Viral Hepat 15:399-408. 2008
    ..Moreover, results suggested that the hepatitis C subtype 3a epidemic has reached a steady state, while the hepatitis C 1a epidemic has not, which therefore might become the predominant subtype among IDUs...
  53. ncbi request reprint A quantitative GFP-based bioassay for the detection of HIV-1 Tat transactivation inhibitors
    D Daelemans
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000, Leuven, Belgium
    J Virol Methods 96:183-8. 2001
    ..The assay can be used for the detection and quantification of HIV transactivation, and for the high throughput evaluation of anti-transactivation drugs in different cellular backgrounds...
  54. ncbi request reprint HIV forensics: pitfalls and acceptable standards in the use of phylogenetic analysis as evidence in criminal investigations of HIV transmission
    E J Bernard
    NAM, London, UK
    HIV Med 8:382-7. 2007
    ..In these trials, the expert opinion of virologists has been of critical importance...
  55. ncbi request reprint Molecular characterization of a complex, recombinant human immunodeficiency virus type 1 (HIV-1) isolate (A/G/J/K/?): evidence to support the existence of a novel HIV-1 subtype
    D Paraskevis
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, 75 Mikras Asias Street, GR 115 27 Athens, Greece
    J Gen Virol 82:2509-14. 2001
    ..Thus, novel recombinants embody partial genomic regions which may have originated either from subtypes that existed in the past and became extinct or from contemporary subtypes that are extremely rare...
  56. ncbi request reprint Evaluation of two commercial kits for the detection of genotypic drug resistance on a panel of HIV type 1 subtypes A through J
    E Fontaine
    , , Luxembourg
    J Acquir Immune Defic Syndr 28:254-8. 2001
    ..Our data therefore suggest that the performance of amplification and sequencing primers must be improved to allow fast and reliable resistance testing for all HIV-1 subtypes...
  57. ncbi request reprint Phylogenetic analysis of the full-length SARS-CoV sequences: evidence for phylogenetic discordance in three genomic regions
    G Magiorkinis
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
    J Med Virol 74:369-72. 2004
    ....
  58. ncbi request reprint Re-analysis of human immunodeficiency virus type 1 isolates from Cyprus and Greece, initially designated 'subtype I', reveals a unique complex A/G/H/K/? mosaic pattern
    D Paraskevis
    National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, M Asias 75, Athens 115 27, Greece
    J Gen Virol 82:575-80. 2001
    ....