Jan Tack

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Gastric motor and sensory function
    Jan Tack
    University Hospital Gasthuisberg, University of Leuven, Belgium
    Curr Opin Gastroenterol 21:665-72. 2005
  2. pmc A controlled crossover study of the selective serotonin reuptake inhibitor citalopram in irritable bowel syndrome
    J Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Gut 55:1095-103. 2006
  3. doi request reprint Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives
    J Tack
    Division of Gastroenterology, Department of Internal Medicine, University Hospital, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Gut 58:357-65. 2009
  4. doi request reprint Functional diarrhea
    Jan Tack
    Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    Gastroenterol Clin North Am 41:629-37. 2012
  5. doi request reprint Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia
    Jan Tack
    Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    Clin Gastroenterol Hepatol 10:1239-45. 2012
  6. doi request reprint Celiac disease
    Kate E Evans
    Department of Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, South Yorkshire, UK
    Gastroenterol Clin North Am 41:639-50. 2012
  7. doi request reprint Prucalopride: evaluation of the pharmacokinetics, pharmacodynamics, efficacy and safety in the treatment of chronic constipation
    Jan Tack
    University of Leuven, Translational Research Center for Gastrointestinal Disorders, Herestraat 49, B 3000 Leuven, Belgium
    Expert Opin Drug Metab Toxicol 8:1327-35. 2012
  8. ncbi request reprint Role of tension receptors in dyspeptic patients with hypersensitivity to gastric distention
    Jan Tack
    Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Belgium
    Gastroenterology 127:1058-66. 2004
  9. ncbi request reprint Pathophysiology and treatment of functional dyspepsia
    Jan Tack
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Belgium
    Gastroenterology 127:1239-55. 2004
  10. doi request reprint Prokinetics and fundic relaxants in upper functional GI disorders
    Jan Tack
    Center for Gastroenterological Research, KU Leuven, Belgium
    Curr Opin Pharmacol 8:690-6. 2008

Collaborators

Detail Information

Publications140 found, 100 shown here

  1. ncbi request reprint Gastric motor and sensory function
    Jan Tack
    University Hospital Gasthuisberg, University of Leuven, Belgium
    Curr Opin Gastroenterol 21:665-72. 2005
    ..This review summarizes recent progress in our understanding of normal and pathologic gastric sensory and motor function...
  2. pmc A controlled crossover study of the selective serotonin reuptake inhibitor citalopram in irritable bowel syndrome
    J Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Gut 55:1095-103. 2006
    ..Selective serotonin reuptake inhibitors (SSRIs) are frequently used in the treatment of irritable bowel syndrome (IBS) although evidence of their efficacy is scarce...
  3. doi request reprint Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives
    J Tack
    Division of Gastroenterology, Department of Internal Medicine, University Hospital, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Gut 58:357-65. 2009
    ..To determine the efficacy, impact on quality of life (QOL) and safety of prucalopride, a selective, high-affinity 5-HT(4) receptor agonist, in patients with chronic constipation...
  4. doi request reprint Functional diarrhea
    Jan Tack
    Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    Gastroenterol Clin North Am 41:629-37. 2012
    ..Diagnostic work-up aims at exclusion of underlying organic disease. Treatment starts with dietary adjustments, aiming at decreasing nutrients that enhance transit and stool and at identifying precipitating food items...
  5. doi request reprint Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia
    Jan Tack
    Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    Clin Gastroenterol Hepatol 10:1239-45. 2012
    ..Buspirone, a 5-hydroxytryptamine 1A receptor agonist, relaxes the proximal stomach in healthy individuals. We studied the effects of buspirone on symptoms and mechanisms of FD...
  6. doi request reprint Celiac disease
    Kate E Evans
    Department of Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, South Yorkshire, UK
    Gastroenterol Clin North Am 41:639-50. 2012
    ..Although the cornerstone of treatment is a gluten-free diet, some patients may still have persisting symptoms and warrant further investigations...
  7. doi request reprint Prucalopride: evaluation of the pharmacokinetics, pharmacodynamics, efficacy and safety in the treatment of chronic constipation
    Jan Tack
    University of Leuven, Translational Research Center for Gastrointestinal Disorders, Herestraat 49, B 3000 Leuven, Belgium
    Expert Opin Drug Metab Toxicol 8:1327-35. 2012
    ..Predominantly, prucalopride is currently used to treat patients that show an insufficient response to laxatives as an alternative form of therapy...
  8. ncbi request reprint Role of tension receptors in dyspeptic patients with hypersensitivity to gastric distention
    Jan Tack
    Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Belgium
    Gastroenterology 127:1058-66. 2004
    ....
  9. ncbi request reprint Pathophysiology and treatment of functional dyspepsia
    Jan Tack
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Belgium
    Gastroenterology 127:1239-55. 2004
  10. doi request reprint Prokinetics and fundic relaxants in upper functional GI disorders
    Jan Tack
    Center for Gastroenterological Research, KU Leuven, Belgium
    Curr Opin Pharmacol 8:690-6. 2008
    ..Recently studied drugs include drugs under investigation including nitrates, serotonin reuptake blockers, 5-HT(1A) receptor agonists (buspirone and R137696), and muscarinc M1/M2 receptor antagonists (acotiamide or Z-338)...
  11. ncbi request reprint Influence of acute serotonin reuptake inhibition on colonic sensorimotor function in man
    J Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 23:265-74. 2006
    ..It is unclear whether decreased serotonin transporter function contributes to sensorimotor abnormalities in irritable bowel syndrome...
  12. doi request reprint Is there a unifying role for visceral hypersensitivity and irritable bowel syndrome in non-erosive reflux disease?
    Jan Tack
    Department of Pathophysiology, Division of Gastroenterology, University of Leuven, Leuven, Belgium
    Digestion 78:42-5. 2008
    ..This review summarizes the current understanding of the role of visceral hypersensitivity in the pathogenesis of NERD symptoms and the mechanisms implicated in the pathogenesis of esophageal hypersensitivity...
  13. ncbi request reprint How to improve drug development for functional disorders
    Jan Tack
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, Herestraat 49, Leuven B 3000, Belgium
    Best Pract Res Clin Gastroenterol 18:787-96. 2004
    ..Future studies might aim at the development of non-invasive test that identify relevant pathophysiological mechanisms, at refining assessment of symptom pattern and at the development of short-term therapeutic trials...
  14. doi request reprint A placebo-controlled trial of the 5-HT1A agonist R-137696 on symptoms, visceral hypersensitivity and on impaired accommodation in functional dyspepsia
    J Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Neurogastroenterol Motil 21:619-26, e23-4. 2009
    ..Adverse events were similar for drug and placebo. A 4-week administration of the fundus-relaxing 5-HT(1A) agonist R-137696 failed to significantly improve symptoms, VH or gastric accommodation compared to placebo...
  15. doi request reprint Weakly acidic reflux
    Jan Tack
    Department of Pathophysiology, University of Leuven, Leuven, Belgium
    Dig Dis 27:58-61. 2009
    ..There is a lack of outcomes studies addressing the issue of reflux inhibitors and surgery for weakly acidic reflux that persists in patients on PPIs...
  16. doi request reprint Mandatory and optional function tests in gastroduodenal disorders
    J Tack
    Division of Gastroenterology, University Hospital Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Best Pract Res Clin Gastroenterol 23:387-93. 2009
    ..The main limitation to a greater clinical usefulness of gastroduodenal function testing is the lack of therapeutic alternatives...
  17. ncbi request reprint Influence of delaying gastric emptying on meal-related symptoms in healthy subjects
    J Tack
    Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 24:1045-50. 2006
    ..Although delayed gastric emptying is often found in functional dyspepsia, a causal role for delayed emptying in inducing symptoms has not been demonstrated...
  18. doi request reprint Pathophysiology, diagnosis and management of postoperative dumping syndrome
    Jan Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Nat Rev Gastroenterol Hepatol 6:583-90. 2009
    ..In patients with treatment-refractory dumping syndrome, surgical reintervention or continuous enteral feeding can be considered, but the outcomes of such approaches are variable...
  19. ncbi request reprint Appropriate management of symptomatic GORD in primary care: has expert opinion changed between 2001 and 2005?
    Jan Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Acta Gastroenterol Belg 70:171-6. 2007
    ..To determine current opinions of clinical experts on the appropriate management of symptomatic GORD in primary care, and to compare these opinions with those from a similar study conducted in 2001...
  20. ncbi request reprint Gastric motor disorders
    J Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gathuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Best Pract Res Clin Gastroenterol 21:633-44. 2007
    ..Disorders of gastric motor function include impaired accommodation, gastroparesis and dumping syndrome. This review summarises current knowledge on the pathophysiology, diagnostic approach and treatment for these disorders...
  21. ncbi request reprint Functional gastroduodenal disorders
    Jan Tack
    Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium
    Gastroenterology 130:1466-79. 2006
    ..The proposed classification requires further research and careful validation but the criteria should be of value for clinical practice; for epidemiological, pathophysiological, and clinical management studies; and for drug development...
  22. ncbi request reprint Influence of ghrelin on gastric emptying and meal-related symptoms in idiopathic gastroparesis
    J Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Aliment Pharmacol Ther 22:847-53. 2005
    ..Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor, is released from the stomach. Animal studies suggest that ghrelin stimulates gastrointestinal motor activity...
  23. pmc Influence of ghrelin on interdigestive gastrointestinal motility in humans
    J Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Gut 55:327-33. 2006
    ....
  24. ncbi request reprint Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome)
    Jan Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B 3000, Leuven, Belgium
    Curr Treat Options Gastroenterol 9:361-8. 2006
    ..Surgical decompression or resection is necessary in case of refractoriness or perforation, respectively...
  25. ncbi request reprint Review article: role of pepsin and bile in gastro-oesophageal reflux disease
    J Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Aliment Pharmacol Ther 22:48-54. 2005
    ..The therapeutic options for the non-acid component of the refluxate, including acid suppression, prokinetics, baclofen and surgery, are discussed...
  26. pmc A randomised controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation
    J Tack
    Department of Gastroenterology, Centre for Gastroenterological Research, University of Leuven, Leuven, Belgium
    Gut 54:1707-13. 2005
    ..It has been proposed that treatments for irritable bowel syndrome with constipation (IBS-C) should provide rapid symptomatic relief, be intermittent, and effective upon repeated use...
  27. pmc Prevalence of acid reflux in functional dyspepsia and its association with symptom profile
    J Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Gut 54:1370-6. 2005
    ..The aim of the present study was to study 24 hour pH monitoring in consecutive functional dyspepsia patients...
  28. ncbi request reprint Recent developments in the pathophysiology and therapy of gastroesophageal reflux disease and nonerosive reflux disease
    Jan Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Curr Opin Gastroenterol 21:454-60. 2005
    ..This review summarizes recent progress in our understanding of the pathophysiology and treatment of gastroesophageal reflux disease...
  29. ncbi request reprint Pathophysiology and treatment of functional dyspepsia
    Jan Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    J Clin Gastroenterol 39:S211-6. 2005
    ..Thus, efforts to further elucidate underlying pathophysiologic mechanisms and identify the appropriate patient population using some type of pathophysiologic testing will be required...
  30. doi request reprint Gastric motor and sensory function
    Jan Tack
    University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Curr Opin Gastroenterol 25:557-65. 2009
    ..This review summarizes recent progress in our understanding of gastric sensory and motor function in health and in disease...
  31. doi request reprint Gastroduodenal motility
    Jan Tack
    Translational Research Center for Gastrointestinal Diseases TARGID, University of Leuven, University Hospital Gasthuisberg, Leuven, Belgium
    Curr Opin Gastroenterol 26:647-55. 2010
    ..This review summarizes recent progress in our understanding of gastroduodenal motility and sensitivity in health and in disease...
  32. ncbi request reprint Influence of tegaserod on proximal gastric tone and on the perception of gastric distension
    J Tack
    Division of Gastroenterology, UZ Gasthuisberg, Leuven, Belgium
    Aliment Pharmacol Ther 18:1031-7. 2003
    ..Tegaserod, a 5-hydroxytryptamine-4 receptor agonist, enhances gastric emptying, but its effects on proximal stomach function have not been studied...
  33. doi request reprint Influence of tegaserod on proximal gastric tone and on the perception of gastric distention in functional dyspepsia
    J Tack
    Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium
    Neurogastroenterol Motil 23:e32-9. 2011
    ..To study the effect of the 5-HT(4) agonist tegaserod on sensitivity to gastric distention and gastric accommodation in FD...
  34. pmc Anti-relaxation therapy in GORD
    J Tack
    Centre for Gastroenterological Research, University of Leuven, Leuven, Belgium
    Gut 50:6-7. 2002
  35. pmc Diagnosis and treatment of chronic constipation--a European perspective
    J Tack
    Division of Gastroenterology, University Hospital Leuven, Leuven, Belgium
    Neurogastroenterol Motil 23:697-710. 2011
    ..Management guidelines and recommendations are limited and are not sufficiently current to include treatments that became available more recently, such as prokinetic agents in Europe...
  36. doi request reprint Functional dyspepsia
    Jan Tack
    Translational Research Center for Gastrointestinal Diseases TARGID, University of Leuven, Belgium
    Curr Opin Gastroenterol 27:549-57. 2011
    ..This review summarizes the recent progress in the epidemiology, pathophysiology and treatment of functional dyspepsia...
  37. ncbi request reprint Clinical and pathophysiological characteristics of acute-onset functional dyspepsia
    Jan Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Gastroenterology 122:1738-47. 2002
    ..The aim of this study was to identify and characterize patients with presumed postinfectious dyspepsia (PD) compared with unspecified-onset dyspepsia (UD)...
  38. pmc Serotonergic modulation of visceral sensation: upper gastrointestinal tract
    J Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Gut 51:i77-80. 2002
    ..Hence serotonergic modulation of upper gut sensitivity appears to be promising for the development of novel approaches to the treatment of functional disorders of the upper gastrointestinal tract...
  39. ncbi request reprint Influence of the selective serotonin re-uptake inhibitor, paroxetine, on gastric sensorimotor function in humans
    J Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 17:603-8. 2003
    ..Selective 5-hydroxytryptamine re-uptake inhibitors act both centrally and peripherally to enhance the availability of physiologically released 5-hydroxytryptamine...
  40. doi request reprint Randomised clinical trial: the safety and efficacy of AST-120 in non-constipating irritable bowel syndrome - a double-blind, placebo-controlled study
    J F Tack
    Translational Research Center for Gastrointestinal Diseases, University of Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 34:868-77. 2011
    ..AST-120 (spherical carbon adsorbent) is a non-absorbed, carbon-based adsorbent with extensive adsorbing capability for histamine, serotonin and other substances implicated in IBS pathogenesis...
  41. ncbi request reprint Causes and treatment of functional dyspepsia
    J Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Curr Gastroenterol Rep 3:503-8. 2001
    ..Psychotherapy can be considered for refractory patients. Several novel drug therapies are under evaluation...
  42. pmc Assessment of meal induced gastric accommodation by a satiety drinking test in health and in severe functional dyspepsia
    J Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Gut 52:1271-7. 2003
    ..Impaired gastric accommodation is a major pathophysiological mechanism in functional dyspepsia. The aim of the present work was to assess a satiety drinking test in the evaluation of accommodation in health and dyspepsia...
  43. ncbi request reprint The influence of cisapride on gastric tone and the perception of gastric distension
    J Tack
    Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Belgium
    Aliment Pharmacol Ther 12:761-6. 1998
    ..Dyspeptic patients are often treated with the prokinetic drug cisapride...
  44. ncbi request reprint Review article: approaches to endoscopic-negative reflux disease: part of the GERD spectrum or a unique acid-related disorder?
    J Tack
    Department of Gastroenterology, University Hospitals, Leuven, Belgium
    Aliment Pharmacol Ther 19:28-34. 2004
    ..g. tricyclic antidepressant agents) may prove beneficial...
  45. doi request reprint Symptom pattern and pathophysiological correlates of weight loss in tertiary-referred functional dyspepsia
    J Tack
    Department of Pathophysiology, Catholic University Leuven, Leuven, Belgium
    Neurogastroenterol Motil 22:29-35, e4-5. 2010
    ..4 and 2.5 kg, respectively). In tertiary care FD, weight loss is strongly associated with two early satiety associated symptom clusters...
  46. pmc Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in humans
    J Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Gut 51:219-24. 2002
    ..In animals, accommodation involves activation of gastric nitrergic neurones. Our aim was to study involvement of nitric oxide in gastric accommodation and in meal induced satiety in humans...
  47. ncbi request reprint Role of impaired gastric accommodation to a meal in functional dyspepsia
    J Tack
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Gastroenterology 115:1346-52. 1998
    ..The aim of this study was to test the hypothesis that impaired gastric accommodation causes early satiety...
  48. ncbi request reprint Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia
    J Tack
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Gastroenterology 121:526-35. 2001
    ..The aim of this study was to define hypersensitivity to gastric distention and its association to specific symptoms in functional dyspepsia...
  49. ncbi request reprint A pilot study on duodenal acid exposure and its relationship to symptoms in functional dyspepsia with prominent nausea
    Kwang Jae Lee
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Am J Gastroenterol 99:1765-73. 2004
    ..However, the relevance of these abnormalities to spontaneous duodenal acid exposure and dyspeptic symptoms in FD is unknown...
  50. ncbi request reprint Regional cerebral blood flow during gastric balloon distention in functional dyspepsia
    Joris Vandenberghe
    Department of Psychiatry, Division of Liaison Psychiatry, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Gastroenterology 132:1684-93. 2007
    ..Our aim was to investigate regional cerebral blood flow during painful proximal gastric distention in hypersensitive FD...
  51. doi request reprint Food and symptom generation in functional gastrointestinal disorders: physiological aspects
    Ricard Farre
    Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 108:698-706. 2013
    ..The colon provides absorption of the water and electrolytes, storage of non-digestible remnants of food, aboral propulsion of contents, and finally evacuation through defecation...
  52. doi request reprint Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H(2)(15)O-PET study
    Lukas Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 105:913-24. 2010
    ....
  53. ncbi request reprint Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans
    Kwang Jae Lee
    Department of Internal Medicine, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 286:G278-84. 2004
    ..Through these mechanisms, increased duodenal acid exposure may be involved in the pathogenesis of dyspeptic symptoms...
  54. doi request reprint Influence of acute tryptophan depletion on gastric sensorimotor function in humans
    Brecht Geeraerts
    Dept of Gastroenterology, Univ Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 300:G228-35. 2011
    ..ATD alters gastric postprandial motor function and distension-induced nausea. These findings confirm involvement of 5-HT in the control of gastric accommodation and sensitivity...
  55. ncbi request reprint Relationship between anxiety and gastric sensorimotor function in functional dyspepsia
    Lukas Van Oudenhove
    Department of Pathophysiology, Gastroenterology Section, University Hospital Gasthuisberg, Leuven, Belgium
    Psychosom Med 69:455-63. 2007
    ..Experimentally induced anxiety in healthy volunteers is associated with changes in sensorimotor function of the proximal stomach...
  56. doi request reprint Efficacy of the long-acting repeatable formulation of the somatostatin analogue octreotide in postoperative dumping
    Joris Arts
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Gastroenterol Hepatol 7:432-7. 2009
    ..We compared the efficacy of subcutaneous octreotide with that of the long-acting repeatable (LAR) octreotide formulation, which is administered monthly, in patients with dumping syndrome...
  57. pmc Specific hunger- and satiety-induced tuning of guinea pig enteric nerve activity
    Lina Roosen
    Laboratory for Enteric Neuroscience LENS, Leuven, Belgium
    J Physiol 590:4321-33. 2012
    ....
  58. doi request reprint Longitudinal and cross-sectional factors associated with long-term clinical course in functional dyspepsia: a 5-year follow-up study
    Sebastien Kindt
    Center for Gastroenterological Research, Department of Pathophysiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 106:340-8. 2011
    ..The aims of this study were to study the long-term evolution of symptoms in a clinical FD population and to identify factors associated with outcome...
  59. doi request reprint Acid and weakly acidic solutions impair mucosal integrity of distal exposed and proximal non-exposed human oesophagus
    Ricard Farre
    Center for Gastroenterological Research, Catholic University Leuven, Belgium
    Gut 59:164-9. 2010
    ..We aimed to assess the effect of oesophageal perfusions with acid and weakly acidic solutions on 'exposed' and 'non-exposed' oesophageal mucosa and its relationship to symptoms in healthy subjects...
  60. doi request reprint Regional brain activity in functional dyspepsia: a H(2)(15)O-PET study on the role of gastric sensitivity and abuse history
    Lukas Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Gastroenterology 139:36-47. 2010
    ..Therefore, we aimed to determine the influence of gastric sensitivity and abuse history on gastric sensation scores and brain activity in homeostatic-afferent, emotional-arousal, and cortical-modulatory brain regions in FD...
  61. ncbi request reprint Unsuppressed postprandial phasic contractility in the proximal stomach in functional dyspepsia: relevance to symptoms
    Magnus Simren
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 98:2169-75. 2003
    ..The aim of the study was to examine postprandial phasic contractility in functional dyspepsia in relation to pathophysiological, clinical, and demographic variables...
  62. ncbi request reprint Influence of sildenafil on gastric sensorimotor function in humans
    Giovanni Sarnelli
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, B 3000 Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 287:G988-92. 2004
    ..The effect of sildenafil on gastric fundus suggests a therapeutic potential for phosphodiesterase inhibitors in patients with impaired gastric accommodation...
  63. doi request reprint Esophageal motility in children with suspected gastroesophageal reflux disease
    Ilse Hoffman
    Division of Pediatrics, University Hospitals Leuven Gasthuisberg, Leuven, Belgium
    J Pediatr Gastroenterol Nutr 50:601-8. 2010
    ....
  64. ncbi request reprint Pathophysiology of functional dyspepsia
    Kwang Jae Lee
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Best Pract Res Clin Gastroenterol 18:707-16. 2004
    ..Psychosocial factors and altered response to duodenal lipids or acid have also been identified as pathophysiologic mechanisms...
  65. doi request reprint Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique
    Ricard Farre
    Translational Research Center for Gastrointestinal Disorders, Gasthuisberg, Leuven 3000, Belgium
    Gut 60:885-92. 2011
    ..Severe erosive oesophagitis is associated with low impedance baseline. We hypothesised that impedance baseline measurements could be used to evaluate changes in oesophageal mucosa integrity in man...
  66. ncbi request reprint Influence of experimentally induced anxiety on gastric sensorimotor function in humans
    Brecht Geeraerts
    Center for Gastroenterological Research, Leuven, Belgium
    Gastroenterology 129:1437-44. 2005
    ..It is unclear whether this reflects common predisposition or a causal relationship. The aim of this study was to investigate whether experimentally induced anxiety would alter gastric sensorimotor function in health...
  67. ncbi request reprint Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia
    Giovanni Sarnelli
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 98:783-8. 2003
    ..The aim of the present study was to investigate in dyspeptic patients the prevalence of delayed gastric emptying for solids or for liquids and to investigate the relationship to the dyspepsia symptom pattern...
  68. ncbi request reprint Gastric fullness, physical activity, and proximal extent of gastroesophageal reflux
    Sara Emerenziani
    Centre for Gastroenterological Research, Catholic University of Leuven, Belgium
    Am J Gastroenterol 100:1251-6. 2005
    ..Abdominal straining, during ambulation, increases the likelihood of gastroesophageal reflux. We assessed the influence of gastric fullness and ambulation on proximal extent of reflux...
  69. ncbi request reprint Impact of coexisting irritable bowel syndrome on symptoms and pathophysiological mechanisms in functional dyspepsia
    Maura Corsetti
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 99:1152-9. 2004
    ..Epidemiological studies suggest considerable overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS)...
  70. ncbi request reprint Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways
    Rosario Cuomo
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 101:804-11. 2006
    ..It has been speculated that it is due to the contractile effect of motilin agonists on the proximal stomach, but the pathway involved and the symptomatic consequences have been incompletely elucidated...
  71. ncbi request reprint Heterogeneity of symptom pattern, psychosocial factors, and pathophysiological mechanisms in severe functional dyspepsia
    Benjamin Fischler
    Department of Psychiatry, University Hospital Gashuisberg, Leuven, Belgium
    Gastroenterology 124:903-10. 2003
    ..We used an evidence-based approach to the determination of subtypes of functional dyspepsia...
  72. ncbi request reprint Duodenogastro-esophageal reflux in children with refractory gastro-esophageal reflux disease
    Ilse Hoffman
    Division of Pediatrics, University Hospitals Leuven, Belgium
    J Pediatr 151:307-11. 2007
    ..To determine the role of duodenogastro-esophageal reflux (DGER) in the pathogenesis of refractory gastro-esophageal reflux disease (GERD) in children...
  73. ncbi request reprint Gastroesophageal reflux disease poorly responsive to single-dose proton pump inhibitors in patients without Barrett's esophagus: acid reflux, bile reflux, or both?
    J Tack
    Center for Gastroenterological Research, Catholic University Leuven, B 3000 Leuven, Belgium
    Am J Gastroenterol 99:981-8. 2004
    ..The aim of the present study was to investigate the role of acid and DGER in patients with reflux disease poorly responsive to PPIs...
  74. ncbi request reprint Review article: the role of bile and pepsin in the pathophysiology and treatment of gastro-oesophageal reflux disease
    J Tack
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Aliment Pharmacol Ther 24:10-6. 2006
    ..The therapeutic options for the non-acid component of the refluxate, including acid suppression, prokinetics, baclofen, surgery and mucosal protective agents like alginates, are discussed...
  75. pmc Influence of erythromycin on gastric emptying and meal related symptoms in functional dyspepsia with delayed gastric emptying
    J Arts
    Department of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Gut 54:455-60. 2005
    ..The aim of the present study was to evaluate the influence on meal induced symptoms of acutely administered erythromycin in patients with gastroparesis...
  76. ncbi request reprint Influence of a lipase inhibitor on gastric sensitivity and accommodation to an orally ingested meal
    B Demarchi
    Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 19:1261-8. 2004
    ..It is unclear whether the same mechanisms control gastric function after an orally ingested meal...
  77. doi request reprint Influence of ghrelin on the gastric accommodation reflex and on meal-induced satiety in man
    D Ang
    Division of Gastroenterology, Department of Pathophysiology, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 21:528-33, e8-9. 2009
    ..5 +/- 70.9 vs 637.5 +/- 56.2 mL, ns). Ghrelin administered during the meal significantly inhibits gastric accommodation in health, but this is not associated with early satiation...
  78. pmc Determinants of symptom pattern in idiopathic severely delayed gastric emptying: gastric emptying rate or proximal stomach dysfunction?
    G Karamanolis
    Center for Gastroenterological Research, KU Leuven, Belgium
    Gut 56:29-36. 2007
    ..Although delayed gastric emptying is traditionally considered the mechanism underlying the symptoms in these patients, poor correlations with symptom severity have been reported...
  79. ncbi request reprint Composition of the postprandial refluxate in patients with gastroesophageal reflux disease
    D Sifrim
    Center for Gastroenterological Research, Catholic University of Leuven, Belgium
    Am J Gastroenterol 96:647-55. 2001
    ..However, patients with GERD have more acid reflux and less nonacid reflux. Differences in the air-liquid composition of the refluxate may contribute to the higher rate of acid reflux observed in these patients...
  80. ncbi request reprint The role of (duodeno)gastroesophagopharyngeal reflux in unexplained excessive throat phlegm
    J Poelmans
    Department of Otorhinolaryngology Head and Neck Surgery, University Hospitals, Leuven, Belgium
    Dig Dis Sci 50:824-32. 2005
    ..Unexplained excessive throat phlegm is a sign suggestive of GER and GEPR, and unexplained yellow throat phlegm a sign suggestive of duodenogastroesophagopharyngeal reflux (DGEPR)...
  81. doi request reprint Prolonged IL-1beta exposure alters neurotransmitter and electrically induced Ca(2+) responses in the myenteric plexus
    S Kindt
    Center for Gastroenterological Research, K U Leuven, Leuven, Belgium
    Neurogastroenterol Motil 22:321-e85. 2010
    ..This cytokine could be implicated in the motility disturbances observed during gastrointestinal inflammation...
  82. doi request reprint Role of endogenous opioids in the control of gastric sensorimotor function
    B Geeraerts
    Division of Gastroenterology, Department of Pathophysiology, University Hospital Gasthuisberg, KU Leuven, Belgium
    Neurogastroenterol Motil 20:1094-102. 2008
    ..These observations suggest that endogenous opioids are involved in the control of gastric accommodation and phasic contractility but not in the control of sensitivity to gastric distension or gastric emptying in healthy volunteers...
  83. doi request reprint Relationship between symptoms and ingestion of a meal in functional dyspepsia
    R Bisschops
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Gut 57:1495-503. 2008
    ..The aim of the present study was to establish the time-course of symptoms in relation to meal ingestion, and to assess the relationship between self-reported meal-related symptoms and pathophysiological mechanisms in FD...
  84. ncbi request reprint Differential effects of baclofen on lower oesophageal sphincter pressure and proximal gastric motility in humans
    K J Lee
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Belgium
    Aliment Pharmacol Ther 18:199-207. 2003
    ....
  85. pmc Differences in the sensorimotor response to distension between the proximal and distal stomach in humans
    K J Lee
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Belgium
    Gut 53:938-43. 2004
    ..Also, it is unclear whether low level gastric distension has a modulatory role on gastric tone and mechanosensitivity...
  86. doi request reprint Prolonged duodenal acid perfusion and dyspeptic symptom occurrence in healthy volunteers
    M Di Stefano
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 21:712-e40. 2009
    ..Through these mechanisms, increased duodenal acid exposure may play a role in the pathophysiology of FD symptoms...
  87. doi request reprint Multivariate analysis of the association of acid and duodeno-gastro-oesophageal reflux exposure with the presence of oesophagitis, the severity of oesophagitis and Barrett's oesophagus
    G H Koek
    Center for Gastroenterological Research, University Hospital Gasthuisberg, Leuven, Belgium
    Gut 57:1056-64. 2008
    ..It is unknown whether DGOR exposure is an independent risk factor for oesophageal lesions. A multivariate analysis was performed on the relationship between oesophageal lesions and demographics and acid and DGOR exposure...
  88. doi request reprint Influence of buspirone on gastric sensorimotor function in man
    L Van Oudenhove
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Aliment Pharmacol Ther 28:1326-33. 2008
    ..Previous studies have suggested involvement of 5HT(1) receptors in the control of gastric tone...
  89. ncbi request reprint Neural regulation of tone in the oesophageal body: in vivo barostat assessment of volume-pressure relationships in the feline oesophagus
    X Zhang
    Centre for Gastroenterological Research, Catholic University of Leuven, Belgium
    Neurogastroenterol Motil 16:13-21. 2004
    ..Therefore, tonic contractile activity in the oesophageal body is mainly caused by a continuous cholinergic excitatory input. A nitric oxide inhibitory mechanism may have a complementary role in the regulation of oesophageal tone...
  90. ncbi request reprint The role of acid and duodenal gastroesophageal reflux in symptomatic GERD
    G H Koek
    Center for Gastroenterological Research, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Gastroenterol 96:2033-40. 2001
    ..CONCLUSIONS: Symptom episodes in patients with presumed GERD are more related to acid reflux than to DGER. DGER does not play a major role in producing typical esophageal symptoms...
  91. pmc Relevance of ineffective oesophageal motility during oesophageal acid clearance
    M Simren
    Centre for Gastroenterological Research, Catholic University of Leuven, Belgium
    Gut 52:784-90. 2003
    ..Intraluminal impedance allows non-radiological monitoring of movement of oesophageal liquids...
  92. ncbi request reprint Calcium signalling and removal mechanisms in myenteric neurones
    P Vanden Berghe
    Center for Gastroenterological Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Neurogastroenterol Motil 14:63-73. 2002
    ..The Ca2+-sequestering components might also have been compensating for each other, as most drugs only delayed and not inhibited Ca2+ removal...
  93. ncbi request reprint Sumatriptan is an agonist at 5-HT receptors on myenteric neurones in the guinea-pig gastric antrum
    J Tack
    Center for G I Research K U Leuven, Belgium, University of Leuven, Leuven, Belgium
    Neurogastroenterol Motil 19:39-46. 2007
    ..The actions of sumatriptan on gastric motility seem to be attributable to a direct action on enteric neurones...
  94. pmc Effect of the GABA(B) agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors
    G H Koek
    Center for Gastroenterological Research, University Hospital Gasthuisberg, Leuven, Belgium
    Gut 52:1397-402. 2003
    ....
  95. ncbi request reprint Improved diagnosis of gastro-oesophageal reflux in patients with unexplained chronic cough
    K Blondeau
    Center for Gastroenterological Research, K U Leuven, Belgium
    Aliment Pharmacol Ther 25:723-32. 2007
    ..Symptoms, oesophageal pHmetry and proton pump inhibitor treatment are used for diagnosing gastro-oesophageal reflux-related cough. Weakly acidic reflux is now increasingly associated with reflux symptoms such as regurgitation or chest pain...
  96. ncbi request reprint Acid infusion enhances duodenal mechanosensitivity in healthy subjects
    Magnus Simren
    Dept of Internal Medicine, Division of Gastroenterology, Univ Hospital Gasthuisberg, University of Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 285:G309-15. 2003
    ..02) compared with before the infusion. In conclusion, duodenal acid enhances mechanical sensitivity in the duodenum, affects gastroduodenal motor function, and might be of importance for dyspeptic symptoms...
  97. ncbi request reprint Symptom patterns and pathophysiological mechanisms in dyspeptic patients with and without Helicobacter pylori
    Giovanni Sarnelli
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Dig Dis Sci 48:2229-36. 2003
    ..In conclusion, in patients with functional dyspepsia the presence of HP infection does not seem to affect significantly the overall prevalence of symptoms or the gastric sensory-motor functions...
  98. doi request reprint Pathogenesis of dyspepsia
    Kostas Mimidis
    Department of Pathophysiology, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium
    Dig Dis 26:194-202. 2008
    ..The present article provides an overview of pathogenetic factors, pathophysiologic mechanisms and their potential roles in FD...
  99. doi request reprint Influence of intra-oesophageal capsaicin instillation on heartburn induction and oesophageal sensitivity in man
    S Kindt
    Department of Pathophysiology, Center for Gastroenterological Research, K U Leuven, Belgium
    Neurogastroenterol Motil 21:1032-e82. 2009
    ..Pretreatment with capsaicin does not desensitize the oesophagus to acid perfusion or to balloon distention...
  100. pmc Perception of changes in wall tension of the proximal stomach in humans
    H Piessevaux
    Department of Internal Medicine, Division of Gastroenterology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Gut 49:203-8. 2001
    ..Hypersensitivity to distension of the stomach is a frequent finding in functional dyspepsia. During gastric distension studies both wall tension and elongation are increased...
  101. ncbi request reprint Mechanisms underlying duodeno-gastric reflux in man
    G H Koek
    Center for Gastroenterological Research, University Hospital Gasthuisberg, 3000 Leuven, Belgium
    Neurogastroenterol Motil 17:191-9. 2005
    ..The mechanisms underlying duodeno-gastric reflux (DGR), a prerequisite for DGER, are poorly understood...