P J Lijnen

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi Proliferation of human peripheral blood mononuclear cells during calcium channel blockade
    P Lijnen
    Department of Molecular and Cardiovascular Research, KULeuven, Belgium
    Am J Hypertens 11:1461-8. 1998
  2. ncbi Stimulation of collagen gel contraction by angiotensin II and III in cardiac fibroblasts
    Paul Lijnen
    Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    J Renin Angiotensin Aldosterone Syst 3:160-6. 2002
  3. ncbi Transforming growth factor-beta 1 promotes contraction of collagen gel by cardiac fibroblasts through their differentiation into myofibroblasts
    P Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, K U Leuven, Belgium
    Methods Find Exp Clin Pharmacol 25:79-86. 2003
  4. ncbi Transforming growth factor-beta 1-mediated collagen gel contraction by cardiac fibroblasts
    Paul Lijnen
    Hypertension Unit, Campus Gasthuisberg, Leuven, B 3000, Belgium
    J Renin Angiotensin Aldosterone Syst 4:113-8. 2003
  5. ncbi Association between transforming growth factor-beta and hypertension
    Paul J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Am J Hypertens 16:604-11. 2003
  6. ncbi Role of intracardiac renin-angiotensin-aldosterone system in extracellular matrix remodeling
    P J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven K U Leuven, Belgium
    Methods Find Exp Clin Pharmacol 25:541-64. 2003
  7. ncbi Collagen production in cardiac fibroblasts during inhibition of angiotensin-converting enzyme and aminopeptidases
    Paul J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Catholic University of Leuven K U Leuven, Belgium
    J Hypertens 22:209-16. 2004
  8. ncbi Reversal of angiotensin II-stimulated collagen gel contraction in cardiac fibroblasts by aminopeptidase inhibition
    Paul J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Katholieke Universiteit Leuven, Leuven, Belgium
    J Cardiovasc Pharmacol 45:68-73. 2005
  9. ncbi Effect of bestatin on angiotensin I-, II- and III-induced collagen gel contraction in cardiac fibroblasts
    Paul Lijnen
    Hypertension Unit, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Renin Angiotensin Aldosterone Syst 5:183-8. 2004
  10. ncbi Collagen production in cardiac fibroblasts during inhibition of aminopeptidase B
    Paul J Lijnen
    Department of Cardiovascular Diseases, Katholoke Universiteit Leuven K U Leuven Belgium
    J Renin Angiotensin Aldosterone Syst 6:69-77. 2005

Detail Information

Publications26

  1. ncbi Proliferation of human peripheral blood mononuclear cells during calcium channel blockade
    P Lijnen
    Department of Molecular and Cardiovascular Research, KULeuven, Belgium
    Am J Hypertens 11:1461-8. 1998
    ....
  2. ncbi Stimulation of collagen gel contraction by angiotensin II and III in cardiac fibroblasts
    Paul Lijnen
    Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    J Renin Angiotensin Aldosterone Syst 3:160-6. 2002
    ....
  3. ncbi Transforming growth factor-beta 1 promotes contraction of collagen gel by cardiac fibroblasts through their differentiation into myofibroblasts
    P Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, K U Leuven, Belgium
    Methods Find Exp Clin Pharmacol 25:79-86. 2003
    ..Because contractile activity was correlated with differentiation, the influence of TGF-beta 1 on cardiac fibroblast-induced collagen gel contraction may depend on the promotion of myofibroblast differentiation...
  4. ncbi Transforming growth factor-beta 1-mediated collagen gel contraction by cardiac fibroblasts
    Paul Lijnen
    Hypertension Unit, Campus Gasthuisberg, Leuven, B 3000, Belgium
    J Renin Angiotensin Aldosterone Syst 4:113-8. 2003
    ..The aim of this study was to determine whether the ability of TGF-beta(1) to affect the contractile activity of cardiac fibroblasts depends on their differentiation into myofibroblasts...
  5. ncbi Association between transforming growth factor-beta and hypertension
    Paul J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
    Am J Hypertens 16:604-11. 2003
    ..A higher plasma TGF-beta(1) concentration is found in hypertensive patients with microalbuminuria and left ventricle hypertrophy. In these patients, AT(1)R antagonism and ACEI reduced these plasma TGF-beta(1) levels significantly...
  6. ncbi Role of intracardiac renin-angiotensin-aldosterone system in extracellular matrix remodeling
    P J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven K U Leuven, Belgium
    Methods Find Exp Clin Pharmacol 25:541-64. 2003
    ....
  7. ncbi Collagen production in cardiac fibroblasts during inhibition of angiotensin-converting enzyme and aminopeptidases
    Paul J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Catholic University of Leuven K U Leuven, Belgium
    J Hypertens 22:209-16. 2004
    ....
  8. ncbi Reversal of angiotensin II-stimulated collagen gel contraction in cardiac fibroblasts by aminopeptidase inhibition
    Paul J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Katholieke Universiteit Leuven, Leuven, Belgium
    J Cardiovasc Pharmacol 45:68-73. 2005
    ..Our data suggest that both alanine and arginine aminopeptidases are involved in the reversal of the angiotensin II-stimulated collagen gel contraction in control and TGF-beta1-treated cardiac fibroblasts or myofibroblasts...
  9. ncbi Effect of bestatin on angiotensin I-, II- and III-induced collagen gel contraction in cardiac fibroblasts
    Paul Lijnen
    Hypertension Unit, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Renin Angiotensin Aldosterone Syst 5:183-8. 2004
    ....
  10. ncbi Collagen production in cardiac fibroblasts during inhibition of aminopeptidase B
    Paul J Lijnen
    Department of Cardiovascular Diseases, Katholoke Universiteit Leuven K U Leuven Belgium
    J Renin Angiotensin Aldosterone Syst 6:69-77. 2005
    ..To determine whether the aminopeptidase B inhibitor, arphamenine A, could affect collagen production and expression in control and TGF-ss1-treated cardiac fibroblasts...
  11. ncbi Transforming growth factor-beta 1-induced collagen production in cultures of cardiac fibroblasts is the result of the appearance of myofibroblasts
    P Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Leuven, Belgium
    Methods Find Exp Clin Pharmacol 24:333-44. 2002
    ..Instead, TGF-beta 1 induces differentiation of fibroblasts to myofibroblasts, the latter having a higher activity for collagen production than the former...
  12. ncbi Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors
    P J Lijnen
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Leuven, Belgium
    J Renin Angiotensin Aldosterone Syst 2:117-22. 2001
    ....
  13. ncbi Induction of cardiac fibrosis by aldosterone
    P Lijnen
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Belgium
    J Mol Cell Cardiol 32:865-79. 2000
    ....
  14. ncbi Proliferation of human peripheral blood mononuclear cells during calcium entry blockade. Role of protein kinase C
    P Lijnen
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven KU Leuven, Belgium
    Methods Find Exp Clin Pharmacol 21:253-9. 1999
    ..Our data show that PBMC treated with the Ca2+ channel blockers nifedipine or mibefradil are still capable of proliferating in response to PMA. However, in PKC-depleted cells, the proliferative response of PBMC was suppressed...
  15. ncbi Antagonism of the renin-angiotensin system, hypertrophy and gene expression in cardiac myocytes
    P Lijnen
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven KU Leuven, Belgium
    Methods Find Exp Clin Pharmacol 21:363-74. 1999
    ..Angiotensin-converting enzyme inhibitors and AngII receptor antagonists of the subtype I not only induce the regression but also prevent the development of cardiac hypertrophy in experimental rat models...
  16. ncbi Induction of cardiac fibrosis by angiotensin II
    P J Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Leuven, Belgium
    Methods Find Exp Clin Pharmacol 22:709-23. 2000
    ..The ability of ANG II to induce collagen synthesis in cardiac fibroblasts may be mediated by increased TGF-beta 1 production...
  17. ncbi Effect of telmisartan on angiotensin II-mediated collagen gel contraction by adult rat cardiac fibroblasts
    P J Lijnen
    Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven Katholieke Universiteit Leuven, Belgium
    J Cardiovasc Pharmacol 38:39-48. 2001
    ....
  18. ncbi In vitro assay of collagen gel contraction by cardiac fibroblasts in serum-free conditions
    P Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Belgium
    Methods Find Exp Clin Pharmacol 23:377-82. 2001
    ..The presence of insulin-transferrin-selenium in the medium caused a more pronounced stimulation of the collagen gel contraction by cardiac fibroblasts, while sodium azide inhibited this contraction...
  19. ncbi Cytosolic calcium and lymphoproliferative response during calcium antagonism in men
    P Lijnen
    Department of Molecular and Cardiovascular Research, KU Leuven, Belgium
    Eur J Clin Pharmacol 54:911-5. 1999
    ....
  20. ncbi Long-term treatment with enalapril or losartan does not show antiproliferative effects in peripheral blood mononuclear cells
    V V Petrov
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven (K.U. Leuven, Belgium
    Methods Find Exp Clin Pharmacol 23:149-52. 2001
    ..Our data show that proliferation was not affected during angiotensin-converting enzyme inhibition with enalapril and angiotensin receptor type 1 antagonism with losartan...
  21. ncbi Arginine-aminopeptidase in rat cardiac fibroblastic cells participates in angiotensin peptide turnover
    V V Petrov
    Hypertension and Cardiovascular Rehabilitation Unit, Campus Gasthuisberg, Department of Molecular and Cardiovascular Research, University of Leuven KULeuven, Herestraat 49, Louvain 3000, Belgium
    Cardiovasc Res 61:724-35. 2004
    ..The aim of the present study was to elucidate the presence in rat cardiac fibroblastic cells of arginine-aminopeptidase and its involvement in the hydrolysis of angiotensin peptides...
  22. ncbi T-lymphocyte and plasma angiotensin-converting enzyme activity during enalapril and losartan administration in humans
    V V Petrov
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven (K.U. Leuven, Leuven, Belgium
    J Cardiovasc Pharmacol 38:578-83. 2001
    ..Angiotensin II receptor type 1 antagonism with losartan had no effect on plasma or lymphocytic angiotensin-converting enzyme...
  23. ncbi Angiotensin II-stimulated collagen production in cardiac fibroblasts is mediated by reactive oxygen species
    Paul Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven K U Leuven, Belgium
    J Hypertens 24:757-66. 2006
    ....
  24. ncbi Inhibition of superoxide dismutase induces collagen production in cardiac fibroblasts
    Paul Lijnen
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Hypertens 21:1129-36. 2008
    ..Its effect was compared with the SOD mimetics tempol and EUK-8 and with polyethyleneglycol (PEG)-SOD...
  25. ncbi TGF-beta1-induced cardiac myofibroblasts are nonproliferating functional cells carrying DNA damages
    Victor V Petrov
    Department of Heart Diseases, University of Leuven KULeuven, Leuven, Belgium
    Exp Cell Res 314:1480-94. 2008
    ..Despite carrying of the DNA damages TGF-beta1-activated MyoFbs are highly functional cells producing lysyl oxidase and contracting the collagen matrix...
  26. ncbi Stimulation of collagen production by transforming growth factor-beta1 during differentiation of cardiac fibroblasts to myofibroblasts
    Victor V Petrov
    Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, Faculty of Medicine, University of Leuven, Leuven, Belgium
    Hypertension 39:258-63. 2002
    ..Instead, TGF-beta(1) induces the differentiation of fibroblasts to myofibroblasts, which have a higher activity for collagen production than fibroblasts...