Research Topics
| Lukas Van OudenhoveSummaryAffiliation: Katholieke Universiteit Leuven Country: Belgium Publications
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Detail Information
Publications
Influence of experimentally induced anxiety on gastric sensorimotor function in humansBrecht Geeraerts
Center for Gastroenterological Research, Leuven, Belgium
Gastroenterology 129:1437-44. 2005..CONCLUSIONS: Experimentally induced anxiety alters gastric sensorimotor function, suggesting that psychological factors may play a causal role in the pathogenesis of some dyspeptic symptoms and mechanisms...
The role of psychosocial factors and psychiatric disorders in functional dyspepsiaLukas Van Oudenhove
Translational Research Centre for Gastrointestinal Disorders TARGID, Department of Clinical and Experimental Medicine, University of Leuven, Herstraat 49, O and N 1, bus 701, B 3000, Belgium
Nat Rev Gastroenterol Hepatol 10:158-67. 2013..We therefore propose an integrated model of functional dyspepsia as a disorder of gut-brain signalling, supporting a biopsychosocial approach to the diagnosis and management of this disorder...- Psychosocial factors, psychiatric illness and functional gastrointestinal disorders: a historical perspectiveLukas Van Oudenhove
University Psychiatric Centre, University Hospital Gasthuisberg, Leuven, Belgium
Digestion 82:201-10. 2010..This provides further support for an integrative, multidisciplinary biopsychosocial approach to FGID... - The philosophical "mind-body problem" and its relevance for the relationship between psychiatry and the neurosciencesLukas Van Oudenhove
Faculty of Medicine, Department of Pathophysiology, University of Leuven, and University Psychiatric Centre, Liaison Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
Perspect Biol Med 53:545-57. 2010..We illustrate how these diverging interpretations result in radically different views on the identity of psychiatry and its relationship with the rapidly expanding domain of neurology/neuroscience... - Risk factors for impaired health-related quality of life in functional dyspepsiaL Van Oudenhove
Department of Pathophysiology, University of Leuven, Belgium
Aliment Pharmacol Ther 33:261-74. 2011..The influence of patient characteristics on HRQoL in functional dyspepsia is poorly understood... - Understanding gut-brain interactions in gastrointestinal pain by neuroimaging: lessons from somatic pain studiesL Van Oudenhove
Department of Pathophysiology, Translational Research Center for Gastrointestinal Disorders TARGID and University Psychiatric Centre, Liaison Psychiatry, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
Neurogastroenterol Motil 23:292-302. 2011..Some limitations of current pain neuroimaging studies will be outlined, before providing a summary of suggestions for moving the visceral pain neuroimaging field forward... - Factors associated with co-morbid irritable bowel syndrome and chronic fatigue-like symptoms in functional dyspepsiaL Van Oudenhove
Department of Pathophysiology, Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
Neurogastroenterol Motil 23:524-e202. 2011.... - Do we have an alternative for the Rome III gastroduodenal symptom-based subgroups in functional gastroduodenal disorders? A cluster analysis approachL Van Oudenhove
Department of Pathophysiology, Gastroenterology Section, University of Leuven, Herestraat 49, Leuven, Belgium
Neurogastroenterol Motil 23:730-8. 2011..We aimed to investigate an alternative subdivision of FGD, taking into account gastric sensorimotor function, anxiety & depression and 'somatization', besides gastroduodenal symptoms... 
Fatty acid-induced gut-brain signaling attenuates neural and behavioral effects of sad emotion in humansLukas Van Oudenhove
Translational Research Centre for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
J Clin Invest 121:3094-9. 2011....- Abuse history, depression, and somatization are associated with gastric sensitivity and gastric emptying in functional dyspepsiaLukas Van Oudenhove
Universitary Psychiatric Centre, Universitary Psychiatric Centre, University Hospital Gasthuisberg, B 3000 Leuven, Belgium
Psychosom Med 73:648-55. 2011..This study sought to determine the association of abuse history, psychiatric comorbidity, and somatization with gastric sensorimotor function... - Regional brain activity in functional dyspepsia: a H(2)(15)O-PET study on the role of gastric sensitivity and abuse historyLukas Van Oudenhove
Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
Gastroenterology 139:36-47. 2010..Therefore, we aimed to determine the influence of gastric sensitivity and abuse history on gastric sensation scores and brain activity in homeostatic-afferent, emotional-arousal, and cortical-modulatory brain regions in FD... - Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H(2)(15)O-PET studyLukas Van Oudenhove
Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
Am J Gastroenterol 105:913-24. 2010.... - Recent insights on central processing and psychological processes in functional gastrointestinal disordersL Van Oudenhove
Translational Research Center for Gastrointestinal Diseases TARGID, Department of Pathophysiology, Leuven, Belgium
Dig Liver Dis 41:781-7. 2009..We will conclude this paper with a paragraph on new insights into treatment... - Relationship between anxiety and gastric sensorimotor function in functional dyspepsiaLukas Van Oudenhove
Department of Pathophysiology, Gastroenterology Section, University Hospital Gasthuisberg, Leuven, Belgium
Psychosom Med 69:455-63. 2007..Experimentally induced anxiety in healthy volunteers is associated with changes in sensorimotor function of the proximal stomach... - Functional brain imaging of gastrointestinal sensation in health and diseaseLukas Van Oudenhove
University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
World J Gastroenterol 13:3438-45. 2007..Finally, brain imaging work investigating differences in brain responses to visceral distension between healthy volunteers and functional gastrointestinal disorder patients will be highlighted... - The role of somatosensory cortical regions in the processing of painful gastric fundic distension: an update of brain imaging findingsL Van Oudenhove
Division of Gastroenterology, Department of Pathophysiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
Neurogastroenterol Motil 20:479-87. 2008..Methodological differences between the brain imaging studies on gastric distension may account for these somewhat discrepant findings... - Cortical deactivations during gastric fundus distension in health: visceral pain-specific response or attenuation of 'default mode' brain function? A H2 15O-PET studyL Van Oudenhove
Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
Neurogastroenterol Motil 21:259-71. 2009..Whether this represents task-independent suspension of 'default mode' activity (as described in various cognitive tasks) or an visceral pain/interoception-specific process remains to be elucidated... - Regional cerebral blood flow during gastric balloon distention in functional dyspepsiaJoris Vandenberghe
Department of Psychiatry, Division of Liaison Psychiatry, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
Gastroenterology 132:1684-93. 2007..Our aim was to investigate regional cerebral blood flow during painful proximal gastric distention in hypersensitive FD... - Influence of acute tryptophan depletion on gastric sensorimotor function in humansBrecht Geeraerts
Dept of Gastroenterology, Univ Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Am J Physiol Gastrointest Liver Physiol 300:G228-35. 2011..ATD alters gastric postprandial motor function and distension-induced nausea. These findings confirm involvement of 5-HT in the control of gastric accommodation and sensitivity... - Longitudinal and cross-sectional factors associated with long-term clinical course in functional dyspepsia: a 5-year follow-up studySebastien Kindt
Center for Gastroenterological Research, Department of Pathophysiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
Am J Gastroenterol 106:340-8. 2011..The aims of this study were to study the long-term evolution of symptoms in a clinical FD population and to identify factors associated with outcome... - Central nervous system involvement in functional gastrointestinal disordersLukas Van Oudenhove
Department of Psychiatry, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
Best Pract Res Clin Gastroenterol 18:663-80. 2004..Third, we will address the issue of high comorbidity with psychiatric disorders. Some hypotheses about common pathophysiological substrates will be discussed... - Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsiaJan Tack
Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
Clin Gastroenterol Hepatol 10:1239-45. 2012..Buspirone, a 5-hydroxytryptamine 1A receptor agonist, relaxes the proximal stomach in healthy individuals. We studied the effects of buspirone on symptoms and mechanisms of FD... - Is the antidepressant venlafaxine effective for the treatment of functional dyspepsia?Lukas Van Oudenhove
University Hospital Leuven, and Department of Pathophysiology, Gastroenterology Section, University of Leuven, Herestraat 49, Leuven, Belgium
Nat Clin Pract Gastroenterol Hepatol 6:74-5. 2009.... - Brain imaging of visceral functions in healthy volunteers and IBS patientsNora Rapps
Department of Internal Medicine VI Psychosomatic Medicine and Psychotherapy, University of Tubingen, Tubingen, Germany
J Psychosom Res 64:599-604. 2008..Subsequently, this article will deal with those brain areas activated by visceral stimulation in IBS patients. Special attention will be paid to recently published studies concerning psychological factors and novel research questions...