Ludwig Missiaen

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function
    Santeri Kiviluoto
    Laboratory of Molecular and Cellular Signaling, Department Molecular Cell Biology, K, U, Leuven, Campus Gasthuisberg O N 1 bus 802, Herestraat 49, BE 3000 Leuven, Belgium
    Skelet Muscle 1:16. 2011
  2. ncbi request reprint Calcium in the Golgi apparatus
    Ludwig Missiaen
    Afdeling Fysiologie, Departement Moleculaire Celbiologie, KULeuven Campus Gasthuisberg O N, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Cell Calcium 41:405-16. 2007
  3. ncbi request reprint Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses
    Leonard Dode
    Laboratory of Physiology, Catholic University of Leuven, Campus Gasthuisberg O N, Herestraat 49, Bus 802, B 3000 Leuven, Belgium
    J Biol Chem 281:3182-9. 2006
  4. ncbi request reprint Regulation of the phosphorylation of the inositol 1,4,5-trisphosphate receptor by protein kinase C
    Elke Vermassen
    Laboratory of Physiology, K U Leuven Campus Gasthuisberg O N, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 319:888-93. 2004
  5. ncbi request reprint Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis
    Zerihun Assefa
    Afdeling Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg O N, Herestraat 49, 3000 Leuven, Belgium
    J Biol Chem 279:43227-36. 2004
  6. pmc Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation
    Veerle Vanderheyden
    Laboratory of Molecular and Cellular Signalling, Department Molecular and Cellular Biology, Campus Gasthuisberg O N1 K U Leuven, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1793:959-70. 2009
  7. pmc Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling
    Leen Verbert
    Laboratory of Molecular and Cellular Signalling, Division of Physiology, Department of Molecular Cell Biology, K U Leuven, Campus Gasthuisberg, O and N1 bus 802, B 3000 Leuven, Belgium
    Biol Cell 100:39-49. 2008
  8. ncbi request reprint Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses
    Leonard Dode
    Laboratory of Physiology, Catholic University of Leuven, Campus Gasthuisberg O N, Herestraat 49, Bus 802, B 3000 Leuven, Belgium
    J Biol Chem 280:39124-34. 2005
  9. ncbi request reprint The 12 kDa FK506-binding protein, FKBP12, modulates the Ca(2+)-flux properties of the type-3 ryanodine receptor
    Kristel Van Acker
    Laboratorium voor Fysiologie, Campus Gasthuisberg O N, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Cell Sci 117:1129-37. 2004
  10. pmc Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain
    Eva Sammels
    Department of Molecular Cell Biology, Laboratory of Molecular and Cellular Signaling, KU Leuven, Campus Gasthuisberg O and N1, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    J Biol Chem 285:18794-805. 2010

Collaborators

Detail Information

Publications41

  1. pmc STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function
    Santeri Kiviluoto
    Laboratory of Molecular and Cellular Signaling, Department Molecular Cell Biology, K, U, Leuven, Campus Gasthuisberg O N 1 bus 802, Herestraat 49, BE 3000 Leuven, Belgium
    Skelet Muscle 1:16. 2011
    ..In any case, the molecular determinants responsible for SOCE in human skeletal muscle and for dysregulated SOCE in patients of muscular dystrophy require further examination...
  2. ncbi request reprint Calcium in the Golgi apparatus
    Ludwig Missiaen
    Afdeling Fysiologie, Departement Moleculaire Celbiologie, KULeuven Campus Gasthuisberg O N, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Cell Calcium 41:405-16. 2007
    ..We will first review the physiology of the SPCAs and then discuss how mutated SPCA1 proteins can lead to an epidermal disorder...
  3. ncbi request reprint Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses
    Leonard Dode
    Laboratory of Physiology, Catholic University of Leuven, Campus Gasthuisberg O N, Herestraat 49, Bus 802, B 3000 Leuven, Belgium
    J Biol Chem 281:3182-9. 2006
    ....
  4. ncbi request reprint Regulation of the phosphorylation of the inositol 1,4,5-trisphosphate receptor by protein kinase C
    Elke Vermassen
    Laboratory of Physiology, K U Leuven Campus Gasthuisberg O N, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 319:888-93. 2004
    ....
  5. ncbi request reprint Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis
    Zerihun Assefa
    Afdeling Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg O N, Herestraat 49, 3000 Leuven, Belgium
    J Biol Chem 279:43227-36. 2004
    ....
  6. pmc Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation
    Veerle Vanderheyden
    Laboratory of Molecular and Cellular Signalling, Department Molecular and Cellular Biology, Campus Gasthuisberg O N1 K U Leuven, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1793:959-70. 2009
    ....
  7. pmc Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling
    Leen Verbert
    Laboratory of Molecular and Cellular Signalling, Division of Physiology, Department of Molecular Cell Biology, K U Leuven, Campus Gasthuisberg, O and N1 bus 802, B 3000 Leuven, Belgium
    Biol Cell 100:39-49. 2008
    ..Expression of this truncated IP(3)R increases the cellular sensitivity to apoptotic stimuli, and it was postulated to be a constitutively active channel...
  8. ncbi request reprint Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses
    Leonard Dode
    Laboratory of Physiology, Catholic University of Leuven, Campus Gasthuisberg O N, Herestraat 49, Bus 802, B 3000 Leuven, Belgium
    J Biol Chem 280:39124-34. 2005
    ..This could be accounted for by an enhanced rate of the E(2)-P hydrolysis, which showed constitutive activation, lacking the SERCA1a-specific dependence on pH and K(+)...
  9. ncbi request reprint The 12 kDa FK506-binding protein, FKBP12, modulates the Ca(2+)-flux properties of the type-3 ryanodine receptor
    Kristel Van Acker
    Laboratorium voor Fysiologie, Campus Gasthuisberg O N, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Cell Sci 117:1129-37. 2004
    ....
  10. pmc Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain
    Eva Sammels
    Department of Molecular Cell Biology, Laboratory of Molecular and Cellular Signaling, KU Leuven, Campus Gasthuisberg O and N1, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    J Biol Chem 285:18794-805. 2010
    ....
  11. ncbi request reprint SPCA1 pumps and Hailey-Hailey disease
    Ludwig Missiaen
    Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 322:1204-13. 2004
    ..Here, we review recent experimental evidence showing that the Golgi apparatus plays a much more important role in intracellular ion homeostasis than previously anticipated...
  12. pmc Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor
    Benoit Devogelaere
    Laboratory of Molecular and Cellular Signalling, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, Campus Gasthuisberg O N1, B 3000 Leuven, Belgium
    Biochem J 407:303-11. 2007
    ..Finally, we have shown that mutational inactivation of the docking site for PP1 on IRBIT increased the affinity of IRBIT for the IP3R. This pinpoints PP1 as a key player in the regulation of IP3R-controlled Ca2+ signals...
  13. doi request reprint Intracellular Ca2+ storage in health and disease: a dynamic equilibrium
    Eva Sammels
    Laboratory of Molecular and Cellular Signaling, Department of Molecular Cell Biology, KULeuven, Campus Gasthuisberg O N1 bus 802, Herestraat 49, B 3000 Leuven, Belgium
    Cell Calcium 47:297-314. 2010
    ..Understanding of the consequences of these mechanisms for cellular Ca2+ signaling could provide a huge therapeutic potential...
  14. ncbi request reprint A novel Ca2+-induced Ca2+ release mechanism in A7r5 cells regulated by calmodulin-like proteins
    Nael Nadif Kasri
    Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg O N, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 278:27548-55. 2003
    ..This CICR mechanism, which may be regulated by members of the family of neuronal Ca2+-sensor proteins, may provide an additional route for Ca2+ release that could allow amplification of small Ca2+ signals...
  15. doi request reprint The IP(3) receptor-mitochondria connection in apoptosis and autophagy
    Jean Paul Decuypere
    Laboratory of Molecular and Cellular Signalling, Dept Molecular and Cellular, Campus Gasthuisberg O N1 K U Leuven, Bus 802, B 3000 Leuven, Belgium
    Biochim Biophys Acta 1813:1003-13. 2011
    ..This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  16. ncbi request reprint Microtubule-dependent redistribution of the type-1 inositol 1,4,5-trisphosphate receptor in A7r5 smooth muscle cells
    Elke Vermassen
    Laboratory of Physiology, CME VIB04, K U Leuven Campus Gasthuisberg O N, Herestraat 49, B 3000 Leuven, Belgium
    J Cell Sci 116:1269-77. 2003
    ..Taken together, these findings suggest a role for protein kinase C and microtubuli in the redistribution of IP(3)R1, which probably occurs via a mechanism of vesicular trafficking...
  17. pmc The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore
    Geert Bultynck
    Department of Molecular Cell Biology, Laboratory of Molecular and Cellular Signaling, K U Leuven, B 3000 Leuven, Belgium
    J Biol Chem 287:2544-57. 2012
    ..Remarkably, one of these residues was not conserved among plant and yeast BI-1 orthologs, indicating that the ER Ca(2+)-leak properties of BI-1 are an added function during evolution...
  18. ncbi request reprint Ca2+ uptake and release properties of a thapsigargin-insensitive nonmitochondrial Ca2+ store in A7r5 and 16HBE14o- cells
    Ludwig Missiaen
    Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg O N, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 277:6898-902. 2002
    ..In conclusion, A7r5 and 16HBE14o- cells express a Pmr1-containing Ca(2+) store with properties that differ substantially from the SERCA-containing Ca(2+) store...
  19. pmc Localization and function of a calmodulin-apocalmodulin-binding domain in the N-terminal part of the type 1 inositol 1,4,5-trisphosphate receptor
    Ilse Sienaert
    Laboratorium voor Fysiologie, Katholieke Universiteit Leuven Campus Gasthuisberg O N, Herestraat 49, B 3000 Leuven, Belgium
    Biochem J 365:269-77. 2002
    ..This suggests that these sequences are components of a discontinuous Ca2+-independent CaM-binding domain, which is probably involved in the inhibition of IP3 binding by CaM...
  20. ncbi request reprint Endogenously bound calmodulin is essential for the function of the inositol 1,4,5-trisphosphate receptor
    Nael Nadif Kasri
    Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg, O N Herestraat 49 802, B 3000 Leuven, Belgium
    J Biol Chem 281:8332-8. 2006
    ..Our data support a new model whereby CaM is constitutively associated with the IP3R and functions as an essential subunit for proper functioning of the IP3R...
  21. pmc The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells
    Valérie Dewaste
    Institute of Interdisciplinary Research, Universite Libre de Bruxelles, Campus Erasme, Bldg C, 808 Route de Lennik, B 1070 Brussels, Belgium
    Biochem J 374:41-9. 2003
    ..The results highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals...
  22. ncbi request reprint Ca(2+) signals in Pmr1-GFP-expressing COS-1 cells with functional endoplasmic reticulum
    Ludwig Missiaen
    Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg, Herestraat 49, Leuven B 3000, Belgium
    Biochem Biophys Res Commun 294:249-53. 2002
    ..These results demonstrate the importance of the Pmr1-containing Ca(2+) store in generating or modifying cellular Ca(2+) signals...
  23. pmc Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction
    Geert Bultynck
    Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg O N, Herestraat 49, B 3000 Leuven, Belgium
    Biochem J 381:87-96. 2004
    ..Our results demonstrate that thimerosal and Ca2+ induce isoform-specific conformational changes in the N-terminal part of IP3R1, leading to the formation of a highly IP3-sensitive Ca2+-release channel...
  24. ncbi request reprint The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions
    Jo Vanoevelen
    Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Campus Gasthuisberg O N, Belgium
    J Biol Chem 280:22800-8. 2005
    ..The expression in COS-1 cells allowed the direct demonstration of (45)Ca(2+) (K(0.5) = 0.27 microm) or (54)Mn(2+) transport into an A23187-releasable compartment...
  25. pmc Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins
    Nael Nadif Kasri
    Laboratorium voor Fysiologie, KU Leuven, Campus Gasthuisberg O N, Leuven, Belgium
    EMBO J 23:312-21. 2004
    ..We also show that phosphorylation of CaBP1 at a casein kinase 2 consensus site regulates its inhibition of IICR. Our data suggest that CaBPs are endogenous regulators of InsP(3)Rs tuning the sensitivity of cells to InsP(3)...
  26. ncbi request reprint Effect of Hailey-Hailey Disease mutations on the function of a new variant of human secretory pathway Ca2+/Mn2+-ATPase (hSPCA1)
    Rebecca J Fairclough
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Dr, United Kingdom
    J Biol Chem 278:24721-30. 2003
    ..These results highlight the crucial role played by Asp-742 in the architecture of the hSPCA1 ion-binding site and reveal a role for Gly-309 in Mn2+ transport selectivity...
  27. ncbi request reprint The contribution of the SPCA1 Ca2+ pump to the Ca2+ accumulation in the Golgi apparatus of HeLa cells assessed via RNA-mediated interference
    Kurt Van Baelen
    Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg O N, Herestraat 49, B 3000, Leuven, Belgium
    Biochem Biophys Res Commun 306:430-6. 2003
    ..However, baseline Ca(2+) oscillations occurred less frequently than in control cells, pointing to a contribution of SPCA1 in the shaping of the cytosolic Ca(2+) signal in HeLa cells...
  28. ncbi request reprint The role of calmodulin for inositol 1,4,5-trisphosphate receptor function
    Nael Nadif Kasri
    Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg O N, Herestraat 49, B 3000, Leuven, Belgium
    Biochim Biophys Acta 1600:19-31. 2002
    ..Special attention will be given to the Ca(2+)-binding proteins (CaBPs) that were shown to activate the IP(3)R in the absence of IP(3)...
  29. ncbi request reprint PMR1/SPCA Ca2+ pumps and the role of the Golgi apparatus as a Ca2+ store
    Frank Wuytack
    Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium
    Pflugers Arch 446:148-53. 2003
    ..Recent observations show that the Golgi apparatus can function as a Ca(2+) store, which can be involved in setting up cytosolic Ca(2+) oscillations...
  30. ncbi request reprint Additional fluxes of activator Ca2+ accompanying Ca2+ release from the sarcoplasmic reticulum triggered by insP3-mobilizing agonists
    Luc Raeymaekers
    Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Belgium
    Novartis Found Symp 246:71-6; discussion 76-80, 221-7. 2002
    ..The best-characterized SOC current, mainly observed in blood cells, is Icrac Recently, it has been proposed that CaTI (TRPV5) forms at least part of the pore of CRAC. This view is challenged by data from our laboratory...
  31. ncbi request reprint Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism
    Jeremy T Smyth
    Molecular and Cellular Biology Program and Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Biol Chem 277:35061-70. 2002
    ..These findings indicate that KN-93 inhibits IP(3)R-1 directly and may therefore be a useful tool in the study of IP(3)R functional regulation...
  32. ncbi request reprint The complex regulatory function of the ligand-binding domain of the inositol 1,4,5-trisphosphate receptor
    Benoit Devogelaere
    Laboratory of Molecular and Cellular Signalling, Division of Physiology, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    Cell Calcium 43:17-27. 2008
    ..In this review, we will focus on recent structural and functional data on the ligand-binding domain that have extended and clarified the view on the molecular mechanisms of IP(3)R regulation...
  33. ncbi request reprint Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes
    Fabrice Vandeput
    Institut de Recherche Interdisciplinaire IRIBHM, Universite Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, 1070 Brussels, Belgium
    FASEB J 21:1481-91. 2007
    ..Thus, our data show for the first time that the frequency of Ca2+ oscillations in response to a Ca2+-mobilizing agonist can be controlled by inhibitors of type-I Ins(1,4,5)P3 5-phosphatase...
  34. ncbi request reprint Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells
    Nael Nadif Kasri
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Cell Calcium 40:41-51. 2006
    ..Finally, we show that the decreased [Ca2+]ER in PS DKO cells was protective against apoptosis...
  35. ncbi request reprint The suppressor domain of inositol 1,4,5-trisphosphate receptor plays an essential role in the protection against apoptosis
    Karolina Szlufcik
    Laboratorium voor Fysiologie, KU Leuven Campus Gasthuisberg O N, Belgium
    Cell Calcium 39:325-36. 2006
    ....
  36. ncbi request reprint Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy
    Esther Buytaert
    Department of Molecular and Cell Biology, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium
    FASEB J 20:756-8. 2006
    ..Thus, following ER photodamage and consequent disruption of Ca2+ homeostasis, BAX and BAK proteins model PDT-mediated cell killing, which is executed through apoptosis in their presence or via an autophagic pathway in their absence...
  37. ncbi request reprint The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+
    Nael Nadif Kasri
    Laboratorium voor Fysiologie, Katholieke Universiteit Leuven Campus Gasthuisberg O N, Leuven, Belgium
    Mol Pharmacol 66:276-84. 2004
    ..We conclude that CaM inhibits IICR via the N-terminal binding site. The inhibition requires Ca(2+) but CaM itself is not the Ca(2+) sensor for the inhibition of the IP(3)R...
  38. ncbi request reprint Uncoupled IP3 receptor can function as a Ca2+-leak channel: cell biological and pathological consequences
    Karolina Szlufcik
    Laboratory of Physiology, KU Leuven, Campus Gasthuisberg, Belgium
    Biol Cell 98:1-14. 2006
    ..In this review we aim to summarize the existing information about functionally uncoupled IP(3)R and RyR channels, and to discuss the concept that those channels can participate in Ca(2+)-leak pathways...
  39. ncbi request reprint The Ca2+/Mn2+ pumps in the Golgi apparatus
    Kurt Van Baelen
    Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg O N, Herestraat 49, B 3000, Leuven, Belgium
    Biochim Biophys Acta 1742:103-12. 2004
    ..Mutations in the human gene encoding the SPCA1 pump (ATP2C1) resulting in Hailey-Hailey disease, an autosomal dominant skin disorder, are discussed...
  40. ncbi request reprint Hyperosmotic stress stimulates inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate formation independently of bis-diphosphoinositol tetrakisphosphate modulation
    Xavier Pesesse
    Interdisciplinary Research Institute IRIBHM, Universite Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, 1070 Bruxelles, Belgium
    Biochem Biophys Res Commun 336:157-62. 2005
    ..A hyperosmotic stress could therefore affect the levels of both hyperphosphorylated inositol phosphates and InsP(3)/InsP(4)-signalling molecules...
  41. ncbi request reprint Suramin and disulfonated stilbene derivatives stimulate the Ca2+-induced Ca2+ -release mechanism in A7r5 cells
    Nael Nadif Kasri
    Laboratorium voor Fysiologie, Katholieke Universiteit Leuven Campus Gasthuisberg Herestraat 49 802, B 3000 Leuven, Belgium
    Mol Pharmacol 68:241-50. 2005
    ..We also investigated the effects of disulfonated stilbene derivatives on IP3-induced Ca2+ release and found, in contrast to the effect on CICR, a strong inhibition by DIDS and 4'-acetoamido-4'-isothiocyanostilbene-2',2'-disulfonic acid...