Jan Tack

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. doi request reprint Treatment of chronic constipation: current pharmacologic approaches and future directions
    Jan Tack
    Division of Gastroenterology, University Hospital, Leuven, Belgium
    Clin Gastroenterol Hepatol 7:502-8; quiz 496. 2009
  2. doi request reprint Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia
    Jan Tack
    University of Leuven, Translational Research Center for Gastrointestinal Disorders, Department of Pathophysiology, Leuven, Belgium
    Expert Opin Investig Drugs 20:701-12. 2011
  3. pmc Gastroparesis: current concepts and management
    Tatsuhiro Masaoka
    Center for Gastroenterological Research, University of Leuven, Leuven, Belgium
    Gut Liver 3:166-73. 2009
  4. pmc Validation of octanoate breath test for measuring gastric emptying in rats
    Ingrid Demedts
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    J Neurogastroenterol Motil 19:171-8. 2013
  5. pmc Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats
    Ingrid Demedts
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    J Neurogastroenterol Motil 19:161-70. 2013
  6. pmc Duodenal implications in the pathophysiology of functional dyspepsia
    Kwang Jae Lee
    Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea
    J Neurogastroenterol Motil 16:251-7. 2010
  7. ncbi request reprint Optimal use of proton pump inhibitors for treating acid peptic diseases in primary care
    J Tack
    Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium
    Acta Gastroenterol Belg 76:393-402. 2013
  8. doi request reprint How can we achieve relief of bowel and abdominal symptoms for patients with irritable bowel syndrome with constipation?
    Jan Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Expert Rev Gastroenterol Hepatol 7:21-6. 2013
  9. doi request reprint Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria
    Jan Tack
    TARGID Translational Research Center for Gastrointestinal Disorders, University of Leuven, Herestraat 49, Leuven 3000, Belgium
    Nat Rev Gastroenterol Hepatol 10:134-41. 2013
  10. pmc Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders
    J Tack
    Department of Clinical and Experimental Medicine, University of Leuven, Belgium
    Aliment Pharmacol Ther 35:745-67. 2012

Detail Information

Publications187 found, 100 shown here

  1. doi request reprint Treatment of chronic constipation: current pharmacologic approaches and future directions
    Jan Tack
    Division of Gastroenterology, University Hospital, Leuven, Belgium
    Clin Gastroenterol Hepatol 7:502-8; quiz 496. 2009
    ....
  2. doi request reprint Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia
    Jan Tack
    University of Leuven, Translational Research Center for Gastrointestinal Disorders, Department of Pathophysiology, Leuven, Belgium
    Expert Opin Investig Drugs 20:701-12. 2011
    ..To date, no treatment of established efficacy in FD is available. Acotiamide (Z-338 or YM443) is a new drug under development for the treatment of FD...
  3. pmc Gastroparesis: current concepts and management
    Tatsuhiro Masaoka
    Center for Gastroenterological Research, University of Leuven, Leuven, Belgium
    Gut Liver 3:166-73. 2009
    ....
  4. pmc Validation of octanoate breath test for measuring gastric emptying in rats
    Ingrid Demedts
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    J Neurogastroenterol Motil 19:171-8. 2013
    ..The aim of this study was to adapt the (14)C-octanoate solid gastric emptying breath test for application in rats, and to validate it against radioscintigraphic method...
  5. pmc Gastrointestinal motility changes and myenteric plexus alterations in spontaneously diabetic biobreeding rats
    Ingrid Demedts
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    J Neurogastroenterol Motil 19:161-70. 2013
    ..We therefore studied the relationship between vagal function, gastrointestinal motiliy and characteristics of the enteric nervous system in the biobreeding (BB) rat known as model for spontaneous type 1 diabetes...
  6. pmc Duodenal implications in the pathophysiology of functional dyspepsia
    Kwang Jae Lee
    Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea
    J Neurogastroenterol Motil 16:251-7. 2010
    ..Furthermore, the causative factors related to the development of duodenal abnormalities in FD warrant further study...
  7. ncbi request reprint Optimal use of proton pump inhibitors for treating acid peptic diseases in primary care
    J Tack
    Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium
    Acta Gastroenterol Belg 76:393-402. 2013
    ..This review summarizes current evidence on treatment of acid-peptic diseases with proton pump inhibitors and provides primary care clinicians with best practice guidelines for optimal use of these drugs...
  8. doi request reprint How can we achieve relief of bowel and abdominal symptoms for patients with irritable bowel syndrome with constipation?
    Jan Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Expert Rev Gastroenterol Hepatol 7:21-6. 2013
    ..Hence, there remains an unmet need for well-tolerated and effective treatments for irritable bowel syndrome with constipation that target abdominal symptoms, including abdominal pain and bowel symptoms. ..
  9. doi request reprint Functional dyspepsia--symptoms, definitions and validity of the Rome III criteria
    Jan Tack
    TARGID Translational Research Center for Gastrointestinal Disorders, University of Leuven, Herestraat 49, Leuven 3000, Belgium
    Nat Rev Gastroenterol Hepatol 10:134-41. 2013
    ..Further randomized controlled trials testing treatment response by subgroup are urgently needed...
  10. pmc Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders
    J Tack
    Department of Clinical and Experimental Medicine, University of Leuven, Belgium
    Aliment Pharmacol Ther 35:745-67. 2012
    ..The nonselective 5-HT(4) receptor agonists, cisapride and tegaserod have been associated with cardiovascular adverse events (AEs)...
  11. doi request reprint Role of Y(2) receptors in the regulation of gastric tone in rats
    P Janssen
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 302:G732-9. 2012
    ..Y(2) receptor antagonists were not able to decrease gastric tone without exogenous administration of PYY(3-36), indicating that Y(2) receptors do not play a crucial role in the determination of gastric tone in physiological conditions...
  12. ncbi request reprint Role of serotonin in gastrointestinal physiology and pathology
    C Cirillo
    Laboratory for Enteric Neuroscience LENS, Leuven, Belgium 2 TARGID, KU Leuven, Leuven, Leuven, Belgium
    Minerva Endocrinol 36:311-24. 2011
    ..Finally, an overview on the therapeutic agents used in clinical practice is provided...
  13. pmc Prevalence and severity of antipsychotic related constipation in patients with schizophrenia: a retrospective descriptive study
    Marc De Hert
    University Psychiatric Centre Catholic University Louvain, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
    BMC Gastroenterol 11:17. 2011
    ..They also have a number of side-effects. Constipation is thought to be common, and a potential serious side-effect, which has received little attention in recent literature...
  14. ncbi request reprint Gastroenterology--15th United European Week. New developments in the treatment of GERD and GI disorders
    Jan Tack
    University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    IDrugs 11:33-5. 2008
  15. doi request reprint Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives
    J Tack
    Division of Gastroenterology, Department of Internal Medicine, University Hospital, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Gut 58:357-65. 2009
    ..To determine the efficacy, impact on quality of life (QOL) and safety of prucalopride, a selective, high-affinity 5-HT(4) receptor agonist, in patients with chronic constipation...
  16. ncbi request reprint Pathogenesis and therapy for idiopathic dyspepsia
    Jan Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Curr Gastroenterol Rep 7:437-44. 2005
    ..Areas of major advances are the role of infection and genetic predisposition and studies on the role of abnormalities in gastric motility and sensitivity...
  17. doi request reprint Increasing body weight enhances prevalence and proximal extent of reflux in GERD patients 'on' and 'off' PPI therapy
    K Blondeau
    Translational Research Center for Gastrointestinal Disorders, K U Leuven, 49 Herestraat, Leuven, Belgium
    Neurogastroenterol Motil 23:724-e327. 2011
    ..We aimed to investigate the association between body mass index (BMI) and abdominal circumference on the incidence and proximal extent of reflux...
  18. doi request reprint Emerging drugs for functional dyspepsia
    Jan Tack
    University of Leuven, TARGID, Department of Pathophysiology, Herestraat 49, 0 and N 1, bus 701, B 3000 Leuven, Belgium
    Expert Opin Emerg Drugs 16:283-92. 2011
    ..Functional dyspepsia (FD) is a highly prevalent condition with a major impact on quality of life and high socio-economic and healthcare costs. To date, no treatment of established efficacy in FD is available...
  19. ncbi request reprint Chemosensitivity of the human gastrointestinal tract in health and in disease
    J Tack
    Gastroenterology Section, Department of Internal Medicine, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 19:241-4. 2007
    ..Our current knowledge of visceral chemosensitivity of the human gastrointestinal tract in health and in disease is reviewed, with a specific focus on the interaction between mechano- and chemosensitive pathways...
  20. ncbi request reprint A dose-ranging, placebo-controlled, pilot trial of Acotiamide in patients with functional dyspepsia
    J Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Neurogastroenterol Motil 21:272-80. 2009
    ..The involved mechanism could at least in part depend on an effect on meal-induced accommodation. 100 mg Acotiamide exhibited the potential to improve FD symptoms and QOL. Further studies are indicated...
  21. doi request reprint Review article: the pathophysiology, differential diagnosis and management of rumination syndrome
    J Tack
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Herestraat 49, Leuven, Vlaanderen, Belgium
    Aliment Pharmacol Ther 33:782-8. 2011
    ..It is now well-recognised that rumination syndrome occurs in patients of all ages and cognitive abilities...
  22. ncbi request reprint The difficult patient with gastroparesis
    Jan Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    Best Pract Res Clin Gastroenterol 21:379-91. 2007
    ..Rarely, in case of debilitating refractory symptoms, experimental or invasive therapies can be tried such as injection of botulinum toxin, enteral feeding tube insertion, gastric electrical stimulation or surgery...
  23. ncbi request reprint Systematic review: the efficacy of treatments for irritable bowel syndrome--a European perspective
    J Tack
    University Hospital of Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 24:183-205. 2006
    ..Irritable bowel syndrome (IBS) is a common, chronic disorder, characterized by abdominal pain/discomfort, bloating and altered bowel habit...
  24. ncbi request reprint Review article: the role of bile and pepsin in the pathophysiology and treatment of gastro-oesophageal reflux disease
    J Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Aliment Pharmacol Ther 24:10-6. 2006
    ..The therapeutic options for the non-acid component of the refluxate, including acid suppression, prokinetics, baclofen, surgery and mucosal protective agents like alginates, are discussed...
  25. ncbi request reprint Sumatriptan is an agonist at 5-HT receptors on myenteric neurones in the guinea-pig gastric antrum
    J Tack
    Center for G I Research K U Leuven, Belgium, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 19:39-46. 2007
    ..The actions of sumatriptan on gastric motility seem to be attributable to a direct action on enteric neurones...
  26. doi request reprint Current and future therapies for chronic constipation
    J Tack
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    Best Pract Res Clin Gastroenterol 25:151-8. 2011
    ..New agents under evaluation include the 5-HT4 agonists velusetrag and naronapride, the guanylate cyclase-C receptor agonist linaclotide and the peripherally acting mu opioid receptor antagonist alvimopan...
  27. ncbi request reprint A pilot study on duodenal acid exposure and its relationship to symptoms in functional dyspepsia with prominent nausea
    Kwang Jae Lee
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Am J Gastroenterol 99:1765-73. 2004
    ..However, the relevance of these abnormalities to spontaneous duodenal acid exposure and dyspeptic symptoms in FD is unknown...
  28. ncbi request reprint Regional cerebral blood flow during gastric balloon distention in functional dyspepsia
    Joris Vandenberghe
    Department of Psychiatry, Division of Liaison Psychiatry, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Gastroenterology 132:1684-93. 2007
    ..Our aim was to investigate regional cerebral blood flow during painful proximal gastric distention in hypersensitive FD...
  29. doi request reprint Influence of acute tryptophan depletion on gastric sensorimotor function in humans
    Brecht Geeraerts
    Dept of Gastroenterology, Univ Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 300:G228-35. 2011
    ..ATD alters gastric postprandial motor function and distension-induced nausea. These findings confirm involvement of 5-HT in the control of gastric accommodation and sensitivity...
  30. doi request reprint Food and symptom generation in functional gastrointestinal disorders: physiological aspects
    Ricard Farre
    Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 108:698-706. 2013
    ..The colon provides absorption of the water and electrolytes, storage of non-digestible remnants of food, aboral propulsion of contents, and finally evacuation through defecation...
  31. ncbi request reprint Relationship between anxiety and gastric sensorimotor function in functional dyspepsia
    Lukas Van Oudenhove
    Department of Pathophysiology, Gastroenterology Section, University Hospital Gasthuisberg, Leuven, Belgium
    Psychosom Med 69:455-63. 2007
    ..Experimentally induced anxiety in healthy volunteers is associated with changes in sensorimotor function of the proximal stomach...
  32. doi request reprint Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H(2)(15)O-PET study
    Lukas Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 105:913-24. 2010
    ....
  33. ncbi request reprint Parallel monitoring of plasma and intraluminal drug concentrations in man after oral administration of fosamprenavir in the fasted and fed state
    Joachim Brouwers
    Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, Gasthuisberg O and N 2 Herestraat 49, box 921, Leuven, Belgium
    Pharm Res 24:1862-9. 2007
    ..Fosamprenavir, a phosphate ester prodrug of the poorly water-soluble HIV-inhibitor amprenavir, was selected as model compound...
  34. doi request reprint Acid and weakly acidic solutions impair mucosal integrity of distal exposed and proximal non-exposed human oesophagus
    Ricard Farre
    Center for Gastroenterological Research, Catholic University Leuven, Belgium
    Gut 59:164-9. 2010
    ..We aimed to assess the effect of oesophageal perfusions with acid and weakly acidic solutions on 'exposed' and 'non-exposed' oesophageal mucosa and its relationship to symptoms in healthy subjects...
  35. doi request reprint Solubility profiling of HIV protease inhibitors in human intestinal fluids
    Benjamin Wuyts
    Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium
    J Pharm Sci 102:3800-7. 2013
    ....
  36. pmc Specific hunger- and satiety-induced tuning of guinea pig enteric nerve activity
    Lina Roosen
    Laboratory for Enteric Neuroscience LENS, Leuven, Belgium
    J Physiol 590:4321-33. 2012
    ....
  37. doi request reprint Regional brain activity in functional dyspepsia: a H(2)(15)O-PET study on the role of gastric sensitivity and abuse history
    Lukas Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Gastroenterology 139:36-47. 2010
    ..Therefore, we aimed to determine the influence of gastric sensitivity and abuse history on gastric sensation scores and brain activity in homeostatic-afferent, emotional-arousal, and cortical-modulatory brain regions in FD...
  38. ncbi request reprint Pathophysiology of functional dyspepsia
    Kwang Jae Lee
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Best Pract Res Clin Gastroenterol 18:707-16. 2004
    ..Psychosocial factors and altered response to duodenal lipids or acid have also been identified as pathophysiologic mechanisms...
  39. ncbi request reprint Unsuppressed postprandial phasic contractility in the proximal stomach in functional dyspepsia: relevance to symptoms
    Magnus Simren
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 98:2169-75. 2003
    ..The aim of the study was to examine postprandial phasic contractility in functional dyspepsia in relation to pathophysiological, clinical, and demographic variables...
  40. ncbi request reprint Influence of sildenafil on gastric sensorimotor function in humans
    Giovanni Sarnelli
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, B 3000 Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 287:G988-92. 2004
    ..The effect of sildenafil on gastric fundus suggests a therapeutic potential for phosphodiesterase inhibitors in patients with impaired gastric accommodation...
  41. doi request reprint Efficacy of the long-acting repeatable formulation of the somatostatin analogue octreotide in postoperative dumping
    Joris Arts
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Gastroenterol Hepatol 7:432-7. 2009
    ..We compared the efficacy of subcutaneous octreotide with that of the long-acting repeatable (LAR) octreotide formulation, which is administered monthly, in patients with dumping syndrome...
  42. ncbi request reprint Contribution of different triggers to the gastric accommodation reflex in humans
    Pieter Vanden Berghe
    Center for Gastroenterological Research K U Leuven, 49 Herestraat, 3000 Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 297:G902-6. 2009
    ..Blocking passage to the duodenum significantly decreases the amplitude of the accommodation reflex and induces early satiety...
  43. doi request reprint Longitudinal and cross-sectional factors associated with long-term clinical course in functional dyspepsia: a 5-year follow-up study
    Sebastien Kindt
    Center for Gastroenterological Research, Department of Pathophysiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 106:340-8. 2011
    ..The aims of this study were to study the long-term evolution of symptoms in a clinical FD population and to identify factors associated with outcome...
  44. ncbi request reprint Esophageal motility in children with suspected gastroesophageal reflux disease
    Ilse Hoffman
    Division of Pediatrics, University Hospitals Leuven Gasthuisberg, Leuven, Belgium
    J Pediatr Gastroenterol Nutr 50:601-8. 2010
    ....
  45. pmc Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces
    Ricard Farre
    Center for Gastroenterological Research, Catholic University Leuven, Belgium
    Gut 56:1191-7. 2007
    ..In the rat, acute stress increases gastric and intestinal mucosa permeability. We investigated whether acute stress can also increase oesophageal mucosa permeability and contribute to the dilation of mucosa intercellular spaces...
  46. doi request reprint Intestinal drug solubility estimation based on simulated intestinal fluids: comparison with solubility in human intestinal fluids
    Sarah Clarysse
    Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, Belgium
    Eur J Pharm Sci 43:260-9. 2011
    ..In conclusion, FaSSIF(c) and FeSSIF(c) can be considered biorelevant media for intestinal solubility estimation. A simpler TPGS-based system may be a valuable alternative with improved stability and lower cost...
  47. doi request reprint Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption
    Pieter Annaert
    Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, Belgium
    Eur J Pharm Sci 39:15-22. 2010
    ..In conclusion, age-dependent permeability of intestinal tissue (rather than age-dependent luminal drug solubility) may contribute to altered intestinal drug absorption in older patients compared to young adults...
  48. ncbi request reprint Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans
    Kwang Jae Lee
    Department of Internal Medicine, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 286:G278-84. 2004
    ..Through these mechanisms, increased duodenal acid exposure may be involved in the pathogenesis of dyspeptic symptoms...
  49. doi request reprint Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique
    Ricard Farre
    Translational Research Center for Gastrointestinal Disorders, Gasthuisberg, Leuven 3000, Belgium
    Gut 60:885-92. 2011
    ..Severe erosive oesophagitis is associated with low impedance baseline. We hypothesised that impedance baseline measurements could be used to evaluate changes in oesophageal mucosa integrity in man...
  50. doi request reprint Botulinum toxin reduces Dysphagia in patients with nonachalasia primary esophageal motility disorders
    Tim Vanuytsel
    Translational Research Center for Gastrointestinal Disorders, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Clin Gastroenterol Hepatol 11:1115-1121.e2. 2013
    ..We investigated the effect of BTX on symptoms of patients with DES or NE and assessed manometry findings in a prospective, double-blind, randomized, controlled study...
  51. doi request reprint The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis
    Pieter Janssen
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 108:1382-91. 2013
    ..In this paper we examined the study-specific correlations between SI and GE, and we performed a meta-regression analysis of the association across multiple studies...
  52. doi request reprint Supersaturation in human gastric fluids
    Jan Bevernage
    Laboratory for Pharmacotechnology and Biopharmacy, KU Leuven, Herestraat 49, Leuven, Belgium
    Eur J Pharm Biopharm 81:184-9. 2012
    ..The current study reports on supersaturation, precipitation and excipient mediated precipitation inhibition of five poorly soluble drugs (loviride, glibenclamide, itraconazole, danazol, and etravirine) in human and simulated gastric fluids...
  53. doi request reprint Abuse history, depression, and somatization are associated with gastric sensitivity and gastric emptying in functional dyspepsia
    Lukas Van Oudenhove
    Universitary Psychiatric Centre, Universitary Psychiatric Centre, University Hospital Gasthuisberg, B 3000 Leuven, Belgium
    Psychosom Med 73:648-55. 2011
    ..This study sought to determine the association of abuse history, psychiatric comorbidity, and somatization with gastric sensorimotor function...
  54. doi request reprint Excipient-mediated supersaturation stabilization in human intestinal fluids
    Jan Bevernage
    Laboratory for Pharmacotechnology and Biopharmacy, O and N2, Herestraat 49 Box 921, 3000 Leuven, Katholieke Universiteit Leuven, Belgium
    Mol Pharm 8:564-70. 2011
    ..However, excipients showing no effect in simple aqueous buffer or FaSSIF/FeSSIF also proved to be ineffective in HIF, indicating the value of these simulation media in the elimination of excipients during formulation development...
  55. ncbi request reprint Influence of experimentally induced anxiety on gastric sensorimotor function in humans
    Brecht Geeraerts
    Center for Gastroenterological Research, Leuven, Belgium
    Gastroenterology 129:1437-44. 2005
    ..It is unclear whether this reflects common predisposition or a causal relationship. The aim of this study was to investigate whether experimentally induced anxiety would alter gastric sensorimotor function in health...
  56. doi request reprint Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia
    Hanne Vanheel
    Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium
    Gut 63:262-71. 2014
    ..Therefore, our aim was to evaluate duodenal mucosal integrity and low-grade inflammation in patients with FD...
  57. pmc Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein
    Sara Janssen
    Translational Research Center for Gastrointestinal Disorders, Catholic University of Leuven, Leuven, Belgium
    PLoS ONE 7:e40168. 2012
    ..We investigated whether the gustatory G-protein, α-gustducin, and the free fatty acid receptors GPR40 and GPR120 are involved in the fatty acid sensing mechanisms of the ghrelin cell...
  58. doi request reprint Nerve activity recordings in routine human intestinal biopsies
    Carla Cirillo
    Laboratory for Enteric Neuroscience LENS, TARGID, KU Leuven, O and N 1 Herestraat 49 box 701, Leuven 3000, Belgium
    Gut 62:227-35. 2013
    ..Until now, neuronal activity recordings from a more accessible human tissue source have remained a true challenge...
  59. ncbi request reprint In vitro behavior of a phosphate ester prodrug of amprenavir in human intestinal fluids and in the Caco-2 system: illustration of intraluminal supersaturation
    Joachim Brouwers
    Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, O and N 2, Herestraat 49 Box 921, 3000 Leuven, Belgium
    Int J Pharm 336:302-9. 2007
    ..4-1 mM) and another buffering compound such as 2-morpholinoethanesulfonic acid (MES)...
  60. ncbi request reprint Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia
    Giovanni Sarnelli
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 98:783-8. 2003
    ..The aim of the present study was to investigate in dyspeptic patients the prevalence of delayed gastric emptying for solids or for liquids and to investigate the relationship to the dyspepsia symptom pattern...
  61. ncbi request reprint Duodenogastro-esophageal reflux in children with refractory gastro-esophageal reflux disease
    Ilse Hoffman
    Division of Pediatrics, University Hospitals Leuven, Belgium
    J Pediatr 151:307-11. 2007
    ..To determine the role of duodenogastro-esophageal reflux (DGER) in the pathogenesis of refractory gastro-esophageal reflux disease (GERD) in children...
  62. ncbi request reprint Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways
    Rosario Cuomo
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 101:804-11. 2006
    ..It has been speculated that it is due to the contractile effect of motilin agonists on the proximal stomach, but the pathway involved and the symptomatic consequences have been incompletely elucidated...
  63. ncbi request reprint Impact of coexisting irritable bowel syndrome on symptoms and pathophysiological mechanisms in functional dyspepsia
    Maura Corsetti
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 99:1152-9. 2004
    ..Epidemiological studies suggest considerable overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS)...
  64. ncbi request reprint Pathophysiology and treatment of functional dyspepsia
    Jan Tack
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Belgium
    Gastroenterology 127:1239-55. 2004
  65. doi request reprint Drug supersaturation in simulated and human intestinal fluids representing different nutritional states
    Jan Bevernage
    Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, O and N 2, Herestraat 49, box 921, 3000 Leuven
    J Pharm Sci 99:4525-34. 2010
    ..The present study illustrates, for the first time, that supersaturation can be created and maintained in HIF, even in the absence of excipients...
  66. ncbi request reprint Regional brain activation during proximal stomach distention in humans: A positron emission tomography study
    Joris Vandenbergh
    Division of Liaison Psychiatry, Department of Psychiatry, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Gastroenterology 128:564-73. 2005
    ..The aim of this study was to investigate regional brain activation during painful and nonpainful proximal gastric distention in humans...
  67. doi request reprint Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia
    Jan Tack
    Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    Clin Gastroenterol Hepatol 10:1239-45. 2012
    ..Buspirone, a 5-hydroxytryptamine 1A receptor agonist, relaxes the proximal stomach in healthy individuals. We studied the effects of buspirone on symptoms and mechanisms of FD...
  68. doi request reprint Conservative management of esophageal perforations during pneumatic dilation for idiopathic esophageal achalasia
    Tim Vanuytsel
    Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    Clin Gastroenterol Hepatol 10:142-9. 2012
    ..We investigated risk factors for esophageal perforation after PD and evaluated safety and long-term outcome of nonsurgical management strategies...
  69. doi request reprint Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs
    Sarah Clarysse
    Laboratory for Pharmacotechnology and Biopharmacy, Campus Gasthuisberg O and N 2, Herestraat 49, Leuven, Belgium
    Pharm Res 26:1456-66. 2009
    ..To explore the effect of the nutritional state on the solubilizing properties of human intestinal fluids (HIF) on a time-after-food administration basis...
  70. ncbi request reprint Characteristics and clinical relevance of proximal esophageal pH monitoring
    Mike Cool
    Department of Medicine, Division of Gastroenterology, University Hospitals Leuven, Belgium
    Am J Gastroenterol 99:2317-23. 2004
    ..The aim of the present study was to study the determinants of proximal esophageal acid exposure (PR) and to evaluate the clinical usefulness of ambulatory proximal pH monitoring...
  71. ncbi request reprint Role of tension receptors in dyspeptic patients with hypersensitivity to gastric distention
    Jan Tack
    Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Belgium
    Gastroenterology 127:1058-66. 2004
    ....
  72. doi request reprint Diabetic gastroparesis
    Christophe Vanormelingen
    TARGID, KU Leuven, Belgium
    Br Med Bull 105:213-30. 2013
    ..Diabetic gastroparesis (DGP) is a gastric complication of diabetes mellitus that causes nausea, vomiting, early satiety, bloating and abdominal pain, in addition to significant morbidity...
  73. ncbi request reprint Heterogeneity of symptom pattern, psychosocial factors, and pathophysiological mechanisms in severe functional dyspepsia
    Benjamin Fischler
    Department of Psychiatry, University Hospital Gashuisberg, Leuven, Belgium
    Gastroenterology 124:903-10. 2003
    ..We used an evidence-based approach to the determination of subtypes of functional dyspepsia...
  74. doi request reprint Acotiamide, a novel gastroprokinetic for the treatment of patients with functional dyspepsia: postprandial distress syndrome
    Ege Altan
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Expert Rev Gastroenterol Hepatol 6:533-44. 2012
    ..A 4-week placebo-controlled Phase III study in PDS patients in Japan confirmed efficacy of acotiamide in relieving postprandial fullness, early satiation and upper abdominal bloating...
  75. doi request reprint Evolving pharmacological approaches in gastroesophageal reflux disease
    Ege Altan
    University of Leuven, Translational Research Center for Gastrointestinal Disorders, Herestraat 49, B 3000, Leuven, Belgium
    Expert Opin Emerg Drugs 17:347-59. 2012
    ..Proton pump inhibitors (PPIs) have considerably improved quality of life in patients with gastroesophageal reflux disease (GERD). However, many patients remain symptomatic despite standard PPI therapy...
  76. doi request reprint Gastroduodenal motility
    Jan Tack
    Translational Research Center for Gastrointestinal Diseases TARGID, University of Leuven, University Hospital Gasthuisberg, Leuven, Belgium
    Curr Opin Gastroenterol 26:647-55. 2010
    ..This review summarizes recent progress in our understanding of gastroduodenal motility and sensitivity in health and in disease...
  77. doi request reprint Pathogenesis of dyspepsia
    Kostas Mimidis
    Department of Pathophysiology, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium
    Dig Dis 26:194-202. 2008
    ..The present article provides an overview of pathogenetic factors, pathophysiologic mechanisms and their potential roles in FD...
  78. doi request reprint Pathophysiology of noncardiac chest pain: not only acid
    Sebastien Kindt
    Department of Gastroenterology, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium
    Dis Mon 54:615-26. 2008
  79. ncbi request reprint Symptom patterns and pathophysiological mechanisms in dyspeptic patients with and without Helicobacter pylori
    Giovanni Sarnelli
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Dig Dis Sci 48:2229-36. 2003
    ..In conclusion, in patients with functional dyspepsia the presence of HP infection does not seem to affect significantly the overall prevalence of symptoms or the gastric sensory-motor functions...
  80. ncbi request reprint Determinants of long-term outcome of patients with reflux-related ear, nose, and throat symptoms
    Johan Poelmans
    Department of Otorhinolaryngology Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium
    Dig Dis Sci 51:282-8. 2006
    ..In patients with reflux-related ENT symptoms, initial findings on upper GI endoscopy and 24-hr pH-metry help to predict the need for maintenance therapy...
  81. ncbi request reprint Inhibitory effects of galanin on evoked [Ca2+]i responses in cultured myenteric neurons
    Giovanni Sarnelli
    Center for Gastroenterological Research, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 286:G1009-14. 2004
    ..Finally, the inhibitory effect of galanin on electrical stimulation, but not on DMPP- and carbachol-induced responses, suggests that, at least for the cholinergic component, galanin acts at the presynaptic level...
  82. pmc Fatty acid-induced gut-brain signaling attenuates neural and behavioral effects of sad emotion in humans
    Lukas Van Oudenhove
    Translational Research Centre for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    J Clin Invest 121:3094-9. 2011
    ....
  83. doi request reprint Effect of pH and comedication on gastrointestinal absorption of posaconazole: monitoring of intraluminal and plasma drug concentrations
    Jeroen Walravens
    Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Pharmacokinet 50:725-34. 2011
    ..In contrast to previously published studies, in which only plasma concentrations were determined, we also explored the gastric and intestinal behaviour of posaconazole after a single oral dose...
  84. doi request reprint A double-blind sham-controlled study of the effect of radiofrequency energy on symptoms and distensibility of the gastro-esophageal junction in GERD
    J Arts
    Department of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 107:222-30. 2012
    ..The objective of this study was to test the hypothesis that Stretta alters GEJ resistance...
  85. doi request reprint Prokinetics and fundic relaxants in upper functional GI disorders
    Jan Tack
    Center for Gastroenterological Research, KU Leuven, Belgium
    Curr Opin Pharmacol 8:690-6. 2008
    ..Recently studied drugs include drugs under investigation including nitrates, serotonin reuptake blockers, 5-HT(1A) receptor agonists (buspirone and R137696), and muscarinc M1/M2 receptor antagonists (acotiamide or Z-338)...
  86. ncbi request reprint Recent developments in the pathophysiology and therapy of gastroesophageal reflux disease and nonerosive reflux disease
    Jan Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Curr Opin Gastroenterol 21:454-60. 2005
    ..This review summarizes recent progress in our understanding of the pathophysiology and treatment of gastroesophageal reflux disease...
  87. doi request reprint Is there a unifying role for visceral hypersensitivity and irritable bowel syndrome in non-erosive reflux disease?
    Jan Tack
    Department of Pathophysiology, Division of Gastroenterology, University of Leuven, Leuven, Belgium
    Digestion 78:42-5. 2008
    ..This review summarizes the current understanding of the role of visceral hypersensitivity in the pathogenesis of NERD symptoms and the mechanisms implicated in the pathogenesis of esophageal hypersensitivity...
  88. ncbi request reprint Intraluminal drug and formulation behavior and integration in in vitro permeability estimation: a case study with amprenavir
    Joachim Brouwers
    Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, Belgium
    J Pharm Sci 95:372-83. 2006
    ..This study illustrates the importance of the evaluation of intraluminal conditions after drug intake and their integration in permeability estimation in vitro...
  89. ncbi request reprint Yield of 24-hour esophageal pH and bilitec monitoring in patients with persisting symptoms on PPI therapy
    George Karamanolis
    Division of Gastroenterology, Department of Pathophysiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Dig Dis Sci 53:2387-93. 2008
    ....
  90. pmc Colitis affects the smooth muscle and neural response to motilin in the rabbit antrum
    Inge Depoortere
    Centre for Gastroenterological Research, Catholic University of Leuven, Leuven, Belgium
    Br J Pharmacol 159:384-93. 2010
    ..This study investigated the effects of colitis on the contractile effects of motilin, an important endocrine regulator of gastric motility, in the antrum...
  91. doi request reprint Prucalopride: a new drug for the treatment of chronic constipation
    Jan Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Expert Rev Gastroenterol Hepatol 3:337-43. 2009
    ..The Phase III studies mainly recruited patients with insufficient response to laxatives, and showed consistent efficacy and excellent tolerability for prucalopride...
  92. ncbi request reprint Influence of 5-HT1 receptor agonists on feline stomach relaxation
    Pieter Janssen
    Center for Gastroenterological Research, University of Leuven, Leuven, Belgium
    Eur J Pharmacol 492:259-67. 2004
    ..Whether the sumatriptan-induced gastric relaxation in cats is due to interaction with 5-HT(1F) receptors could not be proven absolutely in view of the lack of selective 5-HT(1F) receptor antagonists...
  93. pmc A randomised controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation
    J Tack
    Department of Gastroenterology, Centre for Gastroenterological Research, University of Leuven, Leuven, Belgium
    Gut 54:1707-13. 2005
    ..It has been proposed that treatments for irritable bowel syndrome with constipation (IBS-C) should provide rapid symptomatic relief, be intermittent, and effective upon repeated use...
  94. ncbi request reprint Gastric motor and sensory function
    Jan Tack
    University Hospital Gasthuisberg, University of Leuven, Belgium
    Curr Opin Gastroenterol 21:665-72. 2005
    ..This review summarizes recent progress in our understanding of normal and pathologic gastric sensory and motor function...
  95. ncbi request reprint Association of the predominant symptom with clinical characteristics and pathophysiological mechanisms in functional dyspepsia
    George Karamanolis
    Center for Gastroenterological Research, University Hospital Gasthuisberg, Leuven, Belgium
    Gastroenterology 130:296-303. 2006
    ..The aim of this study was to analyze the relationship of predominant pain or discomfort with pathophysiological mechanisms and to evaluate whether considering individual predominant symptoms yields better results...
  96. ncbi request reprint Renzapride: a new drug for the treatment of constipation in the irritable bowel syndrome
    Emidio Scarpellini
    Catholic University of Leuven, University Hospital Gasthuisberg, Department of Internal Medicine, Division of Gastroenterology, Leuven, Belgium
    Expert Opin Investig Drugs 17:1663-70. 2008
    ..Phase II studies indicated potential beneficial effects on symptoms and bowel habits in patients with constipation-predominant IBS and mixed-type IBS. The outcome of Phase III studies is currently under evaluation...
  97. ncbi request reprint Pathophysiology and treatment of functional dyspepsia
    Jan Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    J Clin Gastroenterol 39:S211-6. 2005
    ..Thus, efforts to further elucidate underlying pathophysiologic mechanisms and identify the appropriate patient population using some type of pathophysiologic testing will be required...
  98. ncbi request reprint Paroxysmal laryngospasm: a typical but underrecognized supraesophageal manifestation of gastroesophageal reflux?
    Johan Poelmans
    Department of Otorhinolaryngology Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium
    Dig Dis Sci 49:1868-74. 2004
    ....
  99. doi request reprint Pathophysiology, diagnosis and management of postoperative dumping syndrome
    Jan Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Nat Rev Gastroenterol Hepatol 6:583-90. 2009
    ..In patients with treatment-refractory dumping syndrome, surgical reintervention or continuous enteral feeding can be considered, but the outcomes of such approaches are variable...
  100. ncbi request reprint Determination of intraluminal theophylline concentrations after oral intake of an immediate- and a slow-release dosage form
    Joachim Brouwers
    Laboratory for Pharmacotechnology and Biopharmacy, O and N Gasthuisberg, Catholic University of Leuven, 3000 Leuven, Belgium
    J Pharm Pharmacol 57:987-96. 2005
    ..In addition, knowledge of luminal drug concentrations may assist in the selection of drug concentrations applied in in-vitro permeability assays...
  101. ncbi request reprint Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation-predominant irritable bowel syndrome
    J Tack
    Universitaire Ziekenhuizen, Leuven, Belgium
    Aliment Pharmacol Ther 23:1655-65. 2006
    ..To investigate the efficacy and safety of renzapride, a potent 5-hydroxytryptamine type-4 receptor full agonist and 5-hydroxytryptamine type-3 receptor antagonist in patients with constipation-predominant irritable bowel syndrome...