Rik Ju Lories

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Bone morphogenetic protein signaling in joint homeostasis and disease
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Rheumatology, University Hospitals Leuven, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Cytokine Growth Factor Rev 16:287-98. 2005
  2. pmc Bone morphogenetic proteins in destructive and remodeling arthritis
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, Belgium
    Arthritis Res Ther 9:207. 2007
  3. doi request reprint To Wnt or not to Wnt: the bone and joint health dilemma
    Rik J Lories
    Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Herestraat 49, B3000 Leuven, Belgium
    Nat Rev Rheumatol 9:328-39. 2013
  4. doi request reprint Etoricoxib and the treatment of ankylosing spondylitis
    Rik J Lories
    University Hospitals Leuven, Division of Rheumatology, Department of Development and Regeneration, Laboratory of Tissue Homeostasis and Disease, Herestraat 49, B3000 Leuven, Belgium
    Expert Opin Drug Metab Toxicol 8:1599-608. 2012
  5. doi request reprint Pathophysiology of new bone formation and ankylosis in spondyloarthritis
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, Leuven, Belgium
    Rheum Dis Clin North Am 38:555-67. 2012
  6. doi request reprint Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis
    Liesbet Lodewyckx
    Division of Rheumatology, University Hospitals Leuven, Herestraat 49, B3000 Leuven, Belgium
    Rheumatology (Oxford) 51:1973-8. 2012
  7. pmc Inhibition of inflammation but not ankylosis by glucocorticoids in mice: further evidence for the entheseal stress hypothesis
    Kirsten Braem
    Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven, Herestraat 49, Leuven, 3000, Belgium
    Arthritis Res Ther 14:R59. 2012
  8. doi request reprint Is psoriatic arthritis a result of abnormalities in acquired or innate immunity?
    Rik J Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven, Herestraat 49, 300 Leuven, Belgium
    Curr Rheumatol Rep 14:375-82. 2012
  9. doi request reprint Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo
    Kirsten Braem
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, KULeuven, Leuven, Belgium
    Ann Rheum Dis 71:722-8. 2012
  10. pmc Flow cytometric characterization of freshly isolated and culture expanded human synovial cell populations in patients with chronic arthritis
    Kristel B Van Landuyt
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Katholieke Universiteit Leuven, Herestraat 49, Leuven, B3000, Belgium
    Arthritis Res Ther 12:R15. 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Bone morphogenetic protein signaling in joint homeostasis and disease
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Rheumatology, University Hospitals Leuven, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Cytokine Growth Factor Rev 16:287-98. 2005
    ..Therefore, modulation of BMP signaling may be an attractive therapeutic target in chronic arthritis to restore homeostasis and function of synovial joints...
  2. pmc Bone morphogenetic proteins in destructive and remodeling arthritis
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, Belgium
    Arthritis Res Ther 9:207. 2007
    ..Data from genetic models support a role for bone morphogenetic protein signaling in cartilage homeostasis. Finally, this signaling pathway is likely to play a steering role in the synovium...
  3. doi request reprint To Wnt or not to Wnt: the bone and joint health dilemma
    Rik J Lories
    Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Herestraat 49, B3000 Leuven, Belgium
    Nat Rev Rheumatol 9:328-39. 2013
    ....
  4. doi request reprint Etoricoxib and the treatment of ankylosing spondylitis
    Rik J Lories
    University Hospitals Leuven, Division of Rheumatology, Department of Development and Regeneration, Laboratory of Tissue Homeostasis and Disease, Herestraat 49, B3000 Leuven, Belgium
    Expert Opin Drug Metab Toxicol 8:1599-608. 2012
    ..The drug has been associated with reduced severe gastrointestinal adverse events. However, the cardiovascular safety of cyclooxygenase 2 inhibitors has been debated...
  5. doi request reprint Pathophysiology of new bone formation and ankylosis in spondyloarthritis
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, Leuven, Belgium
    Rheum Dis Clin North Am 38:555-67. 2012
    ..In addition, proposed biomarkers of new bone formation are evaluated and the translational current and future challenges are discussed with regards to new bone formation in spondyloarthritis...
  6. doi request reprint Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis
    Liesbet Lodewyckx
    Division of Rheumatology, University Hospitals Leuven, Herestraat 49, B3000 Leuven, Belgium
    Rheumatology (Oxford) 51:1973-8. 2012
    ..Lrp5(-)(/)(-) mice also have low bone mass phenotypes. Recently an OA-susceptibility locus containing the LRP5 gene was suggested. We investigated the effects of loss of Lrp5 in joint biology in three different mouse models of OA...
  7. pmc Inhibition of inflammation but not ankylosis by glucocorticoids in mice: further evidence for the entheseal stress hypothesis
    Kirsten Braem
    Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven, Herestraat 49, Leuven, 3000, Belgium
    Arthritis Res Ther 14:R59. 2012
    ..Here, we further investigated the relationship between inflammation and ankylosis by focusing on the early phase of the spontaneous arthritis model...
  8. doi request reprint Is psoriatic arthritis a result of abnormalities in acquired or innate immunity?
    Rik J Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven, Herestraat 49, 300 Leuven, Belgium
    Curr Rheumatol Rep 14:375-82. 2012
    ..In this review, we compare the current paradigm of psoriasis to mechanisms that likely play a role in psoriatic arthritis and provide an overview of the role of immune mechanisms in the different features of the disease...
  9. doi request reprint Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo
    Kirsten Braem
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, KULeuven, Leuven, Belgium
    Ann Rheum Dis 71:722-8. 2012
    ....
  10. pmc Flow cytometric characterization of freshly isolated and culture expanded human synovial cell populations in patients with chronic arthritis
    Kristel B Van Landuyt
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Katholieke Universiteit Leuven, Herestraat 49, Leuven, B3000, Belgium
    Arthritis Res Ther 12:R15. 2010
    ..The aim of this study was to develop flow cytometry for the quantitative analysis of synovial cell populations pre and post culture and to characterize mesenchymal cell populations residing in the inflammatory synovium...
  11. pmc Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis
    Rik J U Lories
    Department of Musculoskeletal Sciences, Division of Rheumatology, Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, Belgium
    Arthritis Res Ther 11:221. 2009
    ..The relationship between inflammation and new bone formation is still unclear. This review summarizes progress made in our understanding of ankylosis and offers an alternative view of the relationship between inflammation and ankylosis...
  12. ncbi request reprint Differences in pathophysiology between rheumatoid arthritis and ankylosing spondylitis
    R J Lories
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, Belgium
    Clin Exp Rheumatol 27:S10-4. 2009
    ..Better insights into their individual characteristics may lead to better therapeutic strategies, specific targets and useful biomarkers...
  13. doi request reprint Bone morphogenetic protein signaling and arthritis
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Musculoskeletal Sciences, Division of Rheumatology, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Cytokine Growth Factor Rev 20:467-73. 2009
    ..These data are presented in the context of a systems biology view of joint diseases based on their histomorphological phenotype rather than on existing clinical classifications...
  14. doi request reprint Are current available therapies disease-modifying in spondyloarthritis?
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, Belgium
    Best Pract Res Clin Rheumatol 24:625-35. 2010
    ....
  15. doi request reprint The bone-cartilage unit in osteoarthritis
    Rik J Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Musculoskeletal Sciences, Division of Rheumatology, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Nat Rev Rheumatol 7:43-9. 2011
    ....
  16. doi request reprint The balance of tissue repair and remodeling in chronic arthritis
    Rik Lories
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Katholieke Universiteit Leuven, Herestraat 49, B3000 Leuven, Belgium
    Nat Rev Rheumatol 7:700-7. 2011
    ..For patients with AS or RA, such strategies will be critically dependent on further research that defines individual risk factors and need for interventions...
  17. doi request reprint Deletion of frizzled-related protein reduces voluntary running exercise performance in mice
    R J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    Osteoarthritis Cartilage 17:390-6. 2009
    ..To study the effect of frizzled-related protein (Frzb) deletion in mice on voluntary running wheel exercise performance and osteoarthritis...
  18. doi request reprint Joint homeostasis, restoration, and remodeling in osteoarthritis
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    Best Pract Res Clin Rheumatol 22:209-20. 2008
    ..Bone and cartilage form a biomechanical unit; stiffer bones might impair cartilage homeostasis. The biology of frizzled related protein provides a basis for the hypothesized inverse relationship between osteoarthritis and osteoporosis...
  19. doi request reprint Inhibition of osteoclasts does not prevent joint ankylosis in a mouse model of spondyloarthritis
    R J U Lories
    Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    Rheumatology (Oxford) 47:605-8. 2008
    ..We tested whether inhibition of bone erosion by targeting osteoclasts, would prevent or influence joint ankylosis in a mouse model...
  20. ncbi request reprint Animal models of spondyloarthritis
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, University Hospitals Leuven, Katholieke Universiteit Leuven, Belgium
    Curr Opin Rheumatol 18:342-6. 2006
    ..The aim of this article is to review new insights into spondyloarthritis obtained in animal models during the last year...
  21. pmc Ankylosing enthesitis, dactylitis, and onychoperiostitis in male DBA/1 mice: a model of psoriatic arthritis
    R J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Rheumatology, University Hospitals Leuven, Katholieke Universiteit Leuven, Belgium
    Ann Rheum Dis 63:595-8. 2004
    ..To further characterise spontaneous arthritis in aging male DBA/1 mice as a model of spondyloarthropathy and psoriatic arthritis with particular attention to signs of inflammation and nail involvement...
  22. ncbi request reprint Functional effects of susceptibility genes in osteoarthritis
    Frederique M F Cornelis
    Department of Musculoskeletal Sciences, K U Leuven, Leuven, Belgium
    Discov Med 12:129-39. 2011
    ....
  23. doi request reprint GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes
    Melina Daans
    Department of Musculoskeletal Sciences, Division of Rheumatology, Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, Leuven, Belgium
    Ann Rheum Dis 70:208-13. 2011
    ..The authors studied the potential mechanisms of GDF5 involvement in osteoarthritis using haploinsufficient Gdf5(Bp-J/+) mice...
  24. doi request reprint Detection, identification and in vivo treatment responsiveness of bone morphogenetic protein (BMP)-activated cell populations in the synovium of patients with rheumatoid arthritis
    P C P M Verschueren
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, Belgium
    Ann Rheum Dis 68:117-23. 2009
    ..To characterise the bone morphogenetic protein (BMP) target cells positive for phosphorylated (P)-SMAD1/5, in rheumatoid arthritis (RA) synovium...
  25. ncbi request reprint Absence of GDF5 does not interfere with LPS Toll-like receptor signaling
    M Daans
    Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Exp Rheumatol 27:495-8. 2009
    ..This may have consequences for immune responses and macrophage function in general, and for arthritis in particular. Here we compared the sensitivity of Gdf5(Bp-J/Bp-J) mice and wild type (WT) mice to LPS...
  26. ncbi request reprint Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis
    Rik J U Lories
    Katholieke Universiteit, Leuven, Belgium
    Arthritis Rheum 56:489-97. 2007
    ..To study the relationship between inflammation and remodeling by inhibiting tumor necrosis factor alpha (TNFalpha) in male DBA/1 mice with spontaneous arthritis, a model of spondylarthritis (SpA)...
  27. ncbi request reprint Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Rheumatology, University Hospitals Leuven, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    Arthritis Rheum 56:4095-103. 2007
    ..In particular, polymorphisms in the FRZB gene, a secreted WNT antagonist, have been associated with osteoarthritis. The aim of this study was to examine cartilage and bone in Frzb(-/-) mice...
  28. ncbi request reprint Contemporary concepts of inflammation, damage and repair in rheumatic diseases
    Frank P Luyten
    University Hospitals Leuven, Division of Rheumatology, Herestraat 49, B 3000 Leuven, Belgium
    Best Pract Res Clin Rheumatol 20:829-48. 2006
    ..Understanding the molecular networks of joint homeostasis, repair and remodelling will be required to achieve this goal. Defining and validating clinical outcomes evaluating remission remain a challenge...
  29. pmc Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Rheumatology, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 115:1571-9. 2005
    ..Our data suggest that BMP signaling is an attractive therapeutic target for interfering with structural changes in spondyloarthropathy either as an alternative or complementary approach to current antiinflammatory treatments...
  30. ncbi request reprint Noggin haploinsufficiency differentially affects tissue responses in destructive and remodeling arthritis
    Rik J U Lories
    University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Arthritis Rheum 54:1736-46. 2006
    ..We undertook this study to determine the effect of shifting the balance in bone morphogenetic protein (BMP) signaling in different mouse models of arthritis...
  31. ncbi request reprint The concept of a "synovio-entheseal complex" and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond
    Dennis McGonagle
    Academic Unit of Musculoskeletal Disease, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds, UK
    Arthritis Rheum 56:2482-91. 2007
  32. ncbi request reprint Mechanisms of pathologic new bone formation
    Kurt de Vlam
    University Hospitals Leuven, Division of Rheumatology, Herestraat 49, B 3000 Leuven, Belgium
    Curr Rheumatol Rep 8:332-7. 2006
    ..Indeed, new bone formation also occurs in diseases such as osteoarthritis and diffuse idiopathic skeletal hyperostosis. Therefore, therapeutic strategies in spondyloarthropathy ideally should control both inflammation and bone formation...
  33. ncbi request reprint Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis
    Rik J U Lories
    Katholieke Universiteit Leuven, Leuven, Belgium
    Arthritis Rheum 48:2807-18. 2003
    ..To examine the expression, regulation, and potential roles of bone morphogenetic proteins (BMPs) in arthritic synovium...