Aernout Luttun

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. doi Keeping your vascular integrity: What can we learn from fish?
    Aernout Luttun
    Center for Molecular and Vascular Biology, KULeuven, Leuven, Belgium
    Bioessays 30:418-22. 2008
  2. doi Differentiation potential of human postnatal mesenchymal stem cells, mesoangioblasts, and multipotent adult progenitor cells reflected in their transcriptome and partially influenced by the culture conditions
    Valerie D Roobrouck
    Stem Cell Institute, K U Leuven, Leuven, Belgium
    Stem Cells 29:871-82. 2011
  3. pmc Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity
    Fernando Ulloa-Montoya
    Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Genome Biol 8:R163. 2007
  4. doi Engineering vascularized bone: osteogenic and proangiogenic potential of murine periosteal cells
    Nick van Gastel
    Laboratory of Clinical and Experimental Endocrinology, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium
    Stem Cells 30:2460-71. 2012
  5. doi Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
    Sonja Loges
    Vesalius Research Center VRC, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
    Blood 115:2264-73. 2010
  6. doi Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis
    Xabier L Aranguren
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Onderwijs and Navorsing 1, Herestraat 49, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 410:121-6. 2011
  7. doi Cell-based vascularization strategies for skin tissue engineering
    Benoit Hendrickx
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    Tissue Eng Part B Rev 17:13-24. 2011
  8. pmc Multipotent adult progenitor cells sustain function of ischemic limbs in mice
    Xabier L Aranguren
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 118:505-14. 2008
  9. pmc TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence
    Abhishek Sohni
    Stem Cell Institute, Department of Development and Regeneration, K U Leuven, Leuven, Belgium
    PLoS ONE 7:e47629. 2012
  10. doi Activation of human endothelial cells from specific vascular beds induces the release of a FVIII storage pool
    Tina Shahani
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    Blood 115:4902-9. 2010

Collaborators

Detail Information

Publications23

  1. doi Keeping your vascular integrity: What can we learn from fish?
    Aernout Luttun
    Center for Molecular and Vascular Biology, KULeuven, Leuven, Belgium
    Bioessays 30:418-22. 2008
    ..Here, we summarize the factors determining vascular integrity and elaborate on the suitability of the zebrafish to study this phenomenon...
  2. doi Differentiation potential of human postnatal mesenchymal stem cells, mesoangioblasts, and multipotent adult progenitor cells reflected in their transcriptome and partially influenced by the culture conditions
    Valerie D Roobrouck
    Stem Cell Institute, K U Leuven, Leuven, Belgium
    Stem Cells 29:871-82. 2011
    ..These studies demonstrate that hMSCs, hMab, and hMAPCs have different properties that are partially mediated by the culture conditions...
  3. pmc Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity
    Fernando Ulloa-Montoya
    Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Genome Biol 8:R163. 2007
    ..Here we compare the transcriptome of pluripotent embryonic stem cells (ESCs), MAPCs, and lineage-restricted mesenchymal stem cells (MSCs) to determine their relationship...
  4. doi Engineering vascularized bone: osteogenic and proangiogenic potential of murine periosteal cells
    Nick van Gastel
    Laboratory of Clinical and Experimental Endocrinology, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium
    Stem Cells 30:2460-71. 2012
    ....
  5. doi Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
    Sonja Loges
    Vesalius Research Center VRC, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
    Blood 115:2264-73. 2010
    ..Hence, inhibition of Gas6 might offer novel opportunities for the treatment of cancer...
  6. doi Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis
    Xabier L Aranguren
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Onderwijs and Navorsing 1, Herestraat 49, B 3000 Leuven, Belgium
    Biochem Biophys Res Commun 410:121-6. 2011
    ..Therefore, the role of NR2F2 in EC fate determination is evolutionary conserved...
  7. doi Cell-based vascularization strategies for skin tissue engineering
    Benoit Hendrickx
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    Tissue Eng Part B Rev 17:13-24. 2011
    ....
  8. pmc Multipotent adult progenitor cells sustain function of ischemic limbs in mice
    Xabier L Aranguren
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 118:505-14. 2008
    ..Thus, unlike BMCs or vascular-committed progenitors, undifferentiated multipotent adult progenitor cells offer the potential to durably repair ischemic damage in peripheral vascular disease patients...
  9. pmc TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence
    Abhishek Sohni
    Stem Cell Institute, Department of Development and Regeneration, K U Leuven, Leuven, Belgium
    PLoS ONE 7:e47629. 2012
    ..The MAPC-SMC differentiation system may be useful for identification of additional critical (co-)regulators of SMC development...
  10. doi Activation of human endothelial cells from specific vascular beds induces the release of a FVIII storage pool
    Tina Shahani
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    Blood 115:4902-9. 2010
    ..Extrahepatic endothelial cells from certain vascular beds therefore appear to be an important FVIII production and storage site with the potential to regulate FVIII secretion in chronic and acute conditions...
  11. doi Integration of blood outgrowth endothelial cells in dermal fibroblast sheets promotes full thickness wound healing
    Benoit Hendrickx
    Center for Molecular and Vascular Biology, KULeuven, Leuven, Belgium
    Stem Cells 28:1165-77. 2010
    ..Overall, this combined tissue engineering approach paves the way for clinical development of a fully autologous vascularized dermal substitute for patients with large skin defects that do not heal properly...
  12. doi Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    Massimiliano Mazzone
    Vesalius Research Center, VIB Vlaams Instituut voor Biotechnologie, Leuven, Belgium
    Cell 136:839-51. 2009
    ..Inhibition of PHD2 may offer alternative therapeutic opportunities for anticancer therapy...
  13. pmc Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
    Xuri Li
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology VIB, University of Leuven, Leuven, Belgium
    J Clin Invest 115:118-27. 2005
    ..Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases...
  14. ncbi Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium
    Nat Med 8:831-40. 2002
    ..Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation...
  15. pmc Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 116:1230-42. 2006
    ..Therefore PlGF may potentially offer therapeutic advantages for fracture repair...
  16. ncbi Vascular progenitors: from biology to treatment
    Aernout Luttun
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Trends Cardiovasc Med 12:88-96. 2002
    ..This review discusses some of the recent insights and outstanding questions on EPCs, both from a biological and therapeutic perspective...
  17. doi Differentiation of multipotent adult progenitor cells into functional endothelial and smooth muscle cells
    Aernout Luttun
    University of Minnesota, Minneapolis, Minnesota, USA
    Curr Protoc Immunol . 2006
    ..It further focuses on the molecular and functional characterization of the obtained cell types...
  18. ncbi Isolation and characterization of kidney-derived stem cells
    Sandeep Gupta
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    J Am Soc Nephrol 17:3028-40. 2006
    ..Oct4 expression was seen in some tubular cells in the adult kidney, suggesting these cells may be candidate renal stem cells. It is proposed that MRPC participate in the regenerative response of the kidney to acute injury...
  19. ncbi Sequential exposure to cytokines reflecting embryogenesis: the key for in vitro differentiation of adult bone marrow stem cells into functional hepatocyte-like cells
    Sarah Snykers
    Department of Toxicology, Vrije Universiteit Brussel, B 1090 Brussels, Belgium
    Toxicol Sci 94:330-41; discussion 235-9. 2006
    ....
  20. ncbi In vitro and in vivo arterial differentiation of human multipotent adult progenitor cells
    Xabier L Aranguren
    Hematology Service and Cell Therapy, Clinica Universitaria, Foundation for Applied Medical Research, Division of Cancer, University of Navarra, Pamplona, Spain
    Blood 109:2634-42. 2007
    ..These results represent the first demonstration of adult stem cells with the potential to be differentiated into different types of ECs in vitro and in vivo and provide a useful human model to study arteriovenous specification...
  21. ncbi Plasticity and cardiovascular applications of multipotent adult progenitor cells
    Beatriz Pelacho
    Foundation for Applied Medical Research
    Nat Clin Pract Cardiovasc Med 4:S15-20. 2007
    ..Here, we focus on the regenerative capacity of multipotent adult progenitor cells in several ischemic mouse models, such as acute and chronic myocardial infarction and limb ischemia...
  22. ncbi Transcriptional characterization of the Notch signaling pathway in rodent multipotent adult progenitor cells
    Melinda Hajdu
    Stem Cell Insitute, University of Minnesota Medical School, Minneapolis, MN, USA
    Pathol Oncol Res 13:302-10. 2007
    ..Our results provide an additional tool and a further basis for a better understanding of stem cell biology...
  23. ncbi Multipotent adult progenitor cell transplantation increases vascularity and improves left ventricular function after myocardial infarction
    Beatriz Pelacho
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Tissue Eng Regen Med 1:51-9. 2007
    ....