Lukas Van Oudenhove

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Influence of experimentally induced anxiety on gastric sensorimotor function in humans
    Brecht Geeraerts
    Center for Gastroenterological Research, Leuven, Belgium
    Gastroenterology 129:1437-44. 2005
  2. doi request reprint The relevance of the philosophical 'mind-body problem' for the status of psychosomatic medicine: a conceptual analysis of the biopsychosocial model
    Lukas Van Oudenhove
    Translational Research Center for Gastrointestinal Disorders TARGID, Department of Clinical and Experimental Medicine, University of Leuven, Leuven, Belgium
    Med Health Care Philos 17:201-13. 2014
  3. doi request reprint The role of psychosocial factors and psychiatric disorders in functional dyspepsia
    Lukas Van Oudenhove
    Translational Research Centre for Gastrointestinal Disorders TARGID, Department of Clinical and Experimental Medicine, University of Leuven, Herstraat 49, O and N 1, bus 701, B 3000, Belgium
    Nat Rev Gastroenterol Hepatol 10:158-67. 2013
  4. doi request reprint Psychosocial factors, psychiatric illness and functional gastrointestinal disorders: a historical perspective
    Lukas Van Oudenhove
    University Psychiatric Centre, University Hospital Gasthuisberg, Leuven, Belgium
    Digestion 82:201-10. 2010
  5. doi request reprint The philosophical "mind-body problem" and its relevance for the relationship between psychiatry and the neurosciences
    Lukas Van Oudenhove
    Faculty of Medicine, Department of Pathophysiology, University of Leuven, and University Psychiatric Centre, Liaison Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    Perspect Biol Med 53:545-57. 2010
  6. doi request reprint Risk factors for impaired health-related quality of life in functional dyspepsia
    L Van Oudenhove
    Department of Pathophysiology, University of Leuven, Belgium
    Aliment Pharmacol Ther 33:261-74. 2011
  7. doi request reprint Understanding gut-brain interactions in gastrointestinal pain by neuroimaging: lessons from somatic pain studies
    L Van Oudenhove
    Department of Pathophysiology, Translational Research Center for Gastrointestinal Disorders TARGID and University Psychiatric Centre, Liaison Psychiatry, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 23:292-302. 2011
  8. doi request reprint Factors associated with co-morbid irritable bowel syndrome and chronic fatigue-like symptoms in functional dyspepsia
    L Van Oudenhove
    Department of Pathophysiology, Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 23:524-e202. 2011
  9. doi request reprint Do we have an alternative for the Rome III gastroduodenal symptom-based subgroups in functional gastroduodenal disorders? A cluster analysis approach
    L Van Oudenhove
    Department of Pathophysiology, Gastroenterology Section, University of Leuven, Herestraat 49, Leuven, Belgium
    Neurogastroenterol Motil 23:730-8. 2011
  10. pmc Fatty acid-induced gut-brain signaling attenuates neural and behavioral effects of sad emotion in humans
    Lukas Van Oudenhove
    Translational Research Centre for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    J Clin Invest 121:3094-9. 2011

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Influence of experimentally induced anxiety on gastric sensorimotor function in humans
    Brecht Geeraerts
    Center for Gastroenterological Research, Leuven, Belgium
    Gastroenterology 129:1437-44. 2005
    ..It is unclear whether this reflects common predisposition or a causal relationship. The aim of this study was to investigate whether experimentally induced anxiety would alter gastric sensorimotor function in health...
  2. doi request reprint The relevance of the philosophical 'mind-body problem' for the status of psychosomatic medicine: a conceptual analysis of the biopsychosocial model
    Lukas Van Oudenhove
    Translational Research Center for Gastrointestinal Disorders TARGID, Department of Clinical and Experimental Medicine, University of Leuven, Leuven, Belgium
    Med Health Care Philos 17:201-13. 2014
    ..Despite the clinical merits of the biopsychosocial model, we submit that it is conceptually underdeveloped or even flawed, which may hamper its use as a proper scientific model. ..
  3. doi request reprint The role of psychosocial factors and psychiatric disorders in functional dyspepsia
    Lukas Van Oudenhove
    Translational Research Centre for Gastrointestinal Disorders TARGID, Department of Clinical and Experimental Medicine, University of Leuven, Herstraat 49, O and N 1, bus 701, B 3000, Belgium
    Nat Rev Gastroenterol Hepatol 10:158-67. 2013
    ..We therefore propose an integrated model of functional dyspepsia as a disorder of gut-brain signalling, supporting a biopsychosocial approach to the diagnosis and management of this disorder...
  4. doi request reprint Psychosocial factors, psychiatric illness and functional gastrointestinal disorders: a historical perspective
    Lukas Van Oudenhove
    University Psychiatric Centre, University Hospital Gasthuisberg, Leuven, Belgium
    Digestion 82:201-10. 2010
    ..This provides further support for an integrative, multidisciplinary biopsychosocial approach to FGID...
  5. doi request reprint The philosophical "mind-body problem" and its relevance for the relationship between psychiatry and the neurosciences
    Lukas Van Oudenhove
    Faculty of Medicine, Department of Pathophysiology, University of Leuven, and University Psychiatric Centre, Liaison Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    Perspect Biol Med 53:545-57. 2010
    ..We illustrate how these diverging interpretations result in radically different views on the identity of psychiatry and its relationship with the rapidly expanding domain of neurology/neuroscience...
  6. doi request reprint Risk factors for impaired health-related quality of life in functional dyspepsia
    L Van Oudenhove
    Department of Pathophysiology, University of Leuven, Belgium
    Aliment Pharmacol Ther 33:261-74. 2011
    ..The influence of patient characteristics on HRQoL in functional dyspepsia is poorly understood...
  7. doi request reprint Understanding gut-brain interactions in gastrointestinal pain by neuroimaging: lessons from somatic pain studies
    L Van Oudenhove
    Department of Pathophysiology, Translational Research Center for Gastrointestinal Disorders TARGID and University Psychiatric Centre, Liaison Psychiatry, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 23:292-302. 2011
    ....
  8. doi request reprint Factors associated with co-morbid irritable bowel syndrome and chronic fatigue-like symptoms in functional dyspepsia
    L Van Oudenhove
    Department of Pathophysiology, Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 23:524-e202. 2011
    ....
  9. doi request reprint Do we have an alternative for the Rome III gastroduodenal symptom-based subgroups in functional gastroduodenal disorders? A cluster analysis approach
    L Van Oudenhove
    Department of Pathophysiology, Gastroenterology Section, University of Leuven, Herestraat 49, Leuven, Belgium
    Neurogastroenterol Motil 23:730-8. 2011
    ..We aimed to investigate an alternative subdivision of FGD, taking into account gastric sensorimotor function, anxiety & depression and 'somatization', besides gastroduodenal symptoms...
  10. pmc Fatty acid-induced gut-brain signaling attenuates neural and behavioral effects of sad emotion in humans
    Lukas Van Oudenhove
    Translational Research Centre for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    J Clin Invest 121:3094-9. 2011
    ....
  11. doi request reprint Abuse history, depression, and somatization are associated with gastric sensitivity and gastric emptying in functional dyspepsia
    Lukas Van Oudenhove
    Universitary Psychiatric Centre, Universitary Psychiatric Centre, University Hospital Gasthuisberg, B 3000 Leuven, Belgium
    Psychosom Med 73:648-55. 2011
    ..This study sought to determine the association of abuse history, psychiatric comorbidity, and somatization with gastric sensorimotor function...
  12. doi request reprint Regional brain activity in functional dyspepsia: a H(2)(15)O-PET study on the role of gastric sensitivity and abuse history
    Lukas Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Gastroenterology 139:36-47. 2010
    ..Therefore, we aimed to determine the influence of gastric sensitivity and abuse history on gastric sensation scores and brain activity in homeostatic-afferent, emotional-arousal, and cortical-modulatory brain regions in FD...
  13. doi request reprint Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H(2)(15)O-PET study
    Lukas Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 105:913-24. 2010
    ....
  14. doi request reprint Recent insights on central processing and psychological processes in functional gastrointestinal disorders
    L Van Oudenhove
    Translational Research Center for Gastrointestinal Diseases TARGID, Department of Pathophysiology, Leuven, Belgium
    Dig Liver Dis 41:781-7. 2009
    ..We will conclude this paper with a paragraph on new insights into treatment...
  15. ncbi request reprint Relationship between anxiety and gastric sensorimotor function in functional dyspepsia
    Lukas Van Oudenhove
    Department of Pathophysiology, Gastroenterology Section, University Hospital Gasthuisberg, Leuven, Belgium
    Psychosom Med 69:455-63. 2007
    ..Experimentally induced anxiety in healthy volunteers is associated with changes in sensorimotor function of the proximal stomach...
  16. ncbi request reprint Functional brain imaging of gastrointestinal sensation in health and disease
    Lukas Van Oudenhove
    University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    World J Gastroenterol 13:3438-45. 2007
    ..Finally, brain imaging work investigating differences in brain responses to visceral distension between healthy volunteers and functional gastrointestinal disorder patients will be highlighted...
  17. doi request reprint Cortical deactivations during gastric fundus distension in health: visceral pain-specific response or attenuation of 'default mode' brain function? A H2 15O-PET study
    L Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 21:259-71. 2009
    ..Whether this represents task-independent suspension of 'default mode' activity (as described in various cognitive tasks) or an visceral pain/interoception-specific process remains to be elucidated...
  18. ncbi request reprint The role of somatosensory cortical regions in the processing of painful gastric fundic distension: an update of brain imaging findings
    L Van Oudenhove
    Division of Gastroenterology, Department of Pathophysiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 20:479-87. 2008
    ..Methodological differences between the brain imaging studies on gastric distension may account for these somewhat discrepant findings...
  19. ncbi request reprint Regional cerebral blood flow during gastric balloon distention in functional dyspepsia
    Joris Vandenberghe
    Department of Psychiatry, Division of Liaison Psychiatry, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Gastroenterology 132:1684-93. 2007
    ..Our aim was to investigate regional cerebral blood flow during painful proximal gastric distention in hypersensitive FD...
  20. doi request reprint Influence of acute tryptophan depletion on gastric sensorimotor function in humans
    Brecht Geeraerts
    Dept of Gastroenterology, Univ Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 300:G228-35. 2011
    ..ATD alters gastric postprandial motor function and distension-induced nausea. These findings confirm involvement of 5-HT in the control of gastric accommodation and sensitivity...
  21. doi request reprint The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis
    Pieter Janssen
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 108:1382-91. 2013
    ..In this paper we examined the study-specific correlations between SI and GE, and we performed a meta-regression analysis of the association across multiple studies...
  22. doi request reprint Longitudinal and cross-sectional factors associated with long-term clinical course in functional dyspepsia: a 5-year follow-up study
    Sebastien Kindt
    Center for Gastroenterological Research, Department of Pathophysiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 106:340-8. 2011
    ..The aims of this study were to study the long-term evolution of symptoms in a clinical FD population and to identify factors associated with outcome...
  23. doi request reprint In functional dyspepsia, hypersensitivity to postprandial distention correlates with meal-related symptom severity
    Ricard Farre
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    Gastroenterology 145:566-73. 2013
    ..We compared the effects of fasting and postprandial stomach distention in patients with functional dyspepsia...
  24. doi request reprint Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia
    Hanne Vanheel
    Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium
    Gut 63:262-71. 2014
    ..Therefore, our aim was to evaluate duodenal mucosal integrity and low-grade inflammation in patients with FD...
  25. doi request reprint Lack of endogenous opioid release during sustained visceral pain: a [11C]carfentanil PET study
    Huynh Giao Ly
    Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Diseases TARGID, University of Leuven, Belgium
    Pain 154:2072-7. 2013
    ..Endogenous opioids may play a less important role in visceral compared to somatic pain...
  26. ncbi request reprint Central nervous system involvement in functional gastrointestinal disorders
    Lukas Van Oudenhove
    Department of Psychiatry, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Best Pract Res Clin Gastroenterol 18:663-80. 2004
    ..Third, we will address the issue of high comorbidity with psychiatric disorders. Some hypotheses about common pathophysiological substrates will be discussed...
  27. doi request reprint Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia
    Jan Tack
    Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    Clin Gastroenterol Hepatol 10:1239-45. 2012
    ..Buspirone, a 5-hydroxytryptamine 1A receptor agonist, relaxes the proximal stomach in healthy individuals. We studied the effects of buspirone on symptoms and mechanisms of FD...
  28. doi request reprint Is the antidepressant venlafaxine effective for the treatment of functional dyspepsia?
    Lukas Van Oudenhove
    University Hospital Leuven, and Department of Pathophysiology, Gastroenterology Section, University of Leuven, Herestraat 49, Leuven, Belgium
    Nat Clin Pract Gastroenterol Hepatol 6:74-5. 2009
    ....
  29. doi request reprint The complexity of globus: a multidisciplinary perspective
    Margot Selleslagh
    Department of Neurosciences, ExpORL and Translational Research Center for Gastrointestinal Disorders TARGID, Herestraat 49 PO 701, 3000 Leuven, Belgium
    Nat Rev Gastroenterol Hepatol 11:220-33. 2014
    ..This approach could be translated to clinical practice by adopting a multidisciplinary method to patients presenting with globus. ..
  30. doi request reprint Severity of fecal urgency and incontinence in inflammatory bowel disease: clinical, manometric and sonographic predictors
    Athanasios Papathanasopoulos
    1st Division of Internal Medicine and Hepato Gastroenterology Unit, Medical School, University of Ioannina, Ioannina, Greece and Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    Inflamm Bowel Dis 19:2450-6. 2013
    ..It is unclear which factors determine their severity. We evaluated associations of clinical activity, anorectal motility, and endoanal sonography with FI severity in IBD...
  31. doi request reprint Serum IL-17A in newly diagnosed treatment-naive patients with ulcerative colitis reflects clinical disease severity and predicts the course of disease
    Lena Ohman
    Departments of Internal Medicine and Clinical Nutrition and Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Translational Research Center for Gastrointestinal Disorders TARGID, Department of Clinical and Experimental Medicine, University of Leuven, Leuven, Belgium
    Inflamm Bowel Dis 19:2433-9. 2013
    ..We investigated whether cytokines in mucosal tissue and serum reflect clinical disease severity at the onset of UC and predict the future disease course...
  32. doi request reprint Brain imaging of visceral functions in healthy volunteers and IBS patients
    Nora Rapps
    Department of Internal Medicine VI Psychosomatic Medicine and Psychotherapy, University of Tubingen, Tubingen, Germany
    J Psychosom Res 64:599-604. 2008
    ..Subsequently, this article will deal with those brain areas activated by visceral stimulation in IBS patients. Special attention will be paid to recently published studies concerning psychological factors and novel research questions...