Ruud van Winkel

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Major changes in glucose metabolism, including new-onset diabetes, within 3 months after initiation of or switch to atypical antipsychotic medication in patients with schizophrenia and schizoaffective disorder
    Ruud van Winkel
    University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium
    J Clin Psychiatry 69:472-9. 2008
  2. doi request reprint Evidence that the COMTVal158Met polymorphism moderates subclinical psychotic and affective symptoms in unaffected first-degree relatives of patients with schizophrenia
    Ruud van Winkel
    University Psychiatric Center, Katholieke Universiteit Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
    Eur Psychiatry 23:219-22. 2008
  3. ncbi request reprint Psychiatric diagnosis as an independent risk factor for metabolic disturbances: results from a comprehensive, naturalistic screening program
    Ruud van Winkel
    University Psychiatric Center Catholic University Leuven, Kortenberg, Belgium
    J Clin Psychiatry 69:1319-27. 2008
  4. ncbi request reprint Premorbid IQ as a predictor for the course of IQ in first onset patients with schizophrenia: a 10-year follow-up study
    Ruud van Winkel
    University Psychiatric Center Katholieke Universiteit Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
    Schizophr Res 88:47-54. 2006
  5. ncbi request reprint Screening for diabetes and other metabolic abnormalities in patients with schizophrenia and schizoaffective disorder: evaluation of incidence and screening methods
    Ruud van Winkel
    University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium
    J Clin Psychiatry 67:1493-500. 2006
  6. pmc A case series: evaluation of the metabolic safety of aripiprazole
    Marc De Hert
    University Psychiatric Center Katholieke Universiteit Leuven, Leuvense Steenweg 517, 3070 Kortenberg, Belgium
    Schizophr Bull 33:823-30. 2007
  7. doi request reprint Prevalence of diabetes and the metabolic syndrome in a sample of patients with bipolar disorder
    Ruud van Winkel
    University Psychiatric Center Katholieke Universiteit Leuven, Kortenberg, Belgium
    Bipolar Disord 10:342-8. 2008
  8. doi request reprint Relationships between physical fitness, physical activity, smoking and metabolic and mental health parameters in people with schizophrenia
    Davy Vancampfort
    University Psychiatric Centre Catholic University Leuven, campus Kortenberg, Kortenberg, Belgium
    Psychiatry Res 207:25-32. 2013
  9. ncbi request reprint Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress in psychosis: an experience-sampling study
    Ruud van Winkel
    University Psychiatric Center Katholieke Universiteit Leuven, Leuvensesteenweg, Kortenberg, Belgium
    Am J Med Genet B Neuropsychiatr Genet 147:10-7. 2008
  10. doi request reprint Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis
    Marc De Hert
    University Psychiatric Centre, Catholic University Leuven, Kortenberg, Belgium
    CNS Drugs 26:733-59. 2012

Detail Information

Publications28

  1. ncbi request reprint Major changes in glucose metabolism, including new-onset diabetes, within 3 months after initiation of or switch to atypical antipsychotic medication in patients with schizophrenia and schizoaffective disorder
    Ruud van Winkel
    University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium
    J Clin Psychiatry 69:472-9. 2008
    ..To investigate 3-month changes in glucose metabolism in a naturalistic sample of patients with schizophrenia newly started on or switched to specific atypical antipsychotic medication therapy...
  2. doi request reprint Evidence that the COMTVal158Met polymorphism moderates subclinical psychotic and affective symptoms in unaffected first-degree relatives of patients with schizophrenia
    Ruud van Winkel
    University Psychiatric Center, Katholieke Universiteit Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
    Eur Psychiatry 23:219-22. 2008
    ....
  3. ncbi request reprint Psychiatric diagnosis as an independent risk factor for metabolic disturbances: results from a comprehensive, naturalistic screening program
    Ruud van Winkel
    University Psychiatric Center Catholic University Leuven, Kortenberg, Belgium
    J Clin Psychiatry 69:1319-27. 2008
    ..Unconfounded differences in inherent vulnerability to metabolic disturbance may be hypothesized for different diagnostic groups with severe mental illness...
  4. ncbi request reprint Premorbid IQ as a predictor for the course of IQ in first onset patients with schizophrenia: a 10-year follow-up study
    Ruud van Winkel
    University Psychiatric Center Katholieke Universiteit Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
    Schizophr Res 88:47-54. 2006
    ..Rather, catching up of cognitive function later in the course of the illness may take place in those whose deficits become apparent in the early phases of illness, whereas those with the most severe premorbid impairments remain stable...
  5. ncbi request reprint Screening for diabetes and other metabolic abnormalities in patients with schizophrenia and schizoaffective disorder: evaluation of incidence and screening methods
    Ruud van Winkel
    University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium
    J Clin Psychiatry 67:1493-500. 2006
    ..To assess the diagnostic properties of 2 different screening guidelines for the detection of diabetes in patients diagnosed with schizophrenia...
  6. pmc A case series: evaluation of the metabolic safety of aripiprazole
    Marc De Hert
    University Psychiatric Center Katholieke Universiteit Leuven, Leuvense Steenweg 517, 3070 Kortenberg, Belgium
    Schizophr Bull 33:823-30. 2007
    ..The MetS was reversed in 50% of patients at 3 months follow-up. Our results support the reversibility of recent onset diabetes on antipsychotic medication when detected early and followed by a switch to aripiprazole...
  7. doi request reprint Prevalence of diabetes and the metabolic syndrome in a sample of patients with bipolar disorder
    Ruud van Winkel
    University Psychiatric Center Katholieke Universiteit Leuven, Kortenberg, Belgium
    Bipolar Disord 10:342-8. 2008
    ..There are limited data on the prevalence of the metabolic abnormalities in disorders other than schizophrenia in which antipsychotic medication is part of routine treatment...
  8. doi request reprint Relationships between physical fitness, physical activity, smoking and metabolic and mental health parameters in people with schizophrenia
    Davy Vancampfort
    University Psychiatric Centre Catholic University Leuven, campus Kortenberg, Kortenberg, Belgium
    Psychiatry Res 207:25-32. 2013
    ..Less physically active patients who smoke and suffer from high levels of negative, depressive and/or cognitive symptoms might benefit from specific rehabilitation interventions aimed at increasing physical fitness...
  9. ncbi request reprint Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress in psychosis: an experience-sampling study
    Ruud van Winkel
    University Psychiatric Center Katholieke Universiteit Leuven, Leuvensesteenweg, Kortenberg, Belgium
    Am J Med Genet B Neuropsychiatr Genet 147:10-7. 2008
    ....
  10. doi request reprint Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis
    Marc De Hert
    University Psychiatric Centre, Catholic University Leuven, Kortenberg, Belgium
    CNS Drugs 26:733-59. 2012
    ..However, until now, the metabolic risk profile of the newly approved SGAs - asenapine, iloperidone, lurasidone and paliperidone (paliperidone extended release and paliperidone palmitate) - has not been compared...
  11. ncbi request reprint Treatment with rosuvastatin for severe dyslipidemia in patients with schizophrenia and schizoaffective disorder
    Marc De Hert
    University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium
    J Clin Psychiatry 67:1889-96. 2006
    ..Use of lipid-lowering drugs such as statins is recommended when lifestyle changes are not sufficient to reach the LDL goal. The efficacy and safety of rosuvastatin treatment were evaluated in schizophrenic patients...
  12. doi request reprint Differential effects of olanzapine and risperidone on plasma adiponectin levels over time: results from a 3-month prospective open-label study
    Martien Wampers
    University Psychiatric Centre Catholic University Leuven, campus Kortenberg, Kortenberg, Belgium
    Eur Neuropsychopharmacol 22:17-26. 2012
    ..The observed olanzapine-associated reduction in plasma adiponectin levels may at least partially contribute to the increased metabolic risk of olanzapine compared to risperidone...
  13. doi request reprint Typical and atypical antipsychotics differentially affect long-term incidence rates of the metabolic syndrome in first-episode patients with schizophrenia: a retrospective chart review
    Marc De Hert
    University Psychiatric Center Katholieke Universiteit Leuven, Leuvense Steenweg 517, 3070 Kortenberg, Belgium
    Schizophr Res 101:295-303. 2008
    ..There are limited data on the prevalence of MetS in patients with schizophrenia at the onset of the disorder and specifically no data on patients treated in the era when only first-generation antipsychotics were available...
  14. ncbi request reprint Remission criteria for schizophrenia: evaluation in a large naturalistic cohort
    Marc De Hert
    University Psychiatric Centre Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
    Schizophr Res 92:68-73. 2007
    ..Little is known, however, about the added value of the time criterion in addition to the cross-sectional severity criterion...
  15. doi request reprint Effects of cannabis use on age at onset in schizophrenia and bipolar disorder
    Marc De Hert
    University Psychiatric Centre Catholic University Leuven campus Kortenberg, Leuvense Steenweg 517, 3070 Kortenberg, Belgium
    Schizophr Res 126:270-6. 2011
    ..Cannabis use may decrease age at onset in both schizophrenia and bipolar disorder, given the evidence for substantial phenotypic and genetic overlap between both disorders...
  16. doi request reprint CNR1 gene and risk of the metabolic syndrome in patients with schizophrenia
    Weiping Yu
    University Psychiatric Center Campus Kortenberg, Katholieke University Leuven, Kortenberg, Belgium
    J Clin Psychopharmacol 33:186-92. 2013
    ..Further studies are needed to uncover the exact molecular basis for this association, which could provide novel treatment targets for the MetS...
  17. ncbi request reprint Prevalence of the metabolic syndrome in patients with schizophrenia treated with antipsychotic medication
    Marc A De Hert
    University Center St Jozef, Catholic University Louvain, Leuvense Steenweg 517, 3070 Kortenberg, Belgium
    Schizophr Res 83:87-93. 2006
    ..The presence of the metabolic syndrome is an important risk factor for cardiovascular disease and diabetes. There are limited data on the prevalence of the metabolic syndrome in European patients suffering from schizophrenia...
  18. ncbi request reprint Body weight and self-esteem in patients with schizophrenia evaluated with B-WISE
    Marc De Hert
    University Psychiatric Center Katholieke Universiteit Leuven, Leuvense Steenweg 517, 3070 Kortenberg, Belgium
    Schizophr Res 88:222-6. 2006
    ..The second objective was to explore the association of B-WISE scores with the metabolic syndrome and glucose abnormalities...
  19. doi request reprint Considering a frame of reference for physical activity research related to the cardiometabolic risk profile in schizophrenia
    Davy Vancampfort
    University Psychiatric Center, Catholic University Leuven, campus Kortenberg, Belgium
    Psychiatry Res 177:271-9. 2010
    ..More research is needed to assist in the practical development of effective evidence-based preventive and curative strategies in psychiatric services for metabolic syndrome in persons with schizophrenia...
  20. ncbi request reprint Anticholinergic use in hospitalised schizophrenic patients in Belgium
    Marc De Hert
    University Psychiatric Centre Katholieke Universiteit Leuven, campus Kortenberg, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
    Psychiatry Res 152:165-72. 2007
    ..However, there were no significant differences in the prevalence of EPS with the exception of akathisia between FGA and SGA. Thus, through the use of anticholinergics, EPS induced by FGA can be effectively reduced...
  21. doi request reprint Age at onset of psychotic disorder: cannabis, BDNF Val66Met, and sex-specific models of gene-environment interaction
    Jeroen Decoster
    University Psychiatric Centre Catholic University Leuven, Kortenberg, Belgium
    Am J Med Genet B Neuropsychiatr Genet 156:363-9. 2011
    ..No compelling evidence was found that BDNF genotype is associated with age at onset of psychotic disorder in the absence of cannabis use...
  22. doi request reprint Metabolic and cardiovascular adverse effects associated with antipsychotic drugs
    Marc De Hert
    University Psychiatric Center, Catholic University Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium marc de hert uc kortenberg be
    Nat Rev Endocrinol 8:114-26. 2012
    ....
  23. pmc Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data
    Carla Truyers
    Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium
    BMC Fam Pract 12:132. 2011
    ..Many studies are performed in specialized settings with a strong focus on schizophrenia. Somatic comorbidity after psychosis is studied, using a general practice comorbidity registration network...
  24. ncbi request reprint Childhood trauma as a cause of psychosis: linking genes, psychology, and biology
    Ruud van Winkel
    Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Can J Psychiatry 58:44-51. 2013
    ....
  25. pmc Metabolic syndrome in people with schizophrenia: a review
    Marc De Hert
    University Psychiatric Center, Catholic University Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
    World Psychiatry 8:15-22. 2009
    ..The somatic treatments offered to people with severe and enduring mental illness should be at par with general health care in the non-psychiatrically ill population...
  26. ncbi request reprint Reversibility of antipsychotic treatment-related diabetes in patients with schizophrenia: a case series of switching to aripiprazole
    Marc De Hert
    Diabetes Care 29:2329-30. 2006
  27. ncbi request reprint Pharmacological treatment of severe dyslipidaemia in patients with schizophrenia
    Linda Hanssens
    Department of Epidemiology and Public Health, Nutrition and Metabolic Disorders CHU Sart Tilman, University Liege, Liege, Belgium
    Int Clin Psychopharmacol 22:43-9. 2007
    ..Statins proved effective in the management of dyslipidaemia in patients with schizophrenia treated with antipsychotics. More complex treatment may be required for associated metabolic disturbances...
  28. ncbi request reprint Clinical trials and tribulations: perspectives on research career development
    Marlene P Freeman
    J Clin Psychiatry 69:470-1. 2008