Yicheng Ni

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Targetability and biodistribution of radioiodinated hypericin: comparison between microdosing and carrier-added preparations
    Marlein Miranda Cona
    Radiology Section, University Hospitals, K U Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Anticancer Agents Med Chem 14:852-61. 2014
  2. pmc Exploring theranostic potentials of radioiodinated hypericin in rodent necrosis models
    Junjie Li
    1 Theragnostic Laboratory, Department of Imaging and Pathology, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium 2 Molecular Small Animal Imaging Centre MoSAIC, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium
    Theranostics 2:1010-9. 2012
  3. pmc Small Molecule Sequential Dual-Targeting Theragnostic Strategy (SMSDTTS): from Preclinical Experiments towards Possible Clinical Anticancer Applications
    Junjie Li
    1 Department of Imaging and Pathology, Biomedical Sciences Group KU Leuven, Belgium 2 Molecular Small Animal Imaging Center, Faculty of Medicine KU Leuven, Belgium
    J Cancer 4:133-45. 2013
  4. pmc Towards stratifying ischemic components by cardiac MRI and multifunctional stainings in a rabbit model of myocardial infarction
    Yuanbo Feng
    1 KU Leuven, Department of Imaging and Pathology, Theragnostic Laboratory, Radiology Section, University Hospital Gasthuisberg, Leuven, Belgium
    Theranostics 4:24-35. 2013
  5. doi request reprint Tumor models and specific contrast agents for small animal imaging in oncology
    Yicheng Ni
    Section of Radiology, Department of Medical Diagnostic Sciences, Biomedical Sciences Group, University of Leuven, Belgium
    Methods 48:125-38. 2009
  6. ncbi request reprint Diffusion-weighted MRI of hepatic tumor in rats: comparison between in vivo and postmortem imaging acquisitions
    Xihe Sun
    Section of Radiology, Department of Medical Diagnostic Science, University Hospitals, University of Leuven, Leuven, Belgium
    J Magn Reson Imaging 29:621-8. 2009
  7. ncbi request reprint Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT
    Humphrey Fonge
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K U Leuven, O and N 2, Box 821, Herestraat 49, BE 3000 Leuven, Belgium
    Eur Heart J 29:260-9. 2008
  8. doi request reprint Treatment of rodent liver tumor with combretastatin a4 phosphate: noninvasive therapeutic evaluation using multiparametric magnetic resonance imaging in correlation with microangiography and histology
    Huaijun Wang
    Department of Medical Diagnostic Science, University of Leuven, Leuven, Belgium
    Invest Radiol 44:44-53. 2009
  9. ncbi request reprint Rodent stroke induced by photochemical occlusion of proximal middle cerebral artery: evolution monitored with MR imaging and histopathology
    Feng Chen
    Department of Radiology, Faculty of Medicine, Catholic University of Leuven, Belgium
    Eur J Radiol 63:68-75. 2007
  10. ncbi request reprint Exploring multifunctional features of necrosis avid contrast agents
    Yicheng Ni
    Department of Radiology, University Hospitals, Catholic University of Leuven, Belgium
    Acad Radiol 9:S488-90. 2002

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Targetability and biodistribution of radioiodinated hypericin: comparison between microdosing and carrier-added preparations
    Marlein Miranda Cona
    Radiology Section, University Hospitals, K U Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Anticancer Agents Med Chem 14:852-61. 2014
    ..To study the effect of co-injecting unlabelled hypericin (Hyp) on biodistribution, necrosis uptake and tumour retention of iodine-123 or iodine-131 labelled hypericin ((123/131)I-Hyp), a necrosis avid agent for an anticancer radiotherapy...
  2. pmc Exploring theranostic potentials of radioiodinated hypericin in rodent necrosis models
    Junjie Li
    1 Theragnostic Laboratory, Department of Imaging and Pathology, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium 2 Molecular Small Animal Imaging Centre MoSAIC, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium
    Theranostics 2:1010-9. 2012
    ..The present animal experiments were conducted to evaluate radioiodinated Hypericin (Hyp) for its regional distribution as well as theranostic potentials...
  3. pmc Small Molecule Sequential Dual-Targeting Theragnostic Strategy (SMSDTTS): from Preclinical Experiments towards Possible Clinical Anticancer Applications
    Junjie Li
    1 Department of Imaging and Pathology, Biomedical Sciences Group KU Leuven, Belgium 2 Molecular Small Animal Imaging Center, Faculty of Medicine KU Leuven, Belgium
    J Cancer 4:133-45. 2013
    ..Meanwhile, possible drawbacks, practical challenges and future improvement with SMSDTTS are discussed, which hopefully may help to push forward this strategy from preclinical experiments towards possible clinical applications...
  4. pmc Towards stratifying ischemic components by cardiac MRI and multifunctional stainings in a rabbit model of myocardial infarction
    Yuanbo Feng
    1 KU Leuven, Department of Imaging and Pathology, Theragnostic Laboratory, Radiology Section, University Hospital Gasthuisberg, Leuven, Belgium
    Theranostics 4:24-35. 2013
    ..We sought to identify critical components of myocardial infarction (MI) including area at risk (AAR), MI-core and salvageable zone (SZ) by using cardiac magnetic resonance imaging (cMRI) and multifunctional stainings in rabbits...
  5. doi request reprint Tumor models and specific contrast agents for small animal imaging in oncology
    Yicheng Ni
    Section of Radiology, Department of Medical Diagnostic Sciences, Biomedical Sciences Group, University of Leuven, Belgium
    Methods 48:125-38. 2009
    ....
  6. ncbi request reprint Diffusion-weighted MRI of hepatic tumor in rats: comparison between in vivo and postmortem imaging acquisitions
    Xihe Sun
    Section of Radiology, Department of Medical Diagnostic Science, University Hospitals, University of Leuven, Leuven, Belgium
    J Magn Reson Imaging 29:621-8. 2009
    ..To determine the feasibility of in vivo diffusion-weighted imaging (DWI) to distinguish between normal liver, viable tumor and necrosis compared to postmortem DWI in a rat model with vascular-targeting treatment...
  7. ncbi request reprint Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT
    Humphrey Fonge
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K U Leuven, O and N 2, Box 821, Herestraat 49, BE 3000 Leuven, Belgium
    Eur Heart J 29:260-9. 2008
    ....
  8. doi request reprint Treatment of rodent liver tumor with combretastatin a4 phosphate: noninvasive therapeutic evaluation using multiparametric magnetic resonance imaging in correlation with microangiography and histology
    Huaijun Wang
    Department of Medical Diagnostic Science, University of Leuven, Leuven, Belgium
    Invest Radiol 44:44-53. 2009
    ....
  9. ncbi request reprint Rodent stroke induced by photochemical occlusion of proximal middle cerebral artery: evolution monitored with MR imaging and histopathology
    Feng Chen
    Department of Radiology, Faculty of Medicine, Catholic University of Leuven, Belgium
    Eur J Radiol 63:68-75. 2007
    ..To longitudinally investigate stroke in rats after photothrombotic occlusion of proximal middle cerebral artery (MCA) with magnetic resonance imaging (MRI) in correlation with histopathology...
  10. ncbi request reprint Exploring multifunctional features of necrosis avid contrast agents
    Yicheng Ni
    Department of Radiology, University Hospitals, Catholic University of Leuven, Belgium
    Acad Radiol 9:S488-90. 2002
  11. ncbi request reprint Diffusion weighted imaging in small rodents using clinical MRI scanners
    Feng Chen
    Biomedical Imaging, Interventional Therapy and Contrast Media Research, Department of Radiology, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Methods 43:12-20. 2007
    ....
  12. ncbi request reprint Murine liver implantation of radiation-induced fibrosarcoma: characterization with MR imaging, microangiography and histopathology
    Huaijun Wang
    Department of Radiology, University Hospitals, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur Radiol 18:1422-30. 2008
    ..05). Liver implantation of RIF-1 in mice proves a feasible and reproducible model and appears promising for use to screen new diagnostics and therapeutics under noninvasive monitoring even with a clinical MRI system...
  13. doi request reprint Comparative study of iodine-123-labeled hypericin and (99m)Tc-labeled hexakis [2-methoxy isobutyl isonitrile] in a rabbit model of myocardial infarction
    Marlein M Cona
    Department of Imaging and Pathology and Molecular Small Animal Imaging Centre MoSAIC, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, Leuven, Belgium Nuclear Medicine Section, University Hospital Group, UZ Leuven, Leuven, Belgium and Faculty of Pharmaceutical Sciences, Biomedical Sciences Group, KU Leuven, Leuven, Belgium
    J Cardiovasc Pharmacol 62:304-11. 2013
    ..I-Hyp distribution in rabbits is characterized by hepatobiliary excretion. (99m)Tc-Sestamibi undergoes hepatorenal elimination...
  14. doi request reprint Radiolabeled iodohypericin as tumor necrosis avid tracer: diagnostic and therapeutic potential
    Marie Van De Putte
    Laboratorium voor Farmaceutische Biologie, Faculteit Farmaceutische Wetenschappen, KU Leuven, Leuven, Belgium
    Int J Cancer 131:E129-37. 2012
    ..In conclusion, we showed that hypericin radiolabeled with iodine is a necrosis avid tracer that can be used both as a tumor diagnostic and therapeutic...
  15. pmc Enhanced antitumor efficacy of a vascular disrupting agent combined with an antiangiogenic in a rat liver tumor model evaluated by multiparametric MRI
    Feng Chen
    Theragnostic Laboratory, Department of Imaging and Pathology, University Hospital, University of Leuven, Leuven, Belgium
    PLoS ONE 7:e41140. 2012
    ..ZdTha showed improved therapeutic efficacy in solid tumors compared to either agent alone. The therapeutic effects were successfully tracked in vivo with multiparametric MRI...
  16. pmc Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts
    Junjie Li
    Theranostic Laboratory, Department of Imaging and Pathology, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium
    Theranostics 3:127-37. 2013
    ..Based on the soil-to-seeds principle, we explored the small-molecular sequential dual-targeting theranostic strategy (SMSDTTS) for prolonged survival and imaging detectability in a xenograft tumor model...
  17. ncbi request reprint Microplasmin and tissue plasminogen activator: comparison of therapeutic effects in rat stroke model at multiparametric MR imaging
    Feng Chen
    Department of Radiology, University Hospitals, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Radiology 244:429-38. 2007
    ..To prospectively compare therapeutic and hemorrhagic effects of microplasmin and tissue plasminogen activator (tPA) in stroke therapy by using multiparametric magnetic resonance (MR) imaging in a photothrombotic rat stroke model...
  18. doi request reprint Comparison of two vascular-disrupting agents at a clinically relevant dose in rodent liver tumors with multiparametric magnetic resonance imaging biomarkers
    Huaijun Wang
    Department of Radiology, University Hospitals, University of Leuven, Belgium
    Anticancer Drugs 23:12-21. 2012
    ..A single dose of vascular-disrupting agent was insufficient to destroy the tumor. The multiparametric MRI biomarkers enabled in-vivo noninvasive comparison of therapeutic efficacy between CA4P and ZD6126...
  19. ncbi request reprint Detection and quantification of acute reperfused myocardial infarction in rabbits using DISA-SPECT/CT and 3.0T cardiac MRI
    Yuanbo Feng
    Theragnostic Laboratory and Radiology Section, Department of Imaging and Pathology, Biomedical Sciences Group, KU Leuven, Leuven, Belgium
    Int J Cardiol 168:4191-8. 2013
    ....
  20. doi request reprint Pretargeting of necrotic tumors with biotinylated hypericin using 123I-labeled avidin: evaluation of a two-step strategy
    Thierry Marysael
    Laboratorium voor Farmaceutische Biologie, Faculteit Farmaceutische Wetenschappen, KU Leuven, Herestraat 49 bus 824, B 3000, Leuven, Belgium
    Invest New Drugs 30:2132-40. 2012
    ..However, for a more efficient accumulation of the effector molecule in necrotic tissue, other pretargeting strategies need to be investigated...
  21. doi request reprint Development and evaluation of a 68Ga labeled pamoic acid derivative for in vivo visualization of necrosis using positron emission tomography
    Kristof Prinsen
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, and Department of Radiology, University Hospital Gasthuisberg, Herestraat 49, Box 821, BE 3000 Leuven, Belgium
    Bioorg Med Chem 18:5274-81. 2010
    ..These results show that 68Ga-bis-DTPA-PA specifically binds to necrotic tissue and is a promising tracer for in vivo visualization of necrosis using PET...
  22. pmc Diffusion-weighted magnetic resonance imaging allows noninvasive in vivo monitoring of the effects of combretastatin a-4 phosphate after repeated administration
    Harriet C Thoeny
    Department of Radiology, University Hospitals Leuven, Herestraat 49, Leuven B 3000, Belgium
    Neoplasia 7:779-87. 2005
    ..Repeated CA-4-P administration retains efficacy in rat rhabdomyosarcomas, with similar findings after each drug administration...
  23. ncbi request reprint Comparison between nonspecific and necrosis-avid gadolinium contrast agents in vascular disrupting agent-induced necrosis of rodent tumors at 3.0T
    Huaijun Wang
    Department of Radiology, University Hospitals, University of Leuven, Belgium
    Invest Radiol 46:531-8. 2011
    ....
  24. doi request reprint Radiolabeling and preliminary biological evaluation of a (99m)Tc(CO)(3) labeled 3,3'-(benzylidene)-bis-(1H-indole-2-carbohydrazide) derivative as a potential SPECT tracer for in vivo visualization of necrosis
    Kristof Prinsen
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Herestraat 49, Box 821, BE 3000 Leuven, Belgium
    Bioorg Med Chem Lett 21:502-5. 2011
    ..The obtained results indicate that (99m)Tc(CO)(3)-bis-DTPA-BI displays selective uptake in necrotic tissue and can be used for in vivo visualization of necrosis by SPECT...
  25. doi request reprint A modified rabbit model of reperfused myocardial infarction for cardiac MR imaging research
    Yuanbo Feng
    Department of Radiology, University Hospitals, Catholic University of Leuven, Leuven, Belgium
    Int J Cardiovasc Imaging 25:289-98. 2009
    ..994). The usefulness of this model was successfully tested for assessing a new contrast agent. The present rabbit MI model may offer a practical platform for more translational research using clinical MRI-facilities...
  26. ncbi request reprint Liver tumor model with implanted rhabdomyosarcoma in rats: MR imaging, microangiography, and histopathologic analysis
    Feng Chen
    Department of Radiology and Laboratory of Experimental Radiobiology and Oncology, University Hospitals, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Radiology 239:554-62. 2006
    ..Implantation of a rhabdomyosarcoma tumor in the livers of rats is feasible and reproducible, and this animal model seems promising for future testing of new diagnostic and therapeutic strategies...
  27. doi request reprint Synthesis and biological evaluation of 68Ga labeled bis-DOTA-3,3'-(benzylidene)-bis-(1H-indole-2-carbohydrazide) as a PET tracer for in vivo visualization of necrosis
    Kristof Prinsen
    KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Laboratory of Radiopharmacy, Herestraat 49, Box 821, BE 3000 Leuven, Belgium
    Bioorg Med Chem Lett 23:3216-20. 2013
    ..The novel (68)Ga labeled tracer showed an improved in vivo stability and could therefore be used for selective non-invasive imaging of necrotic cell death using PET...
  28. ncbi request reprint Evaluation of tumor affinity of mono-[(123)I]iodohypericin and mono-[(123)I]iodoprotohypericin in a mouse model with a RIF-1 tumor
    Humphrey Fonge
    Laboratory of Radiopharmacy, Faculty of Pharmaceutical Sciences, KU Leuven, Herestraat 49, Box 821, B 3000, Leuven
    Contrast Media Mol Imaging 2:113-9. 2007
    ..Mono-[(123)I]iodohypericin appears to be more promising as a tumor diagnostic agent, given its faster clearance from all organs...
  29. doi request reprint Study on the microbial safety of an infusion set for contrast-enhanced imaging
    Marlein Miranda Cona
    Radiology Section, Department of Imaging and Pathology, Biomedical Sciences Group, University of Leuven, Belgium
    Invest Radiol 47:247-51. 2012
    ..The purpose of this experiment was to verify whether a newly developed replaceable patient-delivery system may allow multiple uses of the system but without such risks...
  30. ncbi request reprint Rat cerebral ischemia induced with photochemical occlusion of proximal middle cerebral artery: a stroke model for MR imaging research
    Feng Chen
    Department of Radiology, University Hospitals, K U Leuven, Herestraat 49, 3000, Leuven, Belgium
    MAGMA 17:103-8. 2004
    ..The present PIT model in rats has been successfully adopted for MRI research, which might be feasible for certain stroke studies and should be beneficial for the evaluation on effects of potential diagnostic and therapeutic approaches...
  31. doi request reprint Morphological, functional and metabolic imaging biomarkers: assessment of vascular-disrupting effect on rodent liver tumours
    Huaijun Wang
    Department of Radiology, University Hospitals, University of Leuven, Leuven, Belgium
    Eur Radiol 20:2013-26. 2010
    ..To evaluate effects of a vascular-disrupting agent on rodent tumour models...
  32. ncbi request reprint Synthesis and biological evaluation of 68Ga-bis-DOTA-PA as a potential agent for positron emission tomography imaging of necrosis
    Kristof Prinsen
    KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Radiopharmacy, Herestraat 49, Box 821, BE 3000, Leuven, Belgium
    Nucl Med Biol 40:816-22. 2013
    ..The resulting complex ((68)Ga-bis-DOTA-PA; (68)Ga-3) was evaluated as a potential radiotracer for imaging tissues undergoing cellular death via necrosis...
  33. ncbi request reprint First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent
    Yicheng Ni
    Department of Radiology, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 33:595-601. 2006
    ..We have labelled hypericin, a polyphenolic polycyclic quinone found in St. John's wort (Hypericum perforatum), with( 123)I and evaluated mono-[(123)I]iodohypericin (MIH) as a potential necrosis-avid diagnostic tracer agent...
  34. ncbi request reprint Magnetic resonance imaging after radiofrequency ablation in a rodent model of liver tumor: tissue characterization using a novel necrosis-avid contrast agent
    Yicheng Ni
    Department of Radiology, University Hospitals, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur Radiol 16:1031-40. 2006
    ..This approach may prove useful for defining the ablated area and identifying residual tumor after RFA...
  35. ncbi request reprint Visualization of stroke with clinical MR imagers in rats: a feasibility study
    Feng Chen
    Department of Radiology, University Hospitals, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Radiology 233:905-11. 2004
    ..05). There was no difference in lesion size at perfusion-weighted MR imaging between superacute and subacute phases (P > .05). Performance of certain stroke-related research in rats is feasible with clinical MR imagers...
  36. ncbi request reprint Preliminary in vivo evaluation of a novel 99mTc-labeled HYNIC-cys-annexin A5 as an apoptosis imaging agent
    Humphrey Fonge
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K U Leuven, O and N 2, Box 821, Herestraat 49, BE 3000 Leuven, Belgium
    Bioorg Med Chem Lett 18:3794-8. 2008
    ..The results indicate that the novel 99mTc-HYNIC-cys-annexin A5 shows similar apoptosis avidity as the 1st generation 99mTc-HYNIC-annexin A5...
  37. ncbi request reprint Delayed perfusion phenomenon in a rat stroke model at 1.5 T MR: an imaging sign parallel to spontaneous reperfusion and ischemic penumbra?
    Feng Chen
    Department of Radiology, University Hospitals, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Radiol 61:70-8. 2007
    ..Delayed perfusion (DP) sign at MR imaging was reported in stroke patients. We sought to experimentally elucidate its relation to spontaneous reperfusion and ischemic penumbra...
  38. ncbi request reprint A dual-targeting anticancer approach: soil and seed principle
    Junjie Li
    Department of Radiology, University of Leuven, Campus Gasthuisberg, Herestraat 49, Leuven 3000, Belgium
    Radiology 260:799-807. 2011
    ..To test the hypothesis that targeting the microenvironment (soil) may effectively kill cancer cells (seeds) through a small-molecular weight sequential dual-targeting theragnostic strategy, or dual-targeting approach...
  39. ncbi request reprint Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model
    Marie Van De Putte
    Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, University Hospital, K U Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Acad Radiol 15:107-13. 2008
    ..In this preclinical proof-of-principle study, the necrosis avid agent hypericin was investigated as a potential early indicator for therapeutic response after ethanol-mediated chemical ablation in murine liver tumors...
  40. ncbi request reprint Dynamic susceptibility contrast-enhanced perfusion MR imaging at 1.5 T predicts final infarct size in a rat stroke model
    Feng Chen
    Department of Radiology, University Hospitals, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Neurosci Methods 141:55-60. 2005
    ..05) suggests that early source images from DSC-PWI at 1.5T MR scanner is feasible to noninvasively predict the final infarct size in rat models of stroke...
  41. doi request reprint A safety study on single intravenous dose of tetrachloro-diphenyl glycoluril [iodogen] dissolved in dimethyl sulphoxide (DMSO)
    Marlein Miranda Cona
    Department of Imaging and Pathology, Biomedical Sciences Group, KU Leuven, Leuven, Belgium
    Xenobiotica 43:730-7. 2013
    ..No pathologies were found by gross and microscopic inspection. 4. A single dose of iodogen/DMSO up to 30.0 mg/kg, over 3000 times the dose in potential human applications, appears safe, with an LD50 doubling that dose in mice...
  42. doi request reprint A review on various targeted anticancer therapies
    Junjie Li
    Section of Radiology, Department of Diagnostic Sciences, Faculty of Medicine, University of Leuven, Herestraat 49, BE 3000, Leuven, Belgium
    Target Oncol 7:69-85. 2012
    ....
  43. ncbi request reprint Continuing pursuit for ideal systemic anticancer radiotherapeutics
    Marlein Miranda Cona
    Radiology Section, Department of Medical Diagnostic Sciences, Biomedical Sciences Group, University of Leuven, Leuven, Belgium
    Invest New Drugs 30:2050-65. 2012
    ..It may considerably enhance the therapeutic response and open a new horizon for improved cancer treatability or curability...
  44. ncbi request reprint Necrosis avidity of (99m)Tc(CO)3-labeled pamoic acid derivatives: synthesis and preliminary biological evaluation in animal models of necrosis
    Humphrey Fonge
    Laboratory of Radiopharmacy, Faculty of Pharmaceutical Sciences, KU Leuven, Herestraat 49, BE 3000, Leuven, Belgium
    Bioconjug Chem 18:1924-34. 2007
    ..99m)Tc(CO) 3-bis-DTPA-pamoate shows high specificity for necrotic tissue and merits further evaluation as a necrosis avid imaging agent. (99m)Tc(CO) 3 -12 is not useful for visualization of necrotic tissue...
  45. doi request reprint Radioiodinated hypericin: its biodistribution, necrosis avidity and therapeutic efficacy are influenced by formulation
    Marlein Miranda Cona
    Department of Imaging and Pathology, Faculty of Medicine Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium
    Pharm Res 31:278-90. 2014
    ..To study whether formulation influences biodistribution, necrosis avidity and tumoricidal effects of the radioiodinated hypericin, a necrosis avid agent for a dual-targeting anticancer radiotherapy...
  46. ncbi request reprint Diffusion-weighted MR imaging in monitoring the effect of a vascular targeting agent on rhabdomyosarcoma in rats
    Harriet C Thoeny
    Department of Radiology, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Radiology 234:756-64. 2005
    ..To evaluate diffusion-weighted magnetic resonance (MR) imaging for monitoring tumor response in rats after administration of combretastatin A4 phosphate...
  47. pmc Diverse responses to vascular disrupting agent combretastatin a4 phosphate: a comparative study in rats with hepatic and subcutaneous tumor allografts using MRI biomarkers, microangiography, and histopathology
    Junjie Li
    Theragnostic Laboratory, Department of Imaging and Pathology, Biomedical Sciences Group, KU Leuven, Leuven, Belgium Molecular Small Animal Imaging Centre MoSAIC, Biomedical Sciences Group, KU Leuven, Leuven, Belgium
    Transl Oncol 6:42-50. 2013
    ..To test this hypothesis, we compared the responses of rodent hepatic and subcutaneous engrafts of rhabdomyosarcoma-1 (R1) to a vascular disrupting agent Combretastatin A4 phosphate (CA4P)...
  48. doi request reprint Preclinical imaging of therapy response using metabolic and apoptosis molecular imaging
    Marijke De Saint-Hubert
    Department of Nuclear Medicine, University Hospital Gasthuisberg Leuven, Leuven, Belgium
    Mol Imaging Biol 13:995-1002. 2011
    ..This study uses an improved apoptosis probe ((99m)Tc-hAnxA5) in combination with [(18)F]FDG imaging to evaluate therapy response...
  49. doi request reprint Improved clearance of radioiodinated hypericin as a targeted anticancer agent by using a duodenal drainage catheter in rats
    Marlein Miranda Cona
    Department of Imaging and Pathology, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium
    Exp Biol Med (Maywood) 238:1437-49. 2013
    ..Radiation overexposure due to the prolonged elimination of iodine-131-labeled hypericin can be prevented using this approach. ..
  50. ncbi request reprint Necrosis avid contrast agents: functional similarity versus structural diversity
    Yicheng Ni
    Department of Radiology, University Hospital, Catholic University of Leuven, Leuven, Belgium
    Invest Radiol 40:526-35. 2005
    ....
  51. doi request reprint Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors
    Thierry Marysael
    Laboratorium voor Farmaceutische Biologie, Faculteit Farmaceutische Wetenschappen, K U Leuven, Herestraat 49 bus 824, 3000 Leuven, Belgium
    J Cancer Res Clin Oncol 137:1619-27. 2011
    ..ZD6126) and sequence of administration (VDA 24 h before HYP vs. HYP 1 h before VDA) to evaluate the effect on hypericin (HYP) accumulation and distribution in necrotic tumors...
  52. ncbi request reprint In vivo hepatocyte MR imaging using lactose functionalized magnetoliposomes
    Ashwini Ketkar-Atre
    Biomedical MRI MoSAIC, Department of Imaging and Pathology, Biomedical Sciences Group, Katholieke Universiteit Leuven, Herestraat 49, B3000 Leuven, Belgium
    Biomaterials 35:1015-24. 2014
    ..These data demonstrate that galactose-functionalized MLs can be used as a hepatocyte targeting MR contrast agent to potentially aid in the diagnosis of hepatic diseases if the non-specific uptake by KCs is taken into account...
  53. ncbi request reprint Synthesis and preliminary evaluation of mono-[123I]iodohypericin monocarboxylic acid as a necrosis avid imaging agent
    Humphrey Fonge
    Laboratory of Radiopharmacy, Faculty of Pharmaceutical Sciences, K U Leuven, BE 3000 Leuven, Belgium
    Bioorg Med Chem Lett 17:4001-5. 2007
    ..The results indicate the feasibility of visualization of necrotic tissue with the novel tracer...
  54. doi request reprint Bipolar radiofrequency ablation with four electrodes: ex vivo liver experiments and finite element method analysis. Influence of inter-electrode distance on coagulation size and geometry
    Stefaan Mulier
    Theragnostic Laboratory, Department of Imaging and Pathology, Biomedical Sciences Group, KU Leuven, Belgium
    Int J Hyperthermia 28:686-97. 2012
    ..The aim of this study was to develop an electrode system with simple needle electrodes which would allow a reliable and predictable ablation zone with radiofrequency ablation (RFA)...
  55. ncbi request reprint Experimental and clinical radiofrequency ablation: proposal for standardized description of coagulation size and geometry
    Stefaan Mulier
    Department of Radiology, Gasthuisberg University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Ann Surg Oncol 14:1381-96. 2007
    ..The aim of this study was to develop a standardized terminology to describe the size and geometry of these zones for experimental and clinical RF...
  56. doi request reprint Biodistribution and radiation dosimetry of radioiodinated hypericin as a cancer therapeutic
    Marlein Miranda Cona
    Department of Imaging and Pathology, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, Leuven, Belgium
    Int J Oncol 44:819-29. 2014
    ..Among normal organs, thyroids, lungs and intestines receive considerable radiation dose, which deserves cautious attention in developing this anticancer approach. ..
  57. doi request reprint Cancer models-multiparametric applications of clinical MRI in rodent hepatic tumor model
    Feng Chen
    Section of Radiology, Department of Medical Diagnostic Sciences, University of Leuven, Leuven, Belgium
    Methods Mol Biol 771:489-507. 2011
    ..In this chapter, the details about this complete MRI protocol and the rodent liver tumor model are described in order to facilitate the readers to perform their own translational animal imaging research...
  58. ncbi request reprint Potentiation of photodynamic therapy with hypericin by mitomycin C in the radiation-induced fibrosarcoma-1 mouse tumor model
    Bin Chen
    Laboratory of Pharmaceutical Biology and Phytopharmacology, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Van Evenstraat 4, B 3000, Leuven, Belgium
    Photochem Photobiol 78:278-82. 2003
    ..No greater skin reaction was observed after the combination of MMC and PDT than after PDT alone. Our study demonstrates that combining hypericin-PDT with MMC can be effective in enhancing tumor response with little side effect...
  59. ncbi request reprint Microplasmin reduces ischemic brain damage and improves neurological function in a rat stroke model monitored with MRI
    Yasuhiro Suzuki
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    Stroke 35:2402-6. 2004
    ..Microplasmin (microPli), a derivative of plasmin lacking the 5 "kringle" domains, was studied in a rat thrombotic stroke model with MRI monitoring...
  60. ncbi request reprint Necrosis-avid contrast agents: introducing nonporphyrin species
    Yicheng Ni
    Biomedical Imaging, Department of Radiology, University Hospitals, K U Leuven, Belgium
    Acad Radiol 9:S98-101. 2002
  61. pmc Automated quantitative gait analysis in animal models of movement disorders
    Caroline Vandeputte
    Laboratory for Neurobiology and Gene Therapy, Molecular Medicine, K U Leuven, Belgium
    BMC Neurosci 11:92. 2010
    ..Static and dynamic gait parameters were measured in all animal models, and these data were compared to readouts of established behavioral tests, such as the cylinder test in the PD and stroke rats and the rotarod tests for the HD group...
  62. ncbi request reprint Evaluation of radiofrequency ablation as an alternative for the treatment of brain tumor in rabbits
    Yi Mia
    Department of Radiology, University Hospitals, KU Leuven, Belgium
    J Neurooncol 56:119-26. 2002
    ..The recognized characters of thermal lesion on MRI and histology may prove valuable in delimitating the ablation range and understanding the biological response of the RFA...
  63. pmc Multiparametric MRI biomarkers for measuring vascular disrupting effect on cancer
    Huaijun Wang
    Huaijun Wang, Guy Marchal, Yicheng Ni, Department of Radiology, University Hospitals, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    World J Radiol 3:1-16. 2011
    ....
  64. doi request reprint Topical HDL administration reduces vein graft atherosclerosis in apo E deficient mice
    Yingmei Feng
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    Atherosclerosis 214:271-8. 2011
    ..Topical high-density lipoprotein (HDL) administration on the adventitial side of vein grafts was evaluated as a new therapeutic modality to improve vein graft patency and function...