Philip Roelandt

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells
    Philip Roelandt
    Interdepartmental Stem Cell Institute Leuven, Catholic University Leuven, and Hepatology Department, University Hospitals Leuven, Leuven, Belgium
    PLoS ONE 5:e12101. 2010
  2. doi request reprint Differentiation of rat multipotent adult progenitor cells to functional hepatocyte-like cells by mimicking embryonic liver development
    Philip Roelandt
    Interdepartmental Stem Cell Institute Leuven, Catholic University Leuven, Leuven, Belgium
    Nat Protoc 5:1324-36. 2010
  3. doi request reprint Directed differentiation of pluripotent stem cells to functional hepatocytes
    Philip Roelandt
    Stem Cell Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    Methods Mol Biol 997:141-7. 2013
  4. pmc Culture of mouse embryonic stem cells with serum but without exogenous growth factors is sufficient to generate functional hepatocyte-like cells
    Karen Pauwelyn
    Stem Cell Institute Leuven, Catholic University Leuven, Belgium
    PLoS ONE 6:e23096. 2011
  5. doi request reprint Heterozygous α1-antitrypsin Z allele mutation in presumed healthy donor livers used for transplantation
    Philip Roelandt
    aDepartment of Gastroenterology, OLV Hospital, Aalst Departments of bHepatology cPathology dHuman Genetics eAbdominal Transplantation Surgery, University Hospitals Leuven, Leuven fHistocompatibility and Immunogenetics Lab, Mechelen, Belgium
    Eur J Gastroenterol Hepatol 25:1335-9. 2013
  6. doi request reprint Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus
    Philip Roelandt
    Interdepartmental Stem Cell Institute Leuven, KU Leuven, Belgium
    J Hepatol 57:246-51. 2012
  7. doi request reprint HNF1B deficiency causes ciliary defects in human cholangiocytes
    Philip Roelandt
    Hepatology Department, University Hospitals Leuven, Belgium
    Hepatology 56:1178-81. 2012
  8. doi request reprint Directed differentiation of murine-induced pluripotent stem cells to functional hepatocyte-like cells
    Pau Sancho-Bru
    Interdepartmental Stem Cell Institute Leuven, Catholic University Leuven, Belgium
    J Hepatol 54:98-107. 2011

Detail Information

Publications8

  1. pmc Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells
    Philip Roelandt
    Interdepartmental Stem Cell Institute Leuven, Catholic University Leuven, and Hepatology Department, University Hospitals Leuven, Leuven, Belgium
    PLoS ONE 5:e12101. 2010
    ..This differentiation protocol will be useful for generating hepatocyte-like cells from rodent and human stem cells, and to gain insight into the early stages of liver development...
  2. doi request reprint Differentiation of rat multipotent adult progenitor cells to functional hepatocyte-like cells by mimicking embryonic liver development
    Philip Roelandt
    Interdepartmental Stem Cell Institute Leuven, Catholic University Leuven, Leuven, Belgium
    Nat Protoc 5:1324-36. 2010
    ....
  3. doi request reprint Directed differentiation of pluripotent stem cells to functional hepatocytes
    Philip Roelandt
    Stem Cell Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    Methods Mol Biol 997:141-7. 2013
    ....
  4. pmc Culture of mouse embryonic stem cells with serum but without exogenous growth factors is sufficient to generate functional hepatocyte-like cells
    Karen Pauwelyn
    Stem Cell Institute Leuven, Catholic University Leuven, Belgium
    PLoS ONE 6:e23096. 2011
    ..These results suggest that differences exist between lineage specific differentiation potential of mESC and hESC, requiring optimization of different protocols for ESC from either species...
  5. doi request reprint Heterozygous α1-antitrypsin Z allele mutation in presumed healthy donor livers used for transplantation
    Philip Roelandt
    aDepartment of Gastroenterology, OLV Hospital, Aalst Departments of bHepatology cPathology dHuman Genetics eAbdominal Transplantation Surgery, University Hospitals Leuven, Leuven fHistocompatibility and Immunogenetics Lab, Mechelen, Belgium
    Eur J Gastroenterol Hepatol 25:1335-9. 2013
    ..We analyzed the incidence, epidemiology, and clinical features of AAT accumulation in the hepatocytes after liver transplantation...
  6. doi request reprint Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus
    Philip Roelandt
    Interdepartmental Stem Cell Institute Leuven, KU Leuven, Belgium
    J Hepatol 57:246-51. 2012
    ..Therefore, there is significant interest in the establishment from of a HCV culture system in human stem cell-derived hepatocyte-like cells...
  7. doi request reprint HNF1B deficiency causes ciliary defects in human cholangiocytes
    Philip Roelandt
    Hepatology Department, University Hospitals Leuven, Belgium
    Hepatology 56:1178-81. 2012
    ..Electron microscopy revealed a paucity or absence of normal primary cilia. Therefore, heterozygous HNF1B deficiency is associated with ciliary anomalies in cholangiocytes, and this may cause cholestasis...
  8. doi request reprint Directed differentiation of murine-induced pluripotent stem cells to functional hepatocyte-like cells
    Pau Sancho-Bru
    Interdepartmental Stem Cell Institute Leuven, Catholic University Leuven, Belgium
    J Hepatol 54:98-107. 2011
    ..Therefore, it is important to develop procedures which are specifically oriented to induce iPS cell differentiation...