Research Topics
Species | Katrijn Van DeunSummaryAffiliation: Katholieke Universiteit Leuven Country: Belgium Publications
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Detail Information
Publications
A flexible framework for sparse simultaneous component based data integrationKatrijn Van Deun
Center for Computational Systems Biology SymBioSys, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
BMC Bioinformatics 12:448. 2011..However, the interpretation of the principal and simultaneous components is often daunting because contributions of each of the biomolecules (transcripts, proteins) have to be taken into account...
Joint mapping of genes and conditions via multidimensional unfolding analysisKatrijn Van Deun
SymBioSys, Catholic University of Leuven, Leuven, Belgium
BMC Bioinformatics 8:181. 2007..Getting a clear visual overview of all these patterns in a single easy-to-grasp representation is a useful preliminary analysis step: We propose to use for this purpose an advanced exploratory method, called multidimensional unfolding...
A structured overview of simultaneous component based data integrationKatrijn Van Deun
SymBioSys, Katholieke Universiteit Leuven, Leuven, Belgium
BMC Bioinformatics 10:246. 2009..In this respect, the family of simultaneous component methods (e.g., SUM-PCA, unrestricted PCovR, MFA, STATIS, and SCA-P) is a natural choice. Yet, different simultaneous component methods may lead to quite different results...
Testing the hypothesis of tissue selectivity: the intersection-union test and a Bayesian approachK Van Deun
Center for Computational Systems Biology SymBioSys, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
Bioinformatics 25:2588-94. 2009..However, two disadvantages of the IUT are that it is conservative and it conveys only the information of the least differing target tissue-other tissue pair...
DISCO-SCA and properly applied GSVD as swinging methods to find common and distinctive processesKatrijn Van Deun
Department of Psychology, Katholieke Universiteit Leuven, Leuven, Belgium
PLoS ONE 7:e37840. 2012....
Integrating functional genomics data using maximum likelihood based simultaneous component analysisRobert A van den Berg
SymBioSys, Katholieke Universiteit Leuven, Leuven, Belgium
BMC Bioinformatics 10:340. 2009..Subsequently, the performance of the two methods is evaluated by analysis of a real life Escherichia coli metabolomics data set...
Using ribosomal protein genes as reference: a tale of cautionLieven Thorrez
Gene Expression Unit, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, Leuven, Belgium
PLoS ONE 3:e1854. 2008..Recently, ribosomal protein genes have been suggested as reference genes based on a meta-analysis of publicly available microarray data...
Tissue-specific disallowance of housekeeping genes: the other face of cell differentiationLieven Thorrez
Gene Expression Unit, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
Genome Res 21:95-105. 2011..Together, we provide a systematic analysis of tissue-specific repression of housekeeping genes, a phenomenon that has not been studied so far on a genome-wide basis and, when perturbed, can lead to human disease...
