Dirk Timmerman

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc DALI: Vitamin D and lifestyle intervention for gestational diabetes mellitus (GDM) prevention: an European multicentre, randomised trial - study protocol
    Judith G M Jelsma
    Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    BMC Pregnancy Childbirth 13:142. 2013
  2. ncbi request reprint Vascular malformations in the uterus: ultrasonographic diagnosis and conservative management
    D Timmerman
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Obstet Gynecol Reprod Biol 92:171-8. 2000
  3. ncbi request reprint The use of mathematical models to evaluate pelvic masses; can they beat an expert operator?
    Dirk Timmerman
    Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Best Pract Res Clin Obstet Gynaecol 18:91-104. 2004
  4. ncbi request reprint The pedicle artery sign based on sonography with color Doppler imaging can replace second-stage tests in women with abnormal vaginal bleeding
    D Timmerman
    Department of Obstetrics and Gynecology, University Hospitals, Katholieke Universiteit Leuven, Belgium
    Ultrasound Obstet Gynecol 22:166-71. 2003
  5. ncbi request reprint Color Doppler imaging is a valuable tool for the diagnosis and management of uterine vascular malformations
    D Timmerman
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 21:570-7. 2003
  6. ncbi request reprint Logistic regression model to distinguish between the benign and malignant adnexal mass before surgery: a multicenter study by the International Ovarian Tumor Analysis Group
    Dirk Timmerman
    Department of Obstetrics and Gynecology, University Hospitals, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Clin Oncol 23:8794-801. 2005
  7. ncbi request reprint Ovarian cancer prediction in adnexal masses using ultrasound-based logistic regression models: a temporal and external validation study by the IOTA group
    D Timmerman
    Department of Obstetrics and Gynecology, University Hospitals, Leuven, Belgium
    Ultrasound Obstet Gynecol 36:226-34. 2010
  8. ncbi request reprint Absence of correlation between risk factors for endometrial cancer and the presence of tamoxifen-associated endometrial polyps in postmenopausal patients with breast cancer
    D Timmerman
    Departments of Obstetrics and Gynaecology, University Hospitals Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Eur J Cancer 36:S40-2. 2000
  9. ncbi request reprint Inclusion of CA-125 does not improve mathematical models developed to distinguish between benign and malignant adnexal tumors
    Dirk Timmerman
    Department of Obstetrics and Gynecology, University Hospitals Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Oncol 25:4194-200. 2007
  10. ncbi request reprint Discrimination between benign and malignant adnexal masses by specialist ultrasound examination versus serum CA-125
    Ben Van Calster
    Department of Electrical Engineering, ESAT SISTA, Katholieke Universiteit Leuven, Belgium
    J Natl Cancer Inst 99:1706-14. 2007

Detail Information

Publications100

  1. pmc DALI: Vitamin D and lifestyle intervention for gestational diabetes mellitus (GDM) prevention: an European multicentre, randomised trial - study protocol
    Judith G M Jelsma
    Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    BMC Pregnancy Childbirth 13:142. 2013
    ..Gestational diabetes mellitus (GDM) is an increasing problem world-wide. Lifestyle interventions and/or vitamin D supplementation might help prevent GDM in some women...
  2. ncbi request reprint Vascular malformations in the uterus: ultrasonographic diagnosis and conservative management
    D Timmerman
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Obstet Gynecol Reprod Biol 92:171-8. 2000
    ..To investigate the presence and outcome of uterine vascular malformations in women with abnormal premenopausal bleeding...
  3. ncbi request reprint The use of mathematical models to evaluate pelvic masses; can they beat an expert operator?
    Dirk Timmerman
    Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Best Pract Res Clin Obstet Gynaecol 18:91-104. 2004
    ..Further refinement of mathematical models and the results of multicentre trials need to be reviewed before the clinical use of mathematical models can be advocated...
  4. ncbi request reprint The pedicle artery sign based on sonography with color Doppler imaging can replace second-stage tests in women with abnormal vaginal bleeding
    D Timmerman
    Department of Obstetrics and Gynecology, University Hospitals, Katholieke Universiteit Leuven, Belgium
    Ultrasound Obstet Gynecol 22:166-71. 2003
    ..We proposed visualization of the pedicle artery on color Doppler imaging as a sign of polyps...
  5. ncbi request reprint Color Doppler imaging is a valuable tool for the diagnosis and management of uterine vascular malformations
    D Timmerman
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 21:570-7. 2003
    ....
  6. ncbi request reprint Logistic regression model to distinguish between the benign and malignant adnexal mass before surgery: a multicenter study by the International Ovarian Tumor Analysis Group
    Dirk Timmerman
    Department of Obstetrics and Gynecology, University Hospitals, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Clin Oncol 23:8794-801. 2005
    ..To collect data for the development of a more universally useful logistic regression model to distinguish between a malignant and benign adnexal tumor before surgery...
  7. ncbi request reprint Ovarian cancer prediction in adnexal masses using ultrasound-based logistic regression models: a temporal and external validation study by the IOTA group
    D Timmerman
    Department of Obstetrics and Gynecology, University Hospitals, Leuven, Belgium
    Ultrasound Obstet Gynecol 36:226-34. 2010
    ....
  8. ncbi request reprint Absence of correlation between risk factors for endometrial cancer and the presence of tamoxifen-associated endometrial polyps in postmenopausal patients with breast cancer
    D Timmerman
    Departments of Obstetrics and Gynaecology, University Hospitals Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Eur J Cancer 36:S40-2. 2000
    ..So far there is no evidence that these polyps are premalignant lesions...
  9. ncbi request reprint Inclusion of CA-125 does not improve mathematical models developed to distinguish between benign and malignant adnexal tumors
    Dirk Timmerman
    Department of Obstetrics and Gynecology, University Hospitals Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Oncol 25:4194-200. 2007
    ....
  10. ncbi request reprint Discrimination between benign and malignant adnexal masses by specialist ultrasound examination versus serum CA-125
    Ben Van Calster
    Department of Electrical Engineering, ESAT SISTA, Katholieke Universiteit Leuven, Belgium
    J Natl Cancer Inst 99:1706-14. 2007
    ..e., ovarian, paraovarian, or tubal) masses. We compared the diagnostic performance of these methods in a large multicenter study...
  11. ncbi request reprint External validation of mathematical models to distinguish between benign and malignant adnexal tumors: a multicenter study by the International Ovarian Tumor Analysis Group
    Caroline Van Holsbeke
    Department of Obstetrics and Gynecology, University Hospitals KU Leuven, Belgium
    Clin Cancer Res 13:4440-7. 2007
    ..However, few of them have been externally validated in new populations. Our aim was to compare their performance on a prospectively collected large multicenter data set...
  12. doi request reprint External validation of diagnostic models to estimate the risk of malignancy in adnexal masses
    Caroline Van Holsbeke
    Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium
    Clin Cancer Res 18:815-25. 2012
    ..To externally validate and compare the performance of previously published diagnostic models developed to predict malignancy in adnexal masses...
  13. ncbi request reprint Prospective internal validation of mathematical models to predict malignancy in adnexal masses: results from the international ovarian tumor analysis study
    Caroline Van Holsbeke
    Department of Obstetrics and Gynecology, University Hospitals Leuven, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Clin Cancer Res 15:684-91. 2009
    ....
  14. doi request reprint A comparison between an ultrasound based prediction model (LR2) and the risk of ovarian malignancy algorithm (ROMA) to assess the risk of malignancy in women with an adnexal mass
    Jeroen Kaijser
    Academic Department of Development and Regeneration, KU Leuven, Leuven, Belgium
    Gynecol Oncol 129:377-83. 2013
    ..An ultrasound based prediction model (LR2) developed by the International Ovarian Tumor Analysis (IOTA) study offers better diagnostic performance than CA125 alone. In this study we compared the diagnostic accuracy between LR2 and ROMA...
  15. pmc A mathematical model for interpretable clinical decision support with applications in gynecology
    Vanya M C A Van Belle
    Department of Electrical Engineering ESAT SCD, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS ONE 7:e34312. 2012
    ..The resulting models can be used to guide clinicians when deciding upon the appropriate treatment, estimating patient-specific risks and to improve communication with patients...
  16. doi request reprint Prospective study to assess short-term intra-articular and tenosynovial changes in the aromatase inhibitor-associated arthralgia syndrome
    Leilani Morales
    Department of Obstetrics and Gynecology, Division of Gynecological Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    J Clin Oncol 26:3147-52. 2008
    ..To date, its exact mechanism remains unclear. The purpose of this study was to investigate the changes in clinical rheumatologic features and magnetic resonance imaging (MRI) of hands and wrists in AI and tamoxifen users...
  17. doi request reprint Subjective assessment by ultrasound is superior to the risk of malignancy index (RMI) or the risk of ovarian malignancy algorithm (ROMA) in discriminating benign from malignant adnexal masses
    Toon Van Gorp
    Department of Obstetrics and Gynaecology, Leuven Cancer Institute, Universitaire Ziekenhuizen Leuven, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Cancer 48:1649-56. 2012
    ..In the present study, the diagnostic accuracy of ROMA was assessed and compared to the diagnostic accuracy of the two most widely used ultrasound methods, namely the risk of malignancy index (RMI) and subjective assessment by ultrasound...
  18. ncbi request reprint Improved modeling of clinical data with kernel methods
    Anneleen Daemen
    Department of Electrical Engineering, Katholieke Universiteit Leuven, and Department of Obstetrics and Gynecology, University Hospitals Leuven, 3001 Leuven, Belgium
    Artif Intell Med 54:103-14. 2012
    ..To improve clinical management, available patient information should be fully exploited. This requires appropriate modeling of relevant parameters...
  19. doi request reprint Prospective assessment of the endometrium in postmenopausal breast cancer patients treated with fulvestrant
    Leilani Morales
    Department of Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Breast Cancer Res Treat 117:77-81. 2009
    ..Furthermore, no new uterine pathologies were detected, indicating that fulvestrant behaves as a pure antiestrogen at the uterine level...
  20. pmc Polytomous diagnosis of ovarian tumors as benign, borderline, primary invasive or metastatic: development and validation of standard and kernel-based risk prediction models
    Ben Van Calster
    Department of Electrical Engineering, ESAT SISTA, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, B 3001 Leuven, Belgium
    BMC Med Res Methodol 10:96. 2010
    ..The main focus is on how different types of models perform and compare...
  21. ncbi request reprint Debilitating musculoskeletal pain and stiffness with letrozole and exemestane: associated tenosynovial changes on magnetic resonance imaging
    Leilani Morales
    Department of General Medical Oncology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Breast Cancer Res Treat 104:87-91. 2007
    ..However, the pathogenesis and anatomic correlate of musculoskeletal pains have not been thoroughly evaluated. Moreover, the impact of AI-induced musculoskeletal symptoms on normal daily functioning needs to be further explored...
  22. doi request reprint Uterine and quality of life changes in postmenopausal women with an asymptomatic tamoxifen-thickened endometrium randomized to continuation of tamoxifen or switching to anastrozole
    Ben Van Calster
    Department of Electrical Engineering ESAT SCD, Katholieke Universiteit Leuven, Leuven, Belgium
    Menopause 18:224-9. 2011
    ....
  23. doi request reprint Assessing the discriminative ability of risk models for more than two outcome categories
    Ben Van Calster
    Department of Development and Regeneration, KU Leuven, University of Leuven, Leuven, Belgium
    Eur J Epidemiol 27:761-70. 2012
    ..For pairwise c-indexes we recommend the 'conditional-risk' method which is consistent with the analytical approach of the multinomial logistic regression used to develop polytomous risk models...
  24. doi request reprint A novel approach to predict the likelihood of specific ovarian tumor pathology based on serum CA-125: a multicenter observational study
    Ben Van Calster
    Department of Obstetrics and Gynecology, University Hospitals K U Leuven, Leuven, Belgium
    Cancer Epidemiol Biomarkers Prev 20:2420-8. 2011
    ..The CA-125 tumor marker has limitations when used to distinguish between benign and malignant ovarian masses. We therefore establish likelihood curves of six subgroups of ovarian pathology based on CA-125 and menopausal status...
  25. pmc Expression profiling to predict the clinical behaviour of ovarian cancer fails independent evaluation
    Olivier Gevaert
    Department of Electrical Engineering ESAT SCD SISTA, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Leuven, Belgium
    BMC Cancer 8:18. 2008
    ..92% accuracy using leave-one-out cross validation techniques in combination with Least Squares Support Vector Machines (LS-SVMs)...
  26. ncbi request reprint Classifying ovarian tumors using Bayesian Multi-Layer Perceptrons and Automatic Relevance Determination: a multi-center study
    Ben Van Calster
    Department of Electrical Engineering, Katholieke Universiteit Leuven, Leuven, Belgium
    Conf Proc IEEE Eng Med Biol Soc 1:5342-5. 2006
    ..The analyses further show that the number of hidden neurons specified in the ARD analyses for input selection may influence model performance...
  27. doi request reprint Interpregnancy weight change and risk for adverse perinatal outcome
    Annick Bogaerts
    KHLim, Limburg Catholic University College, PHL University College, Department of Healthcare Research, Hasselt, the Departments of Psychology and Development and Regeneration, KU Leuven, the Center of Human Genetics, University Hospitals Leuven, and the Department of Obstetrics and Gynaecology Division of Mother and Child, University Hospitals, Leuven, and the Department of Welfare, Public Health and Family, Flemish Government, and the Flemish Study Center for Perinatal Epidemiology, Brussels, Belgium and the Department of Psychology, Tilburg University, Tilburg, The Netherlands
    Obstet Gynecol 122:999-1009. 2013
    ..To examine the association between interpregnancy weight change and the risk for adverse maternal and neonatal outcomes...
  28. doi request reprint Simple dichotomous updating methods improved the validity of polytomous prediction models
    Kirsten Van Hoorde
    Department of Electrical Engineering ESAT SCD, KU Leuven University of Leuven, Leuven, Belgium
    J Clin Epidemiol 66:1158-65. 2013
    ..Prediction models may perform poorly in a new setting. We aimed to determine which model updating methods should be applied for models predicting polytomous outcomes, which often suffer from one or more categories with low prevalence...
  29. doi request reprint The use of a new gel foam for the evaluation of tubal patency
    Dominique Van Schoubroeck
    Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium
    Gynecol Obstet Invest 75:152-6. 2013
    ..To evaluate the feasibility and the reliability of hysterosalpingo-foam sonography (HyFoSy) using gel foam in the assessment of tubal patency...
  30. doi request reprint Screening for uterine tumours
    Thierry Van den Bosch
    Department of Obstetrics and Gynecology, University Hospitals, Herestraat 49, 3000 Leuven, Belgium
    Best Pract Res Clin Obstet Gynaecol 26:257-66. 2012
    ..To date, mass screening for uterine malignancies is not feasible or effective...
  31. doi request reprint Detection of endometrial pathology using saline infusion sonography versus gel instillation sonography: a prospective cohort study
    Erika Werbrouck
    Department of Obstetrics and Gynecology, University Hospitals, and Department of Electrical Engineering, ESAT SCD, Katholieke Universiteit Leuven, Leuven, Belgium
    Fertil Steril 95:285-8. 2011
    ..To compare saline infusion sonography (SIS) with gel instillation sonography (GIS) in terms of feasibility and diagnostic accuracy...
  32. doi request reprint Ultrasound experience substantially impacts on diagnostic performance and confidence when adnexal masses are classified using pattern recognition
    Caroline Van Holsbeke
    Department of Obstetrics and Gynaecology, University Hospitals Leuven, Belgium
    Gynecol Obstet Invest 69:160-8. 2010
    ....
  33. ncbi request reprint Using literature and data to learn Bayesian networks as clinical models of ovarian tumors
    Peter Antal
    Department of Electrical Engineering, ESAT SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, B 3001 Leuven, Belgium
    Artif Intell Med 30:257-81. 2004
    ..Finally, we report the benefit of such informative text-based priors on the performance of a Bayesian network for the classification of ovarian tumors from clinical data...
  34. pmc Screening for data clustering in multicenter studies: the residual intraclass correlation
    Laure Wynants
    KU Leuven Department of Development and Regeneration, Leuven, Belgium
    BMC Med Res Methodol 13:128. 2013
    ..g. local referral patterns. The aim of this research is to derive measures for the degree of clustering. We present a method to detect heavily clustered variables and to identify physicians with outlying measurements...
  35. pmc Evaluation of markers and risk prediction models: overview of relationships between NRI and decision-analytic measures
    Ben Van Calster
    Department of Development and Regeneration, KU Leuven University of Leuven, Leuven, Belgium
    Med Decis Making 33:490-501. 2013
    ..The net reclassification improvement (NRI) is increasingly popular to compare predictions with 1 or more risk thresholds, but decision-analytic approaches have also been proposed...
  36. ncbi request reprint High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners
    Christel Meuleman
    Leuven University Fertility Centre, Department of Obstetrics and Gynecology, University Hospital Leuven, Herestraat 49, Leuven, Belgium
    Fertil Steril 92:68-74. 2009
    ..To determine the prevalence of histologically proven endometriosis in a subset of infertile women...
  37. ncbi request reprint Occurrence and outcome of residual trophoblastic tissue: a prospective study
    Thierry Van den Bosch
    Department of Obstetrics and Gynecology, University Hospitals, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Ultrasound Med 27:357-61. 2008
    ....
  38. ncbi request reprint Treatment modalities in endometrial cancer
    Frederic Amant
    Leuven Cancer Institute LKI, UZ Gasthuisberg, Katholieke Universiteit, Leuven, Belgium
    Curr Opin Oncol 19:479-85. 2007
    ..Endometrial cancer is the most common malignancy of the female genital tract. This review highlights new insights and these will change current practice...
  39. ncbi request reprint Acute effects of tamoxifen and third-generation aromatase inhibitors on menopausal symptoms of breast cancer patients
    Leilani Morales
    Department of Medical Oncology, University Hospitals, Leuven, Belgium
    Anticancer Drugs 15:753-60. 2004
    ..Our results underscore the need for safe and effective non-hormonal interventions to alleviate vasomotor and musculoskeletal symptoms which were the most prevalent and severe symptoms...
  40. ncbi request reprint Application of proteomics in ovarian cancer: which sample should be used?
    Isabelle Cadron
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Gynecol Oncol 115:497-503. 2009
    ..This review gives an overview of proteomic studies performed in ovarian cancer focusing on the nature of samples that have been used...
  41. doi request reprint An application of methods for the probabilistic three-class classification of pregnancies of unknown location
    Ben Van Calster
    Department of Electrical Engineering ESAT SISTA, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, B 3001 Leuven, Belgium
    Artif Intell Med 46:139-54. 2009
    ..We focused on probabilistic classification because of the importance of uncertainty information in medical decision making...
  42. ncbi request reprint Predicting the prognosis of breast cancer by integrating clinical and microarray data with Bayesian networks
    Olivier Gevaert
    Department of Electrical Engineering ESAT SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Leuven, Belgium
    Bioinformatics 22:e184-90. 2006
    ..Therefore Bayesian networks automatically perform feature selection by identifying the (in)dependency relationships with the class variable...
  43. ncbi request reprint Body mass index and HER-2 overexpression in breast cancer patients over 50 years of age
    T Van Mieghem
    Department of Obstetrics and Gynaecology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium
    Breast Cancer Res Treat 106:127-33. 2007
    ..It is unknown whether circulating estrogens affect HER-2 expression. We hypothesize that the postmenopausal body mass index (BMI) as a surrogate marker for bio-available estrogens, is inversely associated with HER-2 over-expression...
  44. doi request reprint 2D versus 3D roadmap for uterine artery catheterization: impact on several angiographic parameters
    Geert Maleux
    Department of Radiology, Section of Interventional Radiology, University Hospitals Leuven, Belgium
    Acta Radiol 55:62-70. 2014
    ..Few data with regard to efficacy and radiation dose are currently available in literature...
  45. ncbi request reprint Presurgical diagnosis of adnexal tumours using mathematical models and scoring systems: a systematic review and meta-analysis
    Jeroen Kaijser
    Department of Development and Regeneration, KU Leuven, Leuven, Belgium
    Hum Reprod Update 20:449-62. 2014
    ..84-0.94], respectively. CONCLUSIONS An evidence-based approach to the preoperative characterization of any adnexal mass should incorporate the use of IOTA Simple Rules or the LR2 model, particularly for women of reproductive age. ..
  46. ncbi request reprint Assessing calibration of multinomial risk prediction models
    Kirsten Van Hoorde
    KU Leuven Department of Electrical Engineering ESAT, STADIUS Center for Dynamical Systems, Signal Processing, and Data Analytics, Leuven, Belgium KU Leuven iMinds Future Health Department, Leuven, Belgium
    Stat Med 33:2585-96. 2014
    ..We conclude that calibration tools can be extended to polytomous outcomes. The polytomous calibration plots are particularly informative through the visual summary of the calibration performance...
  47. doi request reprint Adenomyosis and subfertility: evidence of association and causation
    Carla Tomassetti
    Department Obstetrics and Gynecology, Leuven University Fertility Center, Leuven, Belgium
    Semin Reprod Med 31:101-8. 2013
    ..More and better designed studies are needed to assess the impact of adenomyosis on infertility in women with the laparoscopic-proven presence or absence of endometriosis...
  48. doi request reprint Extending the c-statistic to nominal polytomous outcomes: the Polytomous Discrimination Index
    Ben Van Calster
    Department of Reproduction, Development, and Regeneration, KU Leuven University of Leuven, Leuven, Belgium
    Stat Med 31:2610-26. 2012
    ..In conclusion, the PDI is attractive because it better matches the requirements of a measure to summarize polytomous discrimination...
  49. ncbi request reprint Endometrial cancer
    Frederic Amant
    Department of Obstetrics and Gynaecology, Division of Gynaecological Oncology, UZ Gasthuisberg, Katholieke Universiteit, Leuven, Belgium
    Lancet 366:491-505. 2005
    ..We review current concepts about epidemiology, pathology, pathogenesis, risk factors and prevention, diagnosis, staging, prognostic factors, treatment, and follow-up of endometrial cancer...
  50. ncbi request reprint Acquired uterine vascular malformations: radiological and clinical outcome after transcatheter embolotherapy
    Geert Maleux
    Department of Radiology, University Hospitals Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
    Eur Radiol 16:299-306. 2006
    ..In case of clinical failure, an underlying neoplastic disease should be considered. Future pregnancy is still possible after embolization...
  51. doi request reprint Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive
    Ben Van Calster
    Multidisciplinary Breast Centre, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium
    Breast Cancer Res Treat 113:181-7. 2009
    ..To examine the frequency of axillary lymph node (ALN) invasion of operable breast cancers by their combined oestrogen receptor (ER), progesterone receptor (PR) and HER-2 status...
  52. ncbi request reprint Ultrasound assessment of endometrial thickness and endometrial polyps in women on hormonal replacement therapy
    Thierry Van den Bosch
    Department of Obstetrics and Gynecology, A Z Heilig Hart, Kliniekstraat 45, 3300 Tienen, Belgium
    Am J Obstet Gynecol 188:1249-53. 2003
    ..This study was performed to evaluate the thickness and the sonographic features of the endometrium in postmenopausal women on hormone replacement therapy (HRT)...
  53. pmc Simple ultrasound rules to distinguish between benign and malignant adnexal masses before surgery: prospective validation by IOTA group
    Dirk Timmerman
    Department of Obstetrics and Gynaecology, University Hospitals KU Leuven, 3000 Leuven, Belgium
    BMJ 341:c6839. 2010
    ....
  54. pmc Balancing false positives and false negatives for the detection of differential expression in malignancies
    F De Smet
    Department of Electrical Engineering, ESAT SCD, K U Leuven, Kasteelpark Arenberg 10, 3001 Leuven Heverlee, Belgium
    Br J Cancer 91:1160-5. 2004
    ..As an example, we apply our method to data sets studying acute leukaemia...
  55. doi request reprint Accuracy of peritoneal fluid measurements by transvaginal ultrasonography
    J Verguts
    Department of Obstetrics and Gynecology, University Hospital Leuven, Campus Gasthuisberg, Leuven, Belgium
    Ultrasound Obstet Gynecol 35:589-92. 2010
    ..To assess the accuracy of the assessment of peritoneal fluid volumes of up to 1 L by transvaginal ultrasonography and to re-evaluate the formula used to calculate total volume from the dimensions of the largest pocket...
  56. ncbi request reprint New crown-rump length curve based on over 3500 pregnancies
    A Pexsters
    Department of Obstetrics and Gynecology, University Hospitals, Katholieke Universiteit Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 35:650-5. 2010
    ..5 weeks' gestation. We compared this with the Robinson and Hadlock CRL curves...
  57. ncbi request reprint Pseudo-Meigs' syndrome caused by a hydropic degenerating uterine leiomyoma with elevated CA 125
    F Amant
    Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium
    Gynecol Oncol 83:153-7. 2001
    ..Uterine leiomyomas rarely cause pseudo-Meigs' syndrome with elevated serum CA 125 levels...
  58. ncbi request reprint Third generation aromatase inhibitors may prevent endometrial growth and reverse tamoxifen-induced uterine changes in postmenopausal breast cancer patients
    L Morales
    Department of Medical Oncology, University Hospitals Leuven, Belgium
    Ann Oncol 16:70-4. 2005
    ..We also assessed the effect of aromatase inhibitors on tamoxifen-induced uterine changes...
  59. ncbi request reprint Prognostic importance of degree of differentiation and cyst rupture in stage I invasive epithelial ovarian carcinoma
    I Vergote
    Department of Gynaecological Oncology, University Hospitals Leuven, Belgium
    Lancet 357:176-82. 2001
    ..We undertook a retrospective study in a large international database to identify the most important prognostic variables...
  60. ncbi request reprint Prospective evaluation of blood flow in the myometrium and uterine arteries in the puerperium
    D Van Schoubroeck
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Belgium
    Ultrasound Obstet Gynecol 23:378-81. 2004
    ..The aim of this study was to investigate the incidence and spontaneous evolution of areas of enhanced vascularization over the whole thickness of the myometrium in asymptomatic women after uncomplicated term pregnancy...
  61. ncbi request reprint Age interacts with the expression of steroid and HER-2 receptors in operable invasive breast cancer
    P Neven
    Department of Obstetrics and Gynaecology, Multidisciplinary Breast Centre, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Breast Cancer Res Treat 110:153-9. 2008
    ..The negative association between the oestrogen receptor (ER) and the human epidermal growth factor receptor 2 (HER-2) in breast cancer travels in both directions. ER+ tumours are less likely HER-2+ and HER-2+ tumours are less likely ER+...
  62. ncbi request reprint Ultrasound determination of chorionicity in twin pregnancy: accuracy and operator experience
    R G Devlieger
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Twin Res 4:223-6. 2001
    ..We conclude that use of a composite of ultrasound markers for early detection of chorionicity and amnionicity is reliable in a clinical setting where physicians with a variable degree of experience perform ultrasound examination...
  63. ncbi request reprint Endometrial safety of third generation aromatase inhibitors versus tamoxifen in breast cancer patients
    L Morales
    Departments of Medical Oncology, Obstetrics and Gynecology, and Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium
    Int J Gynecol Cancer 16:515-7. 2006
    ..This implies that the absence of a stimulatory effect on the uterus would be one of the benefits gained with aromatase inhibitor therapy and may decrease or even obviate the need for gynecological interventions...
  64. ncbi request reprint Intima-media thickness measurements in the fetus and mother during pregnancy: a feasibility study
    Sander Galjaard
    KU Leuven Department of Development and Regeneration Pregnancy, Fetus and Neonate, Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium
    Ultrasound Med Biol 40:1949-57. 2014
    ..01). IMT measurements are feasible in some maternal and fetal vessels of interest. Further studies are underway to obtain more insight into vascular development during normal and pathologic pregnancies. ..
  65. ncbi request reprint Imaging techniques for the pre-surgical diagnosis of adnexal tumours
    Jeroen Kaijser
    KU Leuven, Department of Development and Regeneration, Leuven, Belgium KU Leuven, Department of Obstetrics and Gynecology and Leuven Cancer Institute, University Hospital KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    Best Pract Res Clin Obstet Gynaecol 28:683-95. 2014
    ....
  66. ncbi request reprint Uterine adenomyosis in the infertility clinic
    Roland Devlieger
    Department of Obstetrics and Gynaecology and Leuven University Fertility Centre, University Hospital Gasthuisberg, K U Leuven, Belgium
    Hum Reprod Update 9:139-47. 2003
    ..Different treatment options are discussed, focusing on conservative management in patients who wish to maintain their childbearing capacity...
  67. ncbi request reprint Clinical management of uterine sarcomas
    Frederic Amant
    Leuven Cancer Institute, Gynaecological Oncology, University Hospital Gasthuisberg, Katholieke Universiteit, Leuven, Belgium
    Lancet Oncol 10:1188-98. 2009
    ..Potential future targets and targeted treatments that are under investigation are presented for both entities...
  68. ncbi request reprint Predicting the outcome of pregnancies of unknown location: Bayesian networks with expert prior information compared to logistic regression
    O Gevaert
    Department of Electrical Engineering ESAT SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg, Leuven, Belgium, and Early Pregnancy, Gynecology Ultrasound and MAS Unit, St George s Hospital Medical School, London, UK
    Hum Reprod 21:1824-31. 2006
    ..Some of these women will have an ectopic pregnancy (EP), and it is this group in the PUL population that poses the greatest concern. The aim of this study was to develop Bayesian networks to predict EPs in the PUL population...
  69. ncbi request reprint Preoperative prediction of malignancy of ovarian tumors using least squares support vector machines
    C Lu
    Department of Electrical Engineering, ESAT SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, B 3001 Leuven, Belgium
    Artif Intell Med 28:281-306. 2003
    ..6%, respectively. These results show that the LS-SVM models have the potential to obtain a reliable preoperative distinction between benign and malignant ovarian tumors, and to assist the clinicians for making a correct diagnosis...
  70. doi request reprint Pain experienced during transvaginal ultrasound, saline contrast sonohysterography, hysteroscopy and office sampling: a comparative study
    T van den Bosch
    Department of Obstetrics and Gynaecology, University Hospitals, K U Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 31:346-51. 2008
    ..To evaluate and compare the pain experienced by women during transvaginal ultrasound, saline contrast sonohysterography (SCSH), diagnostic hysteroscopy and office sampling...
  71. doi request reprint Ultrasound methods to distinguish between malignant and benign adnexal masses in the hands of examiners with different levels of experience
    C Van Holsbeke
    Department of Obstetrics and Gynaecology, University Hospitals Leuven, Belgium
    Ultrasound Obstet Gynecol 34:454-61. 2009
    ....
  72. ncbi request reprint Bayesian applications of belief networks and multilayer perceptrons for ovarian tumor classification with rejection
    Peter Antal
    Electrical Engineering Department ESAT SCD, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, B 3001 Heverlee, Leuven, Belgium
    Artif Intell Med 29:39-60. 2003
    ..Furthermore, we report the performance of Bayesian belief networks when they are allowed to exclude hard cases based on various measures of prediction uncertainty...
  73. doi request reprint Prospective external validation of the 'ovarian crescent sign' as a single ultrasound parameter to distinguish between benign and malignant adnexal pathology
    C Van Holsbeke
    Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 36:81-7. 2010
    ....
  74. ncbi request reprint A thin and regular endometrium on ultrasound is very unlikely in patients with endometrial malignancy
    T van den Bosch
    Department of Obstetrics and Gynecology, University Hospitals Leuven, K U Leuven, Belgium
    Ultrasound Obstet Gynecol 29:674-9. 2007
    ..To evaluate the clinical and sonographic features in patients with endometrial malignancy in whom endometrial thickness on ultrasound examination had been recorded in our database to be < 5 mm...
  75. doi request reprint Prevalent breast cancer patients with a homozygous mutant status for CYP2D6*4: response and biomarkers in tamoxifen users
    A S Dieudonné
    Department of Obstetrics and Gynecology, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Breast Cancer Res Treat 118:531-8. 2009
    ..They support clinical trials prospectively testing the effect of CYP2D6 genetic variability in response to tamoxifen before denying this drug to breast cancer patients only based on their CYP2D6*4 status...
  76. ncbi request reprint Associated malformations and chromosomal anomalies in 42 cases of prenatally diagnosed diaphragmatic hernia
    I Witters
    Department of Obstetrics and Gynecology, University of Leuven, B-3000 Leuven, Belgium
    Am J Med Genet 103:278-82. 2001
    ..The in utero diagnosis of CDH implies a detailed echographic examination to exclude additional anomalies. The risk for a syndromal or chromosomal malformation becomes small when no additional anomalies are seen on ultrasound...
  77. ncbi request reprint Color Doppler and gray-scale ultrasound evaluation of the postpartum uterus
    T van den Bosch
    Department of Obstetrics and Gynecology, A Z Heilig Hart, Tienen, Belgium
    Ultrasound Obstet Gynecol 20:586-91. 2002
    ..To evaluate the color Doppler and gray-scale sonographic appearance of the uterus after pregnancy, with special attention to the occurrence of areas of enhanced vascularity and placental remnants...
  78. ncbi request reprint Acoustic streaming in two endometriomas: the exception to the rule?
    C Van Holsbeke
    Department of Obstetrics and Gynecology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Genk, Belgium
    Ultrasound Obstet Gynecol 27:89-90. 2006
    ..It has previously been demonstrated that the absence of acoustic streaming in endometriomas could be a pathognomonic feature of endometriomas. In this report we demonstrate the presence of acoustic streaming in two endometriomas...
  79. ncbi request reprint Simple ultrasound-based rules for the diagnosis of ovarian cancer
    D Timmerman
    Department of Obstetrics and Gynecology, University Hospitals KU Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 31:681-90. 2008
    ..To derive simple and clinically useful ultrasound-based rules for discriminating between benign and malignant adnexal masses...
  80. ncbi request reprint Gel infusion sonography in the evaluation of the uterine cavity
    T van den Bosch
    Department of Obstetrics and Gynecology, University Hospitals, KU Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 34:711-4. 2009
    ..To compare gel infusion sonohysterography (GIS) with saline contrast sonohysterography (SCSH) with regard to technical feasibility and procedure-related pain experienced by patients...
  81. doi request reprint Imaging of gynecological disease (3): clinical and ultrasound characteristics of granulosa cell tumors of the ovary
    C Van Holsbeke
    Department of Obstetrics and Gynecology, University Hospitals KU Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 31:450-6. 2008
    ..To describe the clinical and ultrasound characteristics of granulosa cell tumors (GCTs) of the ovary, and to define the ultrasound appearance of GCTs based on pattern recognition...
  82. ncbi request reprint Preoperative diagnosis of ovarian tumors using Bayesian kernel-based methods
    B Van Calster
    Department of Electrical Engineering ESAT SCD, Katholieke Universiteit Leuven, and Department of Obstetrics and Gynecology, University Hospitals K U Leuven, Belgium
    Ultrasound Obstet Gynecol 29:496-504. 2007
    ..To develop flexible classifiers that predict malignancy in adnexal masses using a large database from nine centers...
  83. doi request reprint Acoustic streaming cannot discriminate reliably between endometriomas and other types of adnexal lesion: a multicenter study of 633 adnexal masses
    C Van Holsbeke
    Department of Obstetrics and Gynaecology, University Hospitals Leuven, Belgium
    Ultrasound Obstet Gynecol 35:349-53. 2010
    ..To determine the ability of acoustic streaming to discriminate between endometriomas and other adnexal masses...
  84. ncbi request reprint New models to predict depth of infiltration in endometrial carcinoma based on transvaginal sonography
    F De Smet
    Department of Electrical Engineering ESAT SCD, Katholieke Universiteit Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 27:664-71. 2006
    ....
  85. ncbi request reprint Endometriomas: their ultrasound characteristics
    C Van Holsbeke
    Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium
    Ultrasound Obstet Gynecol 35:730-40. 2010
    ..To describe the ultrasound characteristics of endometriomas in pre- and postmenopausal patients and to develop rules that characterize endometriomas...
  86. doi request reprint Real-time ultrasound vs. evaluation of static images in the preoperative assessment of adnexal masses
    C Van Holsbeke
    Department of Obstetrics and Gynaecology, University Hospitals Leuven, Belgium
    Ultrasound Obstet Gynecol 32:828-31. 2008
    ..e. subjective evaluation of gray-scale and Doppler ultrasound findings, is as accurate when based on static images as it is when based on a real-time ultrasound examination...
  87. ncbi request reprint Ultrasound examination of the endometrium before and after Pipelle endometrial sampling
    T van den Bosch
    Department of Obstetrics and Gynecology, A Z Heilig Hart, Tienen, Belgium
    Ultrasound Obstet Gynecol 26:283-6. 2005
    ..To evaluate if, and to what extent, Pipelle de Cornier endometrial sampling influences the ultrasonographic features of the endometrium...
  88. ncbi request reprint Uterine intramural bone after mid-trimester termination of pregnancy may not affect fertility: a case report
    T van den Bosch
    Department of Obstetrics and Gynaecology, A Z Heilig Hart, Tienen, Belgium
    Ultrasound Obstet Gynecol 22:407-8. 2003
    ..This case illustrates the risk of myometrial penetration during mid-trimester TOP by D&E. Removal of intramural bony fragments may not be needed in an asymptomatic patient, as their presence does not seem to compromise fertility...
  89. ncbi request reprint Preoperative prediction of malignancy of ovarian tumours using modified sequential non-uniform procedure
    Viktoriya Stalbovskaya
    Conf Proc IEEE Eng Med Biol Soc 2007:5403-6. 2007
    ..The performance of the model was assessed using ROC analysis and gave 86.9% of sensitivity and 84.3% of specificity with overall accuracy level of 84.9%...
  90. ncbi request reprint A new method for modeling preoperative diagnosis of ovarian tumors
    Viktoriya Stalbovskaya
    Signal Processing and Multimedia Communications Group, School of Computing, Communications and Electronics, University of Plymouth, Plymouth PL4 8AA, UK
    IEEE Trans Biomed Eng 54:2064-72. 2007
    ..The method is also generic and can be readily adapted for other classifications problems in biomedicine...
  91. ncbi request reprint Independent test set performance in the prediction of early relapse in ovarian cancer with gene expression profiles
    Frank De Smet
    Clin Cancer Res 11:7958-9; author reply 7959. 2005
  92. ncbi request reprint Chlamydia trachomatis infection in patients attending an Early Pregnancy Unit: prevalence, symptoms, pregnancy location and viability
    Emma Kirk
    Early Pregnancy and Gynaecological Ultrasound Unit, St George s, University of London, London, Cranmer Terrace, UK
    Acta Obstet Gynecol Scand 87:601-7. 2008
    ..To assess the prevalence of Chlamydia trachomatis and its relationship to age, ethnicity, symptomatology, pregnancy location and viability in women attending an Early Pregnancy Unit...
  93. ncbi request reprint Aromatase inhibitors and postmenopausal breast cancer patients with tamoxifen-induced endometrial pathology
    Leilani Morales
    Clin Cancer Res 12:5603. 2006
  94. ncbi request reprint Significance of secondary ultrasonographic endometrial thickening in postmenopausal tamoxifen-treated women
    Dirk Timmerman
    Cancer 98:431-2; author reply 432-3. 2003
  95. ncbi request reprint Molecular profiling of platinum resistant ovarian cancer: use of the model in clinical practice
    Olivier Gevaert
    Int J Cancer 119:1511; author reply 1512. 2006
  96. ncbi request reprint Clinical information does not improve the performance of mathematical models in predicting the outcome of pregnancies of unknown location
    George Condous
    Early Pregnancy, Gynaecological Ultrasound and MAS Unit, St George s, University of London, London, United Kingdom
    Fertil Steril 88:572-80. 2007
    ..To see if the incorporation of clinical variables can improve the diagnostic performance of logistic regression models in the prediction of pregnancy of unknown location (PUL) outcome...
  97. ncbi request reprint Monochorionic diamniotic twins: complications and management options
    Liesbeth Lewi
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Centre for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Curr Opin Obstet Gynecol 15:177-94. 2003
    ..This is because of the unpredictable vascular anastomoses and the often asymmetrical distribution of the single placenta between both twins...
  98. ncbi request reprint The hCG ratio can predict the ultimate viability of the intrauterine pregnancies of uncertain viability in the pregnancy of unknown location population
    Tommaso Bignardi
    Early Pregnancy and Gynaecological Ultrasound Unit, Department of Obstetrics and Gynaecology, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Hum Reprod 23:1964-7. 2008
    ..To determine whether hCG ratio at 48 h can predict ultimate viability of intrauterine pregnancies of uncertain viability (IPUVs) in the pregnancy of unknown location (PUL) population...
  99. ncbi request reprint Ultrasound characteristics of different types of adnexal malignancies
    Lil Valentin
    Department of Obstetrics and Gynecology, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Gynecol Oncol 102:41-8. 2006
    ..e., borderline ovarian tumors, primary invasive ovarian epithelial cancer stage 1, primary invasive ovarian epithelial cancer stages 2-4, rare types of malignancy, and metastatic tumors...
  100. ncbi request reprint The use of contrasted transvaginal sonography in the diagnosis of gynecologic diseases: a preliminary study
    Antonia Carla Testa
    Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, Largo A Gemelli 8, 00168 Rome, Italy
    J Ultrasound Med 24:1267-78. 2005
    ....