C Mathieu

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint [1,25-dihydroxyvitamin D3: the endocrine system meets the immune system]
    C Mathieu
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie LEGENDO, Onderwijs en Navorsing, Gasthuisberg, Herestraat 49, B 3000 Leuven
    Verh K Acad Geneeskd Belg 64:71-80; discussion 80-2. 2002
  2. ncbi request reprint Vitamin D and diabetes
    C Mathieu
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Catholic University of Leuven, Herestraat 49, 3000, Leuven, Belgium
    Diabetologia 48:1247-57. 2005
  3. doi request reprint The scientific evidence: vildagliptin and the benefits of islet enhancement
    C Mathieu
    Department of Endocrinology, Catholic University of Leuven, Leuven, Belgium
    Diabetes Obes Metab 11:9-17. 2009
  4. ncbi request reprint Switching from premixed insulin to basal-bolus insulin glargine plus rapid-acting insulin: the ATLANTIC study
    C Mathieu
    Department of Endocrinology, University Hospital Gasthuisberg, Leuven, Belgium
    Acta Clin Belg 68:28-33. 2013
  5. pmc Barriers and facilitators to evidence based care of type 2 diabetes patients: experiences of general practitioners participating to a quality improvement program
    Geert Goderis
    Department of General Practice, Katholieke Universiteit, Leuven, Belgium
    Implement Sci 4:41. 2009
  6. pmc Interdisciplinary diabetes care teams operating on the interface between primary and specialty care are associated with improved outcomes of care: findings from the Leuven Diabetes Project
    Liesbeth Borgermans
    Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium
    BMC Health Serv Res 9:179. 2009
  7. pmc Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome?
    Anali Conesa-Botella
    Institute of Tropical Medicine, Department of Clinical Sciences, Antwerp, Belgium
    AIDS Res Ther 6:4. 2009
  8. pmc Vildagliptin: a new oral treatment for type 2 diabetes mellitus
    Chantal Mathieu
    Department of Endocrinology, Katholieke Universiteit Leuven, UZ Gasthuisberg, Herestraat 49, Leuven, Belgium
    Vasc Health Risk Manag 4:1349-60. 2008
  9. doi request reprint Reaching glycaemic targets while minimizing hypoglycaemia in insulin-treated type 2 diabetes patients
    C Mathieu
    Department of Endocrinology, Catholic University, Leuven, Belgium
    Diabetes Obes Metab 10:14-23. 2008
  10. ncbi request reprint Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice
    A Giulietti
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Catholic University of Leuven, UZ Gasthuisberg, Onderwijs en Navorsing, Herestraat 49, 3000, Leuven, Belgium
    Diabetologia 47:451-62. 2004

Collaborators

Detail Information

Publications66

  1. ncbi request reprint [1,25-dihydroxyvitamin D3: the endocrine system meets the immune system]
    C Mathieu
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie LEGENDO, Onderwijs en Navorsing, Gasthuisberg, Herestraat 49, B 3000 Leuven
    Verh K Acad Geneeskd Belg 64:71-80; discussion 80-2. 2002
    ..1,25(OH)2D3 and its analogues can therefore be considered as interventions aimed at the prevention or treatment of human type 1 diabetes...
  2. ncbi request reprint Vitamin D and diabetes
    C Mathieu
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Catholic University of Leuven, Herestraat 49, 3000, Leuven, Belgium
    Diabetologia 48:1247-57. 2005
    ..Vitamin D deficiency may, therefore, be involved in the pathogenesis of both forms of diabetes, and a better understanding of the mechanisms involved could lead to the development of preventive strategies...
  3. doi request reprint The scientific evidence: vildagliptin and the benefits of islet enhancement
    C Mathieu
    Department of Endocrinology, Catholic University of Leuven, Leuven, Belgium
    Diabetes Obes Metab 11:9-17. 2009
    ..Improvement of beta- and alpha-cell function through incretin enhancement with vildagliptin results in more physiologic meal-related and fasting glycaemia profiles...
  4. ncbi request reprint Switching from premixed insulin to basal-bolus insulin glargine plus rapid-acting insulin: the ATLANTIC study
    C Mathieu
    Department of Endocrinology, University Hospital Gasthuisberg, Leuven, Belgium
    Acta Clin Belg 68:28-33. 2013
    ..The aim was to evaluate the efficacy and safety of switching from twice-daily premixed insulin to basal glargine plus rapid-acting insulin in a "real-world" clinical practice setting in Belgium and The Netherlands...
  5. pmc Barriers and facilitators to evidence based care of type 2 diabetes patients: experiences of general practitioners participating to a quality improvement program
    Geert Goderis
    Department of General Practice, Katholieke Universiteit, Leuven, Belgium
    Implement Sci 4:41. 2009
    ..This QIP was implemented to promote compliance with international guidelines...
  6. pmc Interdisciplinary diabetes care teams operating on the interface between primary and specialty care are associated with improved outcomes of care: findings from the Leuven Diabetes Project
    Liesbeth Borgermans
    Department of General Practice, Katholieke Universiteit Leuven, Leuven, Belgium
    BMC Health Serv Res 9:179. 2009
    ..A third hypothesis was that patients who used the IDCT in an Advanced quality Improvement Program (AQIP) would have significantly better outcomes compared to users of a Usual Quality Improvement Program (UQIP)...
  7. pmc Is vitamin D deficiency involved in the immune reconstitution inflammatory syndrome?
    Anali Conesa-Botella
    Institute of Tropical Medicine, Department of Clinical Sciences, Antwerp, Belgium
    AIDS Res Ther 6:4. 2009
    ..The active form of vitamin D, 1,25-dihydroxyvitamin D, is a key player in the clearance of pathogens and influences the level of inflammation and macrophage activation...
  8. pmc Vildagliptin: a new oral treatment for type 2 diabetes mellitus
    Chantal Mathieu
    Department of Endocrinology, Katholieke Universiteit Leuven, UZ Gasthuisberg, Herestraat 49, Leuven, Belgium
    Vasc Health Risk Manag 4:1349-60. 2008
    ....
  9. doi request reprint Reaching glycaemic targets while minimizing hypoglycaemia in insulin-treated type 2 diabetes patients
    C Mathieu
    Department of Endocrinology, Catholic University, Leuven, Belgium
    Diabetes Obes Metab 10:14-23. 2008
    ..Furthermore, insulin glargine is associated with greater improvements in glycaemic control vs. intensification of oral therapy. Thus, insulin glargine should be a preferred option when starting insulin therapy for people with T2DM...
  10. ncbi request reprint Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice
    A Giulietti
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Catholic University of Leuven, UZ Gasthuisberg, Onderwijs en Navorsing, Herestraat 49, 3000, Leuven, Belgium
    Diabetologia 47:451-62. 2004
    ..To evaluate whether a similar dietary deficiency affects diabetes incidence in NOD mice, we generated NOD mice with vitamin D deficiency in early life...
  11. ncbi request reprint An overview of real-time quantitative PCR: applications to quantify cytokine gene expression
    A Giulietti
    Laboratory for Experimental Medicine and Endocrinology (LEGENDO, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Methods 25:386-401. 2001
    ....
  12. ncbi request reprint NOD macrophages produce high levels of inflammatory cytokines upon encounter of apoptotic or necrotic cells
    K Stoffels
    Laboratory for Experimental Endocrinology and Medicine, Catholic University of Leuven, UZ Gasthuisberg, Onderwijs en Navorsing, Herestraat 49, 3000 Leuven, Belgium
    J Autoimmun 23:9-15. 2004
    ....
  13. ncbi request reprint Role of CD4+ and CD8+ T cells in the rejection of heart or islet xenografts in recipients with xenotolerance in the innate immune compartment
    T deVos
    Laboratory for Experimental Transplantation, University of Leuven, Leuven, Belgium
    Transplant Proc 37:516-7. 2005
    ....
  14. doi request reprint Unraveling the effects of 1,25OH2D3 on global gene expression in pancreatic islets
    H Wolden-Kirk
    Clinical and Experimental Endocrinology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, BOX 902, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 136:68-79. 2013
    ..The aim of the present study was to investigate how active vitamin D, 1,25(OH)2D3, affects beta cells directly by establishing its effects on global gene expression in healthy murine islets...
  15. ncbi request reprint Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents
    C Gysemans
    LEGENDO, UZ Gasthuisberg O and N, Herestraat 49, 3000 Leuven, Belgium
    Diabetologia 46:1115-23. 2003
    ..The aim of this study was to explore in a model of spontaneous diabetes, the NOD mouse, the potential of anti-inflammatory agents in the prevention of PNF after xenogeneic islet transplantation...
  16. pmc Treatment of autoimmune diabetes recurrence in non-obese diabetic mice by mouse interferon-beta in combination with an analogue of 1alpha,25-dihydroxyvitamin-D3
    C Gysemans
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Belgium
    Clin Exp Immunol 128:213-20. 2002
    ..Therefore, we conclude that a combination of IFN-beta and TX 527 delays autoimmune diabetes recurrence in islet grafts in spontaneously diabetic NOD mice...
  17. ncbi request reprint 1Alpha,25-dihydroxyvitamin D3 restores thymocyte apoptosis sensitivity in non-obese diabetic (NOD) mice through dendritic cells
    B Decallonne
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Catholic University of Leuven, Onderwijs en Navorsing, Herestraat 49, 3000 Leuven, Belgium
    J Autoimmun 24:281-9. 2005
    ..We studied whether modulation of thymocyte apoptosis is due to direct effects on thymic T lymphocytes or indirect effects via thymic dendritic cells, since both cell types constitute known targets for 1alpha,25OH2D3...
  18. ncbi request reprint Break of tolerance via donor-specific blood transfusion by high doses of steroids: a differential effect after intestinal transplantation and heart transplantation
    T Koshiba
    Abdominal Transplant Surgery Department, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Transplant Proc 35:3153-5. 2003
    ..Tolerance requires active mechanisms. How immunosuppressors affects tolerance is poorly understood...
  19. ncbi request reprint Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes
    H Callewaert
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, UZ Gasthuisberg O and N, Katholieke Universiteit Leuven, Leuven, Belgium
    Cell Transplant 16:527-37. 2007
    ..The high price to pay to reach stable and strong transgene expression in islet cells is certainly an important cell loss...
  20. pmc The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression
    L Overbergh
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Catholic University of Leuven, U Z Gasthuisberg, Leuven, Belgium
    J Biomol Tech 14:33-43. 2003
    ....
  21. ncbi request reprint Mechanism and potential of the growth-inhibitory actions of vitamin D and ana-logs
    G Eelen
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Curr Med Chem 14:1893-910. 2007
    ..Furthermore, the mode of action and possible clinical application of chemically modified 1,25-(OH) (2)D(3)-analogs will be discussed...
  22. ncbi request reprint Immune regulation of 1alpha-hydroxylase in murine peritoneal macrophages: unravelling the IFNgamma pathway
    K Stoffels
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Onderwijs en Navorsing, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 103:567-71. 2007
    ..The data confirm a crucial role for STAT1alpha as well as for C/EBPbeta in the regulation of 1alpha-hydroxylase in monocytes...
  23. ncbi request reprint Validation of real-time RT-PCR assays for mRNA quantification in baboons
    L Overbergh
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Belgium
    Cytokine 31:454-8. 2005
    ..In conclusion, by performing a simple validation experiment, real-time PCR assays based on human sequences, which are easily available, can be applied for analysis of baboon samples...
  24. ncbi request reprint Combination of a 1,25-dihydroxyvitamin D3 analog and a bisphosphonate prevents experimental autoimmune encephalomyelitis and preserves bone
    E van Etten
    Laboratory of Experimental Medicine and Endocrinology, Catholic University of Leuven, Herestraat 49, Belgium
    Bone 32:397-404. 2003
    ..01). Less calcemic analogs of 1,25-dihydroxyvitamin D(3), in combination with bone sparing products such as bisphosphonates allow immune modulation in vivo without affecting bone...
  25. ncbi request reprint Diabetes and peripheral vascular disease
    E Huysman
    Department of Endocrinology, UZ Gasthuisberg, KULeuven, Leuven, Belgium
    Acta Chir Belg 109:587-94. 2009
    ....
  26. ncbi request reprint Transforming growth factor-beta inhibits lymphokine activated killer cytotoxicity of bone marrow cells: implications for the graft-versus-leukemia effect in irradiation allogeneic bone marrow chimeras
    A D Billiau
    Laboratory of Experimental Transplantation, Catholic University of Leuven, Belgium
    Transplantation 71:292-9. 2001
    ..The cytokine profile, induced by irradiation in host hematopoietic organs, can significantly modify posttransplant immunological processes such as the GVL effect and graft-versus-host disease (GVHD)...
  27. ncbi request reprint In vitro and in vivo analysis of the immune system of vitamin D receptor knockout mice
    C Mathieu
    Laboratory of Experimental Medicine and Endocrinology, LEGENDO, Catholic University of Leuven, Belgium
    J Bone Miner Res 16:2057-65. 2001
    ..This study proves that although 1,25(OH)2D3 is a pharmacologic and probably a physiological immunomodulator, its immune function is redundant. Moreover, we confirm the essential role of calcium in the immune system...
  28. ncbi request reprint PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D
    E Vanoirbeek
    Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium
    Oncogene . 2013
    ..This study provides mechanistic insights into the anticancer activities of 1,25(OH)2D3 in human breast cancer cells.Oncogene advance online publication, 15 April 2013; doi:10.1038/onc.2013.123...
  29. ncbi request reprint Posttransplantation diabetes mellitus in FK-506-treated renal transplant recipients: analysis of incidence and risk factors
    B D Maes
    Department of Medicine, University Hospital Gathuisberg, Leuven, Belgium
    Transplantation 72:1655-61. 2001
    ..Higher trough levels of FK-506 during the first month, acute rejections, and higher BMI were the most obvious risk factors...
  30. ncbi request reprint Diabetic management in high risk patients (pregnancy, insulin pumps)
    G Vanhaverbeke
    Laboratory and Clinic of Experimental Medicine and Endocrinology, Leuven, Belgium
    Acta Clin Belg 59:173-81. 2004
    ..Insulin pumps are often used in pregnant patients, allowing an even better glycemic control with less hypoglycemia. An absolute requirement for CSII therapy to be successful is patient education and motivation by an experienced team...
  31. doi request reprint Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics
    K Van Acker
    Department of Endocrinology, St Jozef Clinic, Bornem, Belgium
    Diabetes Metab 35:206-13. 2009
    ..The association of DPN and DPN-P with other diabetic complications, the impact on quality of life (QoL) and pain management were also investigated...
  32. doi request reprint Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance
    M Maris
    Catholic University of Leuven, Leuven, Belgium
    Diabetologia 55:1167-78. 2012
    ..C/EBP homologous protein (CHOP) is induced by ER stress and has a central role in apoptotic execution pathways triggered by ER stress. The aim of this study was to characterise the role of CHOP in obesity and insulin resistance...
  33. ncbi request reprint Defective activation-induced cell death in NOD T lymphocytes: 1,25-dihydroxyvitamin D3 restores defect
    B Decallonne
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie LEGENDO, Katholieke Universiteit Leuven, Leuven, Belgium
    Ann N Y Acad Sci 1005:176-7. 2003
    ....
  34. ncbi request reprint Combined use of FTY720 and cyclosporine A prevents chronic allograft vasculopathy
    T Koshiba
    Abdominal Transplant Surgery, Leuven, Belgium
    Transplant Proc 34:748-9. 2002
  35. doi request reprint Discovery of molecular pathways mediating 1,25-dihydroxyvitamin d3 protection against cytokine-induced inflammation and damage of human and male mouse islets of langerhans
    H Wolden-Kirk
    Clinical and Experimental Endocrinology H W K, D R, H K, L O, C M, University Hospital Gasthuisberg, Gene Expression Unit L V L, F S, Department of Molecular and Cellular Medicine, Department of Microbiology and Immunology P P, B 3000 Leuven, Belgium Hans Christian Andersen Children s Hospital H W K, H T C and Department of Clinical Genetics K B, D L E, Odense University Hospital, DK 5000, Odense, Denmark Department of Endocrinology and Metabolism M B, P M, Metabolic Unit, and Department of General Pathology M M, University of Pisa, Pisa, Italy and Laboratory of Experimental Medicine D L E, Universite Libre de Bruxelles, B 1070 Brussels, Belgium
    Endocrinology 155:736-47. 2014
    ..These effects may contribute to the beneficial effects of 1,25(OH)2D3 against the induction of autoimmune diabetes. ..
  36. ncbi request reprint Immunomodulation by 1,25-dihydroxyvitamin D3: therapeutic implications in hemodialysis and renal transplantation
    C Mathieu
    Department of Endocrinology, UZ Gasthuisberg, Leuven, Belgium
    Clin Nephrol 66:275-83. 2006
    ..Initiation of vitamin D-based therapies at earlier stages of chronic kidney disease may impact the immune status of patients who progress to require dialysis or transplantation...
  37. ncbi request reprint Gestational diabetes: overview of the new consensus screening strategy and diagnostic criteria
    K Benhalima
    Department of Endocrinology, UZ Gasthuisberg, KU Leuven, Leuven
    Acta Clin Belg 67:255-61. 2012
    ..7%. We feel that more data are necessary on the cost-effectiveness of an universal screening strategy using an OGTT with more stringent diagnostic criteria for GDM, especially in a population with a low background prevalence of GDM...
  38. pmc Involvement of 4-1BB (CD137)-4-1BBligand interaction in the modulation of CD4 T cell-mediated inflammatory colitis
    P Maerten
    Laboratory of Experimental Immunology, University Hospital, Katholieke Universiteit Leuven, Belgium
    Clin Exp Immunol 143:228-36. 2006
    ..In conclusion, our data provide evidence that 4-1BB-4-1BBL interaction modulates the effector CD4+ T cell-driven immune response and cytokine production in experimental colitis without affecting regulatory T cell function...
  39. ncbi request reprint SGLT2-inhibitors: a novel class for the treatment of type 2 diabetes introduction of SGLT2-inhibitors in clinical practice
    J Cuypers
    Department of Internal Medicine, UZ Gasthuisberg, KU Leuven, Belgium
    Acta Clin Belg 68:287-93. 2013
    ..A large randomized control trial is therefore warranted by the FDA. This review provides an overview of the current evidence available so far on the therapeutic potential of the SGLT2-inhibitors for the treatment of T2DM...
  40. ncbi request reprint Can we reduce hypoglycaemia with insulin detemir?
    C Mathieu
    Department of Endocrinology, Katholieke Universitet, Leuven, UZ Gasthuisberg O and N, Leuven B 3000, Belgium
    Int J Obes Relat Metab Disord 28:S35-40. 2004
    ....
  41. doi request reprint Air pollution-associated procoagulant changes: the role of circulating microvesicles
    J Emmerechts
    Center for Molecular and Vascular Biology, Unit of Lung Toxicology, University of Leuven, Leuven, Belgium
    J Thromb Haemost 10:96-106. 2012
    ..Epidemiological studies suggest an association between exposure to particulate matter (PM) in air pollution and the risk of venous thromboembolism (VTE)...
  42. doi request reprint Low doses of anti-CD3, ciclosporin A and the vitamin D analogue, TX527, synergise to delay recurrence of autoimmune diabetes in an islet-transplanted NOD mouse model of diabetes
    F Baeke
    Laboratory for Clinical and Experimental Endocrinology, Campus Gasthuisberg O and N1, Herestraat 49 bus 902, 3000 Leuven, Belgium
    Diabetologia 55:2723-32. 2012
    ....
  43. ncbi request reprint Markers for cardiovascular disease in monozygotic twins discordant for the use of third-generation oral contraceptives
    R J F Loos
    Department of Sport and Movement Sciences, Faculty of Physical Education and Physiotherapy, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    J Hum Hypertens 17:481-5. 2003
    ..Some changes are beneficial (increased HDL-cholesterol), whereas others may be deleterious (increased BP and triglyceride levels) or have unknown effects at this time (increased IGFBP-1 levels)...
  44. doi request reprint β-Cell differentiation and regeneration in type 1 diabetes
    L Ding
    Laboratory of Clinical and Experimental Endocrinology, Campus Gasthuisberg O and N1, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Diabetes Obes Metab 15:98-104. 2013
    ....
  45. doi request reprint Glucagon-like peptide-1: modulator of β-cell dysfunction and death
    D Rondas
    Laboratory for Clinical and Experimental Endocrinology, 3000, Leuven, Belgium
    Diabetes Obes Metab 15:185-92. 2013
    ..In this review, we focus on the different, short- and long-term action mechanisms of GLP-1 with specific emphasis on its role as a modulator of β-cell function and survival. ..
  46. ncbi request reprint Diabetes and pregnancy: beyond glucose?
    C Mathieu
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Diabetologia 48:1714-5. 2005
  47. ncbi request reprint Dual role of interferon-gamma signalling pathway in sensitivity of pancreatic beta cells to immune destruction
    C A Gysemans
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Belgium
    Diabetologia 44:567-74. 2001
    ..The aim of this study was to investigate the effects of a global disruption of IFN-gamma signalling, or a selective disruption of IRF-1, on beta-cell sensitivity to in vivo immune destruction...
  48. ncbi request reprint Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells
    M C Chen
    Gene Expression Unit, Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium
    Diabetologia 44:325-32. 2001
    ..The production of MCP-1 by pancreatic beta cells could contribute to the recruitment of mononuclear cells into pancreatic islets in early Type I diabetes...
  49. pmc Comparative therapeutic effects of orally administered 1,25-dihydroxyvitamin D(3) and 1alpha-hydroxyvitamin D(3) on type-1 diabetes in non-obese diabetic mice fed a normal-calcaemic diet
    J P Driver
    The Jackson Laboratory, Bar Harbor, ME, USA
    Clin Exp Immunol 151:76-85. 2008
    ..In future, the dietary supplementation of novel low-calcaemic D3 analogues may enable their continuous delivery at levels that inhibit T1D development in susceptible humans consuming normal levels of Ca...
  50. ncbi request reprint Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts
    C A Gysemans
    Laboratory for Experimental Medicine and Endocrinology, Catholic University Leuven, Gasthuisberg, Belgium
    Diabetes 49:1992-7. 2000
    ..These data suggest that early islet xenograft failure is more common in spontaneously diabetic NOD mice and could be due to a nonspecific inflammatory reaction locally in the grafts...
  51. ncbi request reprint Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index
    I Weets
    Diabetes Research Center, Free University, Brussels, Belgium
    Diabetologia 44:40-7. 2001
    ....
  52. ncbi request reprint Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D
    R St-Arnaud
    Genetics Unit, Shriners Hospital for Children, Montreal, Quebec, Canada
    Endocrinology 141:2658-66. 2000
    ..Our results confirm the physiological importance of the 24-OHase enzyme for maintaining vitamin D homeostasis, and they reveal that 24,25-dihydroxyvitamin D is a dispensable metabolite during bone development...
  53. ncbi request reprint A murine interleukin-4-Ig fusion protein regulates the expression of Th1- and Th2-specific cytokines in the pancreas of NOD mice
    M Walz
    German Diabetes Research Institute, Clinical Department, Heinrich Heine University, Duesseldorf, Germany
    Horm Metab Res 34:561-9. 2002
    ..In most experiments, the biological activity of IL-4-Ig and IL-4 was comparable. We conclude that treatment with the chimeric protein IL-4-Ig effectively downregulates Th1 responses but simultaneously augments intra-islet infiltration...
  54. ncbi request reprint IA-2 autoantibodies predict impending type I diabetes in siblings of patients
    K Decochez
    Diabetes Research Centre, Free University of Brussels, Belgium
    Diabetologia 45:1658-66. 2002
    ..We compared its predictive value with that of positivity for a particular type of islet autoantibody, directed against the IA-2 antigen...
  55. ncbi request reprint IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice
    A K Cardozo
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik 808, CP 618, 1070 Brussels, Belgium
    Diabetologia 46:255-66. 2003
    ....
  56. ncbi request reprint Two Caucasian families with the hepatocyte nuclear factor-1alpha mutation Tyr218Cys
    M Hummel
    Diabetes Research Institute and Academical Hospital Munich Schwabing, Munich, Germany
    Exp Clin Endocrinol Diabetes 115:62-4. 2007
    ..Clinical and laboratory examinations are shown in detail. Patients with HNF-1alpha related MODY may develop the full spectrum of diabetic complications. Therefore, early detection of family members with MODY3 is warranted...
  57. pmc Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes
    I Truyen
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    Clin Exp Immunol 149:243-50. 2007
    ..Together with initially IA-2A-positive relatives these individuals qualify for standardized beta cell function tests in view of prevention trials...
  58. ncbi request reprint The age at diagnosis of type 1 diabetes continues to decrease in Belgian boys but not in girls: a 15-year survey
    I Weets
    Diabetes Research Center, Free University Brussels, Belgium
    Diabetes Metab Res Rev 23:637-43. 2007
    ..Preliminary Belgian data suggested that this anticipation occurred preferentially in boys. We investigated whether this gender-specific anticipation could be confirmed over a 15-year observation period...
  59. ncbi request reprint Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives
    I Truyen
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, 1090, Brussels, Belgium
    Diabetologia 50:2143-6. 2007
    ..We investigated whether adiponectin, an insulin sensitiser, can serve as an additional predictive marker for type 1 diabetes in first-degree relatives of known patients...
  60. ncbi request reprint [Prevention of type 1 diabetes: interventions in mice and in humans]
    C Mathieu
    Departement d Endocrinologie, UZ Gasthuisberg, KULeuven
    Rev Med Liege 60:303-5. 2005
    ..In the coming years, major advances in prevention of type 1 diabetes are to be expected...
  61. ncbi request reprint Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, Munich 80804, Germany
    Curr Diab Rep 8:87-93. 2008
    ....
  62. ncbi request reprint Promoting targeted screening for Type 2 diabetes mellitus: the contribution of community pharmacists
    S Simoens
    Diabet Med 22:812-3. 2005
  63. ncbi request reprint Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes
    K Decochez
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    Diabetologia 48:687-94. 2005
    ..We investigated whether specific combinations of immune and genetic markers can identify subgroups with more homogeneous progression to clinical onset...
  64. ncbi request reprint Human pancreatic duct cells can produce tumour necrosis factor-alpha that damages neighbouring beta cells and activates dendritic cells
    B Movahedi
    Diabetes Research Centre, Brussels Free University VUB and JDRF Centre for Beta Cell Therapy in Europe, Laarbeeklaan 103, 1090 Brussels, Belgium
    Diabetologia 47:998-1008. 2004
    ..We investigated whether human duct cells are a source of TNFalpha-mediated interactions with beta cells and immune cells. This cytokine has been implicated in the development of autoimmune diabetes in mice...
  65. ncbi request reprint The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells
    D Pavlovic
    Eizirik, Department of Metabolism and Endocrinology, Diabetes Research Center, Laarbeeklaan 103, 1090 Brussels, Belgium
    Eur Cytokine Netw 10:403-12. 1999
    ..These effects are absent in purified beta-cells, suggesting that IRF-1 may mediate its effects on whole islets via activation of non-endocrine cells (e.g. macrophages and ductal cells) present in these preparations...
  66. ncbi request reprint Identification of novel and recurrent glucokinase mutations in Belgian and Luxembourg maturity onset diabetes of the young patients
    L Vits
    Clin Genet 70:355-9. 2006