K Mubagwa

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Channels involved in transient currents unmasked by removal of extracellular calcium in cardiac cells
    Regina Macianskiene
    Laboratory of Cardiac Cellular Research, Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Belgium
    Am J Physiol Heart Circ Physiol 282:H1879-88. 2002
  2. pmc Mechanisms underlying the frequency dependence of contraction and [Ca(2+)](i) transients in mouse ventricular myocytes
    Gudrun Antoons
    Laboratory of Experimental Cardiology, University of Leuven, Belgium
    J Physiol 543:889-98. 2002
  3. ncbi request reprint Spatial and temporal inhomogeneities during Ca2+ release from the sarcoplasmic reticulum in pig ventricular myocytes
    Frank R Heinzel
    Laboratory of Experimental Cardiology, University of Leuven, Leuven, Belgium
    Circ Res 91:1023-30. 2002
  4. ncbi request reprint Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure
    Gudrun Antoons
    Laboratory of Experimental Cardiology, University of Leuven, Campus Gasthuisberg O N 704, Herestraat 49, B 3000 Leuven, Belgium
    J Mol Cell Cardiol 40:350-60. 2006
  5. ncbi request reprint Calcium uptake by the sarcoplasmic reticulum, high energy content and histological changes in ischemic cardiomyopathy
    K Mubagwa
    Laboratory of Experimental Cardiac Surgery, Katholieke Universiteit Leuven, Belgium
    Cardiovasc Res 37:515-23. 1998
  6. ncbi request reprint KB130015, a new amiodarone derivative with multiple effects on cardiac ion channels
    Kanigula Mubagwa
    Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Belgium
    Cardiovasc Drug Rev 21:216-35. 2003
  7. ncbi request reprint Adenosine, adenosine receptors and myocardial protection: an updated overview
    K Mubagwa
    Centre for Experimental Surgery and Anaesthesiology, University of Leuven, 3000, Leuven, Belgium
    Cardiovasc Res 52:25-39. 2001
  8. pmc Action potential changes associated with a slowed inactivation of cardiac voltage-gated sodium channels by KB130015
    R Macianskiene
    Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Leuven B 3000, Belgium
    Br J Pharmacol 139:1469-79. 2003
  9. ncbi request reprint Suppression of transient outward potassium currents in mouse ventricular myocytes by imidazole antimycotics and by glybenclamide
    M J Hernandez-Benito
    Laboratory of Cardiac Cellular Research, Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Leuven, Belgium
    J Pharmacol Exp Ther 298:598-606. 2001
  10. pmc Extracellular divalent cations block a cation non-selective conductance unrelated to calcium channels in rat cardiac muscle
    K Mubagwa
    Centrum voor Experimentele Heelkunde en Anesthesiologie, University of Leuven, Belgium
    J Physiol 502:235-47. 1997

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Channels involved in transient currents unmasked by removal of extracellular calcium in cardiac cells
    Regina Macianskiene
    Laboratory of Cardiac Cellular Research, Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Belgium
    Am J Physiol Heart Circ Physiol 282:H1879-88. 2002
    ..They could be increased by BAY K-8644 or by isoproterenol. We conclude that the I(to)-like currents are due to monovalent cation flow through L-type Ca(2+) channels, which in pig myocytes show low sensitivity to nifedipine...
  2. pmc Mechanisms underlying the frequency dependence of contraction and [Ca(2+)](i) transients in mouse ventricular myocytes
    Gudrun Antoons
    Laboratory of Experimental Cardiology, University of Leuven, Belgium
    J Physiol 543:889-98. 2002
    ..Small changes in this balance may contribute to variability in frequency-dependent behaviour. In addition, there may be a regulation of the contractile response downstream of [Ca(2+)](i)...
  3. ncbi request reprint Spatial and temporal inhomogeneities during Ca2+ release from the sarcoplasmic reticulum in pig ventricular myocytes
    Frank R Heinzel
    Laboratory of Experimental Cardiology, University of Leuven, Leuven, Belgium
    Circ Res 91:1023-30. 2002
    ..This lower number of functional couplons contributes to a slower overall rate of rise of [Ca2+]i...
  4. ncbi request reprint Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure
    Gudrun Antoons
    Laboratory of Experimental Cardiology, University of Leuven, Campus Gasthuisberg O N 704, Herestraat 49, B 3000 Leuven, Belgium
    J Mol Cell Cardiol 40:350-60. 2006
    ..This represents a novel paradigm for altered Ca(2+) handling in heart failure, underscoring the importance of phosphorylation pathways...
  5. ncbi request reprint Calcium uptake by the sarcoplasmic reticulum, high energy content and histological changes in ischemic cardiomyopathy
    K Mubagwa
    Laboratory of Experimental Cardiac Surgery, Katholieke Universiteit Leuven, Belgium
    Cardiovasc Res 37:515-23. 1998
    ..Sarcoplasmic reticulum (SR) Ca2+ uptake, myocardial high energy content and histology were examined in different zones of hearts from patients with ischemic cardiomyopathy...
  6. ncbi request reprint KB130015, a new amiodarone derivative with multiple effects on cardiac ion channels
    Kanigula Mubagwa
    Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Belgium
    Cardiovasc Drug Rev 21:216-35. 2003
    ..At high concentrations KB015 exerts a positive inotropic action. It also interacts with thyroid hormone nuclear receptors. Its toxic effects remain largely unexplored, but it is well tolerated during chronic administration...
  7. ncbi request reprint Adenosine, adenosine receptors and myocardial protection: an updated overview
    K Mubagwa
    Centre for Experimental Surgery and Anaesthesiology, University of Leuven, 3000, Leuven, Belgium
    Cardiovasc Res 52:25-39. 2001
    ..In addition, more studies are needed to clarify the signalling mechanisms by which A(3) receptor activation or overexpression may promote apoptosis and cellular injury, as reported by a few recent studies...
  8. pmc Action potential changes associated with a slowed inactivation of cardiac voltage-gated sodium channels by KB130015
    R Macianskiene
    Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Leuven B 3000, Belgium
    Br J Pharmacol 139:1469-79. 2003
    ..6 It is suggested that a prolongation of short action potentials by drugs or mutations that only slow I(Na) inactivation does not necessarily imply identical changes in other species or in different myocardial regions...
  9. ncbi request reprint Suppression of transient outward potassium currents in mouse ventricular myocytes by imidazole antimycotics and by glybenclamide
    M J Hernandez-Benito
    Laboratory of Cardiac Cellular Research, Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Leuven, Belgium
    J Pharmacol Exp Ther 298:598-606. 2001
    ..These data demonstrate a pharmacological separation of I(to) components using antimycotic drugs but not glybenclamide...
  10. pmc Extracellular divalent cations block a cation non-selective conductance unrelated to calcium channels in rat cardiac muscle
    K Mubagwa
    Centrum voor Experimentele Heelkunde en Anesthesiologie, University of Leuven, Belgium
    J Physiol 502:235-47. 1997
    ..6. These results suggest that a novel conductance pathway, permeable to monovalent cations but not to Cl- and blocked by divalent cations, exists in ventricular myocytes...
  11. ncbi request reprint Improved functional recovery after ischemic preconditioning in the globally ischemic rabbit heart is not mediated by adenosine A1 receptor activation
    M Hendrikx
    Laboratory for Experimental Cardiac Surgery, Katholieke Universiteit Leuven, Belgium
    Basic Res Cardiol 88:576-93. 1993
    ..Administration of exogenous adenosine reduces functional impairment to a certain extent, but less than preconditioning...
  12. ncbi request reprint Modulation of the extracellular divalent cation-inhibited non-selective conductance in cardiac cells by metabolic inhibition and by oxidants
    R Macianskiene
    Laboratory of Cardiac Cellular Research, Centre for Experimental Surgery and Anaesthesiology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Leuven, B-3000, Belgium
    J Mol Cell Cardiol 33:1371-85. 2001
    ....
  13. pmc Induction of a novel cation current in cardiac ventricular myocytes by flufenamic acid and related drugs
    R Macianskiene
    Division of Experimental Cardiac Surgery, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Br J Pharmacol 161:416-29. 2010
    ..Interest in non-selective cation channels has increased recently following the discovery of transient receptor potential (TRP) proteins, which constitute many of these channels...
  14. ncbi request reprint Antiarrhythmic drugs and cardiac ion channels: mechanisms of action
    E Carmeliet
    Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Belgium
    Prog Biophys Mol Biol 70:1-72. 1998
    ..Finally, the question is asked as to whether the available drugs by their action on channels and receptors modify the vulnerable parameter in the desired way to stop or prevent arrhythmias...
  15. ncbi request reprint Deterioration of the protein kinase C-K(ATP) channel pathway in regulation of coronary flow in hypercholesterolaemic rabbits
    E Pongo
    Centre of Experimental Surgery and Anaesthesiology, Katholieke Universiteit Minderbroedenstraat 17, B-3000, Leuven, Belgium
    Eur J Pharmacol 418:217-23. 2001
    ..We conclude that non-cholesterol mevalonate products are necessary for the functional integrity of the protein kinase C-K(ATP) channel pathway in the rabbit heart...
  16. ncbi request reprint Slowing of the inactivation of cardiac voltage-dependent sodium channels by the amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015)
    R Macianskiene
    Centre for Experimental Surgery and Anaesthesiology, University of Leuven, Leuven, Belgium
    J Pharmacol Exp Ther 304:130-8. 2003
    ..These data suggest the existence of a binding site for KB and T3 on Na+ channels...
  17. ncbi request reprint [Na(+)] in the subsarcolemmal 'fuzzy' space and modulation of [Ca(2+)](i) and contraction in cardiac myocytes
    Fons Verdonck
    Interdisciplinary Research Center, Katholieke University of Leuven, Campus Kortrijk, Kortrijk, Belgium
    Cell Calcium 35:603-12. 2004
    ..This has implications for modulation of [Ca(2+)](i) during a single beat as well as during alterations in Na(+) fluxes seen in pathological conditions...
  18. ncbi request reprint The amiodarone derivative KB130015 [2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran] induces an Na+-dependent increase of [Ca2+] in ventricular myocytes
    Virginie Bito
    Laboratory of Experimental Cardiology, Catholic University Leuven, Campus Gasthuisberg O N 7th Floor, Herestraat 49, B 3000 Leuven, Belgium
    J Pharmacol Exp Ther 316:162-8. 2006
    ..This effect is partially offset by a decrease in I(CaL) resulting in a mild inotropic effect without the signs of Ca(2+) overload and related arrhythmias usually associated with Na(+) channel openers...
  19. doi request reprint Inhibition of the magnesium-sensitive TRPM7-like channel in cardiac myocytes by nonhydrolysable GTP analogs: involvement of phosphoinositide metabolism
    Regina Macianskiene
    Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    Cell Physiol Biochem 22:109-18. 2008
    ..A magnesium-inhibited, transient receptor potential melastatin 7 (TRPM7)-like channel is expressed in cardiac cell membranes. The role and regulation of this channel by intracellular nucleotides and membrane components remain unclear...
  20. ncbi request reprint Regulation of cation channels in cardiac and smooth muscle cells by intracellular magnesium
    Kanigula Mubagwa
    Division of Experimental Cardiac Surgery, Department of Heart and Vessel Diseases, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Arch Biochem Biophys 458:73-89. 2007
    ..Modifications of cardiovascular electrical or mechanical function, possibly resulting in arrhythmias or hypertension, may result from such changes of Mg(i)(2+) and their effects on cation channels...
  21. ncbi request reprint ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes
    Asfree Gwanyanya
    Experimental Cardiac Surgery, Heart and Vessel Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Physiol Cell Physiol 291:C627-35. 2006
    ..Finally, loading ATP-depleted cells with exogenous PIP(2) (10 microM) prevented rundown. These results suggest that PIP(2), likely generated by ATP-utilizing lipid kinases, is necessary for maintaining cardiac MIC channel activity...
  22. pmc Magnesium-inhibited, TRPM6/7-like channel in cardiac myocytes: permeation of divalent cations and pH-mediated regulation
    Asfree Gwanyanya
    Centre for Experimental Surgery and Anaesthesiology, Katholieke Universiteit, Leuven, Belgium
    J Physiol 559:761-76. 2004
    ..Our results suggest that IMIC in cardiac cells is due to TRPM channels, most probably to TRPM6 or TRPM7 channels or to their heteromultimeres...
  23. ncbi request reprint Reduced synchrony of Ca2+ release with loss of T-tubules-a comparison to Ca2+ release in human failing cardiomyocytes
    William E Louch
    Laboratory of Experimental Cardiology, University of Leuven, Campus Gasthuisberg O N 7th Floor, Herestraat 49, B 3000 Leuven, Belgium
    Cardiovasc Res 62:63-73. 2004
    ..A partial loss of T-tubules has been described in myocytes from failing canine and human hearts. We examined how graded reduction of T-tubule density would affect the synchrony of Ca2+ release...
  24. pmc Monovalent cation (MC) current in cardiac and smooth muscle cells: regulation by intracellular Mg2+ and inhibition by polycations
    Sergey I Zakharov
    Vascular Biology Unit, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, U S A
    Br J Pharmacol 138:234-44. 2003
    ..7 It is concluded that MC current could be regulated by intracellular Mg(2+), and low concentrations of extracellular spermine could be used to discriminate it from SOC current, and to assess its role in cellular function...
  25. ncbi request reprint Overexpression of the Na/Ca exchanger shapes stimulus-induced cytosolic Ca(2+) oscillations in insulin-producing BRIN-BD11 cells
    Fran├žoise Van Eylen
    Laboratory of Pharmacology, Brussels University School of Medicine, Brussels, Belgium
    Diabetes 51:366-75. 2002
    ....
  26. ncbi request reprint Does adenosine protect the heart by acting on the sarcoplasmic reticulum?
    Kanigula Mubagwa
    Cardiovasc Res 53:286-9. 2002