Johan Nuyts

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc Modelling the physics in the iterative reconstruction for transmission computed tomography
    Johan Nuyts
    Department of Nuclear Medicine and Medical Imaging Research Center, KU Leuven, Leuven, Belgium
    Phys Med Biol 58:R63-96. 2013
  2. doi request reprint Completion of a truncated attenuation image from the attenuated PET emission data
    Johan Nuyts
    Nuclear Medicine, KU Leuven, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 32:237-46. 2013
  3. doi request reprint Performance of MAP reconstruction for hot lesion detection in whole-body PET/CT: an evaluation with human and numerical observers
    Johan Nuyts
    Department of Nuclear Medicine, K U Leuven, B3000Leuven, Belgium
    IEEE Trans Med Imaging 28:67-73. 2009
  4. doi request reprint Small animal imaging with multi-pinhole SPECT
    Johan Nuyts
    Nuclear Medicine, Katholieke Universiteit Leuven, UZ Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium
    Methods 48:83-91. 2009
  5. doi request reprint Biological image-guided radiotherapy in rectal cancer: challenges and pitfalls
    Sarah Roels
    Department of Radiation Oncology, Leuven Cancer Institute, University Hospital Leuven, Herestraat 49, Leuven, Belgium
    Int J Radiat Oncol Biol Phys 75:782-90. 2009
  6. ncbi request reprint Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT
    Humphrey Fonge
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K U Leuven, O and N 2, Box 821, Herestraat 49, BE 3000 Leuven, Belgium
    Eur Heart J 29:260-9. 2008
  7. ncbi request reprint Comparison between MAP and postprocessed ML for image reconstruction in emission tomography when anatomical knowledge is available
    Johan Nuyts
    Nuclear Medicine, K U Leuven, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 24:667-75. 2005
  8. ncbi request reprint Construction and evaluation of multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain
    Cindy Casteels
    Division of Nuclear Medicine, University Hospital Gasthuisberg and Katholieke Universiteit Leuven, Leuven, Belgium
    J Nucl Med 47:1858-66. 2006
  9. doi request reprint Radiolabeling and preliminary biological evaluation of a (99m)Tc(CO)(3) labeled 3,3'-(benzylidene)-bis-(1H-indole-2-carbohydrazide) derivative as a potential SPECT tracer for in vivo visualization of necrosis
    Kristof Prinsen
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Herestraat 49, Box 821, BE 3000 Leuven, Belgium
    Bioorg Med Chem Lett 21:502-5. 2011
  10. pmc Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts
    Junjie Li
    Theranostic Laboratory, Department of Imaging and Pathology, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium
    Theranostics 3:127-37. 2013

Collaborators

Detail Information

Publications52

  1. pmc Modelling the physics in the iterative reconstruction for transmission computed tomography
    Johan Nuyts
    Department of Nuclear Medicine and Medical Imaging Research Center, KU Leuven, Leuven, Belgium
    Phys Med Biol 58:R63-96. 2013
    ..The widespread implementation of IR with a highly accurate model-based correction, however, still requires significant effort. In addition, new hardware will provide new opportunities and challenges to improve CT with new modelling...
  2. doi request reprint Completion of a truncated attenuation image from the attenuated PET emission data
    Johan Nuyts
    Nuclear Medicine, KU Leuven, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 32:237-46. 2013
    ..The results on a PET/MRI patient study with 18F-FDG are presented as well...
  3. doi request reprint Performance of MAP reconstruction for hot lesion detection in whole-body PET/CT: an evaluation with human and numerical observers
    Johan Nuyts
    Department of Nuclear Medicine, K U Leuven, B3000Leuven, Belgium
    IEEE Trans Med Imaging 28:67-73. 2009
    ..The CHO was then applied to evaluate the performance of priors with reduced penalty for large differences. For these priors, a poorer detection performance was obtained...
  4. doi request reprint Small animal imaging with multi-pinhole SPECT
    Johan Nuyts
    Nuclear Medicine, Katholieke Universiteit Leuven, UZ Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium
    Methods 48:83-91. 2009
    ..This paper discusses how these problems can be solved to implement micro-SPECT imaging on a rotating gamma camera...
  5. doi request reprint Biological image-guided radiotherapy in rectal cancer: challenges and pitfalls
    Sarah Roels
    Department of Radiation Oncology, Leuven Cancer Institute, University Hospital Leuven, Herestraat 49, Leuven, Belgium
    Int J Radiat Oncol Biol Phys 75:782-90. 2009
    ..To investigate the feasibility of integrating multiple imaging modalities for image-guided radiotherapy in rectal cancer...
  6. ncbi request reprint Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT
    Humphrey Fonge
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K U Leuven, O and N 2, Box 821, Herestraat 49, BE 3000 Leuven, Belgium
    Eur Heart J 29:260-9. 2008
    ....
  7. ncbi request reprint Comparison between MAP and postprocessed ML for image reconstruction in emission tomography when anatomical knowledge is available
    Johan Nuyts
    Nuclear Medicine, K U Leuven, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 24:667-75. 2005
    ..This can be done by applying a so-called prewhitening filter. However, because the prewhitening filter is shift variant and object dependent, it seems that MAP reconstruction is the more efficient method...
  8. ncbi request reprint Construction and evaluation of multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain
    Cindy Casteels
    Division of Nuclear Medicine, University Hospital Gasthuisberg and Katholieke Universiteit Leuven, Leuven, Belgium
    J Nucl Med 47:1858-66. 2006
    ..Also, the feasibility of individual rat brain statistical parametric mapping (SPM) was explored for (18)F-FDG and DAT imaging of a 6-hydroxydopamine (6OHDA) model of Parkinson's disease...
  9. doi request reprint Radiolabeling and preliminary biological evaluation of a (99m)Tc(CO)(3) labeled 3,3'-(benzylidene)-bis-(1H-indole-2-carbohydrazide) derivative as a potential SPECT tracer for in vivo visualization of necrosis
    Kristof Prinsen
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Herestraat 49, Box 821, BE 3000 Leuven, Belgium
    Bioorg Med Chem Lett 21:502-5. 2011
    ..The obtained results indicate that (99m)Tc(CO)(3)-bis-DTPA-BI displays selective uptake in necrotic tissue and can be used for in vivo visualization of necrosis by SPECT...
  10. pmc Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts
    Junjie Li
    Theranostic Laboratory, Department of Imaging and Pathology, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium
    Theranostics 3:127-37. 2013
    ..Based on the soil-to-seeds principle, we explored the small-molecular sequential dual-targeting theranostic strategy (SMSDTTS) for prolonged survival and imaging detectability in a xenograft tumor model...
  11. ncbi request reprint Evaluation of anatomy based reconstruction for partial volume correction in brain FDG-PET
    Kristof Baete
    Department of Nuclear Medicine, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Neuroimage 23:305-17. 2004
    ..004). The patient study confirmed the applicability of A-MAP in clinical practice. Conclusion: A-MAP is a promising technique for voxel-based partial volume correction of FDG-PET of the human brain...
  12. pmc Fisher information-based evaluation of image quality for time-of-flight PET
    Kathleen Vunckx
    Department of Nuclear Medicine, K U Leuven, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 29:311-21. 2010
    ..Although the maximum CNR is not very sensitive to the time resolution error, using an inaccurate TOF kernel tends to introduce artifacts in the reconstructed image...
  13. doi request reprint Effect of overlapping projections on reconstruction image quality in multipinhole SPECT
    Kathleen Vunckx
    Department of Nuclear Medicine, K U Leuven, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 27:972-83. 2008
    ..The reconstruction images provide insight in the multiplexing and truncation artifacts...
  14. doi request reprint Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET
    Christophe M Deroose
    Division of Nuclear Medicine, University Hospital Leuven, Leuven, Belgium
    Nucl Med Biol 39:1266-74. 2012
    ..We investigated varicella zoster virus thymidine kinase (VZV-tk) as new PRG with radiolabeled bicyclic nucleoside analogues (BCNAs) as PET tracers...
  15. ncbi request reprint Optimization of geometrical calibration in pinhole SPECT
    Dirk Beque
    Department of Nuclear Medicine, KU Leuven, 3000 Leuven, Belgium
    IEEE Trans Med Imaging 24:180-90. 2005
    ..The study demonstrates, however, that, with the proposed calibration setups, the error in reconstructed images is comparable to the error in the phantom model...
  16. ncbi request reprint Anatomical-based FDG-PET reconstruction for the detection of hypo-metabolic regions in epilepsy
    Kristof Baete
    Department of Nuclear Medicine, UZ Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 23:510-9. 2004
    ..We can conclude that the use of anatomical information combined with prior information about the underlying pathology is very promising for the detection of subtle hypo-metabolic regions in the brain of patients with epilepsy...
  17. doi request reprint Anatomy-based reconstruction of FDG-PET images with implicit partial volume correction improves detection of hypometabolic regions in patients with epilepsy due to focal cortical dysplasia diagnosed on MRI
    Karolien Goffin
    Division of Nuclear Medicine and Medical Imaging Center, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 37:1148-55. 2010
    ....
  18. ncbi request reprint Necrosis avidity of (99m)Tc(CO)3-labeled pamoic acid derivatives: synthesis and preliminary biological evaluation in animal models of necrosis
    Humphrey Fonge
    Laboratory of Radiopharmacy, Faculty of Pharmaceutical Sciences, KU Leuven, Herestraat 49, BE 3000, Leuven, Belgium
    Bioconjug Chem 18:1924-34. 2007
    ..99m)Tc(CO) 3-bis-DTPA-pamoate shows high specificity for necrotic tissue and merits further evaluation as a necrosis avid imaging agent. (99m)Tc(CO) 3 -12 is not useful for visualization of necrotic tissue...
  19. doi request reprint Suppression of metal artifacts in CT using a reconstruction procedure that combines MAP and projection completion
    Catherine Lemmens
    Department of Nuclear Medicine, K U Leuven, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 28:250-60. 2009
    ..This constrained image is the basis for an image-based projection completion procedure. The algorithm was validated on simulations, phantom and patient data, and compared with other metal artifact reduction algorithms...
  20. doi request reprint Preliminary in vivo evaluation of a novel 99mTc-labeled HYNIC-cys-annexin A5 as an apoptosis imaging agent
    Humphrey Fonge
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K U Leuven, O and N 2, Box 821, Herestraat 49, BE 3000 Leuven, Belgium
    Bioorg Med Chem Lett 18:3794-8. 2008
    ..The results indicate that the novel 99mTc-HYNIC-cys-annexin A5 shows similar apoptosis avidity as the 1st generation 99mTc-HYNIC-annexin A5...
  21. doi request reprint Morphological, functional and metabolic imaging biomarkers: assessment of vascular-disrupting effect on rodent liver tumours
    Huaijun Wang
    Department of Radiology, University Hospitals, University of Leuven, Leuven, Belgium
    Eur Radiol 20:2013-26. 2010
    ..To evaluate effects of a vascular-disrupting agent on rodent tumour models...
  22. doi request reprint A dual-targeting anticancer approach: soil and seed principle
    Junjie Li
    Department of Radiology, University of Leuven, Campus Gasthuisberg, Herestraat 49, Leuven 3000, Belgium
    Radiology 260:799-807. 2011
    ..To test the hypothesis that targeting the microenvironment (soil) may effectively kill cancer cells (seeds) through a small-molecular weight sequential dual-targeting theragnostic strategy, or dual-targeting approach...
  23. doi request reprint [18F]EF3 is not superior to [18F]FMISO for PET-based hypoxia evaluation as measured in a rat rhabdomyosarcoma tumour model
    Ludwig Dubois
    Department of Nuclear Medicine, University Hospital Gasthuisberg and KU Leuven, 3000, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 36:209-18. 2009
    ....
  24. doi request reprint Simultaneous reconstruction of activity and attenuation in time-of-flight PET
    Ahmadreza Rezaei
    Nuclear Medicine Department, K U Leuven, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 31:2224-33. 2012
    ..However, some constraining is still mandatory, because the TOF data determine the attenuation sinogram only up to a constant offset...
  25. ncbi request reprint The influence of attenuation correction and reconstruction techniques on the detection of hypo-perfused lesions in brain SPECT images
    Shivani Ghoorun
    Department of Nuclear Medicine, UZ Gasthuisberg KULeuven, Leuven, Belgium
    Nucl Med Commun 27:765-72. 2006
    ..We evaluated the effects of attenuation correction and reconstruction techniques on the detection of hypoperfused lesions in brain SPECT imaging...
  26. doi request reprint Detection and quantification of acute reperfused myocardial infarction in rabbits using DISA-SPECT/CT and 3.0T cardiac MRI
    Yuanbo Feng
    Theragnostic Laboratory and Radiology Section, Department of Imaging and Pathology, Biomedical Sciences Group, KU Leuven, Leuven, Belgium
    Int J Cardiol 168:4191-8. 2013
    ....
  27. doi request reprint Comparative study of iodine-123-labeled hypericin and 99mTc-labeled hexakis [2-methoxy isobutyl isonitrile] in a rabbit model of myocardial infarction
    Marlein M Cona
    Department of Imaging and Pathology and Molecular Small Animal Imaging Centre MoSAIC, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, Leuven, Belgium Nuclear Medicine Section, University Hospital Group, UZ Leuven, Leuven, Belgium and Faculty of Pharmaceutical Sciences, Biomedical Sciences Group, KU Leuven, Leuven, Belgium
    J Cardiovasc Pharmacol 62:304-11. 2013
    ..The selectivity of I-Hyp for infarcted myocardium and Tc-Sestamibi for normal myocardium was confirmed. I-Hyp distribution in rabbits is characterized by hepatobiliary excretion. Tc-Sestamibi undergoes hepatorenal elimination...
  28. pmc Exploring theranostic potentials of radioiodinated hypericin in rodent necrosis models
    Junjie Li
    1 Theragnostic Laboratory, Department of Imaging and Pathology, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium 2 Molecular Small Animal Imaging Centre MoSAIC, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium
    Theranostics 2:1010-9. 2012
    ..The present animal experiments were conducted to evaluate radioiodinated Hypericin (Hyp) for its regional distribution as well as theranostic potentials...
  29. ncbi request reprint A penalized-likelihood image reconstruction method for emission tomography, compared to postsmoothed maximum-likelihood with matched spatial resolution
    Johan Nuyts
    Department of Nuclear Medicine, K U Leuven, Herestraat 49, B3000 Leuven, Belgium
    IEEE Trans Med Imaging 22:1042-52. 2003
    ..For this experiment, the noise properties of the PL algorithm were not superior to those of postsmoothed ML reconstruction...
  30. ncbi request reprint Synthesis and evaluation of a (99m)Tc-MAMA-propyl-thymidine complex as a potential probe for in vivo visualization of tumor cell proliferation with SPECT
    Sofie Celen
    Laboratory for Radiopharmacy, K U Leuven, B 3000 Leuven, Belgium
    Nucl Med Biol 34:283-91. 2007
    ..Accordingly, we have synthesized (99m)Tc-MAMA-propyl-thymidine and evaluated it as a potential tumor tracer...
  31. doi request reprint Evaluation of three MRI-based anatomical priors for quantitative PET brain imaging
    Kathleen Vunckx
    Department of Nuclear Medicine, KU Leuven, Leuven, Belgium
    IEEE Trans Med Imaging 31:599-612. 2012
    ..The performance of the segmentation-based prior is quite sensitive to the accuracy of the segmentation. In contrast to the joint entropy-prior, the Bowsher-prior is easily tuned and does not suffer from convergence problems...
  32. doi request reprint Site-specific labeling of 'second generation' annexin V with 99mTc(CO)3 for improved imaging of apoptosis in vivo
    Marijke De Saint-Hubert
    Department of Nuclear Medicine, University Hospital Gasthuisberg Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Bioorg Med Chem 18:1356-63. 2010
    ..The apoptosis binding was most prominent for the HIS-tagged 'second generation' AnxV labeled with (99m)Tc(CO)(3) in comparison to (99m)Tc-HYNIC-cys-AnxV and (99m)Tc(CO)(3)-DTPA-cys-AnxV...
  33. doi request reprint Perturbative refinement of the geometric calibration in pinhole SPECT
    Michel Defrise
    Department of Nuclear Medicine, Vrije Universiteit Brussel, Brussels, Belgium
    IEEE Trans Med Imaging 27:204-14. 2008
    ..The performance of the method is illustrated using simulated and measured micro-SPECT data...
  34. ncbi request reprint Effect of corticosteroids on 18F-FDG uptake in tumor lesions after chemotherapy
    Lieselot Brepoels
    Department of Nuclear Medicine, University Hospital Gasthuisberg and Catholic University Leuven, Leuven, Belgium
    J Nucl Med 48:390-7. 2007
    ..The aim of this study was to investigate whether this inflammation is suppressed by the administration of corticosteroids and, in turn, can improve the correlation of (18)F-FDG uptake with tumor cell kill...
  35. ncbi request reprint Characterization of pinhole SPECT acquisition geometry
    Dirk Beque
    Department of Nuclear Medicine, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 22:599-612. 2003
    ..The method is based on a single SPECT scan of a simple calibration phantom, executed immediately after the actual SPECT acquisition. The method is also applicable to cone-beam SPECT and X-ray CT...
  36. ncbi request reprint Recombinant P-selectin glycoprotein ligand-immunoglobulin, a P-selectin antagonist, as an adjunct to thrombolysis in acute myocardial infarction. The P-Selectin Antagonist Limiting Myonecrosis (PSALM) trial
    Paul Mertens
    Department of Cardiology, University of Leuven, Leuven, Belgium
    Am Heart J 152:125.e1-8. 2006
    ..We performed a mechanistic study with positron emission tomography to test the potential benefits of rPSGL-Ig in patients with ST-segment elevation acute myocardial infarction...
  37. doi request reprint Impact of metal artefacts due to EEG electrodes in brain PET/CT imaging
    Catherine Lemmens
    Department of Nuclear Medicine and Medical Imaging Center, University Hospital Gasthuisberg and Katholieke Universiteit Leuven, Leuven, Belgium
    Phys Med Biol 53:4417-29. 2008
    ..When quantification is performed, the bias becomes an issue especially when comparing brain images with and without EEG monitoring...
  38. ncbi request reprint First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent
    Yicheng Ni
    Department of Radiology, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 33:595-601. 2006
    ..We have labelled hypericin, a polyphenolic polycyclic quinone found in St. John's wort (Hypericum perforatum), with( 123)I and evaluated mono-[(123)I]iodohypericin (MIH) as a potential necrosis-avid diagnostic tracer agent...
  39. doi request reprint Comparison between parallel hole and rotating slat collimation: analytical noise propagation models
    Lin Zhou
    Department of Nuclear Medicine, K U Leuven, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 29:2038-52. 2010
    ..3b) Pixel variance and variances of ROIs with varying sizes yield very similar relative performance for RS versus PH...
  40. doi request reprint Biological image-guided radiotherapy in rectal cancer: is there a role for FMISO or FLT, next to FDG?
    Sarah Roels
    Leuven Cancer Institute, Radiation Oncology, University Hospital Leuven, Leuven, Belgium
    Acta Oncol 47:1237-48. 2008
    ..The purpose of this study is to investigate the use of PET/CT with fluorodeoxyglucose (FDG), fluorothymidine (FLT) and fluoromisonidazole (FMISO) for radiotherapy (RT) target definition and evolution in rectal cancer...
  41. doi request reprint Metal artifact reduction in computed tomography using local models in an image block-iterative scheme
    Katrien Van Slambrouck
    Department of Nuclear Medicine, KU Leuven, Leuven, Belgium
    Med Phys 39:7080-93. 2012
    ..The hypothesis of this work is that these complex models only need to be applied in the vicinity of the metals and that a less complex model can be used for the remainder of the reconstruction volume...
  42. ncbi request reprint The value of (18)FDG-PET for the detection of infected hip prosthesis
    Benedicte Vanquickenborne
    Department of Nuclear Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 30:705-15. 2003
    ..In this preliminary study, (18)FDG-PET scans alone showed the same sensitivity as combined BS and LS, although the specificity was slightly lower...
  43. doi request reprint Do androgens control the uptake of 18F-FDG, 11C-choline and 11C-acetate in human prostate cancer cell lines?
    Kimy M Emonds
    Department of Nuclear Medicine, University Hospital Gasthuisberg Leuven, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 38:1842-53. 2011
    ..The aim of this study was to evaluate the impact of androgen ablation therapy in different prostate cancer (PCa) cell lines--reflecting different stages of the disease--on (18)F-fluorodeoxyglucose (FDG), 11C-choline and 11C-acetate uptake...
  44. doi request reprint Multi-pinhole SPECT calibration: influence of data noise and systematic orbit deviations
    Lin Zhou
    Department of Nuclearmedicine, K U Leuven, B 3000 Leuven, Belgium
    IEEE Trans Med Imaging 30:1795-807. 2011
    ..The two distance-fixing approaches yield similar reconstruction accuracy. Our theoretical results are supported by reconstruction images of a Jaszczak-type phantom scan...
  45. ncbi request reprint Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression
    Erwin Lauwers
    Laboratory for Neurobiology and Gene Therapy, K U Leuven, Leuven, Belgium
    Neurobiol Aging 28:248-57. 2007
    ..MicroSPECT imaging enables non-invasive imaging of the neurodegeneration allowing longitudinal follow-up in this new animal model for Parkinson's disease and the evaluation of neuroprotective drugs...
  46. doi request reprint Time-of-flight PET data determine the attenuation sinogram up to a constant
    Michel Defrise
    Department of Nuclear Medicine, Vrije Universiteit Brussel, B 1090 Brussels, Belgium
    Phys Med Biol 57:885-99. 2012
    ..The stability of the method is illustrated numerically by means of a 2D simulation...
  47. ncbi request reprint Reducing loss of image quality because of the attenuation artifact in uncorrected PET whole-body images
    Johan Nuyts
    Nuclear Medicine, Katholieke Universiteit Leuven, Belgium
    J Nucl Med 43:1054-62. 2002
    ..In this study, we analyzed the causes of the artifact and proposed a new algorithm to reduce the adverse effects on visual image quality...
  48. ncbi request reprint Cardiac phantom measurement validating the methodology for a cardiac multi-centre trial with positron emission tomography
    Johan Nuyts
    Nuclear Medicine, UZ Gasthuisberg, K U Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Nucl Med Mol Imaging 29:1588-93. 2002
    ..6+/-0.8 mm. The same procedure produced a defect size of zero in the studies of normal volunteers. This study indicates that cardiac studies from multiple PET systems can be pooled for statistical analysis...
  49. doi request reprint Patchwork reconstruction with resolution modeling for digital breast tomosynthesis
    Koen Michielsen
    Department of Imaging and Pathology, and Medical Imaging Research Center, KU Leuven, Leuven 3000, Belgium
    Med Phys 40:031105. 2013
    ..They propose a modified grouped coordinate ascent algorithm that includes a specific acquisition model to compensate for this deterioration...
  50. pmc Preclinical evaluation of carbon-11 and fluorine-18 sulfonamide derivatives for in vivo radiolabeling of erythrocytes
    Olivier Gheysens
    Laboratory of Radiopharmacy, Katholieke Universiteit Leuven, O and N2, Herestraat 49, Box 821, Leuven, BE 3000, Belgium
    EJNMMI Res 3:4. 2013
    ..abstract:..
  51. doi request reprint Noninvasive and quantitative monitoring of adult neuronal stem cell migration in mouse brain using bioluminescence imaging
    Veerle Reumers
    Neurobiology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, Flanders, Belgium
    Stem Cells 26:2382-90. 2008
    ..Long-term expression of brain-derived neurotrophic factor in the subventricular zone attenuated neurogenesis, as detected by histology and BLI. In vivo monitoring of the impact of drugs or genes on adult neurogenesis is now within reach...
  52. ncbi request reprint Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial
    Stefan Janssens
    Department of Cardiology, Gasthuisberg University Hospital, University of Leuven, Leuven, Belgium
    Lancet 367:113-21. 2006
    ..Our aim was to investigate the effect of autologous bone marrow-derived stem cell (BMSC) transfer in the infarct-related artery on LV function and structure...