J Staessen

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc Bone resorption and environmental exposure to cadmium in women: a population study
    Rudolph Schutte
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Environ Health Perspect 116:777-83. 2008
  2. ncbi request reprint Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials
    J A Staessen
    Department of Molecular and Cardiovasuclar Research, Univeristy of Leuven, Belgium
    Lancet 355:865-72. 2000
  3. ncbi request reprint Antihypertensive treatment based on conventional or ambulatory blood pressure measurement. A randomized controlled trial. Ambulatory Blood Pressure Monitoring and Treatment of Hypertension Investigators
    J A Staessen
    Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement voor Moleculair en Cardiovasculaire Onderzoek, Katholieke Universiteit Leuven, Belgium
    JAMA 278:1065-72. 1997
  4. ncbi request reprint Subgroup and per-protocol analysis of the randomized European Trial on Isolated Systolic Hypertension in the Elderly
    J A Staessen
    Department of Cardiovascular and Molecular Research, University of Leuven, Belgium
    Arch Intern Med 158:1681-91. 1998
  5. ncbi request reprint Calcium channel blockade and cardiovascular prognosis in the European trial on isolated systolic hypertension
    J A Staessen
    Klinisch Laboratorium Hypertensie, Inwendige Geneeskunde Cardiologie, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Hypertension 32:410-6. 1998
  6. ncbi request reprint Cardiovascular protection and blood pressure reduction: a meta-analysis
    J A Staessen
    Studiecoördinatiecentrum, Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    Lancet 358:1305-15. 2001
  7. ncbi request reprint Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Public Health and Environmental Exposure to Cadmium (PheeCad) Study Group
    J A Staessen
    The Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Belgium
    Lancet 353:1140-4. 1999
  8. ncbi request reprint Predicting cardiovascular risk using conventional vs ambulatory blood pressure in older patients with systolic hypertension. Systolic Hypertension in Europe Trial Investigators
    J A Staessen
    Department of Molecular and Cardiovascular Research, University of Louvain, Leuven, Belgium
    JAMA 282:539-46. 1999
  9. ncbi request reprint Development of diagnostic thresholds for automated measurement of blood pressures in adults
    J A Staessen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Blood Press Monit 4:127-36. 1999
  10. ncbi request reprint Task force IV: Clinical use of ambulatory blood pressure monitoring. Participants of the 1999 Consensus Conference on Ambulatory Blood Pressure Monitoring
    J A Staessen
    Study Co Ordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Blood Press Monit 4:319-31. 1999

Collaborators

Detail Information

Publications121 found, 100 shown here

  1. pmc Bone resorption and environmental exposure to cadmium in women: a population study
    Rudolph Schutte
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Environ Health Perspect 116:777-83. 2008
    ..Environmental exposure to cadmium decreases bone density indirectly through hypercalciuria resulting from renal tubular dysfunction...
  2. ncbi request reprint Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials
    J A Staessen
    Department of Molecular and Cardiovasuclar Research, Univeristy of Leuven, Belgium
    Lancet 355:865-72. 2000
    ..We therefore undertook a quantitative overview of the trials to further evaluate the risks associated with systolic blood pressure in treated and untreated older patients with isolated systolic hypertension..
  3. ncbi request reprint Antihypertensive treatment based on conventional or ambulatory blood pressure measurement. A randomized controlled trial. Ambulatory Blood Pressure Monitoring and Treatment of Hypertension Investigators
    J A Staessen
    Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement voor Moleculair en Cardiovasculaire Onderzoek, Katholieke Universiteit Leuven, Belgium
    JAMA 278:1065-72. 1997
    ..Ambulatory blood pressure (ABP) monitoring is used increasingly in clinical practice, but how it affects treatment of blood pressure has not been determined...
  4. ncbi request reprint Subgroup and per-protocol analysis of the randomized European Trial on Isolated Systolic Hypertension in the Elderly
    J A Staessen
    Department of Cardiovascular and Molecular Research, University of Leuven, Belgium
    Arch Intern Med 158:1681-91. 1998
    ....
  5. ncbi request reprint Calcium channel blockade and cardiovascular prognosis in the European trial on isolated systolic hypertension
    J A Staessen
    Klinisch Laboratorium Hypertensie, Inwendige Geneeskunde Cardiologie, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Hypertension 32:410-6. 1998
    ....
  6. ncbi request reprint Cardiovascular protection and blood pressure reduction: a meta-analysis
    J A Staessen
    Studiecoördinatiecentrum, Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    Lancet 358:1305-15. 2001
    ..We aimed to investigate whether pharmacological properties of antihypertensive drugs or reduction of systolic pressure accounted for cardiovascular outcome in hypertensive or high-risk patients...
  7. ncbi request reprint Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Public Health and Environmental Exposure to Cadmium (PheeCad) Study Group
    J A Staessen
    The Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Belgium
    Lancet 353:1140-4. 1999
    ..Chronic low-level exposure to cadmium may promote calcium loss via urinary excretion. We undertook a prospective population study to investigate whether environmental exposure to cadmium lowers bone density and increases risk of fractures...
  8. ncbi request reprint Predicting cardiovascular risk using conventional vs ambulatory blood pressure in older patients with systolic hypertension. Systolic Hypertension in Europe Trial Investigators
    J A Staessen
    Department of Molecular and Cardiovascular Research, University of Louvain, Leuven, Belgium
    JAMA 282:539-46. 1999
    ..The clinical use of ambulatory blood pressure (BP) monitoring requires further validation in prospective outcome studies...
  9. ncbi request reprint Development of diagnostic thresholds for automated measurement of blood pressures in adults
    J A Staessen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Blood Press Monit 4:127-36. 1999
    ..In conclusion, the newer techniques of blood pressure measurement are now well established in the diagnosis and management of adult subjects with hypertension...
  10. ncbi request reprint Task force IV: Clinical use of ambulatory blood pressure monitoring. Participants of the 1999 Consensus Conference on Ambulatory Blood Pressure Monitoring
    J A Staessen
    Study Co Ordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Blood Press Monit 4:319-31. 1999
    ..To reach a consensus on the clinical use of ambulatory blood pressure monitoring (ABPM)...
  11. ncbi request reprint Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population
    J A Staessen
    Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Belgium
    J Hypertens 19:1349-58. 2001
    ..However, most studies in humans focused on single-gene effects and disregarded epistasis, the suppression or potentiation of a gene by other non-allelic genes...
  12. ncbi request reprint Exposure to cadmium and conventional and ambulatory blood pressures in a prospective population study. Public Health and Environmental Exposure to Cadmium Study Group
    J A Staessen
    Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement voor Cardiovasculair en Moleculair Onderzoek, Katholieke Universiteit Leuven, Belgium
    Am J Hypertens 13:146-56. 2000
    ....
  13. ncbi request reprint Diagnostic thresholds for the clinical use of ambulatory blood pressure monitoring
    J A Staessen
    Department of Cardiovascular and Molecular Research, University of Leuven, Belgium
    Acta Physiol Pharmacol Bulg 24:53-64. 1999
    ....
  14. ncbi request reprint Menopause and the characteristics of the large arteries in a population study
    J A Staessen
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Campus Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Hum Hypertens 15:511-8. 2001
    ..We hypothesise that this phenomenon may contribute to the rise in systolic pressure and pulse pressure in women beyond age 50 and, in turn, may lead to a slight dilatation of the common carotid artery...
  15. ncbi request reprint Development of diagnostic thresholds for automated self-measurement of blood pressure in adults. First International Consensus Conference on Blood Pressure Self-Measurement
    J A Staessen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Blood Press Monit 5:101-9. 2000
    ..However, the present proposal could guide clinicians who wish to use self-measurement to refine the diagnosis and the management of hypertension based on conventional sphygmomanometry...
  16. pmc Modern approaches to blood pressure measurement
    J A Staessen
    Studiecoördinatie Centrum, Laboratorium Hypertensie, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Occup Environ Med 57:510-20. 2000
    ..Although apparently simple, this procedure is fraught with many potential sources of error. This review focuses on two alternative techniques of BP measurement: ambulatory monitoring and self measurement...
  17. ncbi request reprint Salt and blood pressure in community-based intervention trials
    J A Staessen
    Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    Am J Clin Nutr 65:661S-670S. 1997
    ..More moderate salt restriction may constitute a more realistic goal, but its influence on blood pressure in the community at large is probably trivial...
  18. ncbi request reprint Task Force II: blood pressure measurement and cardiovascular outcome
    J A Staessen
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    Blood Press Monit 6:355-70. 2001
    ..To reach a consensus on the prognostic significance of new techniques of automated blood pressure measurement...
  19. ncbi request reprint Registration of trials and protocols
    Jan A Staessen
    Studiecoördinatiecentrum, Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    Lancet 362:1009-10. 2003
  20. ncbi request reprint What can be expected from optimal blood pressure control?
    Jan A Staessen
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    J Hypertens Suppl 21:S3-9. 2003
    ..In diabetic patients, nitrendipine reduced the risk of proteinuria, decreased total mortality, and markedly improved cardiovascular prognosis. Taken together, these findings emphasize the desirability of tight blood pressure control...
  21. ncbi request reprint Cardiovascular prevention and blood pressure reduction: a quantitative overview updated until 1 March 2003
    Jan A Staessen
    Studiecoördinatiecentrum, Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    J Hypertens 21:1055-76. 2003
    ..Furthermore, we observed that in clinical trials in hypertensive or high-risk patients gradients in systolic pressure accounted for most differences in outcome...
  22. ncbi request reprint Essential hypertension
    Jan A Staessen
    Studiecoördinatiecentrum, Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement voor Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    Lancet 361:1629-41. 2003
    ....
  23. ncbi request reprint Outcome beyond blood pressure control?
    Jan A Staessen
    Study Coordinating Centre, Laboratory of Hypertension, Department of Molecular and Cardiovascular Research, University of Leuven, Campus Gasthuisberg, Herestraat 49, Belgium
    Eur Heart J 24:504-14. 2003
  24. ncbi request reprint Renal function, cytogenetic measurements, and sexual development in adolescents in relation to environmental pollutants: a feasibility study of biomarkers
    J A Staessen
    Studiecoördinatiecentrum, Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    Lancet 357:1660-9. 2001
    ..Human exposure to chemicals is normally monitored by measurement of environmental pollutants in external media. We investigated whether biomarkers in adolescents can show exposure to, and health effects of, common environmental pollutants...
  25. ncbi request reprint Ambulatory pulse pressure as predictor of outcome in older patients with systolic hypertension
    Jan A Staessen
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    Am J Hypertens 15:835-43. 2002
    ....
  26. ncbi request reprint Do ancillary properties of antihypertensive drugs explain the outcome results of recent trials?
    Jan A Staessen
    Study Coordinating Centre, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    J Nephrol 15:422-7. 2002
    ..In a quantitative overview of published trials, we investigated whether some pharmacological properties of antihypertensive drugs, besides reduction in blood pressure, explain cardiovascular outcomes in hypertensive or high-risk patients...
  27. ncbi request reprint Calcium-channel blockade and cardiovascular prognosis: recent evidence from clinical outcome trials
    Jan A Staessen
    Study Coordinating Centre, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    Am J Hypertens 15:85S-93S. 2002
    ..These findings emphasize the desirability of tight BP control. The hypothesis that angiotensin converting enzyme inhibitors or alpha-blockers might influence outcome beyond their BP lowering-effects was not confirmed...
  28. ncbi request reprint Antihypertensive treatment based on blood pressure measurement at home or in the physician's office: a randomized controlled trial
    Jan A Staessen
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    JAMA 291:955-64. 2004
    ..Self-measurement of blood pressure is increasingly used in clinical practice, but how it affects the treatment of hypertension requires further study...
  29. ncbi request reprint Erythrocyte and leucocyte sodium and potassium transport systems during long-term diuretic administration in men
    P Lijnen
    Department of Pathophysiology, University Hospital Gasthuisberg, University of Leuven, Belgium
    J Hypertens 6:639-45. 1988
    ....
  30. ncbi request reprint Plasma atrial natriuretic peptide and the renin-aldosterone system during long-term administration of the diuretic xipamide in man
    P Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, University Hospital Gasthuisberg, University of Leuven, Belgium
    Eur J Clin Pharmacol 36:111-7. 1989
    ..Our data suggest that the changes in plasma renin, aldosterone, and alpha-atrial natriuretic peptide during xipamide administration may be related to diuretic-induced volume contraction...
  31. ncbi request reprint Ambulatory blood pressure and left ventricular structure and function in relation to the G-protein beta3-subunit polymorphism C825T in White Europeans
    A Olszanecka
    Study Coordinating Center, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    J Hum Hypertens 17:325-32. 2003
    ..In conclusion, in TT homozygotes of both generations, early left ventricular relaxation was reduced. In TT homozygous parents, the latter observation might be because of the higher systolic pressure associated with the TT genotype...
  32. ncbi request reprint Response of ambulatory blood pressure to antihypertensive therapy guided by clinic pressure
    R Fagard
    Department of Pathophysiology, University of Leuven, Belgium
    Am J Hypertens 6:648-53. 1993
    ..abstract truncated at 250 words)..
  33. ncbi request reprint Renal function in relation to three candidate genes
    J G Wang
    Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Univsiteit Leuven, Belgium
    Am J Kidney Dis 38:1158-68. 2001
    ....
  34. ncbi request reprint Comparison of the effect of celiprolol and nifedipine on blood pressure and plasma lipids
    R Van Hoof
    Hypertensie en Cardiovasculaire Revalidatie Eenheid, Katholieke Universiteit Leuven, Belgium
    J Cardiovasc Pharmacol 20:268-73. 1992
    ..As compared with nifedipine, celiprolol after 12-week therapy had a rather favorable plasma lipid profile. The clinical relevance of such findings, in terms of prevention of cardiovascular complications, has yet to be established...
  35. ncbi request reprint Is a high serum cholesterol level associated with longer survival in elderly hypertensives?
    J Staessen
    Klinisch Laboratorium Hypertensie, Inwendige Geneeskunde Cardiologie, U Z Gasthuisberg, Leuven, Belgium
    J Hypertens 8:755-61. 1990
    ..03), non-cardiovascular (P = 0.03) and cancer (P = 0.04) mortality during follow-up on double-blind treatment. Total and non-cardiovascular mortality were also negatively correlated with haemoglobin and body weight at randomization...
  36. ncbi request reprint Pulse rate and sodium intake interact to determine blood pressure. A population study
    J Staessen
    Department of Pathophysiology, University of Leuven, Belgium
    Am J Hypertens 4:107-12. 1991
    ....
  37. ncbi request reprint Intra-erythrocyte cation concentrations in relation to the C1797T beta-adducin polymorphism in a general population
    T Richart
    Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium
    J Hum Hypertens 21:387-92. 2007
    ..Changes in intra-erythrocyte cations in ADD2 1797CC homozygous men might lead to osmotic fragility of erythrocytes, but to what extent they reflect systemic changes or are possibly involved in blood pressure regulation remains unknown...
  38. ncbi request reprint The determinants and prognostic significance of serum uric acid in elderly patients of the European Working Party on High Blood Pressure in the Elderly trial
    J Staessen
    Klinisch Laboratorium Hypertensie, Inwendige Geneeskunde Cardiologie, Leuven, Belgium
    Am J Med 90:50S-54S. 1991
    ..Gender and renal function were the major determinants of serum uric acid in elderly hypertensive patients...
  39. ncbi request reprint In vitro effect of xipamide on sodium-potassium transport systems in human erythrocytes
    P Lijnen
    Department of Pathophysiology, University of Leuven, Belgium
    Methods Find Exp Clin Pharmacol 10:527-30. 1988
    ..However, a decrease in the Na+, K+-pump and the Na+, K+-cotransport activity and a rise in the passive permeability of the cell membrane was only observed starting from a concentration of 10(-4) M xipamide...
  40. ncbi request reprint APTH--a trial on ambulatory blood pressure monitoring and treatment of hypertension: objectives and protocol
    J Staessen
    Department of Pathophysiology, Katholieke Universiteit Leuven, Belgium
    Acta Cardiol 48:25-42. 1993
    ....
  41. ncbi request reprint The diurnal blood pressure profile. A population study
    J Staessen
    Department of Pathophysiology, University of Leuven, Belgium
    Am J Hypertens 5:386-92. 1992
    ..Thus, one 24 h recording is insufficient to fully characterize an individual's diurnal BP profile...
  42. ncbi request reprint Follow-up of renal function in treated and untreated older patients with isolated systolic hypertension. Systolic Hypertension in Europe (Syst-Eur) Trial Investigators
    S M Voyaki
    Departement voor Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Belgium
    J Hypertens 19:511-9. 2001
    ....
  43. doi request reprint Arterial properties in relation to genetic variation in alpha-adducin and the renin-angiotensin system in a White population
    J Seidlerova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Hum Hypertens 23:55-64. 2009
    ..ADD1 and AT1R interactively determine the elastic properties of the femoral artery. There is a single-gene effect of the AGT promoter haplotypes on brachial properties and PRA...
  44. ncbi request reprint Multiple standardized clinic blood pressures may predict left ventricular mass as well as ambulatory monitoring. A metaanalysis of comparative studies
    R Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Belgium
    Am J Hypertens 8:533-40. 1995
    ....
  45. ncbi request reprint Effect of age on the hemodynamic response to posture in nonelderly hypertensive patients
    R Fagard
    Department of Pathophysiology, Faculty of Medicine, University of Leuven, Belgium
    Am J Hypertens 7:30-5. 1994
    ..The increase of heart rate in response to the upright posture is less pronounced at older age, whereas the reflex control of the peripheral vasculature is preserved and blood pressure maintained...
  46. ncbi request reprint Blood pressure during long-term converting-enzyme inhibition predicts the curability of renovascular hypertension by angioplasty
    J Staessen
    Department of Pathophysiology, , Katholieke Universiteit, Leuven, Belgium
    Am J Hypertens 1:208-14. 1988
    ..Thus, blood pressure measurements during long-term CEI predict the curability by PTRA of renovascular hypertension and can be employed either alone or in association with the RVR...
  47. ncbi request reprint Hormonal effects of the diuretic xipamide in healthy men
    P Lijnen
    Department of Pathophysiology, University of Leuven, Belgium
    Cardiovasc Drugs Ther 5:741-6. 1991
    ..The changes in plasma renin, aldosterone, and alpha-atrial natriuretic peptide during xipamide administration may be related to diuretic-induced volume contraction...
  48. ncbi request reprint Arterial structure and function and environmental exposure to cadmium
    R Schutte
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Occup Environ Med 65:412-9. 2008
    ..Few studies have addressed the effect of cadmium toxicity on arterial properties...
  49. ncbi request reprint Dihydropyridine calcium-channel blockers for antihypertensive treatment in older patients--evidence from the Systolic Hypertension in Europe Trial
    J A Staessen
    , Laboratorium Hypertensie, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
    S Afr Med J 91:1060-8. 2001
    ..CONCLUSION: Stepwise antihypertensive drug treatment, starting with the dihydropiridine calcium-channel blocker nitrendipine, improves prognosis in elderly patients with isolated systolic hypertension...
  50. ncbi request reprint Converting enzyme inhibitors in the treatment of elderly hypertensives
    A Amery
    Department of Pathophysiology, University of Leuven, Belgium
    Acta Cardiol 44:269-87. 1989
    ....
  51. ncbi request reprint Reference values for self-recorded blood pressure: a meta-analysis of summary data
    L Thijs
    Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    Arch Intern Med 158:481-8. 1998
    ..The latter 2 methods were applied in untreated subjects not selected on the basis of their blood pressure...
  52. ncbi request reprint Relationships of heart rate and heart rate variability with conventional and ambulatory blood pressure in the population
    R H Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Belgium
    J Hypertens 19:389-97. 2001
    ....
  53. ncbi request reprint Improved outcomes with antihypertensive medication in the elderly with isolated systolic hypertension
    J G Wang
    Study Coordinating Center, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    Drugs Aging 18:345-53. 2001
    ..The pooled results of 15,693 older patients with isolated systolic hypertension prove that antihypertensive drug treatment isjustified if on repeated clinic measurements SBP is 160 mm Hg or higher...
  54. ncbi request reprint Response to antihypertensive therapy in older patients with sustained and nonsustained systolic hypertension. Systolic Hypertension in Europe (Syst-Eur) Trial Investigators
    R H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Catholic University of Leuven, Leuven, Belgium
    Circulation 102:1139-44. 2000
    ....
  55. ncbi request reprint The pulse pressure-to-stroke index ratio predicts cardiovascular events and death in uncomplicated hypertension
    R H Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, KU Leuven, Belgium
    J Am Coll Cardiol 38:227-31. 2001
    ..The goal of this study was to assess the prognostic power of the pulse pressure-to-stroke index (PP-to-SVi) ratio for cardiovascular events and mortality in patients with uncomplicated hypertension...
  56. doi request reprint Night-day blood pressure ratio and dipping pattern as predictors of death and cardiovascular events in hypertension
    R H Fagard
    Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, Leuven, Belgium
    J Hum Hypertens 23:645-53. 2009
    ....
  57. ncbi request reprint Influence of demographic, anthropometric and lifestyle characteristics on heart rate and its variability in the population
    R H Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven K U, Belgium
    J Hypertens 17:1589-99. 1999
    ....
  58. ncbi request reprint Should pulse pressure become part of the Framingham risk score?
    T S Nawrot
    Studiecoördinatiecentrum, Laboratorium Hypertensie, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    J Hum Hypertens 18:279-86. 2004
    ..37 (CI: 1.16-1.69). These prospective data suggest that pulse pressure may improve the Framingham risk prediction among middle-aged and older individuals. Further studies, especially in the Framingham cohort, are warranted...
  59. ncbi request reprint Interaction between nonsteroidal anti-inflammatory drug intake and calcium-channel blocker-based antihypertensive treatment in the Syst-Eur trial
    H Celis
    The Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    J Hum Hypertens 15:613-8. 2001
    ....
  60. ncbi request reprint The relationship between blood pressure and blood lead in NHANES III. National Health and Nutritional Examination Survey
    E Den Hond
    Hypertension and Cardiovascular Revalidation Unit, Department of Molecular and Cardiovascular Research, Katholieke Universiteit Leuven, Leuven, Belgium
    J Hum Hypertens 16:563-8. 2002
    ..0003), -0.2 (-0.5 to -0.1, P = 0.13), 0.3 (-0.3 to 1.0, P = 0.28) and 0.5 (0.01 to 1.1, P = 0.047) mm Hg, respectively. In conclusion, there is no consistent relationship between blood pressure and blood lead in the NHANES III dataset...
  61. ncbi request reprint Power spectral analysis of heart rate variability by autoregressive modelling and fast Fourier transform: a comparative study
    R H Fagard
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Belgium
    Acta Cardiol 53:211-8. 1998
    ..To compare the results from autoregressive modelling (ARM) and from fast Fourier transform (FFT), the most commonly used methods for the analysis of short-term heart rate variability in the frequency domain...
  62. ncbi request reprint Risk and benefit of treatment of isolated systolic hypertension in the elderly: evidence from the Systolic Hypertension in Europe Trial
    H Celis
    Studiecoördinatiecentrum, Laboratorium Hypertensie, Campus Gasthuisbrg, Leuven, Belgium
    Curr Opin Cardiol 16:342-8. 2001
    ..Finally, a meta-analysis partly based on Syst-Eur data showed that in older hypertensive patients pulse pressure and not mean pressure is the major determinant of cardiovascular risk...
  63. ncbi request reprint An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis
    T S Nawrot
    University of Leuven K U Leuven, Studiecoördinatie Centrum, Department Moleculair en Cardiovasculair Onderzoek, Herestraat 49, B 3000 Leuven, Belgium
    J Hum Hypertens 16:123-31. 2002
    ..5 to +1.4 mm Hg; P < 0.001) and with a 0.6 mm Hg increase in the diastolic pressure (95% CI +0.4 to +0.8 mm Hg; P < 0.001). On balance, this meta-analysis suggests that there can only be a weak association between BP and blood lead...
  64. ncbi request reprint Life style as a determinant of blood pressure in the general population
    J A Staessen
    Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    Am J Hypertens 7:685-94. 1994
    ..By contrast, blood pressure variability, as measured in the present study, was only to a minor extent influenced by life style...
  65. ncbi request reprint Antihypertensive drug therapy in older patients
    J G Wang
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Curr Opin Nephrol Hypertens 10:263-9. 2001
    ..The hypothesis that angiotensin-converting enzyme inhibitors or alpha-blockers might influence outcome over and beyond that expected on the basis of their blood pressure lowering effects still remains to be proved...
  66. ncbi request reprint Benefits of antihypertensive drug treatment in elderly patients with isolated systolic hypertension
    J G Wang
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Herestraat 49, B-3000, Leuven, Belgium
    Neth J Med 58:248-54. 2001
    ..The pooled results of 15693 older patients with isolated systolic hypertension prove that antihypertensive drug treatment is justified if on repeated clinic measurements systolic blood pressure is 160 mmHg or higher...
  67. ncbi request reprint Context-dependency of the relation between left ventricular mass and AGT gene variants
    T Kuznetsova
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Campus Gasthuisberg, University of Leuven, Belgium
    J Hum Hypertens 19:155-63. 2005
    ..This relation was observed in Slavic male offspring. It was therefore dependent on gender, age and ecogenetic context, and in addition it appeared to be modulated by the trophic effects of salt intake on LVM...
  68. ncbi request reprint The benefit of treating isolated systolic hypertension
    J G Wang
    Study Coordinating Center, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, B-3000 Leuven, Belgium
    Curr Hypertens Rep 3:333-9. 2001
    ..The pooled results of 15,693 older patients with isolated systolic hypertension prove that antihypertensive drug treatment is justified if systolic blood pressure on repeated clinic measurements is 160 mm Hg or higher...
  69. ncbi request reprint Fourier analysis of blood pressure profiles
    J A Staessen
    Department of Pathophysiology, Katholieke Universiteit Leuven, Belgium
    Am J Hypertens 6:184S-187S. 1993
    ..By using the procedures of linear multiple regression, commonly provided by software packages, the calculations can be readily implemented on microcomputers without requiring advanced skills in mathematics or programming techniques...
  70. doi request reprint Diagnostic thresholds for ambulatory blood pressure monitoring based on 10-year cardiovascular risk
    Masahiro Kikuya
    The Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Blood Press Monit 12:393-5. 2007
    ..In conclusion, population-based outcome-driven thresholds for optimal and normal ABP are lower than those currently proposed by hypertension guidelines...
  71. ncbi request reprint Ambulatory arterial stiffness index and 24-hour ambulatory pulse pressure as predictors of mortality in Ohasama, Japan
    Masahiro Kikuya
    Tohoku University Graduate School of Medicine and Pharmaceutical Science, 1 1 Seiryomachi, Sendai, Japan
    Stroke 38:1161-6. 2007
    ..We investigated the prognostic value of AASI and PP in relation to fatal outcomes...
  72. ncbi request reprint Obesity is associated with increased arterial stiffness from adolescence until old age
    Pantelis E Zebekakis
    The Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    J Hypertens 23:1839-46. 2005
    ..We therefore investigated whether the relationship between arterial stiffness and body mass index (BMI) was consistent across an age range from 10 to 86 years...
  73. ncbi request reprint Blood pressure and blood selenium: a cross-sectional and longitudinal population study
    Tim S Nawrot
    Studies Coordinating Centre, Laboratory of Hypertension, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Campus Gasthuisberg, University of Leuven, Leuven, Belgium
    Eur Heart J 28:628-33. 2007
    ..Western Europeans have low blood levels of selenium (BSe), an antioxidant trace element. In a Flemish population, we investigated the cross-sectional and longitudinal association of blood pressure (BP) with BSe...
  74. ncbi request reprint -391 C to G substitution in the regulator of G-protein signalling-2 promoter increases susceptibility to the metabolic syndrome in white European men: consistency between molecular and epidemiological studies
    Kathleen Freson
    Center for Molecular and Vascular Biology, University Hospital Gasthuisberg, University of Leuven, Belgium
    J Hypertens 25:117-25. 2007
    ..The regulator of G-protein signalling-2 (RGS2) is a key factor in adipogenesis. We hypothesized that the metabolic syndrome, of which obesity is an important component, might be related to genetic variation in RGS2...
  75. ncbi request reprint Ambulatory arterial stiffness index predicts stroke in a general population
    Tine W Hansen
    Research Center for Prevention and Health, Copenhagen, Denmark
    J Hypertens 24:2247-53. 2006
    ..The ambulatory arterial stiffness index (AASI) can be computed from individual 24-h blood pressure recordings...
  76. ncbi request reprint Progression to hypertension in the non-hypertensive participants in the Flemish Study on Environment, Genes and Health Outcomes
    Haifeng Zhang
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Hypertens 24:1719-27. 2006
    ..To evaluate the consistency between a randomly recruited Western European population and the participants of the Framingham Heart Study, with respect to the rates and determinants of progression to hypertension...
  77. ncbi request reprint Carotid intima-media thickness and antihypertensive treatment: a meta-analysis of randomized controlled trials
    Ji Guang Wang
    Studies Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, University of Leuven, Belgium
    Stroke 37:1933-40. 2006
    ..We reviewed the randomized controlled trials that evaluated the effects of an antihypertensive drug versus placebo or another antihypertensive agent of a different class on carotid intima-media thickness...
  78. ncbi request reprint Sodium excretion as a modulator of genetic associations with cardiovascular phenotypes in the European Project on Genes in Hypertension
    Tatiana Kuznetsova
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    J Hypertens 24:235-42. 2006
    ..The EPOGH therefore highlights the concept that phenotype-genotype relations can only be studied within a defined ecogenetic context...
  79. ncbi request reprint Ambulatory arterial stiffness index derived from 24-hour ambulatory blood pressure monitoring
    Yan Li
    Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Institute of Hypertension, Shanghai Second Medical University, Shanghai, China
    Hypertension 47:359-64. 2006
    ..Pending additional validation in outcome studies, normal values of AASI are probably <0.50 and 0.70 in young and older subjects, respectively...
  80. doi request reprint Prognostic value of ambulatory heart rate revisited in 6928 subjects from 6 populations
    Tine W Hansen
    Research Center for Prevention and Health and Department of Clinical Physiology, Faculty of Health Sciences, Hvidovre University Hospital, Copenhagen, Denmark
    Hypertension 52:229-35. 2008
    ..With the exception of the night:day heart rate ratio, heart rate did not add to the risk stratification for fatal combined with nonfatal cardiovascular events. Thus, heart rate adds little to the prediction of cardiovascular risk...
  81. ncbi request reprint Intrafamilial correlations of carotid intima-media thickness and flow-mediated dilation in a Siberian population
    Andrew Ryabikov
    Laboratory of Internal Medicine and Department of Non invasive Diagnostics, Institute of Internal Medicine, Siberian Branch of the Russian Academy of Medical Science, Novosibirsk, Russia
    Am J Hypertens 20:248-54. 2007
    ..The goal of our study was to assess the sex-specific intrafamilial aggregation of ultrasonographic carotid intima-media thickness (IMT) and brachial flow-mediated vasodilation (FMD) in a Siberian population...
  82. ncbi request reprint Diagnostic thresholds for ambulatory blood pressure monitoring based on 10-year cardiovascular risk
    Masahiro Kikuya
    Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Circulation 115:2145-52. 2007
    ..Current diagnostic thresholds for ambulatory blood pressure (ABP) mainly rely on statistical parameters derived from reference populations. We determined an outcome-driven reference frame for ABP measurement...
  83. doi request reprint Treatment of hypertension in patients 80 years of age or older
    Nigel S Beckett
    Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
    N Engl J Med 358:1887-98. 2008
    ..Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death...
  84. doi request reprint Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population
    Tatiana Kuznetsova
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Hypertens 26:1229-36. 2008
    ..We investigated the possible association between left ventricular diastolic function and the ADD1 Gly460Trp and ADD3 IVS11 +386A>G polymorphisms alone and in combination...
  85. ncbi request reprint Anthropometric and lifestyle factors associated with white-coat, masked and sustained hypertension in a Chinese population
    Gu Liang Wang
    Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University Medical School, China
    J Hypertens 25:2398-405. 2007
    ..We investigated to what extent anthropometric and lifestyle factors contributed to the classification of Chinese individuals into groups with white-coat, masked and sustained hypertension (HT)...
  86. doi request reprint Is blood pressure during the night more predictive of cardiovascular outcome than during the day?
    Yan Li
    Department of Cardiovascular Diseases, Division of Hypertension and Cardiovascular Rehabilitation, Studies Coordinating Centre, University of Leuven, Leuven, Belgium
    Blood Press Monit 13:145-7. 2008
    ..The increased mortality in patients with higher NDR probably indicates reverse causality. Our findings support recording the ambulatory BP during the whole day...
  87. ncbi request reprint The International Database of Ambulatory Blood Pressure in relation to Cardiovascular Outcome (IDACO): protocol and research perspectives
    Lutgarde Thijs
    Studies Coordinating Centre, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Blood Press Monit 12:255-62. 2007
    ..We are constructing a new resource of longitudinal population studies to investigate with great precision to what extent the ambulatory blood pressure improves risk stratification...
  88. ncbi request reprint Is isolated nocturnal hypertension a novel clinical entity? Findings from a Chinese population study
    Yan Li
    Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University Medical School, Shanghai, China
    Hypertension 50:333-9. 2007
    ..In conclusion, isolated nocturnal HT can only be diagnosed by ambulatory blood pressure monitoring, is prevalent among Chinese, and is associated with increased arterial stiffness...
  89. ncbi request reprint Short-term and long-term repeatability of the morning blood pressure in older patients with isolated systolic hypertension
    Barbara Wizner
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    J Hypertens 26:1328-35. 2008
    ..Using 24-h ambulatory blood pressure monitoring, we studied the repeatability of the morning blood pressure in older (> or =60 years) patients with isolated systolic hypertension...
  90. ncbi request reprint 'Beyond blood pressure' means multiple risk factor intervention, not pleiotropic antihypertensive drugs
    Jan A Staessen
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Curr Opin Cardiol 22:335-43. 2007
    ..We examined the role of blood pressure-lowering compared with class-specific properties of antihypertensive drugs in cardiovascular prevention...
  91. ncbi request reprint Angiotensin-converting enzyme I/D and alpha-adducin Gly460Trp polymorphisms: from angiotensin-converting enzyme activity to cardiovascular outcome
    Yan Li
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Research, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Hypertension 49:1291-7. 2007
    ....
  92. ncbi request reprint Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study
    Eamon Dolan
    The ADAPT Centre, Beaumont Hospital, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Hypertension 47:365-70. 2006
    ..89; P=0.47 versus 0.40). AASI is a novel measure of arterial stiffness, which can be readily determined from ambulatory blood pressure recordings and which independently predicts cardiovascular mortality, even in normotensive subjects...
  93. ncbi request reprint Rationale and methodology of monitoring ambulatory blood pressure and arterial compliance in the Hypertension in the Very Elderly Trial
    Elisabete Pinto
    Faculty of Medicine, Imperial College London, Hammersmith Campus, UK
    Blood Press Monit 11:3-8. 2006
    ..This is a side project of the Hypertension in the Very Elderly Trial...
  94. ncbi request reprint Results of the pilot study for the Hypertension in the Very Elderly Trial
    Christopher J Bulpitt
    Faculty of Medicine, Imperial College London, UK
    J Hypertens 21:2409-17. 2003
    ..The risks and benefits of treating hypertension in individuals older than 80 years are uncertain. A meta-analysis has suggested that a reduction in stroke events of 36% may have to be balanced against a 14% increase in total mortality...
  95. ncbi request reprint Systolic blood pressure variability as a risk factor for stroke and cardiovascular mortality in the elderly hypertensive population
    Edward Pringle
    Royal Sussex County Hospital, Brighton, UK
    J Hypertens 21:2251-7. 2003
    ..To investigate whether baseline systolic blood pressure variability was a risk factor for stroke, cardiovascular mortality or cardiac events during the Syst-Eur trial...
  96. ncbi request reprint beta-Adducin polymorphisms, blood pressure, and sodium excretion in three European populations
    Valerie Tikhonoff
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Am J Hypertens 16:840-6. 2003
    ..Genetic determinants of complex quantitative traits such as BP can only be investigated within their epidemiologic context...
  97. ncbi request reprint Blood pressure phenotypes in relation to the beta-adducin C1797T polymorphism in the European Project on Genes in Hypertension (EPOGH)
    Valerie Tikhonoff
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Blood Press Monit 8:151-4. 2003
    ..Subjects were genotyped for the beta-adducin C1797 T polymorphism. Both a population-based association study and a family-based analysis were performed...
  98. ncbi request reprint An epidemiological study of blood pressure and metabolic phenotypes in relation to the Gbeta3 C825T polymorphism
    Eva Brand
    Department of Endocrinology and Nephrology, Benjamin Franklin Medical Centre, Freie Universitat Berlin, Germany
    J Hypertens 21:729-37. 2003
    ..We studied the C825T polymorphism in relation to blood pressure, obesity and intermediate phenotypes in a Caucasian population...
  99. ncbi request reprint Haematological phenotypes in relation to the C1797T beta-adducin polymorphism in a Caucasian population
    Ji Guang Wang
    Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement voor Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Clin Sci (Lond) 104:369-76. 2003
    ..This genotype may slightly potentiate the structural and functional haematological disturbances associated with alcohol intake...
  100. ncbi request reprint Association between hypertension and variation in the alpha- and beta-adducin genes in a white population
    Ji Guang Wang
    Studiecoördinatiecentrum, Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement voor Moleculair en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
    Kidney Int 62:2152-9. 2002
    ..In the present study, we investigated in multivariate analyses whether the risk of hypertension was associated with the C1797T polymorphism of the beta-adducin gene...