K Talavera

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. doi request reprint Differential Effects of Bitter Compounds on the Taste Transduction Channels TRPM5 and IP3 Receptor Type 3
    Maarten Gees
    Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, Herestraat 49, Campus Gasthuisberg, O and N1 Box 802, KU Leuven, B 3000 Leuven, Belgium
    Chem Senses 39:295-311. 2014
  2. doi request reprint Nicotine activates the chemosensory cation channel TRPA1
    Karel Talavera
    Laboratory for Ion Channel Research, Department of Molecular Cell Biology, KU Leuven, Leuven, Belgium
    Nat Neurosci 12:1293-9. 2009
  3. ncbi request reprint The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions
    Karel Talavera
    Laboratory of Ion Channel Research, Dept of Molecular Cell Biology, Herestraat 49, Campus Gasthuisberg, O and N1, KU Leuven, B 3000 Leuven, Belgium
    FASEB J 22:1343-55. 2008
  4. ncbi request reprint Influence of temperature on taste perception
    K Talavera
    Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Cell Mol Life Sci 64:377-81. 2007
  5. ncbi request reprint Evidence for common structural determinants of activation and inactivation in T-type Ca2+ channels
    Karel Talavera
    Laboratorium voor Fysiologie, KU Leuven, Campus Gasthuisberg, Leuven, Belgium
    Pflugers Arch 453:189-201. 2006
  6. ncbi request reprint Heat activation of TRPM5 underlies thermal sensitivity of sweet taste
    Karel Talavera
    Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 438:1022-5. 2005
  7. pmc The amino side of the C-terminus determines fast inactivation of the T-type calcium channel alpha1G
    M Staes
    Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, B-3000 Leuven, Belgium
    J Physiol 530:35-45. 2001
  8. pmc TRPA1 acts as a cold sensor in vitro and in vivo
    Yuji Karashima
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, Campus Gasthuisberg O and N1, Katholieke Universiteit Leuven, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 106:1273-8. 2009
  9. doi request reprint Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole
    Victor Meseguer
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, Campus Gasthuisberg O and N1, KU Leuven, B 3000 Leuven, Belgium
    J Neurosci 28:576-86. 2008
  10. ncbi request reprint Bimodal action of menthol on the transient receptor potential channel TRPA1
    Yuji Karashima
    Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Neurosci 27:9874-84. 2007

Collaborators

Detail Information

Publications29

  1. doi request reprint Differential Effects of Bitter Compounds on the Taste Transduction Channels TRPM5 and IP3 Receptor Type 3
    Maarten Gees
    Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, Herestraat 49, Campus Gasthuisberg, O and N1 Box 802, KU Leuven, B 3000 Leuven, Belgium
    Chem Senses 39:295-311. 2014
    ..Our results demonstrate that bitter compounds have differential effects on key elements of the sweet taste transduction pathway, suggesting for heterogeneous mechanisms of bitter-sweet taste interactions. ..
  2. doi request reprint Nicotine activates the chemosensory cation channel TRPA1
    Karel Talavera
    Laboratory for Ion Channel Research, Department of Molecular Cell Biology, KU Leuven, Leuven, Belgium
    Nat Neurosci 12:1293-9. 2009
    ..The identification of TRPA1 as a nicotine target suggests that existing models of nicotine-induced irritation should be revised and may facilitate the development of smoking cessation therapies with less adverse effects...
  3. ncbi request reprint The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions
    Karel Talavera
    Laboratory of Ion Channel Research, Dept of Molecular Cell Biology, Herestraat 49, Campus Gasthuisberg, O and N1, KU Leuven, B 3000 Leuven, Belgium
    FASEB J 22:1343-55. 2008
    ..The inhibition of TRPM5 by bitter compounds constitutes the molecular basis of a novel mechanism of taste interactions, whereby the bitter tastant inhibits directly the sweet transduction pathway...
  4. ncbi request reprint Influence of temperature on taste perception
    K Talavera
    Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Cell Mol Life Sci 64:377-81. 2007
    ..Vice versa, the analysis of the thermodynamic properties of these events may assist to unveil the nature of several taste processes...
  5. ncbi request reprint Evidence for common structural determinants of activation and inactivation in T-type Ca2+ channels
    Karel Talavera
    Laboratorium voor Fysiologie, KU Leuven, Campus Gasthuisberg, Leuven, Belgium
    Pflugers Arch 453:189-201. 2006
    ..1. Our results indicate that common structures, most likely the S6 transmembrane segments, are involved in the conformational changes occurring during both channel activation and inactivation...
  6. ncbi request reprint Heat activation of TRPM5 underlies thermal sensitivity of sweet taste
    Karel Talavera
    Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 438:1022-5. 2005
    ....
  7. pmc The amino side of the C-terminus determines fast inactivation of the T-type calcium channel alpha1G
    M Staes
    Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, B-3000 Leuven, Belgium
    J Physiol 530:35-45. 2001
    ....
  8. pmc TRPA1 acts as a cold sensor in vitro and in vivo
    Yuji Karashima
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, Campus Gasthuisberg O and N1, Katholieke Universiteit Leuven, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 106:1273-8. 2009
    ..Finally, cold plate and tail-flick experiments reveal TRPA1-dependent, cold-induced nociceptive behavior in mice. We conclude that TRPA1 acts as a major sensor for noxious cold...
  9. doi request reprint Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole
    Victor Meseguer
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, Campus Gasthuisberg O and N1, KU Leuven, B 3000 Leuven, Belgium
    J Neurosci 28:576-86. 2008
    ..Together, our results identify TRP channels in sensory neurons as molecular targets of CLT, and offer means to develop novel CLT preparations with fewer unwanted sensory side effects...
  10. ncbi request reprint Bimodal action of menthol on the transient receptor potential channel TRPA1
    Yuji Karashima
    Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Neurosci 27:9874-84. 2007
    ....
  11. pmc Extracellular Ca2+ modulates the effects of protons on gating and conduction properties of the T-type Ca2+ channel alpha1G (CaV3.1)
    Karel Talavera
    Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, Belgium
    J Gen Physiol 121:511-28. 2003
    ....
  12. ncbi request reprint T-type calcium channels: the never ending story
    Bernd Nilius
    Laboratorium voor Fysiologie, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Cell Calcium 40:81-8. 2006
    ..Finally, an overview is given how research on T-type Ca2+ channels has developed in the last years and in which topics it is branching out, a process, which is still ongoing...
  13. pmc Modulation of the cold-activated cation channel TRPM8 by surface charge screening
    Frank Mahieu
    KU Leuven, Laboratory of Ion Channel Research, Department of Molecular Cell Biology, Leuven, Belgium
    J Physiol 588:315-24. 2010
    ..These results represent the first description of the effects of surface charge screening on a TRP channel and provide a straightforward explanation for the known effects of extracellular Ca(2+) on cold-sensitive neurons...
  14. ncbi request reprint Permeation and selectivity of TRP channels
    Grzegorz Owsianik
    Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Annu Rev Physiol 68:685-717. 2006
    ..This review gives an overview of available experimental and theoretical data and discusses the functional impact of pore-structure modifications on TRP channel properties...
  15. ncbi request reprint TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli
    Thomas Voets
    Laboratory of Ion Channel Research, Division of Physiology, Department of Molecular Cell Biology, Campus Gasthuisberg O and N1, KU Leuven, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Nat Chem Biol 3:174-82. 2007
    ..Based on these findings, we present a Monod-Wyman-Changeux-type model explaining the combined effects of voltage, temperature and menthol on TRPM8 gating...
  16. pmc Pore structure influences gating properties of the T-type Ca2+ channel alpha1G
    Karel Talavera
    Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, Belgium
    J Gen Physiol 121:529-40. 2003
    ..These changes are independent of the alterations of the selectivity properties and channel protonation...
  17. doi request reprint Differential contribution of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1 to chloride handling in rat embryonic dorsal root ganglion neurons and motor neurons
    J N Chabwine
    Department of Molecular and Cell Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    FASEB J 23:1168-76. 2009
    ..The high NKCC1 activity in DRGNs is important for maintaining high [Cl(-)](i), whereas lower NKCC1 activity in MNs allows large [Cl(-)](i) variations during neuronal activity...
  18. ncbi request reprint Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice
    Nina D Ullrich
    Laboratorium voor Fysiologie, Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Cell Calcium 37:267-78. 2005
    ..TRPM4 displayed a 10-fold higher affinity for block by flufenamic acid. Importantly, ATP4- blocked TRPM4 with high affinity (IC50 of 0.8+/-0.1 microM), whereas TRPM5 is insensitive to ATP4- at concentrations up to 1 mM...
  19. pmc Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1
    Yuji Karashima
    Department of Molecular Cell Biology, Katholieke Universiteit Leuven, Belgium
    Biophys J 98:773-83. 2010
    ..We conclude that the pore of TRPA1 is dynamic and supports a surprisingly large Ca(2+) influx...
  20. pmc Gating of TRP channels: a voltage connection?
    Bernd Nilius
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Leuven, Belgium
    J Physiol 567:35-44. 2005
    ..Some structural considerations will be given indicating that, although the voltage sensor is not yet known, the C-terminus may substantially change the voltage dependence of these channels...
  21. pmc Mechanism of arachidonic acid modulation of the T-type Ca2+ channel alpha1G
    Karel Talavera
    Laboratorium voor Fysiologie, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Gen Physiol 124:225-38. 2004
    ..Slow-inactivating alpha(1G) mutants showed an increased affinity for AA with respect to the wild type, indicating that the structural determinants of fast inactivation are involved in the AA-channel interaction...
  22. ncbi request reprint Biophysics and structure-function relationship of T-type Ca2+ channels
    Karel Talavera
    Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Cell Calcium 40:97-114. 2006
    ..Certainly, more structure-function studies are needed for a better understanding of T-type channel physiology and the rational design of treatments against T-type channel-related pathologies...
  23. ncbi request reprint Aspartate residues of the Glu-Glu-Asp-Asp (EEDD) pore locus control selectivity and permeation of the T-type Ca(2+) channel alpha(1G)
    K Talavera
    Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium
    J Biol Chem 276:45628-35. 2001
    ..The mutation of both divergent aspartates only partially confers HVA channel permeation properties to the alpha(1G) Ca(2+) channel subunit...
  24. pmc Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding
    Thomas Gevaert
    Department of Urology, University Hospital Gasthuisberg, Leuven, Belgium
    J Clin Invest 117:3453-62. 2007
    ..These data demonstrate a previously unrecognized role for TRPV4 in voiding behavior, raising the possibility that TRPV4 plays a critical role in urothelium-mediated transduction of intravesical mechanical pressure...
  25. pmc Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice
    Barbara Colsoul
    Laboratory of Ion Channel Research and Gene Expression Unit, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, B 3001 Louvain, Belgium
    Proc Natl Acad Sci U S A 107:5208-13. 2010
    ..As a consequence, glucose-induced insulin release from Trpm5(-/-) pancreatic islets is significantly reduced, resulting in an impaired glucose tolerance in Trpm5(-/-) mice...
  26. ncbi request reprint Sensing with TRP channels
    Thomas Voets
    Laboratory of Physiology, Campus Gasthuisberg O and N, KU Leuven, B 3000 Leuven, Belgium
    Nat Chem Biol 1:85-92. 2005
    ..Activation of TRP channels is highly sensitive to a variety of chemical and physical stimuli, allowing them to function as dedicated biological sensors that are essential in processes such as vision, taste, tactile sensation and hearing...
  27. ncbi request reprint Methodological considerations to understand the sensory function of TRP channels
    Victor M Meseguer
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, 03550 San Juan de Alicante, Spain
    Curr Pharm Biotechnol 12:3-11. 2011
    ....
  28. ncbi request reprint Occurrence of a tetrodotoxin-sensitive calcium current in rat ventricular myocytes after long-term myocardial infarction
    Julio L Alvarez
    INSERM U 390, Physiopathologie Cardiovasculaire, CHU Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, F 34295 Montpellier cedex 5, France
    Cardiovasc Res 63:653-61. 2004
    ..To determine the characteristics of a TTX-sensitive Ca(2+) current that occurred only following remodelling after myocardial infarction in Wistar rat...
  29. ncbi request reprint Role of T-type Ca2+ channels in the heart
    Guy Vassort
    INSERM U 637, Physiopathologie Cardiovasculaire, CHU Arnaud de Villeneuve, Montpellier, France
    Cell Calcium 40:205-20. 2006
    ..ICaT contributes also to Ca2+-dependent hormonal secretion. This review further emphasizes the difficulties encountered in analysing this current...