T Roskams

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. doi request reprint Pathology of early hepatocellular carcinoma: conventional and molecular diagnosis
    Tania Roskams
    Department of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
    Semin Liver Dis 30:17-25. 2010
  2. ncbi request reprint Fas and Fas ligand: strong co-expression in human hepatocytes surrounding hepatocellular carcinoma; can cancer induce suicide in peritumoural cells?
    T Roskams
    Laboratory for Histo and Cytochemistry, University of Leuven, Belgium
    J Pathol 191:150-3. 2000
  3. ncbi request reprint Liver stem cells and their implication in hepatocellular and cholangiocarcinoma
    T Roskams
    Head Liver Research Unit, Department of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
    Oncogene 25:3818-22. 2006
  4. pmc Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosis
    Bart Spee
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Comp Hepatol 6:8. 2007
  5. pmc Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours
    Renee Ghm van Sprundel
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Comp Hepatol 9:4. 2010
  6. ncbi request reprint The role of immunohistochemistry in diagnosis
    Tania Roskams
    Departments of Morphology and Molecular Pathology, Head Liver Research Unit, Medical School, University of Leuven, Belgium
    Clin Liver Dis 6:571-89, x. 2002
  7. ncbi request reprint Neuroregulation of the neuroendocrine compartment of the liver
    Tania Roskams
    Department of Pathology, University of Leuven, Belgium
    Anat Rec A Discov Mol Cell Evol Biol 280:910-23. 2004
  8. doi request reprint Relationships among stellate cell activation, progenitor cells, and hepatic regeneration
    Tania Roskams
    Head Liver Research Unit, Department of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
    Clin Liver Dis 12:853-60, ix. 2008
  9. doi request reprint Embryology of extra- and intrahepatic bile ducts, the ductal plate
    T Roskams
    Department of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
    Anat Rec (Hoboken) 291:628-35. 2008
  10. doi request reprint Anatomic pathology of hepatocellular carcinoma: impact on prognosis and response to therapy
    Tania Roskams
    Department of Pathology, Laboratory of Morphology and Molecular Pathology, University Hospitals of Leuven, Minderbroederstraat 12, B 3000 Leuven, Belgium
    Clin Liver Dis 15:245-59, vii-x. 2011

Collaborators

Detail Information

Publications124 found, 100 shown here

  1. doi request reprint Pathology of early hepatocellular carcinoma: conventional and molecular diagnosis
    Tania Roskams
    Department of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
    Semin Liver Dis 30:17-25. 2010
    ..Glypican-3, heat shock protein 70, and glutamine synthetase have been already validated and can be used as a panel of stains to confirm the pathologist's histopathologic diagnosis and to solve difficult cases...
  2. ncbi request reprint Fas and Fas ligand: strong co-expression in human hepatocytes surrounding hepatocellular carcinoma; can cancer induce suicide in peritumoural cells?
    T Roskams
    Laboratory for Histo and Cytochemistry, University of Leuven, Belgium
    J Pathol 191:150-3. 2000
    ..Within the tumour, the Fas-Fas-L apoptosis pathway seems to be little involved...
  3. ncbi request reprint Liver stem cells and their implication in hepatocellular and cholangiocarcinoma
    T Roskams
    Head Liver Research Unit, Department of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
    Oncogene 25:3818-22. 2006
    ..Hepatocellular carcinomas expressing progenitor cell/ductular markers like cytokeratin 19 have a more aggressive clinical course. It is therefore important to recognize this entity...
  4. pmc Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosis
    Bart Spee
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Comp Hepatol 6:8. 2007
    ..Canine cirrhotic samples were compared to human liver samples from cirrhotic stages of alcoholic liver disease (hALC) and chronic hepatitis C infection (hHC)...
  5. pmc Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours
    Renee Ghm van Sprundel
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Comp Hepatol 9:4. 2010
    ..CONCLUSIONS: K19 positive hepatocellular neoplasias are highly comparable to man and occur in 12% of canine hepatocellular tumours and are associated with a poorly differentiated histology and aggressive tumour behaviour...
  6. ncbi request reprint The role of immunohistochemistry in diagnosis
    Tania Roskams
    Departments of Morphology and Molecular Pathology, Head Liver Research Unit, Medical School, University of Leuven, Belgium
    Clin Liver Dis 6:571-89, x. 2002
    ..Algorythms for the typing of lymphomas and for the differentiation of primary tumors versus metastases are proposed as well. The immunohistochemical criteria for the diagnosis of premalignant lesions are discussed...
  7. ncbi request reprint Neuroregulation of the neuroendocrine compartment of the liver
    Tania Roskams
    Department of Pathology, University of Leuven, Belgium
    Anat Rec A Discov Mol Cell Evol Biol 280:910-23. 2004
    ..Moreover, since there is a shortage of donor organs, a better understanding of the mechanisms of regeneration could have therapeutic possibilities, which could even obviate the need for orthotopic liver transplantation...
  8. doi request reprint Relationships among stellate cell activation, progenitor cells, and hepatic regeneration
    Tania Roskams
    Head Liver Research Unit, Department of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
    Clin Liver Dis 12:853-60, ix. 2008
    ..In addition, recent studies suggest a role for HSCs themselves for being progenitors of epithelial cells through a transitional mesenchymal phase...
  9. doi request reprint Embryology of extra- and intrahepatic bile ducts, the ductal plate
    T Roskams
    Department of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium
    Anat Rec (Hoboken) 291:628-35. 2008
    ..Lack of remodeling of the ductal plate results in the persistence of an excess of embryonic bile duct structures remaining in their primitive ductal plate configuration. This abnormality has been termed the ductal plate malformation...
  10. doi request reprint Anatomic pathology of hepatocellular carcinoma: impact on prognosis and response to therapy
    Tania Roskams
    Department of Pathology, Laboratory of Morphology and Molecular Pathology, University Hospitals of Leuven, Minderbroederstraat 12, B 3000 Leuven, Belgium
    Clin Liver Dis 15:245-59, vii-x. 2011
    ..Tumor tissue acquisition should be mandatory, reversing the practice that was established years ago when targeted HCC therapy was but a pipe dream...
  11. doi request reprint Hepatic progenitor cells: an update
    Tania Roskams
    Liver Research Unit, Department of Morphology and Molecular Pathology, University of Leuven, Minderbroederstraat 12, Leuven, Belgium
    Clin Liver Dis 14:705-18. 2010
    ..In this way, the patients' own regenerative response could be supported, which could eventually even avoid the need for transplantation in several patients...
  12. ncbi request reprint Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with non-cirrhotic and cirrhotic chronic viral hepatitis
    L Libbrecht
    Department of Pathology, University Hospitals, University of Leuven, Leuven, Belgium
    Histopathology 39:66-73. 2001
    ..If these results are confirmed, the presence of LLCD can be used to identify a subgroup of patients at high risk for HCC requiring more intensive screening...
  13. ncbi request reprint Effect of nutritional supplement challenge in patients with isolated high-grade prostatic intraepithelial neoplasia
    S Joniau
    Department of Urology, University Hospitals Katholieke Universiteit Leuven, Leuven, Belgium
    Urology 69:1102-6. 2007
    ..To investigate, through a prospective follow-up study, the effects of a dietary supplementation challenge in men with isolated high-grade prostatic intraepithelial neoplasia (HGPIN)...
  14. ncbi request reprint Alpha B-crystallin expression in human and rat hepatic stellate cells
    D Cassiman
    Laboratory of Cell Pharmacology, University of Leuven, Belgium
    J Hepatol 35:200-7. 2001
    ..We searched for factors implicated in early hepatic stellate cell (HSC) activation in diseased liver, by means of suppression subtractive hybridization (SSH)...
  15. ncbi request reprint A stable model of cirrhotic portal hypertension in the rat: thioacetamide revisited
    W Laleman
    Department pf Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Clin Invest 36:242-9. 2006
    ..We chronologically characterized the effect of thioacetamide, administrated orally and adapted weekly to weight changes, focusing on the optimal moment to obtain all typical features of portal hypertension and cirrhosis...
  16. ncbi request reprint The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells
    L Libbrecht
    Laboratory for Histo and Cytochemistry, University of Leuven, Belgium
    J Hepatol 33:76-84. 2000
    ..In view of the known role of rat oval cells in regeneration and hepatocarcinogenesis, we investigated a possible correlation between human putative progenitor cells and different types of dysplastic foci...
  17. ncbi request reprint Hepatic progenitor cells in hepatocellular adenomas
    L Libbrecht
    Department of Pathology, University Hospitals, University of Leuven, Leuven, Belgium
    Am J Surg Pathol 25:1388-96. 2001
    ..Our study shows that hepatic progenitor cells are present in a considerable proportion of hepatocellular adenomas, supporting the hypothesis that human hepatic progenitor cells can play a role in the development of hepatocellular tumors...
  18. ncbi request reprint The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin
    A Durnez
    Department of Morphology and Molecular Pathology, KULeuven University Hospital Gasthuisberg, Belgium
    Histopathology 49:138-51. 2006
    ..Therefore, our aim was to study the occurrence and clinicopathological characteristics of HCC expressing CK7 and/or CK19 in 109 Caucasian patients...
  19. ncbi request reprint Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man
    T Roskams
    Laboratory for Histo and Cytochemistry, University of Leuven, Belgium
    J Hepatol 29:455-63. 1998
    ..We compared the results with different rat models: the choline-deficient acetylaminofluorene (CDAAF)- and alpha-naphthylisothiocyanate (ANIT)-model, using immunohistochemistry and electron microscopy...
  20. ncbi request reprint Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases
    L Libbrecht
    Laboratory of Morphology and Molecular Pathology, University of Leuven, Minderbroedersstraat 12, 3000 Leuven, Belgium
    Histochem Cell Biol 116:233-9. 2001
    ..Our results suggest that NCAM may have a function in the development of the intrahepatic bile ducts and that NCAM-positive immature biliary cells can contribute to the repair of damaged bile ducts in chronic liver diseases...
  21. doi request reprint Potentiation of adverse effects of cold by warm ischemia in circulatory death donors for porcine liver transplantation
    D Monbaliu
    Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    Transplant Proc 44:2874-9. 2012
    ..We sought to determine how prolonged cold ischemia, after a short, normally well-tolerated period of warm ischemia affects graft function and recipient survival using a porcine model of liver transplantation...
  22. ncbi request reprint An improved model of acute liver failure based on transient ischemia of the liver
    I Fourneau
    Department of Abdominal Transplant Surgery, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Arch Surg 135:1183-9. 2000
    ..A reproducible and potentially reversible model of acute liver failure in the pig is feasible based on transient ischemia of the liver...
  23. ncbi request reprint Deep intralobular extension of human hepatic 'progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis: can 'progenitor cells' migrate?
    L Libbrecht
    Laboratory for Histo and Cytochemistry, University of Leuven, Minderbroedersstraat 12, B 3000 Leuven, Belgium
    J Pathol 192:373-8. 2000
    ....
  24. doi request reprint Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling
    Bart Spee
    Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium
    Gut 59:247-57. 2010
    ..However, in human diseases molecular mechanisms involved in proliferation and differentiation of HPCs are poorly understood...
  25. ncbi request reprint HBx or HCV core gene expression in HepG2 human liver cells results in a survival benefit against oxidative stress with possible implications for HCC development
    Tamara Severi
    Laboratory of Hepatology, University Hospital Gasthuisberg, O and N Building Bus 703, Herestraat 49, Leuven, Belgium
    Chem Biol Interact 168:128-34. 2007
    ..In conclusion, HBx and HCV core expression in HepG2 cells leads to a survival benefit under oxidative stress which in vivo can be induced during inflammation...
  26. ncbi request reprint Liver transplantation for polycystic liver disease
    J Pirenne
    Liver Transplant Group, Katholiek Universiteit Leuven, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Liver Transpl 7:238-45. 2001
    ..Patient symptoms and chances of definitive palliation offered by OLT must be balanced against the risks of transplantation and lifelong commitment to immunosuppression...
  27. ncbi request reprint Cancer cell dissemination during curative surgery for colorectal liver metastases
    B Topal
    Department of Abdominal Surgery, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Surg Oncol 31:506-11. 2005
    ..Haematogenous and intrahepatic cancer cell dissemination was evaluated, and its impact on cancer recurrence was assessed...
  28. ncbi request reprint Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors
    D Cassiman
    Laboratory of Cell Pharmacology, Leuven University, Belgium
    Hepatology 33:148-58. 2001
    ..In analogy with findings in other organs and systems, neurotrophins are hypothesized to play a role in the pathophysiology of liver disease...
  29. ncbi request reprint Liver fatty acid-binding protein: an early and sensitive plasma marker of hepatocellular damage and a reliable predictor of graft viability after liver transplantation from non-heart-beating donors
    D Monbaliu
    University Hospitals Leuven Leuven, Belgium
    Transplant Proc 37:413-6. 2005
    ..In a pig model for liver transplantation (LTx) from non-heart-beating donors (NHBD), we evaluated plasma changes of L-FABP early after reperfusion of grafts exposed to increasing periods of warm ischemia (WI)...
  30. ncbi request reprint Hemodynamic, biochemical, and morphological characteristics during preservation of normal porcine livers by hypothermic machine perfusion
    D Monbaliu
    Abdominal Transplant Surgery Department, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Transplant Proc 39:2652-8. 2007
    ..In conclusion, this study showed that hypothermic machine perfusion was feasible. During hypothermic machine perfusion, was easily assessed hemodynamic, biochemical, and morphological parameters...
  31. ncbi request reprint Hypericin-based fluorescence diagnosis of bladder carcinoma
    Marie Ange D'Hallewin
    Department of Urology, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    BJU Int 89:760-3. 2002
    ..To determine the use of hypericin instillation for the fluorescent detection of papillary bladder cancer and carcinoma in situ...
  32. ncbi request reprint Glypican-3 expression distinguishes small hepatocellular carcinomas from cirrhosis, dysplastic nodules, and focal nodular hyperplasia-like nodules
    Louis Libbrecht
    Department and Laboratories of Pathology, University and University Hospitals of Leuven, Leuven, Belgium
    Am J Surg Pathol 30:1405-11. 2006
    ..83 and 1, respectively, for needle biopsies. Because the result of the staining was easily interpretable, immunohistochemistry for GPC3 is valuable ancillary tool in the histopathologic diagnosis of small focal lesions in cirrhosis...
  33. ncbi request reprint Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-gamma-producing lymphocytes and IL-6- and TNF-alpha-producing macrophages
    An D Billiau
    Pediatric Rheumatology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Blood 105:1648-51. 2005
    ....
  34. doi request reprint The extent of vacuolation in non-heart-beating porcine donor liver grafts prior to transplantation predicts their viability
    Diethard Monbaliu
    Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    Liver Transpl 14:1256-65. 2008
    ..Further studies are now warranted to evaluate whether these anoxic changes that are associated with liver graft viability in pigs also apply to human NHBD liver biopsies...
  35. ncbi request reprint Halofuginone can worsen liver fibrosis in bile duct obstructed rats
    Marc Van de Casteele
    Deparment of Hepatology, University Hospital Gasthuisbergs, Catholic University of Leuven, B 3000 Leuven, Belgium
    Liver Int 24:502-9. 2004
    ..Halofuginone (HF) is an antifibrotic agent in rat models of liver fibrosis caused by repetitive intoxications. A beneficial effect of HF on a biliary type of liver fibrosis has not been proven yet...
  36. ncbi request reprint Preneoplastic lesions in human hepatocarcinogenesis
    Louis Libbrecht
    Liver Research Unit of the Laboratory of Morphology and Molecular Pathology, Department of Pathology, University and University Hospitals of Leuven, 3000 Leuven, Belgium
    Liver Int 25:16-27. 2005
    ..We propose three criteria by which good mimickers can be identified...
  37. ncbi request reprint Livers from non-heart-beating donors tolerate short periods of warm ischemia
    Diethard Monbaliu
    Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    Transplantation 79:1226-30. 2005
    ..This study aims to develop a reproducible large animal model of liver transplantation using non-heart-beating donors and, in this model, to define the tolerance of the liver to warm ischemia...
  38. ncbi request reprint Peripheral bile duct paucity and cholestasis in the liver of a patient with Alagille syndrome: further evidence supporting a lack of postnatal bile duct branching and elongation
    Louis Libbrecht
    Department of Pathology, University Hospitals of Leuven, Minderbroedersstraat 12, 3000 Leuven, Belgium
    Am J Surg Pathol 29:820-6. 2005
    ..Our findings also suggest that anomalies of the intrahepatic arterial branches may be part of AGS in some patients...
  39. ncbi request reprint Combined 'en bloc' liver and pancreas transplantation in patients with liver disease and type 1 diabetes mellitus
    Jacques Pirenne
    Department of Abdominal Transplant Surgery Transplant Coordination, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Am J Transplant 4:1921-7. 2004
    ..Surgical, medical and immunological aspects of combined liver-pancreas transplantation are discussed in the light of the existing relevant literature...
  40. doi request reprint Expression of multidrug resistance-associated protein 1 in hepatocellular carcinoma is associated with a more aggressive tumour phenotype and may reflect a progenitor cell origin
    Sara Vander Borght
    Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium
    Liver Int 28:1370-80. 2008
    ....
  41. ncbi request reprint CC-type chemokine receptor 5-Delta32 mutation protects against primary sclerosing cholangitis
    Liesbet Henckaerts
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Inflamm Bowel Dis 12:272-7. 2006
    ..We therefore investigated the role of the functional 32-bp deletion in this gene (CCR5-Delta32) with regard to susceptibility to PSC...
  42. ncbi request reprint Liver regeneration in acute severe liver impairment: a clinicopathological correlation study
    Aezam Katoonizadeh
    Department of Hepatology, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium
    Liver Int 26:1225-33. 2006
    ..Upon transit amplification, the progenitor cells generate new hepatocytes and biliary cells to restore liver homeostasis...
  43. ncbi request reprint Metanephric adenoma during pregnancy: clinical presentation, histology, and cytogenetics
    Evelyne Lerut
    Department of Morphology and Molecular Pathology, University Hospitals Leuven, B 3000 Leuven, Belgium
    Hum Pathol 37:1227-32. 2006
    ..The further pregnancy went on well. The karyotype of the tumor was 46,XX,t(1;22)(q22;q13),t(15;16)(q21;p13). To our knowledge, this is the first report on these chromosomal abnormalities in metanephric adenoma...
  44. doi request reprint Cystic fibrosis transmembrane conductance regulator gene polymorphisms in patients with primary sclerosing cholangitis
    Liesbet Henckaerts
    Department of Gastroenterology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Hepatol 50:150-7. 2009
    ..The histological features in the liver of PSC patients are similar to those observed in cystic fibrosis (CF). Our aim was to study whether variants in the CFTR gene are associated with the occurrence and/or evolution of PSC...
  45. ncbi request reprint Focal lesions in cirrhotic explant livers: pathological evaluation and accuracy of pretransplantation imaging examinations
    Louis Libbrecht
    Department of Pathology, University Hospitals, University of Leuven, Leuven, Belgium
    Liver Transpl 8:749-61. 2002
    ..Regular contrast-enhanced MR examination of cirrhotic patients waiting for liver transplantation is the best tool for the early detection of (pre)malignant lesions...
  46. ncbi request reprint Hepatic progenitor cells in human liver diseases
    Louis Libbrecht
    Department of Pathology and the Laboratory of Morphology and Molecular Pathology, University Hospitals, University of Leuven, 3000, Leuven, Belgium
    Semin Cell Dev Biol 13:389-96. 2002
    ..Analogous to oval cells in animal liver, there is evidence that human hepatic progenitor cells may be able to give rise to hepatocellular carcinoma and other liver tumors...
  47. ncbi request reprint An uncommon tumor in a renal graft recipient: a diagnostic and therapeutic challenge
    Kathleen Claes
    Department of Nephrology and Transplantation, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Kidney Dis 40:E21. 2002
    ..This case report also illustrates the different imaging modalities that can be used for the diagnosis of neuroendocrine tumors...
  48. ncbi request reprint Ultrastructural visualization of hepatitis C virus components in human and primate liver biopsies
    Rita De Vos
    Department of Morphology and Molecular Pathology, U Z K U Leuven, Minderbroedersstraat 12, Leuven, Belgium
    J Hepatol 37:370-9. 2002
    ..No conclusive studies were conducted yet on human liver biopsies. This paper describes the ultrastructural findings of hepatitis C virus components in liver biopsies...
  49. ncbi request reprint Liver pathology and hepatocarcinogenesis in a long-term mouse model of erythropoietic protoporphyria
    Louis Libbrecht
    Department of Pathology, University Hospitals Leuven, Leuven, Belgium
    J Pathol 199:191-200. 2003
    ..The classical stages of hepatocarcinogenesis were observed and hepatic progenitor cells appear to be involved in this process. PP acts as the promoting agent and is probably also the initiating agent...
  50. ncbi request reprint The correlation between portal myofibroblasts and development of intrahepatic bile ducts and arterial branches in human liver
    Louis Libbrecht
    Laboratory of Morphology and Molecular Pathology, Department of Pathology, University of Leuven, Belgium
    Liver 22:252-8. 2002
    ....
  51. pmc Complex genomic rearrangement of ALK loci associated with integrated human Epstein-Barr virus in a post-transplant myogenic liver tumor
    Maria Debiec-Rychter
    Center for Human Genetics, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Am J Pathol 163:913-22. 2003
    ..In this respect, the observed phenotypic heterogeneity most likely reflects divergence during neoplastic progression, with the subsequent expansion of morphologically and molecularly distinct but cytogenetically related clones...
  52. ncbi request reprint Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer
    Johannes V Swinnen
    Laboratory for Experimental Medicine and Endocrinology, Department of Developmental Biology, Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Int J Cancer 98:19-22. 2002
    ....
  53. ncbi request reprint Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers
    David Cassiman
    Laboratory of Cell Pharmacology, Herestraat 49, B 3000 Leuven, Belgium
    J Hepatol 36:200-9. 2002
    ..We studied the distribution and expression profile of mesenchymal (myo)fibroblast-like populations in fibrotic and cirrhotic liver, in an attempt to elucidate their possible interrelationships...
  54. ncbi request reprint Cirrhosis reversal: a duel between dogma and myth
    Valeer J Desmet
    Department of Pathology, K U Leuven, Leuven, Belgium
    J Hepatol 40:860-7. 2004
  55. ncbi request reprint Expression of hepatitis C virus core protein impairs DNA repair in human hepatoma cells
    Jos F van Pelt
    Department of Liver and Pancreatic Diseases, University Hospital Gasthuisberg, Herestraat 49, Leuven B 3000, Belgium
    Cancer Lett 209:197-205. 2004
    ..Interestingly, expression of the full-length HCV core did increase the cell doubling time in one of the cell lines we had developed that could not be attributed to an increase in apoptosis or change in telomerase activity in these cells...
  56. ncbi request reprint Steroid-free immunosuppression during and after liver transplantation--a 3-yr follow-up report
    Jacques Pirenne
    Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    Clin Transplant 17:177-82. 2003
    ..We report the long-term (median = 40 months) follow-up data of a prospective pilot study designed to determine whether liver transplantation could be performed with no steroids at all (neither during nor after surgery)...
  57. pmc Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease
    Tania Roskams
    Departments of Morphology and Molecular Pathology and Hepatology, University of Leuven, Leuven, Belgium
    Am J Pathol 163:1301-11. 2003
    ..The activation of progenitor cells during fatty liver disease may increase the risk for hepatocellular cancer, similar to that observed in the Solt-Farber model of hepatocarcinogenesis in rats...
  58. doi request reprint Septuagenarian and octogenarian donors provide excellent liver grafts for transplantation
    T Darius
    Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
    Transplant Proc 44:2861-7. 2012
    ..We examined the results at our center of liver transplantation (OLT) using livers from donors ≥ 70 years old...
  59. ncbi request reprint Emerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer: a review
    P Schoffski
    Leuven Cancer Institute, Department of General Medical Oncology, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium
    Ann Oncol 17:1185-96. 2006
    ..Studies now in progress will determine whether benefits seen second-line will also be evident first-line, and whether the activity of novel agents can be increased by combining them with each other, with cytokines, or with chemotherapy...
  60. ncbi request reprint Does ex vivo vascular resistance reflect viability of non-heart-beating donor livers?
    K Derveaux
    University Hospitals, Leuven, Belgium
    Transplant Proc 37:338-9. 2005
    ..This study was designed to determine whether ex vivo vascular resistance of livers correlates with the length of warm ischemia (WI), and, thus, with viability of NHB livers...
  61. ncbi request reprint Value of carbon dioxide wedged venography and transvenous liver biopsy in the definitive diagnosis of Abernethy malformation
    B Collard
    Department of Radiology, University Hospital Gasthuisberg, Leuven, Belgium
    Abdom Imaging 31:315-9. 2006
    ..This technique can be considered a valuable alternative diagnostic tool to catheter arteriography and percutaneous transhepatic liver biopsy...
  62. pmc Synaptophysin: A novel marker for human and rat hepatic stellate cells
    D Cassiman
    Laboratory of Liver and Pancreatic Diseases, Leuven University, Leuven, Belgium
    Am J Pathol 155:1831-9. 1999
    ..In addition, the presence of synaptic vesicles in stellate cell processes suggests a hitherto unknown mechanism of interaction with neighboring cells...
  63. ncbi request reprint Clinicopathological features of focal nodular hyperplasia-like nodules in 130 cirrhotic explant livers
    Louis Libbrecht
    Department of Pathology, University Hospitals Leuven, Leuven, Belgium
    Am J Gastroenterol 101:2341-6. 2006
    ..Therefore, we performed a detailed pathological evaluation of 130 cirrhotic explant livers and correlated these data with the clinical features of the patients...
  64. doi request reprint Hepatosplenic gammadelta T-cell lymphoma after liver transplantation: report of the first 2 cases and review of the literature
    Philip R Roelandt
    Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    Liver Transpl 15:686-92. 2009
    ..Therefore, a diagnostic algorithm is proposed...
  65. ncbi request reprint Hepatic immunohistochemical staining with a monoclonal antibody against HCV-E2 to evaluate antiviral therapy and reinfection of liver grafts in hepatitis C viral infection
    Chris Verslype
    Department of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    J Hepatol 38:208-14. 2003
    ..A simple and reproducible hepatic immunohistochemical staining (IHS) for hepatitis C virus (HCV) is not available. We aimed to validate hepatic IHS with monoclonal antibody (Mab) IG222, directed against the HCV-envelope 2 (E2) protein...
  66. doi request reprint Diffusion-weighted MRI provides additional value to conventional dynamic contrast-enhanced MRI for detection of hepatocellular carcinoma
    Vincent Vandecaveye
    Department of Radiology, University Hospitals Leuven, B 3000, Leuven, Belgium
    Eur Radiol 19:2456-66. 2009
    ..DW-MRI with b600-SI(ratio) improved the detection of small HCC and the differentiation of pseudotumoral lesions compared with conventional MRI...
  67. pmc The vagal nerve stimulates activation of the hepatic progenitor cell compartment via muscarinic acetylcholine receptor type 3
    David Cassiman
    Laboratory of Cell Pharmacology, University of Leuven, Leuven, Belgium
    Am J Pathol 161:521-30. 2002
    ..These findings may be of clinical importance for patients with a transplant liver...
  68. ncbi request reprint Human hepatic progenitor cells express vasoactive intestinal peptide receptor type 2 and receive nerve endings
    David Cassiman
    Department of Hepatology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Liver Int 27:323-8. 2007
    ..VIP expressing nerves are known to be present in the liver...
  69. doi request reprint Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin
    Mina Komuta
    Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium
    Hepatology 47:1544-56. 2008
    ..05), while albumin was downregulated in CLC (P = 0.007) toward K19-negative HCCs. Comparison of CLC with K19-positive HCCs indicated a high homology. CONCLUSION: All these findings highly suggest a progenitor cell origin of CLC...
  70. pmc In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats
    M Van de Casteele
    Laboratory of Hepatology, University Hospital Gasthuisberg, Leuven, B 3000 Leuven, Belgium
    Gut 51:440-5. 2002
    ..Enhanced endothelin-1 and decreased activity of hepatic constitutive endothelial nitric oxide synthase (NOS 3) was reported in carbon tetrachloride (CCl(4)) cirrhotic rat liver...
  71. ncbi request reprint Aggregated colon cancer cells have a higher metastatic efficiency in the liver compared with nonaggregated cells: an experimental study
    B Topal
    Department of Abdominal Surgery, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium
    J Surg Res 112:31-7. 2003
    ..The aim of the present study was to compare in the liver the metastatic efficiency of viable nonaggregated colon cancer cells versus cell aggregates for equivalent numbers of cancer cells...
  72. ncbi request reprint Both retinoids and androgens are required to maintain or promote functional differentiation in reaggregation cultures of human prostate epithelial cells
    Karine Goossens
    Laboratory for Experimental Medicine and Endocrinology Onderwijs en Navorsing, Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Prostate 53:34-49. 2002
    ..Here, we investigated whether differentiation could be restored or preserved by using three-dimensional reaggregation cultures treated with retinoids and/or androgens...
  73. ncbi request reprint Molecular diagnostic approach to liver tissue as an ancillary tool for liver histopathology
    Louis Libbrecht
    Liver Research Unit of the Laboratory of Morphology and Molecular Pathology and Department of Pathology, University Hospitals of Leuven, Leuven, Belgium
    Semin Liver Dis 26:328-36. 2006
    ..It is very likely that ancillary molecular techniques will be applied in routine practice to improve diagnosis and prognostication of liver tumors in the foreseeable future...
  74. ncbi request reprint Porphyria cutanea tarda and liver disease. A retrospective analysis of 17 cases from a single centre and review of the literature
    David Cassiman
    Department of Hepatology, University Hospital Gasthuisberg, University of Leuven, Belgium
    Acta Gastroenterol Belg 71:237-42. 2008
    ..g. HCV infection, haemochromatosis and especially alcoholic liver disease. We conducted a retrospective analysis on the prevalence of liver disorders in association with Porphyria Cutanea Tarda (PCT), in a university referral centre...
  75. ncbi request reprint A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis
    Wim Laleman
    Laboratories of Hepatology, University Hospital Gasthuisberg, Leuven, Belgium
    Hepatology 42:1382-90. 2005
    ..2%). In conclusion, in rats with TAA-induced cirrhosis, decreased eNOS enzyme levels seem to be responsible for impaired NOS activity; in rats with biliary cirrhosis, an endogenous NOS inhibitor, ADMA, may mediate decreased NOS activity...
  76. ncbi request reprint Matrix metalloproteinases and atrial remodeling in patients with mitral valve disease and atrial fibrillation
    Wim Anne
    Department of Cardiology, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Cardiovasc Res 67:655-66. 2005
    ..Our aim was to study atrial structural remodeling and the expression of the angiotensin receptor subtypes and MMPs and their inhibitors (TIMPs) in patients with mitral valve disease with and without AF...
  77. doi request reprint Quantitation of replication of the HCV genome in human livers with end-stage cirrhosis by strand-specific real-time RT-PCR assays: methods and clinical relevance
    Lan Lin
    Department of Hepatology, University Hospitals, Leuven, Belgium
    J Med Virol 81:1569-75. 2009
    ..This suggests the existence of an extra-hepatic location of HCV with comparable viral replication rate being responsible for the infection of the newly transplanted liver...
  78. ncbi request reprint High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB
    Tine Van de Sande
    Laboratory for Experimental Medicine and Endocrinology, University of Leuven, B 3000 Leuven, Belgium
    J Pathol 206:214-9. 2005
    ....
  79. doi request reprint Early features of acute-on-chronic alcoholic liver failure: a prospective cohort study
    Aezam Katoonizadeh
    Department of Liver and Pancreaticobiliary Disorders, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium
    Gut 59:1561-9. 2010
    ..Acute-on-chronic liver failure' (ACLF) is characterised in a more advanced stage by liver failure associated with multiple other end-organ failure. The global clinical characteristics of this entity remain, however, ill-defined...
  80. pmc Elucidation of the tumoritropic principle of hypericin
    M Van de Putte
    Laboratorium voor Farmaceutische Biologie, Faculteit Farmaceutische Wetenschappen, KU Leuven, Van Evenstraat 4, B 3000 Leuven, Belgium
    Br J Cancer 92:1406-13. 2005
    ....
  81. ncbi request reprint Histopathology of portal hypertension: a practical guideline
    T Roskams
    Department of Pathology, K U Leuven, Leuven, Belgium
    Histopathology 42:2-13. 2003
  82. ncbi request reprint The effect of imatinib mesylate on the contractility of isolated rabbit myometrial strips
    G Hutchings
    Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Gynecol Obstet Invest 62:79-83. 2006
    ..C-kit receptor expressing interstitial cells generate and coordinate the electrical signals that control peristalsis in the gut. However, the function of interstitial cells in the myometrium is not known...
  83. ncbi request reprint Is low-grade prostatic intraepithelial neoplasia a risk factor for cancer?
    L Goeman
    UZ Gasthuisberg, Department of Urology, Leuven, Belgium
    Prostate Cancer Prostatic Dis 6:305-10. 2003
    ..The likely outcome of isolated low-grade PIN (LGPIN) lesions in prostate biopsies remains unclear. A follow-up study of 106 patients with LGPIN- and HGPIN lesions was performed...
  84. ncbi request reprint Both Ca2+ -dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine
    Wim Laleman
    Dept of Hepatology, Univ Hospital Gasthuisberg, K U Leuven, Leuven, Belgium
    Am J Physiol Gastrointest Liver Physiol 292:G556-64. 2007
    ....
  85. pmc Correlations between age, Charlson score and outcome in clinical unilateral T3a prostate cancer
    Chao Yu Hsu
    Department of Urology, University Hospitals KULeuven, Leuven, Belgium
    Asian J Androl 11:131-7. 2009
    ..However, the patients need to be counseled regarding possible surgery-related side effects, such as urinary incontinence and erectile dysfunction, which are age- and comorbidity-dependent...
  86. ncbi request reprint Comparing results after surgery in patients with clinical unilateral T3a prostate cancer treated with or without neoadjuvant androgen-deprivation therapy
    Chao Yu Hsu
    Department of Urology, University Hospitals KU Leuven, Leuven, Belgium
    BJU Int 99:311-4. 2007
    ....
  87. ncbi request reprint Permeation of hypericin in spheroids composed of different grade transitional cell carcinoma cell lines and normal human urothelial cells
    Ann Huygens
    Laboratorium voor Farmaceutische Biologie en Fytofarmacologie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Leuven, Belgium
    J Urol 174:69-72. 2005
    ..We investigated the importance of E-cadherin expression on the selective accumulation of hypericin in superficial bladder cancer after intravesical instillation...
  88. doi request reprint Tracheal allotransplantation after withdrawal of immunosuppressive therapy
    Pierre Delaere
    Department of Otolaryngology and Head and Neck, University Hospital Leuven, Leuven, Belgium
    N Engl J Med 362:138-45. 2010
    ..After withdrawal of immunosuppressive therapy, the tracheal allograft was moved to its correct anatomical position with an intact blood supply. No treatment-limiting adverse effects occurred...
  89. ncbi request reprint Self-terminating AF depends on electrical remodeling while persistent AF depends on additional structural changes in a rapid atrially paced sheep model
    Wim Anne
    Department of Cardiology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    J Mol Cell Cardiol 43:148-58. 2007
    ..Fibrosis development in our model is the result of an increased expression of AT-II in combination with changes in MMP expression. Inhibition of the angiotensin pathway suppresses atrial fibrosis and the development of persistent AF...
  90. ncbi request reprint Transferrin-conjugated liposome targeting of photosensitizer AlPcS4 to rat bladder carcinoma cells
    Annelies S L Derycke
    Laboratory for Pharmaceutical Biology and Phytopharmacology, Faculty of Pharmaceutical Sciences, K U Leuven, Leuven, Belgium
    J Natl Cancer Inst 96:1620-30. 2004
    ....
  91. doi request reprint Where is TRPV1 expressed in the bladder, do we see the real channel?
    Wouter Everaerts
    Department of Surgery, Laboratory of Experimental Urology, Campus Gasthuisberg, KU Leuven, Herestraat 49, Bus 7003, 3000, Leuven, Belgium
    Naunyn Schmiedebergs Arch Pharmacol 379:421-5. 2009
    ..In conclusion, we think that the use of negative controls on knockout mice, whenever available, is mandatory when conducting immunohistochemical localization studies...
  92. ncbi request reprint Antivascular tumor eradication by hypericin-mediated photodynamic therapy
    Bin Chen
    Laboratorium voor Farmaceutische Biologie en Fytofarmacologie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Leuven, Belgium
    Photochem Photobiol 76:509-13. 2002
    ..Our results strongly suggest that targeting the tumor vasculature by applying short drug-light interval PDT with hypericin might be a promising way to eradicate solid tumors...
  93. doi request reprint Cholestatic liver disease in long-term infantile nephropathic cystinosis
    Tom Cornelis
    Department of Nephrology, University Hopsital Gasthuisberg, University of Leuven, Leuven, Belgium
    J Gastroenterol Hepatol 23:e428-31. 2008
    ..Infantile cystinosis typically leads to end-stage renal disease, necessitating renal replacement therapy. Liver disease in cystinosis is rare and is mostly reported as nodular regenerative hyperplasia leading to portal hypertension...
  94. ncbi request reprint Microscopic quantification of hypercin fluorescence in an orthotopic rat bladder tumor model after intravesical instillation
    Appolinary A R Kamuhabwa
    Laboratorium voor Farmaceutische Biologie en Fytofarmacologie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Oncol 22:933-7. 2003
    ..The results suggest that under these conditions, PDT with hypericin is likely to produce uniform urothelial tumor eradication, without causing damage to the underlying muscle layers...
  95. ncbi request reprint Outcome of surgery for clinical unilateral T3a prostate cancer: a single-institution experience
    Chao Yu Hsu
    Department of Urology, University Hospitals KULeuven, Leuven, Belgium
    Eur Urol 51:121-8; discussion 128-9. 2007
    ..The optimal management of locally advanced prostate cancer (cT3) is still a matter of debate. The objective of this study is to present 10-year outcomes of radical prostatectomy (RP) in unilateral cT3a disease...
  96. ncbi request reprint Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection
    Sebastien Dharancy
    Equipe Mixte INSERM 0114, Centre Hospitalier Universitaire, Lille, France
    Gastroenterology 128:334-42. 2005
    ....
  97. ncbi request reprint Transforming growth factor beta-1 signalling in canine hepatic diseases: new models for human fibrotic liver pathologies
    Bart Spee
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Liver Int 26:716-25. 2006
    ..The purpose of this study was to validate spontaneous chronic hepatitis and cirrhosis in dogs as a potential large animal model for fibrotic liver disease in humans by evaluating their molecular pathophysiology...
  98. ncbi request reprint Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin
    Marco Marzioni
    Department of Medical Physiology, Scott and White Hospital, and Texas A and M University Health System Science Center, 702 Southwest H K Dodgen Loop, Temple, TX 76504, USA
    Gastroenterology 128:121-37. 2005
    ..The endogenous factors that regulate cholangiocyte proliferation are poorly understood. Therefore, we studied the role of the neuroendocrine hormone serotonin as a modulator of cholangiocyte proliferation...
  99. ncbi request reprint Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera
    Philip Meuleman
    Center for Vaccinology, Ghent University and Hospital, Ghent, Belgium
    Hepatology 41:847-56. 2005
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  100. ncbi request reprint Chromosome changes in sarcomatoid renal carcinomas are different from those in renal cell carcinomas
    Paola Dal Cin
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Brookline Avenue, Boston, MA, USA
    Cancer Genet Cytogenet 134:38-40. 2002
    ..Sarcomatoid transformation thus may occur occasionally in RCC without the characteristic chromosome changes but also, and perhaps more frequently, in a subgroup of RCC without the characteristic chromosome changes...
  101. ncbi request reprint Human hepatocytes secrete soluble CD14, a process not directly influenced by HBV and HCV infection
    Philip Meuleman
    Center for Vaccinology, Ghent University and Hospital, Building A, 1st Floor, De Pintelaan 185, B 9000 Ghent, Belgium
    Clin Chim Acta 366:156-62. 2006
    ..Chronic hepatitis B (HBV) and hepatitis C (HCV) patients have elevated plasma levels of soluble CD14 (sCD14). We examined whether human hepatocytes produce sCD14 in vivo, and whether HBV or HCV infections influence this chimeric production...