Research Topics
Species | Johan NuytsSummaryAffiliation: Katholieke Universiteit Leuven Country: Belgium Publications
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Publications
Completion of a truncated attenuation image from the attenuated PET emission dataJohan Nuyts
Nuclear Medicine, KU Leuven, B 3000 Leuven, Belgium
IEEE Trans Med Imaging 32:237-46. 2013..The results on a PET/MRI patient study with 18F-FDG are presented as well...- Performance of MAP reconstruction for hot lesion detection in whole-body PET/CT: an evaluation with human and numerical observersJohan Nuyts
Department of Nuclear Medicine, K U Leuven, B3000Leuven, Belgium
IEEE Trans Med Imaging 28:67-73. 2009..The CHO was then applied to evaluate the performance of priors with reduced penalty for large differences. For these priors, a poorer detection performance was obtained... - Small animal imaging with multi-pinhole SPECTJohan Nuyts
Nuclear Medicine, Katholieke Universiteit Leuven, UZ Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium
Methods 48:83-91. 2009..This paper discusses how these problems can be solved to implement micro-SPECT imaging on a rotating gamma camera... 
Comparison between MAP and postprocessed ML for image reconstruction in emission tomography when anatomical knowledge is availableJohan Nuyts
Nuclear Medicine, K U Leuven, B 3000 Leuven, Belgium
IEEE Trans Med Imaging 24:667-75. 2005..This can be done by applying a so-called prewhitening filter. However, because the prewhitening filter is shift variant and object dependent, it seems that MAP reconstruction is the more efficient method...- Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECTHumphrey Fonge
Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K U Leuven, O and N 2, Box 821, Herestraat 49, BE 3000 Leuven, Belgium
Eur Heart J 29:260-9. 2008.... - Radiolabeling and preliminary biological evaluation of a (99m)Tc(CO)(3) labeled 3,3'-(benzylidene)-bis-(1H-indole-2-carbohydrazide) derivative as a potential SPECT tracer for in vivo visualization of necrosisKristof Prinsen
Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Herestraat 49, Box 821, BE 3000 Leuven, Belgium
Bioorg Med Chem Lett 21:502-5. 2011..The obtained results indicate that (99m)Tc(CO)(3)-bis-DTPA-BI displays selective uptake in necrotic tissue and can be used for in vivo visualization of necrosis by SPECT... - Evaluation of anatomy based reconstruction for partial volume correction in brain FDG-PETKristof Baete
Department of Nuclear Medicine, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
Neuroimage 23:305-17. 2004..004). The patient study confirmed the applicability of A-MAP in clinical practice. Conclusion: A-MAP is a promising technique for voxel-based partial volume correction of FDG-PET of the human brain... - Effect of overlapping projections on reconstruction image quality in multipinhole SPECTKathleen Vunckx
Department of Nuclear Medicine, K U Leuven, B 3000 Leuven, Belgium
IEEE Trans Med Imaging 27:972-83. 2008..The reconstruction images provide insight in the multiplexing and truncation artifacts... 
Fisher information-based evaluation of image quality for time-of-flight PETKathleen Vunckx
Department of Nuclear Medicine, K U Leuven, B 3000 Leuven, Belgium
IEEE Trans Med Imaging 29:311-21. 2010..Although the maximum CNR is not very sensitive to the time resolution error, using an inaccurate TOF kernel tends to introduce artifacts in the reconstructed image...- Anatomical-based FDG-PET reconstruction for the detection of hypo-metabolic regions in epilepsyKristof Baete
Department of Nuclear Medicine, UZ Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
IEEE Trans Med Imaging 23:510-9. 2004..We can conclude that the use of anatomical information combined with prior information about the underlying pathology is very promising for the detection of subtle hypo-metabolic regions in the brain of patients with epilepsy... - Optimization of geometrical calibration in pinhole SPECTDirk Beque
Department of Nuclear Medicine, KU Leuven, 3000 Leuven, Belgium
IEEE Trans Med Imaging 24:180-90. 2005..The study demonstrates, however, that, with the proposed calibration setups, the error in reconstructed images is comparable to the error in the phantom model... - Anatomy-based reconstruction of FDG-PET images with implicit partial volume correction improves detection of hypometabolic regions in patients with epilepsy due to focal cortical dysplasia diagnosed on MRIKarolien Goffin
Division of Nuclear Medicine and Medical Imaging Center, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
Eur J Nucl Med Mol Imaging 37:1148-55. 2010.... - Preliminary in vivo evaluation of a novel 99mTc-labeled HYNIC-cys-annexin A5 as an apoptosis imaging agentHumphrey Fonge
Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K U Leuven, O and N 2, Box 821, Herestraat 49, BE 3000 Leuven, Belgium
Bioorg Med Chem Lett 18:3794-8. 2008..The results indicate that the novel 99mTc-HYNIC-cys-annexin A5 shows similar apoptosis avidity as the 1st generation 99mTc-HYNIC-annexin A5... - Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenograftsJunjie Li
Theranostic Laboratory, Department of Imaging and Pathology, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium
Theranostics 3:127-37. 2013..Based on the soil-to-seeds principle, we explored the small-molecular sequential dual-targeting theranostic strategy (SMSDTTS) for prolonged survival and imaging detectability in a xenograft tumor model... - Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PETChristophe M Deroose
Division of Nuclear Medicine, University Hospital Leuven, Leuven, Belgium
Nucl Med Biol 39:1266-74. 2012..We investigated varicella zoster virus thymidine kinase (VZV-tk) as new PRG with radiolabeled bicyclic nucleoside analogues (BCNAs) as PET tracers... - The influence of attenuation correction and reconstruction techniques on the detection of hypo-perfused lesions in brain SPECT imagesShivani Ghoorun
Department of Nuclear Medicine, UZ Gasthuisberg-KULeuven, Leuven, Belgium
Nucl Med Commun 27:765-72. 2006..CONCLUSION: Uniform attenuation correction is adequate for lesion detection while maximum likelihood provides enhanced lesion detection when compared to filtered back-projection... - Evaluation of three MRI-based anatomical priors for quantitative PET brain imagingKathleen Vunckx
Department of Nuclear Medicine, KU Leuven, Leuven, Belgium
IEEE Trans Med Imaging 31:599-612. 2012..The performance of the segmentation-based prior is quite sensitive to the accuracy of the segmentation. In contrast to the joint entropy-prior, the Bowsher-prior is easily tuned and does not suffer from convergence problems... - Site-specific labeling of 'second generation' annexin V with 99mTc(CO)3 for improved imaging of apoptosis in vivoMarijke De Saint-Hubert
Department of Nuclear Medicine, University Hospital Gasthuisberg Leuven, Herestraat 49, B 3000 Leuven, Belgium
Bioorg Med Chem 18:1356-63. 2010..The apoptosis binding was most prominent for the HIS-tagged 'second generation' AnxV labeled with (99m)Tc(CO)(3) in comparison to (99m)Tc-HYNIC-cys-AnxV and (99m)Tc(CO)(3)-DTPA-cys-AnxV... - Perturbative refinement of the geometric calibration in pinhole SPECTMichel Defrise
Department of Nuclear Medicine, Vrije Universiteit Brussel, Brussels, Belgium
IEEE Trans Med Imaging 27:204-14. 2008..The performance of the method is illustrated using simulated and measured micro-SPECT data... - Biological image-guided radiotherapy in rectal cancer: challenges and pitfallsSarah Roels
Department of Radiation Oncology, Leuven Cancer Institute, University Hospital Leuven, Herestraat 49, Leuven, Belgium
Int J Radiat Oncol Biol Phys 75:782-90. 2009..To investigate the feasibility of integrating multiple imaging modalities for image-guided radiotherapy in rectal cancer... - Effect of corticosteroids on 18F-FDG uptake in tumor lesions after chemotherapyLieselot Brepoels
Department of Nuclear Medicine, University Hospital Gasthuisberg and Catholic University Leuven, Leuven, Belgium
J Nucl Med 48:390-7. 2007..The aim of this study was to investigate whether this inflammation is suppressed by the administration of corticosteroids and, in turn, can improve the correlation of (18)F-FDG uptake with tumor cell kill... - Exploring theranostic potentials of radioiodinated hypericin in rodent necrosis modelsJunjie Li
1 Theragnostic Laboratory, Department of Imaging and Pathology, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium 2 Molecular Small Animal Imaging Centre MoSAIC, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium
Theranostics 2:1010-9. 2012..The present animal experiments were conducted to evaluate radioiodinated Hypericin (Hyp) for its regional distribution as well as theranostic potentials... - A dual-targeting anticancer approach: soil and seed principleJunjie Li
Department of Radiology, University of Leuven, Campus Gasthuisberg, Herestraat 49, Leuven 3000, Belgium
Radiology 260:799-807. 2011..To test the hypothesis that targeting the microenvironment (soil) may effectively kill cancer cells (seeds) through a small-molecular weight sequential dual-targeting theragnostic strategy, or dual-targeting approach... - Necrosis avidity of (99m)Tc(CO)3-labeled pamoic acid derivatives: synthesis and preliminary biological evaluation in animal models of necrosisHumphrey Fonge
Laboratory of Radiopharmacy, Faculty of Pharmaceutical Sciences, KU Leuven, Herestraat 49, BE 3000, Leuven, Belgium
Bioconjug Chem 18:1924-34. 2007..99m)Tc(CO) 3-bis-DTPA-pamoate shows high specificity for necrotic tissue and merits further evaluation as a necrosis avid imaging agent. (99m)Tc(CO) 3 -12 is not useful for visualization of necrotic tissue... - Suppression of metal artifacts in CT using a reconstruction procedure that combines MAP and projection completionCatherine Lemmens
Department of Nuclear Medicine, K U Leuven, B 3000 Leuven, Belgium
IEEE Trans Med Imaging 28:250-60. 2009..This constrained image is the basis for an image-based projection completion procedure. The algorithm was validated on simulations, phantom and patient data, and compared with other metal artifact reduction algorithms... - A penalized-likelihood image reconstruction method for emission tomography, compared to postsmoothed maximum-likelihood with matched spatial resolutionJohan Nuyts
Department of Nuclear Medicine, K U Leuven, Herestraat 49, B3000 Leuven, Belgium
IEEE Trans Med Imaging 22:1042-52. 2003..For this experiment, the noise properties of the PL algorithm were not superior to those of postsmoothed ML reconstruction... - Simultaneous reconstruction of activity and attenuation in time-of-flight PETAhmadreza Rezaei
Nuclear Medicine Department, K U Leuven, B 3000 Leuven, Belgium
IEEE Trans Med Imaging 31:2224-33. 2012..However, some constraining is still mandatory, because the TOF data determine the attenuation sinogram only up to a constant offset... - Comparison between parallel hole and rotating slat collimation: analytical noise propagation modelsLin Zhou
Department of Nuclear Medicine, K U Leuven, B 3000 Leuven, Belgium
IEEE Trans Med Imaging 29:2038-52. 2010..3b) Pixel variance and variances of ROIs with varying sizes yield very similar relative performance for RS versus PH... - [18F]EF3 is not superior to [18F]FMISO for PET-based hypoxia evaluation as measured in a rat rhabdomyosarcoma tumour modelLudwig Dubois
Department of Nuclear Medicine, University Hospital Gasthuisberg and KU Leuven, 3000, Leuven, Belgium
Eur J Nucl Med Mol Imaging 36:209-18. 2009.... - Characterization of pinhole SPECT acquisition geometryDirk Beque
Department of Nuclear Medicine, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
IEEE Trans Med Imaging 22:599-612. 2003..The method is based on a single SPECT scan of a simple calibration phantom, executed immediately after the actual SPECT acquisition. The method is also applicable to cone-beam SPECT and X-ray CT... - Metal artifact reduction in computed tomography using local models in an image block-iterative schemeKatrien Van Slambrouck
Department of Nuclear Medicine, KU Leuven, Leuven, Belgium
Med Phys 39:7080-93. 2012..The hypothesis of this work is that these complex models only need to be applied in the vicinity of the metals and that a less complex model can be used for the remainder of the reconstruction volume... - Do androgens control the uptake of 18F-FDG, 11C-choline and 11C-acetate in human prostate cancer cell lines?Kimy M Emonds
Department of Nuclear Medicine, University Hospital Gasthuisberg Leuven, Leuven, Belgium
Eur J Nucl Med Mol Imaging 38:1842-53. 2011..The aim of this study was to evaluate the impact of androgen ablation therapy in different prostate cancer (PCa) cell lines--reflecting different stages of the disease--on (18)F-fluorodeoxyglucose (FDG), 11C-choline and 11C-acetate uptake... - The value of (18)FDG-PET for the detection of infected hip prosthesisBenedicte Vanquickenborne
Department of Nuclear Medicine, University Hospital Gasthuisberg, Leuven, Belgium
Eur J Nucl Med Mol Imaging 30:705-15. 2003..In this preliminary study, (18)FDG-PET scans alone showed the same sensitivity as combined BS and LS, although the specificity was slightly lower... - Multi-pinhole SPECT calibration: influence of data noise and systematic orbit deviationsLin Zhou
Department of Nuclearmedicine, K U Leuven, B 3000 Leuven, Belgium
IEEE Trans Med Imaging 30:1795-807. 2011..The two distance-fixing approaches yield similar reconstruction accuracy. Our theoretical results are supported by reconstruction images of a Jaszczak-type phantom scan... - Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpressionErwin Lauwers
Laboratory for Neurobiology and Gene Therapy, K U Leuven, Leuven, Belgium
Neurobiol Aging 28:248-57. 2007..MicroSPECT imaging enables non-invasive imaging of the neurodegeneration allowing longitudinal follow-up in this new animal model for Parkinson's disease and the evaluation of neuroprotective drugs... - Time-of-flight PET data determine the attenuation sinogram up to a constantMichel Defrise
Department of Nuclear Medicine, Vrije Universiteit Brussel, B 1090 Brussels, Belgium
Phys Med Biol 57:885-99. 2012..The stability of the method is illustrated numerically by means of a 2D simulation... - Reducing loss of image quality because of the attenuation artifact in uncorrected PET whole-body imagesJohan Nuyts
Nuclear Medicine, Katholieke Universiteit Leuven, Belgium
J Nucl Med 43:1054-62. 2002..In this study, we analyzed the causes of the artifact and proposed a new algorithm to reduce the adverse effects on visual image quality... - Synthesis and evaluation of a (99m)Tc-MAMA-propyl-thymidine complex as a potential probe for in vivo visualization of tumor cell proliferation with SPECTSofie Celen
Laboratory for Radiopharmacy, K U Leuven, B 3000 Leuven, Belgium
Nucl Med Biol 34:283-91. 2007..Accordingly, we have synthesized (99m)Tc-MAMA-propyl-thymidine and evaluated it as a potential tumor tracer... - Cardiac phantom measurement validating the methodology for a cardiac multi-centre trial with positron emission tomographyJohan Nuyts
Nuclear Medicine, UZ Gasthuisberg, K U Leuven, Herestraat 49, 3000 Leuven, Belgium
Eur J Nucl Med Mol Imaging 29:1588-93. 2002..6+/-0.8 mm. The same procedure produced a defect size of zero in the studies of normal volunteers. This study indicates that cardiac studies from multiple PET systems can be pooled for statistical analysis... - Preclinical evaluation of carbon-11 and fluorine-18 sulfonamide derivatives for in vivo radiolabeling of erythrocytesOlivier Gheysens
Laboratory of Radiopharmacy, Katholieke Universiteit Leuven, O and N2, Herestraat 49, Box 821, Leuven, BE 3000, Belgium
EJNMMI Res 3:4. 2013..abstract:.. - Patchwork reconstruction with resolution modeling for digital breast tomosynthesisKoen Michielsen
Department of Imaging and Pathology, and Medical Imaging Research Center, KU Leuven, Leuven 3000, Belgium
Med Phys 40:031105. 2013..Further study of the negative results of the classification task showed performance variations throughout the volume linked to the changing noise structure introduced by the combination of the resolution model and the smoothing prior... - Noninvasive and quantitative monitoring of adult neuronal stem cell migration in mouse brain using bioluminescence imagingVeerle Reumers
Neurobiology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium
Stem Cells 26:2382-90. 2008..Long-term expression of brain-derived neurotrophic factor in the subventricular zone attenuated neurogenesis, as detected by histology and BLI. In vivo monitoring of the impact of drugs or genes on adult neurogenesis is now within reach...