J V Swinnen

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Androgen activation of the sterol regulatory element-binding protein pathway: Current insights
    Hannelore V Heemers
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Mol Endocrinol 20:2265-77. 2006
  2. ncbi request reprint Increased lipogenesis in cancer cells: new players, novel targets
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Leuven, Belgium
    Curr Opin Clin Nutr Metab Care 9:358-65. 2006
  3. ncbi request reprint Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside
    Annelies Beckers
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Gasthuisberg, O and N, Herestraat 49 bus 902, B 3000, Leuven, Belgium
    Mol Cancer Ther 5:2211-7. 2006
  4. ncbi request reprint Identification of diazepam-binding Inhibitor/Acyl-CoA-binding protein as a sterol regulatory element-binding protein-responsive gene
    J V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, Catholic University of Leuven, B 3000 Leuven, Belgium
    J Biol Chem 273:19938-44. 1998
  5. ncbi request reprint Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, Department of Developmental Biology, Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Int J Cancer 98:19-22. 2002
  6. ncbi request reprint Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, University of Leuven, Leuven, Belgium
    Cancer Res 65:2441-8. 2005
  7. ncbi request reprint Androgens, lipogenesis and prostate cancer
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 92:273-9. 2004
  8. ncbi request reprint Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University of Leuven, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 302:898-903. 2003
  9. ncbi request reprint Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway
    H Heemers
    Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, K.U. Leuven, B-3000 Leuven, Belgium
    Mol Endocrinol 15:1817-28. 2001
  10. ncbi request reprint E2F activity is biphasically regulated by androgens in LNCaP cells
    K Hofman
    Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Leuven, B-3000, Belgium
    Biochem Biophys Res Commun 283:97-101. 2001

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Androgen activation of the sterol regulatory element-binding protein pathway: Current insights
    Hannelore V Heemers
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Mol Endocrinol 20:2265-77. 2006
    ..This review aims to analyze current insights into the molecular mechanism(s) underlying androgen activation of the SREBP pathway and to ascertain the extent to which this phenomenon can be generalized to androgen-responsive cell systems...
  2. ncbi request reprint Increased lipogenesis in cancer cells: new players, novel targets
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Leuven, Belgium
    Curr Opin Clin Nutr Metab Care 9:358-65. 2006
    ....
  3. ncbi request reprint Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside
    Annelies Beckers
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Gasthuisberg, O and N, Herestraat 49 bus 902, B 3000, Leuven, Belgium
    Mol Cancer Ther 5:2211-7. 2006
    ....
  4. ncbi request reprint Identification of diazepam-binding Inhibitor/Acyl-CoA-binding protein as a sterol regulatory element-binding protein-responsive gene
    J V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, Catholic University of Leuven, B 3000 Leuven, Belgium
    J Biol Chem 273:19938-44. 1998
    ..These findings indicate that the promoter for DBI/ACBP contains a functional SRE that allows DBI/ACBP to be coregulated with other genes involved in lipid metabolism...
  5. ncbi request reprint Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, Department of Developmental Biology, Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Int J Cancer 98:19-22. 2002
    ....
  6. ncbi request reprint Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, University of Leuven, Leuven, Belgium
    Cancer Res 65:2441-8. 2005
    ..These findings point toward a central tie between energy, anabolism, and cancer and suggest that the cellular energy sensing machinery in cancer cells is an exploitable target for cancer prevention and/or therapy...
  7. ncbi request reprint Androgens, lipogenesis and prostate cancer
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 92:273-9. 2004
    ....
  8. ncbi request reprint Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University of Leuven, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 302:898-903. 2003
    ....
  9. ncbi request reprint Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway
    H Heemers
    Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, K.U. Leuven, B-3000 Leuven, Belgium
    Mol Endocrinol 15:1817-28. 2001
    ....
  10. ncbi request reprint E2F activity is biphasically regulated by androgens in LNCaP cells
    K Hofman
    Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Leuven, B-3000, Belgium
    Biochem Biophys Res Commun 283:97-101. 2001
    ..These results indicate that the biphasic dose response of LNCaP proliferation to androgen is closely reflected in Rb phosphorylation, E2F activity and p27(KIP1) protein expression...
  11. ncbi request reprint An aged rat model of partial androgen deficiency: prevention of both loss of bone and lean body mass by low-dose androgen replacement
    D Vanderschueren
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Belgium
    Endocrinology 141:1642-7. 2000
    ..Therefore, the threshold concentration of testosterone necessary for prevention of both bone and lean body mass loss in aged male rats is clearly lower than for prostate and seminal vesicles...
  12. ncbi request reprint A human gene encoding diazepam-binding inhibitor/acy1-CoA-binding protein: transcription and hormonal regulation in the androgen-sensitive human prostatic adenocarcinoma cell line LNCaP
    J V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, Catholic University of Leuven, Belgium
    DNA Cell Biol 15:197-208. 1996
    ....
  13. ncbi request reprint Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform
    P Alen
    Division of Biochemistry, Faculty of Medicine, Campus Gasthuisberg, University of Leuven, Belgium
    Mol Endocrinol 13:117-28. 1999
    ..Further experiments will be required to highlight the in vivo role of ELE1 in nuclear receptor functioning...
  14. ncbi request reprint The retinoblastoma protein-associated transcription repressor RBaK interacts with the androgen receptor and enhances its transcriptional activity
    K Hofman
    Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Mol Endocrinol 31:583-96. 2003
    ..Moreover, the double interaction of RBaK with the retinoblastoma protein and with the androgen receptor provides a novel link between the androgen receptor and the regulation of the cell cycle...
  15. ncbi request reprint Evidence from the aged orchidectomized male rat model that 17beta-estradiol is a more effective bone-sparing and anabolic agent than 5alpha-dihydrotestosterone
    L Vandenput
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Belgium
    J Bone Miner Res 17:2080-6. 2002
    ..Overall, these data suggest that androgen action on bone and body composition is dependent on stimulation of both androgen receptors (ARs) and estrogen receptors (ERs)...
  16. ncbi request reprint The estrogen receptor ligand ICI 182,780 does not impair the bone-sparing effects of testosterone in the young orchidectomized rat model
    L Vandenput
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Leuven, Belgium
    Calcif Tissue Int 70:170-5. 2002
    ..The absence of effects on body growth via the growth hormone--insulin-like growth factor-I axis may be a possible explanation for the lack of skeletal effects of this selective estrogen receptor antagonist...
  17. doi request reprint Early effects of Sertoli cell-selective androgen receptor ablation on testicular gene expression
    A Willems
    Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Leuven, Belgium
    Int J Androl 33:507-17. 2010
    ..It is concluded that the SCARKO model indicates incipient androgen action in mouse Sertoli cells from day 4 onwards...
  18. ncbi request reprint Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic adenocarcinoma cell line LNCaP
    W Ulrix
    Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 273:4660-5. 1998
    ....
  19. ncbi request reprint Selective activation of the fatty acid synthesis pathway in human prostate cancer
    J V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, Gasthuisberg, Catholic University of Leuven, Belgium
    Int J Cancer 88:176-9. 2000
    ..These findings point to selective activation of the fatty acid synthesis pathway and suggest a shift in the balance of lipogenic gene expression in a subgroup of prostate cancers...
  20. pmc Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins
    J V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, Catholic University of Leuven, Belgium
    Proc Natl Acad Sci U S A 94:12975-80. 1997
    ..These data support the hypothesis that SREBPs are involved in the coordinate regulation of lipogenic gene expression by androgens and provide evidence for the existence of a cascade mechanism of androgen-regulated gene expression...
  21. ncbi request reprint Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation
    Koen Brusselmans
    Laboratory for Experimental Medicine and Endocrinology, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 282:18777-85. 2007
    ..These findings significantly underscore the importance of de novo cholesterol synthesis for cancer cell biology and suggest that SQS is a potential novel target for antineoplastic intervention...
  22. ncbi request reprint Androgen regulation of the messenger RNA encoding diazepam-binding inhibitor/acyl-CoA-binding protein in the human prostatic adenocarcinoma cell line LNCaP
    J V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Catholic University of Leuven, Belgium
    Mol Cell Endocrinol 104:153-62. 1994
    ....
  23. ncbi request reprint RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells
    Koen Brusselmans
    Laboratory for Experimental Medicine and Endocrinology, University of Leuven, Leuven, Belgium
    Cancer Res 65:6719-25. 2005
    ....
  24. doi request reprint Molecular imaging of prostate cancer
    K M Emonds
    Department of Nuclear Medicine, University Hospital Gasthuisberg, Herestraat 49, Bus 7003, B 3000 Leuven, Belgium
    Methods 48:193-9. 2009
    ..The development of new specific receptor ligands and targeted probes and antibodies holds great promise to further enhance the performance of molecular imaging and to further improve the diagnosis and monitoring of prostate cancer...
  25. ncbi request reprint Lipase-based quantitation of triacylglycerols in cellular lipid extracts: requirement for presence of detergent and prior separation by thin-layer chromatography
    P P Van Veldhoven
    Katholieke Universiteit Leuven, Belgium
    Lipids 32:1297-300. 1997
    ..The activity of the latter enzyme was followed either colorimetrically in the presence of 4-aminoantipyrine and 2,4,6-tribromo-3-hydroxybenzoic acid or fluorimetrically in the presence of homovanillic acid...
  26. ncbi request reprint Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity
    Koen Brusselmans
    Laboratory for Experimental Medicine and Endocrinology, Department of Developmental Biology, Katholieke Universiteit Leuven, B 3000, Leuven, Belgium
    J Biol Chem 280:5636-45. 2005
    ....
  27. ncbi request reprint Identification of an androgen response element in intron 8 of the sterol regulatory element-binding protein cleavage-activating protein gene allowing direct regulation by the androgen receptor
    Hannelore Heemers
    Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Biol Chem 279:30880-7. 2004
    ..The identification of a steroid response element in intron 8 of the SCAP gene further supports the contention that SCAP is a direct target for steroid hormone action...
  28. ncbi request reprint Androgen regulation of lipogenesis
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, K U Leuven, Gasthuisberg, Leuven, Belgium
    Adv Exp Med Biol 506:379-87. 2002
  29. ncbi request reprint Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo
    Hannelore Heemers
    Faculty of Medicine, LEGENDO, Onderwijs en Navorsing 9, Gasthuisberg, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Mol Cell Endocrinol 205:21-31. 2003
    ..Taken together, these findings provide evidence for a coordinate regulation of lipogenic gene expression not only in prostate cancer cell lines in culture but also in non-cancerous androgen-responsive tissues in vivo...
  30. ncbi request reprint RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells
    Ellen de Schrijver
    Laboratory for Experimental Medicine and Endocrinology, Department of Developmental Biology, Gasthuisberg, Catholic University of Leuven, B 3000 Leuven, Belgium
    Cancer Res 63:3799-804. 2003
    ....
  31. ncbi request reprint Effects and characterization of paracrine factors produced by human prostate stromal cells in bioassays using rat Sertoli cells, LNCaP tumor cells, and cultured prostate epithelial cells
    K Goossens
    Laboratory for Experimental Medicine and Endocrinology, Onderwijs en Navorsing, Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Prostate 48:104-17. 2001
    ..In the two homologous systems studied, differentiating effects could not be demonstrated and discordant effects were noted on proliferation. Various bioassay systems will be required to identify the spectrum of mediators present in PFCM...
  32. ncbi request reprint Indirect mechanisms and cascades of androgen action
    G Verhoeven
    Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, Catholic University of Leuven, Belgium
    Mol Cell Endocrinol 151:205-12. 1999
    ..Such indirect effects may induce cascade-like actions and may play an important role in more complex effects of androgens involving coordinated responses of genes, cells and organs...
  33. doi request reprint De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation
    Evelien Rysman
    Laboratory for Experimental Medicine and Endocrinology, K U Leuven, Leuven, Belgium
    Cancer Res 70:8117-26. 2010
    ..These findings provide important new insights into the role of de novo lipogenesis in cancer cells, and they provide a rationale for the use of lipogenesis inhibitors as antineoplastic agents and as chemotherapeutic sensitizers...
  34. ncbi request reprint Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells
    Tine Van de Sande
    Laboratory for Experimental Medicine and Endocrinology, Gasthuisberg, Catholic University of Leuven, B 3000 Leuven, Belgium
    Cancer Res 62:642-6. 2002
    ..Taken together, these results demonstrate that inactivation of PTEN and subsequent activation of the PI3k/Akt kinase pathway may play an important role in the overexpression of the FAS protein in cancer cells...
  35. ncbi request reprint Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells
    Annelies Beckers
    Laboratory for Experimental Medicine and Endocrinology, Gasthuisberg, KU Leuven, Leuven, Belgium
    Cancer Res 67:8180-7. 2007
    ....
  36. ncbi request reprint Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells
    Koen Brusselmans
    Laboratory for Experimental Medicine and Endocrinology, Department of Developmental Biology, Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Int J Cancer 106:856-62. 2003
    ..These findings establish EGCG as a potent natural inhibitor of FAS in intact cells and strengthen the molecular basis for the use of EGCG as a chemopreventive and therapeutic antineoplastic agent...
  37. ncbi request reprint Testosterone prevents orchidectomy-induced bone loss in estrogen receptor-alpha knockout mice
    L Vandenput
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Leuven, Belgium
    Biochem Biophys Res Commun 285:70-6. 2001
    ..In conclusion, although functional ERalpha may play a significant role during male skeletal development, this receptor does not seem essential for androgen-mediated skeletal maintenance in older male mice...
  38. doi request reprint Organotypic cultures of prepubertal mouse testes: a method to study androgen action in sertoli cells while preserving their natural environment
    Karel De Gendt
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Biol Reprod 81:1083-92. 2009
    ..In conclusion, organotypic cultures represent the first in vitro approach to preserving androgen responsiveness of putative SC-expressed genes. This approach facilitates detailed analysis of their regulation in ways not possible in vivo...
  39. ncbi request reprint The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice
    Evi Denolet
    Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, Belgium
    Mol Endocrinol 20:321-34. 2006
    ..Moreover, they suggest that protease inhibitors and other proteins related to tubular restructuring and cell junction dynamics may be controlled in part by androgens...
  40. pmc Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model
    Kris Schauwaers
    Molecular Endocrinology Laboratory, Department of Molecular Cell Biology, Catholic University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 104:4961-6. 2007
    ..In this report, we present the first in vivo evidence of the existence of two functionally different types of AREs and demonstrate that AR-regulated gene expression can be targeted based on this distinction...
  41. ncbi request reprint Both retinoids and androgens are required to maintain or promote functional differentiation in reaggregation cultures of human prostate epithelial cells
    Karine Goossens
    Laboratory for Experimental Medicine and Endocrinology Onderwijs en Navorsing, Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Prostate 53:34-49. 2002
    ..Here, we investigated whether differentiation could be restored or preserved by using three-dimensional reaggregation cultures treated with retinoids and/or androgens...
  42. ncbi request reprint High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB
    Tine Van de Sande
    Laboratory for Experimental Medicine and Endocrinology, University of Leuven, B 3000 Leuven, Belgium
    J Pathol 206:214-9. 2005
    ....
  43. pmc Androgens and spermatogenesis: lessons from transgenic mouse models
    Guido Verhoeven
    Department of Experimental Medicine, Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Philos Trans R Soc Lond B Biol Sci 365:1537-56. 2010
    ..Further research will be needed to decide which of these genes are physiologically relevant and to identify genes that can be used as diagnostic tools or targets to modulate the effects of androgens in spermatogenesis...
  44. ncbi request reprint Coactivation of an endogenous progesterone receptor by TIF2 in COS-7 cells
    Kurt Hofman
    Laboratory for Experimental Medicine and Endocrinology, LEGENDO, Onderwijs en Navorsing, Gasthuisberg, Herestraat 49, Catholic University of Leuven, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 295:469-74. 2002
    ....
  45. ncbi request reprint Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model
    Liesbeth Vandenput
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
    J Bone Miner Res 19:1462-70. 2004
    ..These data show an essential role for androgen receptor-mediated androgen action in periosteal bone formation...
  46. ncbi request reprint Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model
    Katrien Venken
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Bone Miner Res 21:576-85. 2006
    ..AR activation dominates normal trabecular bone development and cortical bone modeling in male mice. Moreover, optimal periosteal bone expansion is only observed in the presence of both AR and ER activation...
  47. ncbi request reprint Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy
    Dieter Mesotten
    Department of Intensive Care Medicine, University Hospital Gasthuisberg, Catholic University Leuven, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 89:219-26. 2004
    ....