Ludo Van Den Bosch

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
    Michael A van Es
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
    Nat Genet 40:29-31. 2008
  2. ncbi request reprint The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis
    L van den Bosch
    Neurobiology, Campus Gasthuisberg O and N2, PB1022, Herestraat 49, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1762:1068-82. 2006
  3. ncbi request reprint Genetics of motor neuron disease
    Ludo Van Den Bosch
    Neurobiology, Campus Gasthuisberg O and N2 PB1022, Herestraat 49, B 3000 Leuven, Belgium
    Curr Neurol Neurosci Rep 6:423-31. 2006
  4. doi request reprint Crosstalk between astrocytes and motor neurons: what is the message?
    L van den Bosch
    Neurobiology, K U Leuven, Campus Gasthuisberg O and N2, Herestraat 49, Leuven, Belgium
    Exp Neurol 211:1-6. 2008
  5. doi request reprint Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS
    Ines Taes
    Experimental Neurology, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease LIND, University of Leuven KU Leuven, Leuven, Belgium
    Hum Mol Genet 22:1783-90. 2013
  6. pmc Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 104:14825-30. 2007
  7. doi request reprint VEGF protects motor neurons against excitotoxicity by upregulation of GluR2
    Elke Bogaert
    Laboratory of Neurobiology, Experimental Neurology, K U Leuven, Leuven, Belgium
    Neurobiol Aging 31:2185-91. 2010
  8. ncbi request reprint Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis
    Maria Andries
    Department of Molecular Cell Biology, Faculty of Medicine, KU Leuven, Campus Gasthuisberg, Leuven, Belgium
    Neurobiol Dis 25:8-16. 2007
  9. ncbi request reprint EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans
    Annelies Van Hoecke
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Nat Med 18:1418-22. 2012
  10. ncbi request reprint GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis
    Philip Van Damme
    Laboratory of Neurobiology, K U Leuven, Campus Gasthuisberg, Leuven, Belgium
    J Neuropathol Exp Neurol 64:605-12. 2005

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
    Michael A van Es
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
    Nat Genet 40:29-31. 2008
    ..30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies...
  2. ncbi request reprint The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis
    L van den Bosch
    Neurobiology, Campus Gasthuisberg O and N2, PB1022, Herestraat 49, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1762:1068-82. 2006
    ..We will discuss point by point these different pathogenic mechanisms that could give rise to classical and/or slow excitotoxicity leading to selective motor neuron death...
  3. ncbi request reprint Genetics of motor neuron disease
    Ludo Van Den Bosch
    Neurobiology, Campus Gasthuisberg O and N2 PB1022, Herestraat 49, B 3000 Leuven, Belgium
    Curr Neurol Neurosci Rep 6:423-31. 2006
    ..We hope that information on the genetic causes of these diseases and the insight into the pathologic processes involved could ultimately lead to therapeutic strategies that prevent or at least slow this degenerative process...
  4. doi request reprint Crosstalk between astrocytes and motor neurons: what is the message?
    L van den Bosch
    Neurobiology, K U Leuven, Campus Gasthuisberg O and N2, Herestraat 49, Leuven, Belgium
    Exp Neurol 211:1-6. 2008
    ..As a consequence, understanding the interactions between motor neurons and astrocytes in health and disease may have important therapeutic implications...
  5. doi request reprint Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS
    Ines Taes
    Experimental Neurology, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease LIND, University of Leuven KU Leuven, Leuven, Belgium
    Hum Mol Genet 22:1783-90. 2013
    ..These findings show that Hdac6, rather than Sirt2, is a therapeutic target for the treatment of ALS. Moreover, Sirt2 appears not to be a major α-tubulin deacetylase in the nervous system...
  6. pmc Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 104:14825-30. 2007
    ..These results reveal a mechanism through which astrocytes influence neuronal functioning in health and disease...
  7. doi request reprint VEGF protects motor neurons against excitotoxicity by upregulation of GluR2
    Elke Bogaert
    Laboratory of Neurobiology, Experimental Neurology, K U Leuven, Leuven, Belgium
    Neurobiol Aging 31:2185-91. 2010
    ..Intracerebroventricular treatment with VEGF similarly induced GluR2 expression in the ventral spinal cord of rats and this mechanism contributes to the protective effect of VEGF on motor neurons...
  8. ncbi request reprint Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis
    Maria Andries
    Department of Molecular Cell Biology, Faculty of Medicine, KU Leuven, Campus Gasthuisberg, Leuven, Belgium
    Neurobiol Dis 25:8-16. 2007
    ..Our in vitro data indicate that this protective mechanism is due to the potentiation by ivermectin of an effect of ATP mediated by the P2X4 receptor...
  9. ncbi request reprint EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans
    Annelies Van Hoecke
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Nat Med 18:1418-22. 2012
    ..This suggests that Epha4 generically modulates the vulnerability of (motor) neurons to axonal degeneration and may represent a new target for therapeutic intervention...
  10. ncbi request reprint GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis
    Philip Van Damme
    Laboratory of Neurobiology, K U Leuven, Campus Gasthuisberg, Leuven, Belgium
    J Neuropathol Exp Neurol 64:605-12. 2005
    ..These findings indicate that GluR2 plays a pivotal role in the vulnerability of motor neurons in vitro and in vivo, and that therapies that limit Ca2+ entry through AMPA receptors might be beneficial in ALS patients...
  11. doi request reprint The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding
    Louis De Muynck
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Neurobiol Aging 34:2541-7. 2013
    ..These results suggest that GRN E mediates the neurotrophic properties of PGRN and that binding to SORT1 is not required for this effect...
  12. doi request reprint Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats
    Sarah Herdewyn
    Laboratory of Neurobiology, Experimental Neurology and Leuven Institute for Neurodegenerative Disorders LIND University of Leuven, Leuven, Belgium
    Neurobiol Aging 34:2302-3. 2013
    ..Overexpression of PGRN in mice and intracerebroventricular delivery of PGRN in rats did not affect onset or progression of motor neuron degeneration. ..
  13. doi request reprint Over-expression of Hsp27 does not influence disease in the mutant SOD1(G93A) mouse model of amyotrophic lateral sclerosis
    Jyothsna Krishnan
    Laboratory of Neurobiology, Campus Gasthuisberg, Leuven, Belgium
    J Neurochem 106:2170-83. 2008
    ..In conclusion, despite the protective action against acute motor neuron injury, Hsp27 alone is not sufficient to protect against the chronic motor neuron injury due to the presence of mutant SOD1...
  14. ncbi request reprint Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death
    Maarten Dewil
    Laboratory for Neurobiology, Experimental Neurology, University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Neurobiol Dis 26:332-41. 2007
    ....
  15. pmc Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis
    Elke Bogaert
    Laboratory for Neurobiology, Experimental Neurology, University of Leuven, Leuven, Belgium
    Neurobiol Aging 33:418-20. 2012
    ..We conclude that polymorphisms in the GluR2 gene (GRIA2) are not a major contributory factor in the pathogenesis of ALS...
  16. doi request reprint G37R SOD1 mutant alters mitochondrial complex I activity, Ca(2+) uptake and ATP production
    Evelyne Coussee
    Research Group Neurodegeneration, Campus Kortrijk, K U Leuven, Belgium
    Cell Calcium 49:217-25. 2011
    ..Together, these findings suggest that the mechanism linking mutant G37R SOD1 and ALS involves mitochondrial respiratory chain deficiency resulting in ATP loss and impairment of mitochondrial and cytosolic Ca(2+) homeostasis...
  17. ncbi request reprint HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease
    Constantin d'Ydewalle
    Vesalius Research Center, VIB and K U Leuven, Campus Gasthuisberg, Leuven, Belgium
    Nat Med 17:968-74. 2011
    ..Our findings demonstrate the pathogenic role of α-tubulin deacetylation in mutant HSPB1-induced neuropathies and offer perspectives for using HDAC6 inhibitors as a therapeutic strategy for hereditary axonopathies...
  18. pmc Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy
    Angela S Laird
    Laboratory of Neurobiology, Department of Experimental Neurology, K U Leuven, Leuven, Belgium
    PLoS ONE 5:e13368. 2010
    ..TDP-43 was found to be nuclear in all conditions described. The findings described here demonstrate that progranulin is neuroprotective in vivo and may have therapeutic potential for at least some forms of motor neuron degeneration...
  19. ncbi request reprint Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration
    Ludo Van Den Bosch
    Laboratory for Neurobiology, Department of Experimental Neurology, School of Medicine, University of Leuven, Leuven, Belgium
    Neurobiol Dis 17:21-8. 2004
    ..Our results show that VEGF is a neurotrophic factor for motor neurons in vitro, and shortage of this neurotrophic factor may contribute to the motor neuron death observed in humans and animals with low VEGF expression levels...
  20. ncbi request reprint Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis
    Maarten Dewil
    Laboratory for Neurobiology, Campus Gasthuisberg, Herestraat 49, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Neuroreport 16:321-4. 2005
    ..Therefore, the effect of pharmacological inhibition of MMP-9 activity is unlikely to be of therapeutical benefit in amyotrophic lateral sclerosis...
  21. pmc Rapamycin increases survival in ALS mice lacking mature lymphocytes
    Kim A Staats
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Mol Neurodegener 8:31. 2013
    ..Rapamycin is frequently used to increase autophagy, but is also a potent immune suppressor. To properly assess the role of rapamycin-induced autophagy, the immune suppressive role of rapamycin should be negated...
  22. doi request reprint HDAC6 at the Intersection of Neuroprotection and Neurodegeneration
    Constantin d'Ydewalle
    Vesalius Research Center, VIB, Campus Gasthuisberg, Leuven, Belgium
    Traffic 13:771-9. 2012
    ..We hypothesize that a disturbance in the equilibrium between the different functions of HDAC6 could play an important role in neurodegeneration...
  23. ncbi request reprint Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish
    Robin Lemmens
    Department of Neurology, University Hospital Gasthuisberg, K U Leuven, Belgium
    Hum Mol Genet 16:2359-65. 2007
    ....
  24. ncbi request reprint The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis
    Philip Van Damme
    Laboratory for Neurobiology, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Neurosci Lett 343:81-4. 2003
    ..NBQX blocked kainate-induced currents and concomitant changes in intracellular Ca(2+), prevented the kainate-induced motor neuron death, and prolonged survival of G93A mice...
  25. pmc Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis
    Thomas Philips
    Laboratory of Neurobiology, Vesalius Research Centre, VIB, 3000 Leuven, Belgium
    Brain 136:471-82. 2013
    ..Our data suggest that oligodendroglial dysfunction may be a contributor to motor neuron degeneration in amyotrophic lateral sclerosis...
  26. doi request reprint Charcot-Marie-Tooth disease: emerging mechanisms and therapies
    Constantin d'Ydewalle
    Vesalius Research Center, VIB, Leuven, Belgium
    Int J Biochem Cell Biol 44:1299-304. 2012
    ..These findings offer new perspectives for a potential therapy to treat axonal Charcot-Marie-Tooth disease and other neurodegenerative disorders characterized by axonal transport defects...
  27. doi request reprint Microglial upregulation of progranulin as a marker of motor neuron degeneration
    Thomas Philips
    Vesalius Research Center, VIB, Leuven, Belgium
    J Neuropathol Exp Neurol 69:1191-200. 2010
    ..These data indicate that upregulation of PGRN is a marker of the microglial response that occurs with progression in motor neuron diseases...
  28. ncbi request reprint Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis: effects of creatine treatment
    Wim Derave
    Exercise Physiology and Biomechanics Laboratory, Department of Kinesiology, Faculty of Physical Education and Physiotherapy, K U Leuven, B 3001, Leuven, Belgium
    Neurobiol Dis 13:264-72. 2003
    ..Furthermore, creatine intake does not exert a beneficial effect on muscle function in a transgenic mouse model of ALS...
  29. ncbi request reprint Long-lasting changes in GABA responsiveness in cultured neurons
    Joelle N Chabwine
    Laboratory of Physiology, Geert Callewaert, KULeuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Neurosci Lett 365:69-72. 2004
    ..These long-lasting changes in GABA responsiveness may have major implications on neuronal excitability...
  30. ncbi request reprint The G93C mutation in superoxide dismutase 1: clinicopathologic phenotype and prognosis
    Luc Régal
    Department of Neurology and Experimental Neurology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Arch Neurol 63:262-7. 2006
    ..Twenty percent of familial amyotrophic lateral sclerosis (ALS) is caused by mutations in the superoxide dismutase 1 gene (SOD1). Few data exist on their clinicopathologic phenotypes...
  31. ncbi request reprint Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases
    Elke Bogaert
    Laboratory of Neurobiology, University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Muscle Nerve 34:391-405. 2006
    ..In this review we critically analyze the data supporting the notion that VEGF is a factor involved in motor neuron degeneration and review the studies linking VEGF to other diseases of the peripheral and central nervous systems...
  32. pmc Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice
    Sarah Herdewyn
    KU Leuven University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease LIND, Leuven, Belgium
    Mol Neurodegener 9:24. 2014
    ..The effect on the enteric and motor phenotype was assessed, both in animals on normal chow or on a jellified fiber deprived diet, aimed at preventing intestinal obstruction...
  33. doi request reprint The neurobiology of amyotrophic lateral sclerosis
    André Bento-Abreu
    Laboratory for Neurobiology, Experimental Neurology, K U Leuven, Herestraat, 3000 Leuven, Belgium
    Eur J Neurosci 31:2247-65. 2010
    ....
  34. pmc Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium
    J Cell Biol 181:37-41. 2008
    ..These results demonstrate that PGRN/GRN is a neurotrophic factor with activities that may be involved in the development of the nervous system and in neurodegeneration...
  35. ncbi request reprint Microglia in amyotrophic lateral sclerosis
    Maarten Dewil
    Laboratory for Neurobiology, University of Leuven, Belgium
    Acta Neurol Belg 107:63-70. 2007
    ..Finally, an overview will be given of the different therapeutic strategies that targeted the inflammatory process in amyotrophic lateral sclerosis...
  36. ncbi request reprint Minocycline delays disease onset and mortality in a transgenic model of ALS
    Ludo Van Den Bosch
    Laboratory for Neurobiology, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Neuroreport 13:1067-70. 2002
    ..These results demonstrate that interference with immuno-inflammatory responses has a beneficial effect in the ALS mice model, suggesting this to be a potential new strategy to treat ALS...
  37. doi request reprint Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 43:75-84. 2013
    ..These findings suggest that the capacity of Aire to regulate expression of a huge array of TRAs relies solely on an unconventional transcriptional mechanism, without intermediary transcription factors...
  38. ncbi request reprint S100A6 overexpression within astrocytes associated with impaired axons from both ALS mouse model and human patients
    Daphne Hoyaux
    Laboratory of Histopathology, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    J Neuropathol Exp Neurol 61:736-44. 2002
    ..Although these results do not give any clue about the beneficial or detrimental role played by S100A6, its induction may be assumed to appropriately serve some function(s)...
  39. ncbi request reprint Upregulation of HSP27 in a transgenic model of ALS
    Vicky Vleminckx
    Dept of Neurology, University of Leuven, Medical School, Belgium
    J Neuropathol Exp Neurol 61:968-74. 2002
    ..The early nuclear localization was confirmed by Western blot analysis of spinal cord nuclear and cytoplasmic fractions. In contrast to HSP27, alphaB-crystallin was localized exclusively in the cytoplasm of reactive glial cells...
  40. ncbi request reprint Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
    Erik Storkebaum
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KU Leuven, Leuven B 3000, Belgium
    Nat Neurosci 8:85-92. 2005
    ..On i.c.v. delivery, Vegf is anterogradely transported and preserves neuromuscular junctions in SOD1(G93A) rats. Our findings in preclinical rodent models of ALS may have implications for treatment of neurodegenerative disease in general...
  41. ncbi request reprint Role of mitochondria in kainate-induced fast Ca2+ transients in cultured spinal motor neurons
    Julian Grosskreutz
    Academic Neurology Unit, University of Sheffield, Medical School, United Kingdom
    Cell Calcium 42:59-69. 2007
    ..This may exert deleterious effects in motor neuron disease where mitochondrial function is thought to be compromised...
  42. doi request reprint Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration
    Koen Poesen
    Vesalius Research Center, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
    J Neurosci 28:10451-9. 2008
    ..The neuroprotective activity of VEGF-B, in combination with its negligible angiogenic/permeability activity, offers attractive opportunities for the treatment of neurodegenerative diseases...
  43. doi request reprint Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase
    Genevieve Gowing
    Laboratory of Molecular Endocrinology, Centre de Recherche du Centre Hospitalier de l Universite Laval, Department of Anatomy and Physiology, Laval University, Quebec City, Quebec, Canada
    J Neurosci 28:10234-44. 2008
    ..This suggests that proliferating microglia-expressing mutant SOD1 are not central contributors of the neurodegenerative process in ALS caused by mutant SOD1...
  44. ncbi request reprint Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy
    Oleg V Evgrafov
    Department of Psychiatry, New York State Psychiatric Institute Research Foundation for Mental Hygiene, Unit 28, 1051 Riverside Drive, New York, New York 10032, USA
    Nat Genet 36:602-6. 2004
    ..Cotransfection of neurofilament light chain (NEFL) and mutant HSPB1 resulted in altered neurofilament assembly in cells devoid of cytoplasmic intermediate filaments...
  45. ncbi request reprint ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study
    Michael A van Es
    Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Lancet Neurol 6:869-77. 2007
    ..ALS is thought to be multifactorial, with both environmental and genetic causes. Our aim was to identify genetic variants that predispose for sporadic ALS...