Philip Van Damme

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Upregulation of HSP27 in a transgenic model of ALS
    Vicky Vleminckx
    Dept of Neurology, University of Leuven, Medical School, Belgium
    J Neuropathol Exp Neurol 61:968-74. 2002
  2. pmc Benefits of intensive insulin therapy on neuromuscular complications in routine daily critical care practice: a retrospective study
    Greet Hermans
    Department of Internal Medicine, Medical Intensive Care Unit, University Hospitals Leuven, Catholic University Leuven, Leuven, Belgium
    Crit Care 13:R5. 2009
  3. pmc Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium
    J Cell Biol 181:37-41. 2008
  4. doi request reprint VEGF protects motor neurons against excitotoxicity by upregulation of GluR2
    Elke Bogaert
    Laboratory of Neurobiology, Experimental Neurology, K U Leuven, Leuven, Belgium
    Neurobiol Aging 31:2185-91. 2010
  5. doi request reprint The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding
    Louis De Muynck
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Neurobiol Aging 34:2541-7. 2013
  6. ncbi request reprint Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis
    Maria Andries
    Department of Molecular Cell Biology, Faculty of Medicine, KU Leuven, Campus Gasthuisberg, Leuven, Belgium
    Neurobiol Dis 25:8-16. 2007
  7. pmc Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 104:14825-30. 2007
  8. doi request reprint Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats
    Sarah Herdewyn
    Laboratory of Neurobiology, Experimental Neurology and Leuven Institute for Neurodegenerative Disorders LIND University of Leuven, Leuven, Belgium
    Neurobiol Aging 34:2302-3. 2013
  9. doi request reprint Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration
    Koen Poesen
    Vesalius Research Center, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
    J Neurosci 28:10451-9. 2008
  10. ncbi request reprint EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans
    Annelies Van Hoecke
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Nat Med 18:1418-22. 2012

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Upregulation of HSP27 in a transgenic model of ALS
    Vicky Vleminckx
    Dept of Neurology, University of Leuven, Medical School, Belgium
    J Neuropathol Exp Neurol 61:968-74. 2002
    ..The early nuclear localization was confirmed by Western blot analysis of spinal cord nuclear and cytoplasmic fractions. In contrast to HSP27, alphaB-crystallin was localized exclusively in the cytoplasm of reactive glial cells...
  2. pmc Benefits of intensive insulin therapy on neuromuscular complications in routine daily critical care practice: a retrospective study
    Greet Hermans
    Department of Internal Medicine, Medical Intensive Care Unit, University Hospitals Leuven, Catholic University Leuven, Leuven, Belgium
    Crit Care 13:R5. 2009
    ..In the present study, we investigated whether these effects are also present in daily clinical practice when IIT is implemented outside of a study protocol...
  3. pmc Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium
    J Cell Biol 181:37-41. 2008
    ..These results demonstrate that PGRN/GRN is a neurotrophic factor with activities that may be involved in the development of the nervous system and in neurodegeneration...
  4. doi request reprint VEGF protects motor neurons against excitotoxicity by upregulation of GluR2
    Elke Bogaert
    Laboratory of Neurobiology, Experimental Neurology, K U Leuven, Leuven, Belgium
    Neurobiol Aging 31:2185-91. 2010
    ..Intracerebroventricular treatment with VEGF similarly induced GluR2 expression in the ventral spinal cord of rats and this mechanism contributes to the protective effect of VEGF on motor neurons...
  5. doi request reprint The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding
    Louis De Muynck
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Neurobiol Aging 34:2541-7. 2013
    ..These results suggest that GRN E mediates the neurotrophic properties of PGRN and that binding to SORT1 is not required for this effect...
  6. ncbi request reprint Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis
    Maria Andries
    Department of Molecular Cell Biology, Faculty of Medicine, KU Leuven, Campus Gasthuisberg, Leuven, Belgium
    Neurobiol Dis 25:8-16. 2007
    ..Our in vitro data indicate that this protective mechanism is due to the potentiation by ivermectin of an effect of ATP mediated by the P2X4 receptor...
  7. pmc Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 104:14825-30. 2007
    ..These results reveal a mechanism through which astrocytes influence neuronal functioning in health and disease...
  8. doi request reprint Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats
    Sarah Herdewyn
    Laboratory of Neurobiology, Experimental Neurology and Leuven Institute for Neurodegenerative Disorders LIND University of Leuven, Leuven, Belgium
    Neurobiol Aging 34:2302-3. 2013
    ..Overexpression of PGRN in mice and intracerebroventricular delivery of PGRN in rats did not affect onset or progression of motor neuron degeneration. ..
  9. doi request reprint Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration
    Koen Poesen
    Vesalius Research Center, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
    J Neurosci 28:10451-9. 2008
    ..The neuroprotective activity of VEGF-B, in combination with its negligible angiogenic/permeability activity, offers attractive opportunities for the treatment of neurodegenerative diseases...
  10. ncbi request reprint EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans
    Annelies Van Hoecke
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Nat Med 18:1418-22. 2012
    ..This suggests that Epha4 generically modulates the vulnerability of (motor) neurons to axonal degeneration and may represent a new target for therapeutic intervention...
  11. ncbi request reprint GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis
    Philip Van Damme
    Laboratory of Neurobiology, K U Leuven, Campus Gasthuisberg, Leuven, Belgium
    J Neuropathol Exp Neurol 64:605-12. 2005
    ..These findings indicate that GluR2 plays a pivotal role in the vulnerability of motor neurons in vitro and in vivo, and that therapies that limit Ca2+ entry through AMPA receptors might be beneficial in ALS patients...
  12. pmc Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis
    Thomas Philips
    Laboratory of Neurobiology, Vesalius Research Centre, VIB, 3000 Leuven, Belgium
    Brain 136:471-82. 2013
    ..Our data suggest that oligodendroglial dysfunction may be a contributor to motor neuron degeneration in amyotrophic lateral sclerosis...
  13. ncbi request reprint Long-lasting changes in GABA responsiveness in cultured neurons
    Joelle N Chabwine
    Laboratory of Physiology, Geert Callewaert, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Neurosci Lett 365:69-72. 2004
    ..These long-lasting changes in GABA responsiveness may have major implications on neuronal excitability...
  14. ncbi request reprint Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases
    Elke Bogaert
    Laboratory of Neurobiology, University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Muscle Nerve 34:391-405. 2006
    ..In this review we critically analyze the data supporting the notion that VEGF is a factor involved in motor neuron degeneration and review the studies linking VEGF to other diseases of the peripheral and central nervous systems...
  15. ncbi request reprint HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease
    Constantin d'Ydewalle
    Vesalius Research Center, VIB and K U Leuven, Campus Gasthuisberg, Leuven, Belgium
    Nat Med 17:968-74. 2011
    ..Our findings demonstrate the pathogenic role of α-tubulin deacetylation in mutant HSPB1-induced neuropathies and offer perspectives for using HDAC6 inhibitors as a therapeutic strategy for hereditary axonopathies...
  16. pmc Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy
    Angela S Laird
    Laboratory of Neurobiology, Department of Experimental Neurology, K U Leuven, Leuven, Belgium
    PLoS ONE 5:e13368. 2010
    ..TDP-43 was found to be nuclear in all conditions described. The findings described here demonstrate that progranulin is neuroprotective in vivo and may have therapeutic potential for at least some forms of motor neuron degeneration...
  17. pmc Rapamycin increases survival in ALS mice lacking mature lymphocytes
    Kim A Staats
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Mol Neurodegener 8:31. 2013
    ..Rapamycin is frequently used to increase autophagy, but is also a potent immune suppressor. To properly assess the role of rapamycin-induced autophagy, the immune suppressive role of rapamycin should be negated...
  18. doi request reprint The neurobiology of amyotrophic lateral sclerosis
    André Bento-Abreu
    Laboratory for Neurobiology, Experimental Neurology, K U Leuven, Herestraat, 3000 Leuven, Belgium
    Eur J Neurosci 31:2247-65. 2010
    ....
  19. doi request reprint Clinical implications of recent breakthroughs in amyotrophic lateral sclerosis
    Philip Van Damme
    Laboratory of Neurobiology, Vesalius Research Center, VIB, University of Leuven, Leuven, Belgium
    Curr Opin Neurol 26:466-72. 2013
    ..This review examines the clinical implications of recent breakthroughs in amyotrophic lateral sclerosis (ALS)...
  20. ncbi request reprint The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis
    Philip Van Damme
    Laboratory for Neurobiology, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Neurosci Lett 343:81-4. 2003
    ..NBQX blocked kainate-induced currents and concomitant changes in intracellular Ca(2+), prevented the kainate-induced motor neuron death, and prolonged survival of G93A mice...
  21. ncbi request reprint Role of mitochondria in kainate-induced fast Ca2+ transients in cultured spinal motor neurons
    Julian Grosskreutz
    Academic Neurology Unit, University of Sheffield, Medical School, United Kingdom
    Cell Calcium 42:59-69. 2007
    ..This may exert deleterious effects in motor neuron disease where mitochondrial function is thought to be compromised...
  22. ncbi request reprint Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
    Erik Storkebaum
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KU Leuven, Leuven B 3000, Belgium
    Nat Neurosci 8:85-92. 2005
    ..On i.c.v. delivery, Vegf is anterogradely transported and preserves neuromuscular junctions in SOD1(G93A) rats. Our findings in preclinical rodent models of ALS may have implications for treatment of neurodegenerative disease in general...